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Cell Dev. Biol."],"abstract":"<jats:p>Disrupted DNA damage signaling greatly threatens cell integrity and plays significant roles in cancer. With recent advances in understanding the human genome and gene regulation in the context of DNA damage, chromatin biology, specifically biology of histone post-translational modifications (PTMs), has emerged as a popular field of study with great promise for cancer therapeutics. Here, we discuss how key histone methylation pathways contribute to DNA damage repair and impact tumorigenesis within this context, as well as the potential for their targeting as part of therapeutic strategies in cancer.<\/jats:p>","DOI":"10.3389\/fcell.2021.735107","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T06:33:27Z","timestamp":1637044407000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Collateral Victim or Rescue Worker?\u2014The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer"],"prefix":"10.3389","volume":"9","author":[{"given":"Lishu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Lomberk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.canlet.2016.07.009","article-title":"G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.","volume":"380","author":"Agarwal","year":"2016","journal-title":"Cancer Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7931","DOI":"10.1093\/nar\/gkv722","article-title":"SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells.","volume":"43","author":"Alagoz","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1002\/bies.20085","article-title":"The PARP superfamily.","volume":"26","author":"Am\u00e9","year":"2004","journal-title":"BioEssays"},{"key":"B4","doi-asserted-by":"publisher","first-page":"17960","DOI":"10.1073\/pnas.1209814109","article-title":"Crystal structure of the human PRMT5:MEP50 complex.","volume":"109","author":"Antonysamy","year":"2012","journal-title":"Proc. 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