{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:52:37Z","timestamp":1770335557541,"version":"3.49.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology. Optic atrophy and hearing impairment are the most prevalent clinical features associated with mutations in the <jats:italic>OPA1<\/jats:italic> gene, but the function of OPA1 in hearing is still unknown. In this study, we examined the ability of Opa1 to protect against cisplatin-induced cochlear cell death <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Our results revealed that knockdown of <jats:italic>Opa1<\/jats:italic> affects mitochondrial function in HEI-OC1 and Neuro 2a cells, as evidenced by an elevated reactive oxygen species (ROS) level and reduced mitochondrial membrane potential. The dysfunctional mitochondria release cytochrome c, which triggers apoptosis. <jats:italic>Opa1<\/jats:italic> expression was found to be significantly reduced after cell exposed to cisplatin in HEI-OC1 and Neuro 2a cells. Loss of Opa1 aggravated the apoptosis and mitochondrial dysfunction induced by cisplatin treatment, whereas overexpression of <jats:italic>Opa1<\/jats:italic> alleviated cisplatin-induced cochlear cell death <jats:italic>in vitro<\/jats:italic> and <jats:italic>in explant<\/jats:italic>. Our results demonstrate that overexpression of <jats:italic>Opa1<\/jats:italic> prevented cisplatin-induced ototoxicity, suggesting that Opa1 may play a vital role in ototoxicity and\/or mitochondria-associated cochlear damage.<\/jats:p>","DOI":"10.3389\/fcell.2021.744838","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T06:17:52Z","timestamp":1632205072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae"],"prefix":"10.3389","volume":"9","author":[{"given":"Tingting","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haishuang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoru","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/sj.onc.1210220","article-title":"The Bcl-2 apoptotic switch in cancer development and therapy.","volume":"26","author":"Adams","year":"2007","journal-title":"Oncogene"},{"key":"B2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/brain\/awm298","article-title":"OPA1 mutations induce mitochondrial DNA instability and optic atrophy \u2018plus\u2019 phenotypes.","volume":"131","author":"Amati-Bonneau","year":"2008","journal-title":"Brain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00418-007-0321-7","article-title":"OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear.","volume":"128","author":"Bette","year":"2007","journal-title":"Histochem. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease.","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cell.2010.02.026","article-title":"Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.","volume":"141","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e003012","DOI":"10.1161\/JAHA.112.003012","article-title":"OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.","volume":"1","author":"Chen","year":"2012","journal-title":"J. Am. Heart Assoc."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2021.03.010","article-title":"Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice.","author":"Cheng","year":"2021","journal-title":"J. Genet. Genomics."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0135083","DOI":"10.1371\/journal.pone.0135083","article-title":"Mechanism of Cisplatin-Induced cytotoxicity is correlated to impaired metabolism due to mitochondrial ROS generation.","volume":"10","author":"Choi","year":"2015","journal-title":"PLoS One"},{"key":"B11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1055\/s-0043-100384","article-title":"OPA1 in lipid metabolism: function of OPA1 in Lipolysis and Thermogenesis of Adipocytes.","volume":"49","author":"Chu","year":"2017","journal-title":"Hormone Metab. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.spen.2017.06.001","article-title":"Dominant Optic Atrophy and Leber\u2019s hereditary optic neuropathy: update on clinical features and current therapeutic approaches.","volume":"24","author":"Chun","year":"2017","journal-title":"Semin. Pediatr. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion.","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.cmet.2015.04.016","article-title":"Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.","volume":"21","author":"Civiletto","year":"2015","journal-title":"Cell Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2467940","DOI":"10.1155\/2017\/2467940","article-title":"The roles of ROS in cancer heterogeneity and therapy.","volume":"2017","author":"de Sa Junior","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.phrs.2018.02.018","article-title":"OPA1: How much do we know to approach therapy?","volume":"131","author":"Del Dotto","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1016\/j.celrep.2017.05.073","article-title":"OPA1 isoforms in the hierarchical organization of mitochondrial functions.","volume":"19","author":"Del Dotto","year":"2017","journal-title":"Cell Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s00439-001-0633-y","article-title":"Mutation spectrum and splicing variants in the OPA1 gene.","volume":"109","author":"Delettre","year":"2001","journal-title":"Hum. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"614954","DOI":"10.3389\/fcell.2020.614954","article-title":"The Role of FoxG1 in the Inner Ear.","volume":"8","author":"Ding","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02422-w","article-title":"Deficiency of Klc2 induces low-frequency sensorineural hearing loss in C57BL\/6 J mice and human.","author":"Fu","year":"","journal-title":"Mol. Neurobiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"692762","DOI":"10.3389\/fncel.2021.692762","article-title":"Mechanism and prevention of ototoxicity induced by aminoglycosides.","volume":"15","author":"Fu","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3389\/fncel.2019.00590","article-title":"Blebbistatin inhibits neomycin-induced apoptosis in hair cell-like HEI-OC-1 cells and in cochlear hair cells.","volume":"13","author":"Gao","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.molmed.2019.08.002","article-title":"Cisplatin-induced ototoxicity: updates on molecular targets.","volume":"25","author":"Gentilin","year":"2019","journal-title":"Trends Mol. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuropharm.2018.10.021","article-title":"The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells.","volume":"144","author":"He","year":"2019","journal-title":"Neuropharmacology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1080\/15548627.2017.1359449","article-title":"Autophagy protects auditory hair cells against neomycin-induced damage.","volume":"13","author":"He","year":"2017","journal-title":"Autophagy"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1916194","article-title":"FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway.","author":"He","year":"2021","journal-title":"Autophagy."},{"key":"B29","doi-asserted-by":"publisher","first-page":"101364","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.","volume":"28","author":"He","year":"2020","journal-title":"Redox Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1146\/annurev.biochem.76.071905.090048","article-title":"The machines that divide and fuse mitochondria.","volume":"76","author":"Hoppins","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/brain\/awm272","article-title":"Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.","volume":"131","author":"Hudson","year":"2008","journal-title":"Brain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1007\/PL00000673","article-title":"Mitochondrial defects and hearing loss.","volume":"57","author":"Hutchin","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.1038\/sj.emboj.7601184","article-title":"Regulation of mitochondrial morphology through proteolytic cleavage of OPA1.","volume":"25","author":"Ishihara","year":"2006","journal-title":"EMBO J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.tcb.2012.10.006","article-title":"Mitochondrial dynamics in neurodegeneration.","volume":"23","author":"Itoh","year":"2013","journal-title":"Trends Cell Biol."},{"key":"B35","first-page":"1","article-title":"Infantile optic atrophy with dominant mode of inheritance: a clinical and genetic study of 19 Danish families.","volume":"164","author":"Kjer","year":"1959","journal-title":"Acta Ophthalmol. Suppl."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e236","DOI":"10.1093\/brain\/aws340","article-title":"Sensorineural hearing loss in OPA1-linked disorders.","volume":"136","author":"Leruez","year":"2013","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1080\/10717544.2018.1461277","article-title":"Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2.","volume":"25","author":"Li","year":"2018","journal-title":"Drug Deliv."},{"key":"B38","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fncel.2018.00139","article-title":"Meclofenamic acid reduces reactive oxygen species accumulation and apoptosis, inhibits excessive autophagy, and protects hair cell-Like HEI-OC1 cells from cisplatin-induced damage.","volume":"12","author":"Li","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e2362","DOI":"10.1038\/cddis.2016.246","article-title":"MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e2136","DOI":"10.1038\/cddis.2016.35","article-title":"Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea.","volume":"7","author":"Liu","year":"2016","journal-title":"Cell Death Dis."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1905466","article-title":"PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.","author":"Liu","year":"2021","journal-title":"Autophagy."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1089\/ars.2017.7288","article-title":"Wnt Signaling Activates TP53-induced glycolysis and apoptosis regulator and protects against cisplatin-induced spiral ganglion neuron damage in the mouse cochlea.","volume":"30","author":"Liu","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"B43","doi-asserted-by":"publisher","first-page":"eaav7803","DOI":"10.1126\/sciadv.aav7803","article-title":"Critical role of spectrin in hearing development and deafness.","volume":"5","author":"Liu","year":"2019","journal-title":"Sci. Adv."},{"key":"B44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.E12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"630361","DOI":"10.3389\/fcell.2021.630361","article-title":"Deletion of in mice does not alter auditory function.","volume":"9","author":"Lv","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/13816818509007861","article-title":"Dominant optic nerve atrophy with progressive hearing loss and chronic progressive external ophthalmoplegia (CPEO).","volume":"5","author":"Meire","year":"1985","journal-title":"Ophthalmic Paediatr. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/nrm3877","article-title":"Mitochondrial dynamics and inheritance during cell division, development and disease.","volume":"15","author":"Mishra","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.freeradbiomed.2011.11.001","article-title":"Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy.","volume":"52","author":"Mukhopadhyay","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s0014-5793(02)02985-x","article-title":"The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.","volume":"523","author":"Olichon","year":"2002","journal-title":"FEBS Lett."},{"key":"B50","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies.","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"B51","doi-asserted-by":"publisher","first-page":"27584","DOI":"10.1074\/jbc.M113.479873","article-title":"Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.","volume":"288","author":"Palmer","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.15252\/embj.201488349","article-title":"OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.","volume":"33","author":"Patten","year":"2014","journal-title":"EMBO J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.1038\/emboj.2011.365","article-title":"Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.","volume":"30","author":"Pidoux","year":"2011","journal-title":"EMBO J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41421-018-0076-4","article-title":"A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells.","volume":"5","author":"Qi","year":"2019","journal-title":"Cell Discov."},{"key":"B55","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3892\/mmr.2017.6627","article-title":"Hydrogen sulfide inhibits mitochondrial fission in neuroblastoma N2a cells through the Drp1\/ERK1\/2 signaling pathway.","volume":"16","author":"Qiao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death.","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"B57","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1620\/tjem.219.177","article-title":"Cisplatin ototoxicity and protection: clinical and experimental studies.","volume":"219","author":"Rybak","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"key":"B58","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.114.5.867","article-title":"Control of mitochondrial morphology by a human mitofusin.","volume":"114","author":"Santel","year":"2001","journal-title":"J. Cell Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1002\/ar.22578","article-title":"Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.","volume":"295","author":"Schacht","year":"2012","journal-title":"Anat. Rec."},{"key":"B60","doi-asserted-by":"publisher","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance.","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1101\/gad.1658508","article-title":"Mitochondrial dynamics and apoptosis.","volume":"22","author":"Suen","year":"2008","journal-title":"Genes Dev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.cmet.2017.04.021","article-title":"Age-Associated Loss of OPA1 in muscle impacts muscle mass, metabolic homeostasis, systemic inflammation, and epithelial senescence.","volume":"25","author":"Tezze","year":"2017","journal-title":"Cell Metab."},{"key":"B63","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/s0161-6420(84)34214-2","article-title":"Dominant optic atrophy, deafness, ptosis, ophthalmoplegia, dystaxia, and myopathy. A new syndrome.","volume":"91","author":"Treft","year":"1984","journal-title":"Ophthalmology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.mrrev.2015.01.001","article-title":"How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.","volume":"764","author":"van Gisbergen","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.cmet.2015.05.007","article-title":"The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage.","volume":"21","author":"Varanita","year":"2015","journal-title":"Cell Metab."},{"key":"B66","doi-asserted-by":"publisher","first-page":"aad0116","DOI":"10.1126\/science.aad0116","article-title":"Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.","volume":"350","author":"Wai","year":"2015","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs.","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1093\/brain\/awq218","article-title":"Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy.","volume":"133","author":"Williams","year":"2010","journal-title":"Brain"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1371\/journal.pgen.0040006","article-title":"The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.","volume":"4","author":"Yarosh","year":"2008","journal-title":"PLoS Genet."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00018-019-03291-2","article-title":"Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.","volume":"77","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3389\/fnmol.2019.00264","article-title":"Pre-treatment With Fasudil prevents neomycin-induced hair cell damage by reducing the accumulation of reactive oxygen Species.","volume":"12","author":"Zhang","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3389\/fcell.2020.00712","article-title":"Citicoline protects auditory hair cells against neomycin-induced damage.","volume":"8","author":"Zhong","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s41419-020-03110-8","article-title":"Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice.","volume":"11","author":"Zhou","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.744838\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T06:17:56Z","timestamp":1632205076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.744838\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,21]]},"references-count":73,"alternative-id":["10.3389\/fcell.2021.744838"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.744838","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,21]]},"article-number":"744838"}}