{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T09:23:42Z","timestamp":1794389022351,"version":"4.9.0"},"reference-count":238,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive physiological deterioration and increased vulnerability to death. Ageing has also been described as the primary risk factor of most neurodegenerative diseases, including Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), and frontotemporal lobar dementia (FTD). These neurodegenerative diseases occur more prevalently in the aged populations. Few effective treatments have been identified to treat these epidemic neurological crises. Neurodegenerative diseases are associated with enormous socioeconomic and personal costs. Here, the pathogenesis of AD, PD, and other neurodegenerative diseases has been presented, including a summary of their known associations with the biological hallmarks of ageing: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion, and altered intercellular communications. Understanding the central biological mechanisms that underlie ageing is important for identifying novel therapeutic targets for neurodegenerative diseases. Potential therapeutic strategies, including the use of NAD\n                    <jats:sup>+<\/jats:sup>\n                    precursors, mitophagy inducers, and inhibitors of cellular senescence, has also been discussed.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2021.683459","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T10:08:04Z","timestamp":1628849284000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":260,"title":["The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration"],"prefix":"10.3389","volume":"9","author":[{"given":"Shofiul","family":"Azam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ezazul","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengasamy","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Kug","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074244","article-title":"Prion protein accumulation in lipid rafts of mouse aging brain.","volume":"8","author":"Agostini","year":"2013","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.neuron.2009.12.016","article-title":"The transcellular spread of cytosolic amyloids, prions, and prionoids.","volume":"64","author":"Aguzzi","year":"2009","journal-title":"Neuron"},{"key":"B3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1750-3639.2002.tb00419.x","article-title":"The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer\u2019s disease.","volume":"12","author":"Aliev","year":"2002","journal-title":"Brain Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/imm.12134","article-title":"Innate and adaptive immune responses in neurodegeneration and repair.","volume":"141","author":"Amor","year":"2014","journal-title":"Immunology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/nan.12625","article-title":"TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis.","volume":"47","author":"Appleby-Mallinder","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01000","article-title":"Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling.","volume":"10","author":"Azam","year":"2019","journal-title":"Front. Immunol."},{"key":"B7","first-page":"109","article-title":"Metabolic stress and disorders related to alterations in mitochondrial fission or fusion.","volume":"5","author":"Babbar","year":"2013","journal-title":"Mol. Cell Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.molcel.2015.01.034","article-title":"Biology of poly(ADP-Ribose) polymerases: the factotums of cell maintenance.","volume":"58","author":"Bai","year":"2015","journal-title":"Mol. Cell."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.tem.2014.11.003","article-title":"Poly(ADP-ribose) polymerases as modulators of mitochondrial activity.","volume":"26","author":"Bai","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/jci95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives.","volume":"128","author":"Baker","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1212\/01.wnl.0000278116.37320.52","article-title":"Dietary patterns and risk of dementia: the Three-City cohort study.","volume":"69","author":"Barberger-Gateau","year":"2007","journal-title":"Neurology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/s0891-5849(02)00780-3","article-title":"Oxidatively modified proteins in aging and disease.","volume":"32","author":"Beal","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/ana.410420416","article-title":"Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.","volume":"42","author":"Beal","year":"1997","journal-title":"Ann. Neurol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s1474-4422(18)30394-6","article-title":"Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies.","volume":"18","author":"Beers","year":"2019","journal-title":"Lancet Neurol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease.","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.freeradbiomed.2016.08.010","article-title":"Investigating mitochondrial redox state using NADH and NADPH autofluorescence.","volume":"100","author":"Blacker","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11481-013-9435-y","article-title":"Neural and immune mechanisms in the pathogenesis of Parkinson\u2019s disease.","volume":"8","author":"Blandini","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1474-4422(19)30287-X","article-title":"The genetic architecture of Parkinson\u2019s disease.","volume":"19","author":"Blauwendraat","year":"2020","journal-title":"Lancet Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaneurol.2013.5847","article-title":"Amyloid-\u03b2 and tau: the trigger and bullet in Alzheimer disease pathogenesis.","volume":"71","author":"Bloom","year":"2014","journal-title":"JAMA Neurol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pneurobio.2015.07.003","article-title":"Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: examples of amyloidopathies, tauopathies and synucleinopathies.","volume":"155","author":"Bourdenx","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/bf00308809","article-title":"Neuropathological stageing of Alzheimer-related changes.","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease.","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: a focus on human studies.","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nn.3850","article-title":"Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.","volume":"17","author":"Brickman","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1523\/jneurosci.23-12-04858.2003","article-title":"Increased susceptibility of striatal mitochondria to calcium-induced permeability transition.","volume":"23","author":"Brustovetsky","year":"2003","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nn.4608","article-title":"Necroptosis activation in Alzheimer\u2019s disease.","volume":"20","author":"Caccamo","year":"","journal-title":"Nat. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/mp.2016.139","article-title":"p62 improves AD-like pathology by increasing autophagy.","volume":"22","author":"Caccamo","year":"","journal-title":"Mol. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.arr.2017.09.001","article-title":"Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.","volume":"40","author":"Calder","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"B30","first-page":"7","article-title":"Biology of healthy aging and longevity.","volume":"68","author":"Carmona","year":"2016","journal-title":"Rev. Invest. Clin."},{"key":"B31","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/nrn1806","article-title":"Normal huntingtin function: an alternative approach to Huntington\u2019s disease.","volume":"6","author":"Cattaneo","year":"2005","journal-title":"Nat. Rev. Nerosci."},{"key":"B32","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1667-1","article-title":"Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients.","volume":"17","author":"Celarain","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson\u2019s disease.","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055375","article-title":"Triggering of inflammasome by aggregated \u03b1-synuclein, an inflammatory response in synucleinopathies.","volume":"8","author":"Codolo","year":"2013","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/mds.25978","article-title":"Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.","volume":"29","author":"Cooper","year":"2014","journal-title":"Mov. Disord."},{"key":"B36","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.trci.2018.03.009","article-title":"Alzheimer\u2019s disease drug development pipeline: 2018.","volume":"4","author":"Cummings","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer\u2019s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1001\/jamaneurol.2013.4544","article-title":"Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study.","volume":"71","author":"Dean","year":"2014","journal-title":"JAMA Neurol."},{"key":"B39","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity.","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-associated microglia: a universal immune sensor of neurodegeneration.","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"9089","DOI":"10.1074\/jbc.m710012200","article-title":"Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.","volume":"283","author":"Devi","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death.","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","article-title":"Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC.","volume":"94","author":"Do Van","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1212\/01.wnl.0000341769.50075.bb","article-title":"Incidence and remaining lifetime risk of Parkinson disease in advanced age.","volume":"72","author":"Driver","year":"2009","journal-title":"Neurology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1093\/brain\/awx258","article-title":"PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer\u2019s disease.","volume":"140","author":"Du","year":"2017","journal-title":"Brain"},{"key":"B47","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/514S2a","article-title":"Molecular biology: remove, reuse, recycle.","volume":"514","author":"Eisenstein","year":"2014","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/jnen\/nlw002","article-title":"Altered proteins in the aging brain.","volume":"75","author":"Elobeid","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B49","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.cell.2016.03.022","article-title":"Whole-genome sequencing of a healthy aging cohort.","volume":"165","author":"Erikson","year":"2016","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1212\/wnl.0000000000006926","article-title":"Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.","volume":"92","author":"Espay","year":"2019","journal-title":"Neurology"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00476","article-title":"Epigenetic modifications in Alzheimer\u2019s neuropathology and therapeutics.","volume":"13","author":"Esposito","year":"2019","journal-title":"Front. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1007\/s11064-012-0799-9","article-title":"Neuroprotective effect of natural products against Alzheimer\u2019s disease.","volume":"37","author":"Essa","year":"2012","journal-title":"Neurochem. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"9461","DOI":"10.18632\/aging.103219","article-title":"Regulation of PGC-1\u03b1 mediated by acetylation and phosphorylation in MPP+ induced cell model of Parkinson\u2019s disease.","volume":"12","author":"Fan","year":"2020","journal-title":"Aging"},{"key":"B54","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease.","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.molmed.2017.08.001","article-title":"NAD(+) in aging: molecular mechanisms and translational implications.","volume":"23","author":"Fang","year":"2017","journal-title":"Trends Mol. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nrm.2016.14","article-title":"Nuclear DNA damage signalling to mitochondria in ageing.","volume":"17","author":"Fang","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.130","article-title":"A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.","volume":"6","author":"Fauster","year":"2015","journal-title":"Cell Death Dis."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101192","article-title":"The involvement of NLRP3 inflammasome in the treatment of Alzheimer\u2019s disease.","volume":"64","author":"Feng","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1523\/jneurosci.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington\u2019s disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry.","volume":"11","author":"Ferrante","year":"1991","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.3233\/JAD-161221","article-title":"The DNA damage response in neurons: die by apoptosis or survive in a senescence-like state?","volume":"60","author":"Fielder","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span\u2013from yeast to humans.","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"B62","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/gerona\/glw053","article-title":"Meta-analysis of telomere length in Alzheimer\u2019s disease.","volume":"71","author":"Forero","year":"2016","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B63","doi-asserted-by":"crossref","first-page":"813.e16","DOI":"10.1016\/j.neuron.2019.12.003","article-title":"Huntington\u2019s disease pathogenesis is modified in vivo by Alfy\/Wdfy3 and selective macroautophagy.","volume":"105","author":"Fox","year":"2020","journal-title":"Neuron"},{"key":"B64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s10522-015-9578-8","article-title":"Inflammaging decreases adaptive and innate immune responses in mice and humans.","volume":"17","author":"Frasca","year":"2016","journal-title":"Biogerontology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1093\/brain\/awp070","article-title":"The relation between inflammation and neurodegeneration in multiple sclerosis brains.","volume":"132","author":"Frischer","year":"2009","journal-title":"Brain"},{"key":"B66","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ."},{"key":"B67","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death 2012.","volume":"19","author":"Galluzzi","year":"2012","journal-title":"Cell Death. Differ."},{"key":"B68","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1515\/revneuro-2016-0035","article-title":"Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics.","volume":"30","author":"Gandhi","year":"2019","journal-title":"Rev. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1007\/s12035-018-1211-9","article-title":"The involvement of NLRP3 on the effects of minocycline in an AD-like pathology induced by \u03b2-amyloid oligomers administered to mice.","volume":"56","author":"Garcez","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B70","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2014.00044","article-title":"Prion protein and aging.","volume":"2","author":"Gasperini","year":"2014","journal-title":"Front. Cell Dev. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"808","DOI":"10.4161\/auto.23922","article-title":"Autophagy and senescence: a partnership in search of definition.","volume":"9","author":"Gewirtz","year":"2013","journal-title":"Autophagy"},{"key":"B72","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease.","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tins.2010.04.003","article-title":"The propagation of prion-like protein inclusions in neurodegenerative diseases.","volume":"33","author":"Goedert","year":"2010","journal-title":"Trends Neurosci."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice.","volume":"10","author":"Gordon","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003051","article-title":"Transcription elongation and tissue-specific somatic CAG instability.","volume":"8","author":"Goula","year":"2012","journal-title":"PLoS Genet."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1177\/1352458513516529","article-title":"Methylation differences at the HLA-DRB1 locus in CD4+ T-Cells are associated with multiple sclerosis.","volume":"20","author":"Graves","year":"2014","journal-title":"Mult. Scler."},{"key":"B77","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/313570","article-title":"Omega-3 fatty acids and depression: scientific evidence and biological mechanisms.","volume":"2014","author":"Grosso","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1016\/j.biocel.2004.04.020","article-title":"Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and \u2018aggresomes\u2019 during oxidative stress, aging, and disease.","volume":"36","author":"Grune","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00159","article-title":"Pathogenic mutations differentially regulate cell-to-cell transmission of \u03b1-synuclein.","volume":"14","author":"Guan","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuint.2017.01.004","article-title":"Ferroptosis and cell death mechanisms in Parkinson\u2019s disease.","volume":"104","author":"Guiney","year":"2017","journal-title":"Neurochem. Int."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1093\/hmg\/ddw180","article-title":"Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.","volume":"25","author":"Hadano","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B83","doi-asserted-by":"crossref","first-page":"253.e6","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes.","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"B84","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/mds.27874","article-title":"Targeting the microglial NLRP3 inflammasome and its role in Parkinson\u2019s disease.","volume":"35","author":"Haque","year":"2020","journal-title":"Mov. Disord."},{"key":"B85","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis.","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/ajcn\/25.8.839","article-title":"Free radical theory of aging: dietary implications.","volume":"25","author":"Harman","year":"1972","journal-title":"Am. J. Clin. Nutr."},{"key":"B87","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains.","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp. Cell Res."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.437","article-title":"Amyloid-\u03b2 1\u201342 oligomer accelerates senescence in adult hippocampal neural stem\/progenitor cells via formylpeptide receptor 2.","volume":"4","author":"He","year":"2013","journal-title":"Cell Death Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1515\/cclm-2017-0870","article-title":"Telomere biology and age-related diseases.","volume":"56","author":"Herrmann","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"key":"B90","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration.","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B91","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-020-00368-6","article-title":"Initiation and propagation of \u03b1-synuclein aggregation in the nervous system.","volume":"15","author":"Hijaz","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B92","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1126\/science.aaw2622","article-title":"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.","volume":"369","author":"Horowitz","year":"2020","journal-title":"Science"},{"key":"B93","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types.","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.18632\/aging.101005","article-title":"Huntington\u2019s disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels.","volume":"8","author":"Horvath","year":"2016","journal-title":"Aging"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.18632\/aging.100859","article-title":"Increased epigenetic age and granulocyte counts in the blood of Parkinson\u2019s disease patients.","volume":"7","author":"Horvath","year":"2015","journal-title":"Aging"},{"key":"B96","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease.","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jamaneurol.2019.3762","article-title":"Minocycline at 2 different dosages vs placebo for patients with mild Alzheimer disease: a randomized clinical trial.","volume":"77","author":"Howard","year":"2020","journal-title":"JAMA Neurol."},{"key":"B98","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-019-0609-7","article-title":"Clinical trials of new drugs for Alzheimer disease.","volume":"27","author":"Huang","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.amjcard.2015.03.060","article-title":"Leukocyte telomere length and coronary artery calcium.","volume":"116","author":"Hunt","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nn.3588","article-title":"Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains.","volume":"17","author":"Huynh","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrn.2017.46","article-title":"The emerging field of epigenetics in neurodegeneration and neuroprotection.","volume":"18","author":"Hwang","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00103","article-title":"Mitochondrial dysfunction in Huntington\u2019s disease; interplay between HSF1, p53 and PGC-1\u03b1 transcription factors.","volume":"13","author":"Intihar","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.pneurobio.2011.04.013","article-title":"DNA repair deficiency in neurodegeneration.","volume":"94","author":"Jeppesen","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/1947601910393957","article-title":"DNA methylation: superior or subordinate in the epigenetic hierarchy?","volume":"2","author":"Jin","year":"2011","journal-title":"Genes Cancer"},{"key":"B105","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway.","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057932","article-title":"Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.","volume":"8","author":"Jin","year":"2013","journal-title":"PLoS One"},{"key":"B107","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.","volume":"11","author":"Jurk","year":"2012","journal-title":"Aging Cell"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023367","article-title":"Autophagy impairment induces premature senescence in primary human fibroblasts.","volume":"6","author":"Kang","year":"2011","journal-title":"PLoS One"},{"key":"B109","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/ana.20476","article-title":"Fruit and vegetable consumption and cognitive decline in aging women.","volume":"57","author":"Kang","year":"2005","journal-title":"Ann. Neurol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"652","DOI":"10.18632\/aging.100069","article-title":"Serum markers of apoptosis decrease with age and cancer stage.","volume":"1","author":"Kavathia","year":"2009","journal-title":"Aging"},{"key":"B111","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms.","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1093\/hmg\/ddr091","article-title":"Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.","volume":"20","author":"Khandelwal","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nature23664","article-title":"Human iPS cell-derived dopaminergic neurons function in a primate Parkinson\u2019s disease model.","volume":"548","author":"Kikuchi","year":"2017","journal-title":"Nature"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1212\/01.wnl.0000160304.00003.ca","article-title":"The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.","volume":"64","author":"Kl\u00fcnemann","year":"2005","journal-title":"Neurology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration.","volume":"9","author":"Knott","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B116","doi-asserted-by":"crossref","DOI":"10.1038\/srep44373","article-title":"Nix restores mitophagy and mitochondrial function to protect against PINK1\/Parkin-related Parkinson\u2019s disease.","volume":"7","author":"Koentjoro","year":"2017","journal-title":"Sci. Rep."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19102937","article-title":"Ageing, cellular senescence and neurodegenerative disease.","volume":"19","author":"Kritsilis","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.physiol.67.040403.103635","article-title":"Molecular and evolutionary basis of the cellular stress response.","volume":"67","author":"K\u00fcltz","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s13353-014-0251-8","article-title":"Osteoarthritis and telomere shortening.","volume":"56","author":"Kuszel","year":"2015","journal-title":"J. Appl. Genet."},{"key":"B120","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"B121","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease.","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/j.freeradbiomed.2012.02.034","article-title":"p53 at the crossroads between cancer and neurodegeneration.","volume":"52","author":"Lanni","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mrfmmm.2014.12.011","article-title":"The impact of base excision DNA repair in age-related neurodegenerative diseases.","volume":"776","author":"Leandro","year":"2015","journal-title":"Mutat. Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature09299","article-title":"Enhancement of proteasome activity by a small-molecule inhibitor of USP14.","volume":"467","author":"Lee","year":"2010","journal-title":"Nature"},{"key":"B125","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5483\/BMBRep.2014.47.8.119","article-title":"Poly (ADP-ribose) in the pathogenesis of Parkinson\u2019s disease.","volume":"47","author":"Lee","year":"2014","journal-title":"BMB Rep."},{"key":"B126","doi-asserted-by":"publisher","first-page":"21479","DOI":"10.1074\/jbc.272.34.21479","article-title":"Blockade of glycosylation promotes acquisition of scrapie-like properties by the prion protein in cultured cells.","volume":"272","author":"Lehmann","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mito.2020.04.012","article-title":"The role of mitochondrial-related nuclear genes in age-related common disease.","volume":"53","author":"Li","year":"2020","journal-title":"Mitochondrion"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1084\/jem.20180139","article-title":"The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.","volume":"215","author":"Li","year":"2018","journal-title":"J. Exp. Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.nbd.2010.11.018","article-title":"Proteasomal dysfunction in aging and Huntington disease.","volume":"43","author":"Li","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.2174\/13895575111091222","article-title":"Polyphenols and neuroprotection against ischemia and neurodegeneration.","volume":"11","author":"Lin","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"key":"B131","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA.","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/nature08514","article-title":"Human DNA methylomes at base resolution show widespread epigenomic differences.","volume":"462","author":"Lister","year":"2009","journal-title":"Nature"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.427","article-title":"Pink1 interacts with \u03b1-synuclein and abrogates \u03b1-synuclein-induced neurotoxicity by activating autophagy.","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"B134","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.bbcan.2016.01.007","article-title":"Cellular senescence and tumor promotion: is aging the key?","volume":"1865","author":"Loaiza","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B135","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging.","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging.","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"B137","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nn.3792","article-title":"The epigenetic landscape of Alzheimer\u2019s disease.","volume":"17","author":"Lord","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B138","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18255-5","article-title":"DNA methylation study of Huntington\u2019s disease and motor progression in patients and in animal models.","volume":"11","author":"Lu","year":"2020","journal-title":"Nat. Commun."},{"key":"B139","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/b978-0-444-52001-2.00004-2","article-title":"Demyelination in multiple sclerosis.","volume":"122","author":"Lubetzki","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer\u2019s disease.","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020586","article-title":"Glial cell development and function in zebrafish.","volume":"7","author":"Lyons","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-e","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes.","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"B143","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.neuron.2014.06.034","article-title":"DNA damage and its links to neurodegeneration.","volume":"83","author":"Madabhushi","year":"2014","journal-title":"Neuron"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/brain\/awn105","article-title":"Mitochondrial defects in acute multiple sclerosis lesions.","volume":"131","author":"Mahad","year":"2008","journal-title":"Brain"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00098","article-title":"Therapeutic approaches targeting protein aggregation in amyotrophic lateral sclerosis.","volume":"13","author":"Malik","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"10","DOI":"10.4103\/1673-5374.125324","article-title":"Senescence in adipose-derived stem cells and its implications in nerve regeneration.","volume":"9","author":"Mantovani","year":"2014","journal-title":"Neural Regen. Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3945\/ajcn.114.092189","article-title":"Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study\u2013a randomized controlled trial.","volume":"101","author":"Mastroiacovo","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/glia.23002","article-title":"Microglia replenished OHSC: a culture system to study in vivo like adult microglia.","volume":"64","author":"Masuch","year":"2016","journal-title":"Glia"},{"key":"B149","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/acel.12468","article-title":"GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.","volume":"15","author":"Matteini","year":"2016","journal-title":"Aging Cell"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025130","article-title":"DNA damage, DNA repair, aging, and neurodegeneration.","volume":"5","author":"Maynard","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B151","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.neurobiolaging.2011.12.014","article-title":"Effects of \u03c9-3 fatty acids on cognitive performance: a meta-analysis.","volume":"33","author":"Mazereeuw","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B152","doi-asserted-by":"publisher","first-page":"5","DOI":"10.18632\/aging.101705","article-title":"ER stress links aging to sporadic ALS.","volume":"11","author":"Medinas","year":"2019","journal-title":"Aging"},{"key":"B153","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3233\/jpd-150543","article-title":"Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases.","volume":"5","author":"Melki","year":"2015","journal-title":"J. Parkinsons Dis."},{"key":"B154","doi-asserted-by":"publisher","first-page":"8266","DOI":"10.1523\/jneurosci.22-18-08266.2002","article-title":"Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington\u2019s disease knock-in mice.","volume":"22","author":"Menalled","year":"2002","journal-title":"J. Neurosci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1093\/brain\/awf167","article-title":"Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis.","volume":"125","author":"Menzies","year":"2002","journal-title":"Brain"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities.","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"B157","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/cdd.2014.151","article-title":"Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.","volume":"22","author":"Menzies","year":"2015","journal-title":"Cell Death Differ."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1084\/jem.20060028","article-title":"Reprogramming of CTLs into natural killer-like cells in celiac disease.","volume":"203","author":"Meresse","year":"2006","journal-title":"J. Exp. Med."},{"key":"B159","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s40266-015-0239-z","article-title":"Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer\u2019s disease: a systematic review and meta-analysis of treatment effect.","volume":"32","author":"Miguel-\u00c1lvarez","year":"2015","journal-title":"Drugs Aging"},{"key":"B160","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1017\/s0029665117004177","article-title":"Diet, nutrition and the ageing brain: current evidence and new directions.","volume":"77","author":"Moore","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"B161","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-017-0154-3","article-title":"Therapeutic potential of autophagy-enhancing agents in Parkinson\u2019s disease.","volume":"12","author":"Moors","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain.","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"key":"B163","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1111\/bph.12476","article-title":"Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?","volume":"171","author":"Muyderman","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41556-019-0287-4","article-title":"NAD(+) metabolism governs the proinflammatory senescence-associated secretome.","volume":"21","author":"Nacarelli","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1126\/science.1205407","article-title":"Spatial coupling of mTOR and autophagy augments secretory phenotypes.","volume":"332","author":"Narita","year":"2011","journal-title":"Science"},{"key":"B167","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1073\/pnas.1221292110","article-title":"Extensive changes in DNA methylation are associated with expression of mutant huntingtin.","volume":"110","author":"Ng","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B168","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/nm.3651","article-title":"Stem cell aging: mechanisms, regulators and therapeutic opportunities.","volume":"20","author":"Oh","year":"2014","journal-title":"Nat. Med."},{"key":"B169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.06741.x","article-title":"Nature and cause of mitochondrial dysfunction in Huntington\u2019s disease: focusing on huntingtin and the striatum.","volume":"114","author":"Oliveira","year":"2010","journal-title":"J. Neurochem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1021\/mp400624v","article-title":"Modulation of blood-brain barrier permeability in mice using synthetic E-cadherin peptide.","volume":"11","author":"On","year":"2014","journal-title":"Mol. Pharm."},{"key":"B171","doi-asserted-by":"crossref","first-page":"108.e6","DOI":"10.1016\/j.neuron.2017.11.036","article-title":"\u03b1-synuclein induces mitochondrial dysfunction through spectrin and the actin cytoskeleton.","volume":"97","author":"Ordonez","year":"2018","journal-title":"Neuron"},{"key":"B172","doi-asserted-by":"crossref","first-page":"E3945","DOI":"10.1073\/pnas.1309991110","article-title":"Polo-like kinase 2 regulates selective autophagic \u03b1-synuclein clearance and suppresses its toxicity in vivo.","volume":"110","author":"Oueslati","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17050685","article-title":"Connecting the dots: from DNA damage and repair to aging.","volume":"17","author":"Pan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington\u2019s disease are a direct effect of polyglutamines.","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"33927","DOI":"10.1074\/jbc.m114.608091","article-title":"The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-\u03b2 production and Tau hyperphosphorylation.","volume":"289","author":"Paris","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25153453","article-title":"Anti-apoptotic effects of carotenoids in neurodegeneration.","volume":"25","author":"Park","year":"2020","journal-title":"Molecules"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0152-8","article-title":"HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis.","volume":"50","author":"Park","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"B178","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease.","volume":"388","author":"Philip","year":"2016","journal-title":"Lancet"},{"key":"B179","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease.","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"B180","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease.","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B181","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease.","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"B182","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2174\/138161210789941793","article-title":"Mechanisms of tumor cell necrosis.","volume":"16","author":"Proskuryakov","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"B183","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration.","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"B184","article-title":"Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson\u2019s disease: evidence from observational studies.","volume":"11","author":"Rees","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"B185","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/454696","article-title":"Adult hippocampal neurogenesis in Parkinson\u2019s disease: impact on neuronal survival and plasticity.","volume":"2014","author":"Regensburger","year":"2014","journal-title":"Neural Plast."},{"key":"B186","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cmet.2017.07.019","article-title":"Regulation of stem cell aging by metabolism and epigenetics.","volume":"26","author":"Ren","year":"2017","journal-title":"Cell Metab."},{"key":"B187","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1586\/14737175.2015.986101","article-title":"Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols.","volume":"15","author":"Rigacci","year":"2015","journal-title":"Expert Rev. Neurother."},{"key":"B188","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1126\/science.1132813","article-title":"100 years and counting: prospects for defeating Alzheimer\u2019s disease.","volume":"314","author":"Roberson","year":"2006","journal-title":"Science"},{"key":"B189","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3233\/jad-2012-120862","article-title":"Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia.","volume":"32","author":"Roberts","year":"2012","journal-title":"J. Alzheimers. Dis."},{"key":"B190","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer\u2019s disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer\u2019s disease type 3 gene.","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"B191","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"B192","first-page":"587","article-title":"Developmental neuroplasticity and the origin of neurodegenerative diseases.","volume":"17","author":"Schaefers","year":"2016","journal-title":"World J. Biol. Psychiatry"},{"key":"B193","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12035-012-8282-9","article-title":"Effects of polyphenols on brain ageing and Alzheimer\u2019s disease: focus on mitochondria.","volume":"46","author":"Schaffer","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"653","DOI":"10.18632\/aging.100594","article-title":"Meta-analysis of genetic variants associated with human exceptional longevity.","volume":"5","author":"Sebastiani","year":"2013","journal-title":"Aging"},{"key":"B195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer\u2019s disease.","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"B196","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/cdd.2014.216","article-title":"Old, new and emerging functions of caspases.","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell Death Differ."},{"key":"B197","first-page":"754","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease.","volume":"375","author":"Sherrington","year":"1995","journal-title":"Funct. Neurol."},{"key":"B198","first-page":"3172","article-title":"Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson\u2019s disease.","volume":"26","author":"Shiba-Fukushima","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B199","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease.","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"B200","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity.","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"B201","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"key":"B202","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B203","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"B204","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/nar\/gku1356","article-title":"DNA polymerase \u03b2 deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.","volume":"43","author":"Sykora","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B205","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbamcr.2013.03.012","article-title":"Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy.","volume":"1843","author":"Tanaka","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B206","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.arr.2015.04.002","article-title":"Programmed cell death in aging.","volume":"23","author":"Tower","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"B207","year":"2018","journal-title":"Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) (NCT02588677) [Online]."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004511","article-title":"Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age.","volume":"10","author":"Vaidya","year":"2014","journal-title":"PLoS Genet."},{"key":"B209","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.arr.2016.08.004","article-title":"Anti-aging pharmacology: promises and pitfalls.","volume":"31","author":"Vaiserman","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1001\/jamainternmed.2015.1668","article-title":"Mediterranean diet and age-related cognitive decline: a randomized clinical trial.","volume":"175","author":"Valls-Pedret","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"B211","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00401-019-02026-8","article-title":"A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer\u2019s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.","volume":"138","author":"van der Lee","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12017-013-8219-0","article-title":"Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington\u2019s disease.","volume":"15","author":"Villar-Men\u00e9ndez","year":"2013","journal-title":"Neuromol. Med."},{"key":"B213","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.","volume":"20","author":"Villeda","year":"2014","journal-title":"Nat. Med."},{"key":"B214","doi-asserted-by":"publisher","first-page":"9119","DOI":"10.1523\/jneurosci.20-24-09119.2000","article-title":"Delaying caspase activation by Bcl-2: a clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis.","volume":"20","author":"Vukosavic","year":"2000","journal-title":"J. Neurosci."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1159\/000481753","article-title":"Edaravone attenuates the proinflammatory response in amyloid-\u03b2-treated microglia by inhibiting NLRP3 inflammasome-mediated IL-1\u03b2 secretion.","volume":"43","author":"Wang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B216","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s12035-014-9015-z","article-title":"Validating GWAS-identified risk loci for Alzheimer\u2019s disease in Han Chinese populations.","volume":"53","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease - insights from amyloid-\u03b2 metabolism beyond the brain.","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"B218","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1073\/pnas.1610099113","article-title":"Caspase-1 causes truncation and aggregation of the Parkinson\u2019s disease-associated protein \u03b1-synuclein.","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B219","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1093\/hmg\/ddx299","article-title":"Inhibition of mitochondrial fragmentation protects against Alzheimer\u2019s disease in rodent model.","volume":"26","author":"Wang","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B220","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances.","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B221","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease.","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"B222","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative stress and mitochondrial dysfunction in Alzheimer\u2019s disease.","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B223","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA base excision repair in brain from individuals with Alzheimer\u2019s disease and amnestic mild cognitive impairment.","volume":"35","author":"Weissman","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B224","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","article-title":"Mitochondrial dysfunction induces senescence with a distinct secretory phenotype.","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab."},{"key":"B225","article-title":"Adherence to Mediterranean diet and risk of developing cognitive disorders: an updated systematic review and meta-analysis of prospective cohort studies.","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"B226","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.465","article-title":"Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim.","volume":"8","author":"Wu","year":"2017","journal-title":"Cell Death Dis."},{"key":"B227","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation.","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"key":"B228","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.1021\/acschemneuro.9b00092","article-title":"Identification of a new \u03b1-synuclein aggregation inhibitor via mass spectrometry based screening.","volume":"10","author":"Xu","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"B229","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1080\/15548627.2018.1532258","article-title":"The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau).","volume":"15","author":"Xu","year":"2019","journal-title":"Autophagy"},{"key":"B230","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4.","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B231","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.1172\/jci130176","article-title":"Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.","volume":"130","author":"Ye","year":"2020","journal-title":"J. Clin. Invest."},{"key":"B232","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","article-title":"Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.","volume":"12","author":"Yoshida","year":"2006","journal-title":"CNS Drug Rev."},{"key":"B233","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/hmg\/ddr235","article-title":"The PINK1\/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons.","volume":"20","author":"Yu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B234","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress.","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B235","article-title":"Novel loci and pathways significantly associated with longevity.","volume":"6","author":"Zeng","year":"2016","journal-title":"Sci. Rep."},{"key":"B236","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00401-020-02131-z","article-title":"DNA methylation age acceleration is associated with ALS age of onset and survival.","volume":"139","author":"Zhang","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/glia.22903","article-title":"Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology.","volume":"64","author":"Zhang","year":"2016","journal-title":"Glia"},{"key":"B238","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.","volume":"112","author":"Zhu","year":"2015","journal-title":"PNAS"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.683459\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T05:22:36Z","timestamp":1699334556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.683459\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":238,"alternative-id":["10.3389\/fcell.2021.683459"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.683459","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"article-number":"683459"}}