{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:04:04Z","timestamp":1783807444306,"version":"3.55.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Intestinal fibrosis is one of the common pathophysiological processes in inflammatory bowel diseases (IBDs). Previously it has been demonstrated that epithelial-mesenchymal transition (EMT) can contribute to the development of intestinal fibrosis. Here we report that conditional ablation of SIRT1, a class III lysine deacetylase, in intestinal epithelial cells exacerbated 2, 4, 6-trinitro-benzene sulfonic acid (TNBS) induced intestinal fibrosis in mice. SIRT1 activity, but not SIRT1 expression, was down-regulated during EMT likely due to up-regulation of its inhibitor deleted in breast cancer 1 (DBC1). TGF-\u03b2 augmented the recruitment of KDM4A, a histone H3K9 demethylase, to the DBC1 promoter in cultured intestinal epithelial cells (IEC-6) leading to DBC1 <jats:italic>trans<\/jats:italic>-activation. KDM4A depletion or inhibition abrogated DBC1 induction by TGF-\u03b2 and normalized SIRT1 activity. In addition, KDM4A deficiency attenuated TGF-\u03b2 induced EMT in IEC-6 cells. In conclusion, our data identify a KDM4-DBC1-SIRT1 pathway that regulates EMT to contribute to intestinal fibrosis.<\/jats:p>","DOI":"10.3389\/fcell.2021.697614","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:45:28Z","timestamp":1632293128000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A KDM4-DBC1-SIRT1 Axis Contributes to TGF-b Induced Mesenchymal Transition of Intestinal Epithelial Cells"],"prefix":"10.3389","volume":"9","author":[{"given":"Baoyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghui","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrgastro.2015.34","article-title":"Epidemiology and risk factors for IBD.","volume":"12","author":"Ananthakrishnan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1093\/cvr\/cvy131","article-title":"Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2\/3 transactivation.","volume":"114","author":"Bugyei-Twum","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"B3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41389-020-00269-9","article-title":"Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion.","volume":"9","author":"Chen","year":"","journal-title":"Oncogenesis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"832","DOI":"10.3389\/fcell.2020.00832","article-title":"MKL1 mediates TGF-\u03b2 induced RhoJ transcription to promote breast cancer cell migration and invasion.","volume":"8","author":"Chen","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"774","DOI":"10.3389\/fcell.2020.00774","article-title":"BRG1 activates PR65A transcription to regulate NO bioavailability in vascular endothelial cell.","volume":"8","author":"Chen","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"617549","DOI":"10.3389\/fcell.2021.617549","article-title":"Activation of TCL transcription by lysine demethylase KDM4B in colorectal cancer cells.","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/1476-4598-13-254","article-title":"Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.","volume":"13","author":"Chen","year":"2014","journal-title":"Mol. Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"40830","DOI":"10.1074\/jbc.m110.153270","article-title":"HDAC3 is negatively regulated by the nuclear protein DBC1.","volume":"285","author":"Chini","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1042\/bj20121085","article-title":"DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbalpha.","volume":"451","author":"Chini","year":"2013","journal-title":"Biochem. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1002\/jcp.26302","article-title":"Narrower insight to SIRT1 role in cancer: a potential therapeutic target to control epithelial-mesenchymal transition in cancer cells.","volume":"233","author":"Choupani","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1165\/rcmb.2016-0192oc","article-title":"Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes.","volume":"58","author":"Chu","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"101718","DOI":"10.1016\/j.redox.2020.101718","article-title":"Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.","volume":"37","author":"Coarfa","year":"2020","journal-title":"Redox Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/nrgastro.2009.222","article-title":"Top-down therapy for IBD: rationale and requisite evidence.","volume":"7","author":"D\u2019Haens","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41575-019-0228-5","article-title":"Interrogating host immunity to predict treatment response in inflammatory bowel disease.","volume":"17","author":"Digby-Bell","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3389\/fcell.2020.00340","article-title":"Activation of TWIST transcription by chromatin remodeling protein BRG1 contributes to liver fibrosis in mice.","volume":"8","author":"Dong","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"617073","DOI":"10.3389\/fcell.2021.617073","article-title":"BRG1 links TLR4 trans-activation to LPS-induced SREBP1a expression and liver injury.","volume":"9","author":"Dong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fcell.2020.00259","article-title":"Brahma related gene 1 (Brg1) regulates cellular cholesterol synthesis by acting as a Co-factor for SREBP2.","volume":"8","author":"Fan","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.4049\/jimmunol.178.9.5859","article-title":"Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis.","volume":"178","author":"Fichtner-Feigl","year":"2007","journal-title":"J. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"20202","DOI":"10.1074\/jbc.m110.102012","article-title":"Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis.","volume":"285","author":"Flier","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"crossref","first-page":"E3246","DOI":"10.1073\/pnas.1421463112","article-title":"Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.","volume":"112","author":"Gao","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"88965","DOI":"10.18632\/oncotarget.21628","article-title":"SIRT1 promotes tumor-like invasion of fibroblast-like synoviocytes in rheumatoid arthritis via targeting TIMP1.","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"B22","doi-asserted-by":"publisher","first-page":"587502","DOI":"10.3389\/fcell.2020.587502","article-title":"BRG1 mediates nephronectin activation in hepatocytes to promote T lymphocyte infiltration in ConA-induced hepatitis.","volume":"8","author":"Hong","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2000157","DOI":"10.1002\/advs.202000157","article-title":"ATM-dependent recruitment of BRD7 is required for transcriptional repression and DNA repair at DNA breaks flanking transcriptional active regions.","volume":"7","author":"Hu","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/jcb.24748","article-title":"Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-beta\/Smad3 pathway.","volume":"115","author":"Huang","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.clim.2017.05.014","article-title":"Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction.","volume":"180","author":"Ishiguro","year":"2017","journal-title":"Clin. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"194507","DOI":"10.1016\/j.bbagrm.2020.194507","article-title":"Nuclear accumulation of MKL1 in luminal breast cancer cells impairs genomic activity of ERalpha and is associated with endocrine resistance.","volume":"1863","author":"Jehanno","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/jci39104","article-title":"The basics of epithelial-mesenchymal transition.","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025.","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B30","doi-asserted-by":"crossref","first-page":"14773","DOI":"10.1038\/ncomms14773","article-title":"Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.","volume":"8","author":"Kawamura","year":"2017","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41419-018-0899-9","article-title":"DBC1 regulates Wnt\/beta-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer.","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/nature06500","article-title":"DBC1 is a negative regulator of SIRT1.","volume":"451","author":"Kim","year":"2008","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"705302","DOI":"10.3389\/fcell.2021.705302","article-title":"Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration.","volume":"9","author":"Kong","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"622866","DOI":"10.3389\/fcell.2021.622866","article-title":"The chromatin remodeling protein BRG1 regulates SREBP maturation by activating SCAP transcription in hepatocytes.","volume":"9","author":"Kong","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B35","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition.","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3109\/00365521.2014.968863","article-title":"Mechanisms of initiation and progression of intestinal fibrosis in IBD.","volume":"50","author":"Latella","year":"2015","journal-title":"Scand. J. Gastroenterol."},{"key":"B37","first-page":"1491","article-title":"Cellular and molecular mediators of intestinal fibrosis.","volume":"11","author":"Lawrance","year":"2017","journal-title":"J. Crohns Colitis"},{"key":"B38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1440-1746.2010.06257.x","article-title":"Environmental risk factors in inflammatory bowel disease.","volume":"25","author":"Leong","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1097\/mib.0b013e3182a8452e","article-title":"Increased activation of latent TGF-beta1 by alphaVbeta3 in human Crohn\u2019s disease and fibrosis in TNBS colitis can be prevented by cilengitide.","volume":"19","author":"Li","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1096\/fj.201700612r","article-title":"SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.","volume":"32","author":"Li","year":"2018","journal-title":"FASEB J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.1016\/j.bbadis.2017.09.008","article-title":"Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.","volume":"1863","author":"Li","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"B42","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3389\/fcell.2020.00794","article-title":"Transcriptional activation of matricellular protein Spondin2 (SPON2) by BRG1 in vascular endothelial cells promotes macrophage chemotaxis.","volume":"8","author":"Li","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/hep.27049","article-title":"Novel role of nuclear receptor Rev-erbalpha in hepatic stellate cell activation: potential therapeutic target for liver injury.","volume":"59","author":"Li","year":"2014","journal-title":"Hepatology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2147\/ott.s137146","article-title":"SIRT1 overexpression protects non-small cell lung cancer cells against osteopontin-induced epithelial-mesenchymal transition by suppressing NF-kappaB signaling.","volume":"11","author":"Li","year":"2018","journal-title":"Onco Targets Ther."},{"key":"B45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41419-020-02744-y","article-title":"Dual roles of chromatin remodeling protein BRG1 in angiotensin II-induced endothelial-mesenchymal transition.","volume":"11","author":"Li","year":"","journal-title":"Cell Death Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3389\/fcell.2020.00569","article-title":"BRG1 stimulates endothelial derived alarmin MRP8 to promote macrophage infiltration in an animal model of cardiac hypertrophy.","volume":"8","author":"Li","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B47","doi-asserted-by":"crossref","first-page":"e2101957","DOI":"10.1002\/advs.202101957","article-title":"DDIT4 S-Nitrosylation Aids p38-MAPK signaling complex assembly to promote hepatic reactive oxygen species production.","volume":"15","author":"Li","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"B48","first-page":"cvab110","article-title":"Myocardin-related transcription factor A (MRTF-A) regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice.","author":"Liu","year":"","journal-title":"Cardiovasc. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"583492","DOI":"10.3389\/fcell.2021.583492","article-title":"Myeloid MKL1 disseminates cues to promote cardiac hypertrophy in mice.","volume":"9","author":"Liu","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e2731","DOI":"10.1038\/cddis.2017.107","article-title":"SRT1720 promotes survival of aged human mesenchymal stem cells via FAIM: a pharmacological strategy to improve stem cell-based therapy for rat myocardial infarction.","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/ecco-jcc\/jjy201","article-title":"Role of epithelial-to-mesenchymal transition in inflammatory bowel disease.","volume":"13","author":"Lovisa","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"B52","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3389\/fcell.2020.00176","article-title":"CDKN2a\/p16 antagonizes hepatic stellate cell activation and liver fibrosis by modulating ROS levels.","volume":"8","author":"Lv","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"101622","DOI":"10.1016\/j.redox.2020.101622","article-title":"KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism.","volume":"36","author":"Maity","year":"2020","journal-title":"Redox Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"194644","DOI":"10.1016\/j.bbagrm.2020.194644","article-title":"Identification of genome-wide targets and DNA recognition sequence of the Arabidopsis HMG-box protein AtHMGB15 during cold stress response.","volume":"1863","author":"Mallik","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B55","doi-asserted-by":"publisher","first-page":"101885","DOI":"10.1016\/j.redox.2021.101885","article-title":"Selective modulation by PARP-1 of HIF-1alpha-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions.","volume":"41","author":"Marti","year":"2021","journal-title":"Redox Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"194643","DOI":"10.1016\/j.bbagrm.2020.194643","article-title":"Hypoxia regulates allele-specific histone modification of the imprinted H19 gene.","volume":"1863","author":"Moon","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B57","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41419-021-04019-6","article-title":"The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury.","volume":"12","author":"Ning","year":"2021","journal-title":"Cell Death Dis."},{"key":"B58","doi-asserted-by":"crossref","first-page":"e2100753","DOI":"10.1002\/advs.202100753","article-title":"Yeast bromodomain factor 1 and its human homolog TAF1 play conserved roles in promoting homologous recombination.","volume":"8","author":"Peng","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"8943","DOI":"10.1093\/nar\/gkaa599","article-title":"Targeted DNA oxidation by LSD1-SMAD2\/3 primes TGF-beta1\/EMT genes for activation or repression.","volume":"48","author":"Pezone","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1124\/jpet.115.224386","article-title":"Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis.","volume":"354","author":"Ponnusamy","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B61","doi-asserted-by":"publisher","first-page":"194703","DOI":"10.1016\/j.bbagrm.2021.194703","article-title":"Tumor-specific overexpression of histone gene, H3C14 in gastric cancer is mediated through EGFR-FOXC1 axis.","volume":"1864","author":"Rashid","year":"2021","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B62","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nrgastro.2009.31","article-title":"Intestinal fibrosis in IBD\u2013a dynamic, multifactorial process.","volume":"6","author":"Rieder","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/gutjnl-2011-300498","article-title":"Interleukin-13 and transforming growth factor beta synergise in the pathogenesis of human intestinal fistulae.","volume":"62","author":"Scharl","year":"2013","journal-title":"Gut"},{"key":"B64","doi-asserted-by":"publisher","first-page":"194488","DOI":"10.1016\/j.bbagrm.2020.194488","article-title":"Activating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C\/EBPbeta to the upstream-promoter during ER stress.","volume":"1863","author":"Shen","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.celrep.2013.03.019","article-title":"SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.","volume":"3","author":"Simic","year":"2013","journal-title":"Cell Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.canlet.2017.09.001","article-title":"SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p.","volume":"409","author":"Sun","year":"2017","journal-title":"Cancer Lett."},{"key":"B67","doi-asserted-by":"publisher","first-page":"581692","DOI":"10.3389\/fcell.2020.581692","article-title":"Epigenetic regulation of a disintegrin and metalloproteinase (ADAM) promotes colorectal cancer cell migration and invasion.","volume":"8","author":"Sun","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"118508","DOI":"10.1016\/j.lfs.2020.118508","article-title":"KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt\/beta-catenin signaling pathway.","volume":"262","author":"Sun","year":"2020","journal-title":"Life Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3389\/fcell.2020.00605","article-title":"On-Target anti-TGF-beta therapies are not succeeding in clinical cancer treatments: what are remaining challenges?","volume":"8","author":"Teixeira","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B70","first-page":"393","article-title":"Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface.","volume":"30","author":"Valatas","year":"2017","journal-title":"Ann. Gastroenterol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"101479","DOI":"10.1016\/j.redox.2020.101479","article-title":"Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production.","volume":"32","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"key":"B72","doi-asserted-by":"crossref","first-page":"101319","DOI":"10.1016\/j.redox.2019.101319","article-title":"PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer.","volume":"28","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"key":"B73","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1038\/s41598-017-17496-7","article-title":"Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle.","volume":"7","author":"Welch","year":"2017","journal-title":"Sci. Rep."},{"key":"B74","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/00054725-200409000-00007","article-title":"Prevention of fibrosis in experimental colitis by captopril: the role of tgf-beta1.","volume":"10","author":"Wengrower","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation.","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"key":"B76","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3389\/fcell.2020.00839","article-title":"An MRTF-A-Sp1-PDE5 axis mediates angiotensin-II-induced cardiomyocyte hypertrophy.","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"591246","DOI":"10.3389\/fcell.2020.591246","article-title":"Epiregulin (EREG) and myocardin related transcription factor A (MRTF-A) form a feedforward loop to drive hepatic stellate cell activation.","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s00432-021-03510-z","article-title":"Resveratrol induces PD-L1 expression through snail-driven activation of Wnt pathway in lung cancer cells.","volume":"147","author":"Yang","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"165723","DOI":"10.1016\/j.bbadis.2020.165723","article-title":"Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.","volume":"1866","author":"Yang","year":"","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B80","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3389\/fcell.2020.00484","article-title":"An interplay between MRTF-A and the histone acetyltransferase TIP60 mediates hypoxia-reoxygenation induced iNOS transcription in macrophages.","volume":"8","author":"Yang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3389\/fphar.2017.00256","article-title":"SRT1720 alleviates ANIT-induced cholestasis in a mouse model.","volume":"8","author":"Yu","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1002\/mc.22898","article-title":"ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1.","volume":"57","author":"Yu","year":"2018","journal-title":"Mol. Carcinog."},{"key":"B83","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1083\/jcb.200809167","article-title":"A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.","volume":"185","author":"Yuan","year":"2009","journal-title":"J. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/annrheumdis-2014-205740","article-title":"Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis.","volume":"75","author":"Zerr","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B85","doi-asserted-by":"publisher","first-page":"194597","DOI":"10.1016\/j.bbagrm.2020.194597","article-title":"Sp4 controls constitutive expression of neuronal serine racemase and NF-E2-related factor-2 mediates its induction by valproic acid.","volume":"1863","author":"Zhang","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B86","doi-asserted-by":"publisher","first-page":"664375","DOI":"10.3389\/fcell.2021.664375","article-title":"The Jumonji domain-containing histone demethylase homolog 1D\/lysine demethylase 7A (JHDM1D\/KDM7A) is an epigenetic activator of RHOJ transcription in breast cancer cells.","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"2002680","DOI":"10.1002\/advs.202002680","article-title":"USP38 couples histone ubiquitination and methylation via KDM5B to resolve inflammation.","volume":"7","author":"Zhao","year":"2020","journal-title":"Adv. Sci. (Weinh)"},{"key":"B88","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bbrc.2008.08.137","article-title":"SIRTUIN 1: regulating the regulator.","volume":"376","author":"Zschoernig","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.697614\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:45:55Z","timestamp":1632293155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.697614\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":88,"alternative-id":["10.3389\/fcell.2021.697614"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.697614","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"article-number":"697614"}}