{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:02:48Z","timestamp":1769216568940,"version":"3.49.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC017741 DC014450 DC013774"],"award-info":[{"award-number":["DC017741 DC014450 DC013774"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA\/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1\u00a0week after noise exposure to determine if they correlated with acute changes in endolymph volume measured in the hours after the noise exposure. After 2\u00a0h of noise at an intensity of 95\u00a0dB SPL or below, both endolymph volume and synaptic counts remained normal. After exposure to 2\u00a0h of 100\u00a0dB SPL noise, mice developed endolymphatic hydrops and had reduced synaptic counts in the basal and middle regions of the cochlea. Furthermore, round-window application of hypertonic saline reduced the degree of endolymphatic hydrops that developed after 100\u00a0dB SPL noise exposure and partially prevented the reduction in synaptic counts in the cochlear base. Taken together, these results indicate that endolymphatic hydrops correlates with noise-induced cochlear synaptopathy, suggesting that these two pathologic findings have a common mechanistic basis.<\/jats:p>","DOI":"10.3389\/fcell.2021.747870","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:58:41Z","timestamp":1636099121000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure"],"prefix":"10.3389","volume":"9","author":[{"given":"Ido","family":"Badash","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.","family":"Qui\u00f1ones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Oghalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juemei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Macias-Escriva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian E.","family":"Applegate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Oghalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/00016487909126417","article-title":"Occupational Hearing LossThe Significance of Asymmetrical Hearing Thresholds","volume":"87","author":"Alberti","year":"1979","journal-title":"Acta Oto-Laryngologica."},{"key":"B2","doi-asserted-by":"publisher","first-page":"20743","DOI":"10.1073\/pnas.1908058116","article-title":"A Tmc1 Mutation Reduces Calcium Permeability and Expression of Mechanoelectrical Transduction Channels in Cochlear Hair Cells","volume":"116","author":"Beurg","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B68","first-page":"881e894","article-title":"Tinnitus and Auditory Perception After a History of Noise Exposure: Relationship to Auditory Brainstem Response Measures","volume":"39","author":"Bramhall","year":"2018","journal-title":"Ear Hear"},{"key":"B3","doi-asserted-by":"publisher","first-page":"858","DOI":"10.21037\/qims.2019.05.10","article-title":"Revealing the Morphology and Function of the Cochlea and Middle Ear with Optical Coherence Tomography","volume":"9","author":"Burwood","year":"2019","journal-title":"Quant. Imaging Med. Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.ne.13.030190.001131","article-title":"The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death","volume":"13","author":"Choi","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1523\/JNEUROSCI.2608-18.2019","article-title":"Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces","volume":"39","author":"Dewey","year":"2019","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1016\/j.celrep.2018.05.024","article-title":"Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea","volume":"23","author":"Dewey","year":"2018","journal-title":"Cel Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S1672-2930(09)50006-2","article-title":"Permeability of Round Window Membrane and its Role for Drug Delivery: Our Own Findings and Literature Review","volume":"4","author":"Duan","year":"2009","journal-title":"J. Otology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0378-5955(95)00158-1","article-title":"Quantitative Evaluation of Myelinated Nerve Fibres and Hair Cells in Cochleae of Humans with Age-Related High-Tone Hearing Loss","volume":"91","author":"Felder","year":"1995","journal-title":"Hearing Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpj.2016.05.032","article-title":"Is TMC1 the Hair Cell Mechanotransducer Channel?","volume":"111","author":"Fettiplace","year":"2016","journal-title":"Biophysical J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1152\/jn.00306.2014","article-title":"Vibration of the Organ of Corti within the Cochlear apex in Mice","volume":"112","author":"Gao","year":"2014","journal-title":"J. Neurophysiol."},{"key":"B11","volume-title":"Primer of Applied Regression and Analysis of Variance","author":"Glantz","year":"2016"},{"key":"B12","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/000164801300366552","article-title":"Clinical Aspects of Round Window Membrane Permeability under Normal and Pathological Conditions","volume":"121","author":"Goycoolea","year":"2001","journal-title":"Acta Oto-Laryngologica"},{"key":"B13","unstructured":"How Prism Computes Two-Way ANOVA2021"},{"key":"B14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuroscience.2018.12.019","article-title":"Acoustic Middle-Ear-Muscle-Reflex Thresholds in Humans with Normal Audiograms: No Relations to Tinnitus, Speech Perception in Noise, or Noise Exposure","volume":"407","author":"Guest","year":"","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.heares.2019.01.018","article-title":"Reliability and Interrelations of Seven Proxy Measures of Cochlear Synaptopathy","volume":"375","author":"Guest","year":"","journal-title":"Hearing Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is Noise-Induced Cochlear Neuropathy Key to the Generation of Hyperacusis or Tinnitus?","volume":"111","author":"Hickox","year":"2014","journal-title":"J. Neurophysiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1523\/JNEUROSCI.0782-16.2016","article-title":"Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK","volume":"36","author":"Hill","year":"2016","journal-title":"J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.1073\/pnas.1914247117","article-title":"Protection of Cochlear Synapses from Noise-Induced Excitotoxic Trauma by Blockade of Ca2+-Permeable AMPA Receptors","volume":"117","author":"Hu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e0125160","DOI":"10.1371\/journal.pone.0125160","article-title":"Immediate and Delayed Cochlear Neuropathy after Noise Exposure in Pubescent Mice","volume":"10","author":"Jensen","year":"2015","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1172\/JCI60405","article-title":"Mechanotransduction in Mouse Inner Ear Hair Cells Requires Transmembrane Channel-like Genes","volume":"121","author":"Kawashima","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"E4853","DOI":"10.1073\/pnas.1720121115","article-title":"Osmotic Stabilization Prevents Cochlear Synaptopathy after Blast Trauma","volume":"115","author":"Kim","year":"","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4434","DOI":"10.1523\/jneurosci.2228-18.2019","article-title":"Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses","volume":"39","author":"Kim","year":"","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1364\/BOE.10.004395","article-title":"Picometer Scale Vibrometry in the Human Middle Ear Using a Surgical Microscope Based Optical Coherence Tomography and Vibrometry System","volume":"10","author":"Kim","year":"","journal-title":"Biomed. Opt. Express"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1364\/OL.43.001966","article-title":"Endoscopic Optical Coherence Tomography Enables Morphological and Subnanometer Vibratory Imaging of the Porcine Cochlea through the Round Window","volume":"43","author":"Kim","year":"","journal-title":"Opt. Lett."},{"key":"B25","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1159\/000274693","article-title":"Membranous Hydrops in the Inner Ear of the guinea Pig after Obliteration of the Endolymphatic Sac","volume":"27","author":"Kimura","year":"1965","journal-title":"Orl"},{"key":"B26","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/jneurosci.2845-09.2009","article-title":"Adding Insult to Injury: Cochlear Nerve Degeneration after \"Temporary\" Noise-Induced Hearing Loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the Noise-Exposed and Aging Cochlea: Primary Neural Degeneration in Acquired Sensorineural Hearing Loss","volume":"330","author":"Kujawa","year":"2015","journal-title":"Hearing Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0121412","DOI":"10.1371\/journal.pone.0121412","article-title":"Unbalanced 2 X 2 Factorial Designs and the Interaction Effect: A Troublesome Combination","volume":"10","author":"Landsheer","year":"2015","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40463-017-0219-x","article-title":"Current Insights in Noise-Induced Hearing Loss: A Literature Review of the Underlying Mechanism, Pathophysiology, Asymmetry, and Management Options","volume":"46","author":"Le","year":"2017","journal-title":"J. Otolaryngol. - Head Neck Surg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.neuroscience.2019.11.004","article-title":"Early Detection of Endolymphatic Hydrops Using the Auditory Nerve Overlapped Waveform (ANOW)","volume":"425","author":"Lee","year":"2020","journal-title":"Neuroscience"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1073\/pnas.1500038112","article-title":"Noninvasive In Vivo Imaging Reveals Differences between Tectorial Membrane and Basilar Membrane Traveling Waves in the Mouse Cochlea","volume":"112","author":"Lee","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8160","DOI":"10.1523\/jneurosci.1157-16.2016","article-title":"Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti","volume":"36","author":"Lee","year":"2016","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10162-015-0510-3","article-title":"Dynamics of Cochlear Synaptopathy after Acoustic Overexposure","volume":"16","author":"Liberman","year":"2015","journal-title":"Jaro"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0162726","DOI":"10.1371\/journal.pone.0162726","article-title":"Toward a Differential Diagnosis of Hidden Hearing Loss in Humans","volume":"11","author":"Liberman","year":"2016","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.heares.2017.01.003","article-title":"Cochlear Synaptopathy in Acquired Sensorineural Hearing Loss: Manifestations and Mechanisms","volume":"349","author":"Liberman","year":"2017","journal-title":"Hearing Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/fnins.2017.00405","article-title":"The Auditory Nerve Overlapped Waveform (ANOW) Detects Small Endolymphatic Manipulations that May Go Undetected by Conventional Measurements","volume":"11","author":"Lichtenhan","year":"2017","journal-title":"Front. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s10162-011-0269-0","article-title":"Biophysical Mechanisms Underlying Outer Hair Cell Loss Associated with a Shortened Tectorial Membrane","volume":"12","author":"Liu","year":"2011","journal-title":"Jaro"},{"key":"B38","doi-asserted-by":"publisher","first-page":"5196","DOI":"10.1364\/boe.430935","article-title":"In Vivo functional Imaging of the Human Middle Ear with a Hand-Held Optical Coherence Tomography Device","volume":"12","author":"Lui","year":"2021","journal-title":"Biomed. Opt. Express"},{"key":"B39","doi-asserted-by":"publisher","first-page":"ENEURO.0078-16.2016","DOI":"10.1523\/ENEURO.0078-16.2016","article-title":"GluA2-Containing AMPA Receptors Distinguish Ribbon-Associated from Ribbonless Afferent Contacts on Rat Cochlear Hair Cells","volume":"3","author":"Martinez-Monedero","year":"2016","journal-title":"eNeuro"},{"key":"B40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0166-2236(87)90023-3","article-title":"Cellular Mechanisms Underlying Excitotoxicity","volume":"10","author":"Mayer","year":"1987","journal-title":"Trends Neurosciences"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.22.12.121715","article-title":"Clinical Translation of Handheld Optical Coherence Tomography: Practical Considerations and Recent Advancements","volume":"22","author":"Monroy","year":"2017","journal-title":"J. Biomed. Opt."},{"key":"B42","doi-asserted-by":"publisher","first-page":"53561","DOI":"10.3791\/53561","article-title":"Whole Mount Dissection and Immunofluorescence of the Adult Mouse Cochlea","volume":"107","author":"Montgomery","year":"2016","journal-title":"JoVE"},{"key":"B43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.heares.2004.08.011","article-title":"A Physiological Place-Frequency Map of the Cochlea in the CBA\/J Mouse","volume":"202","author":"M\u00fcller","year":"2005","journal-title":"Hearing Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/00003446-199312000-00008","article-title":"Reduced Variance in the Latency and Amplitude of the Fifth Wave of Auditory Brain Stem Response after Normalization for Head Size","volume":"14","author":"Nikiforidis","year":"1993","journal-title":"Ear and Hearing"},{"key":"B45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fncel.2019.00261","article-title":"Inner Ear Therapeutics: An Overview of Middle Ear Delivery","volume":"13","author":"Patel","year":"2019","journal-title":"Front. Cel. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.heares.2017.10.007","article-title":"Effects of Noise Exposure on Young Adults with Normal Audiograms II: Behavioral Measures","volume":"356","author":"Prendergast","year":"2017","journal-title":"Hearing Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1097\/00001756-199806220-00037","article-title":"Excitotoxicity and Repair of Cochlear Synapses after Noise-Trauma Induced Hearing Loss","volume":"9","author":"Puel","year":"1998","journal-title":"Neuroreport"},{"key":"B48","doi-asserted-by":"publisher","first-page":"330","DOI":"10.3109\/00016489309135819","article-title":"Pathophysiology of the Glutamatergic Synapses in the Cochlea","volume":"113","author":"Pujol","year":"1993","journal-title":"Acta Oto-Laryngologica"},{"key":"B49","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1749-6632.1999.tb08646.x","article-title":"Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings","volume":"884","author":"Pujol","year":"1999","journal-title":"Ann. N. Y Acad. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"14972","DOI":"10.1523\/JNEUROSCI.4028-10.2010","article-title":"Ringing Ears: The Neuroscience of Tinnitus","volume":"30","author":"Roberts","year":"2010","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0378-5955(83)90031-x","article-title":"Functional Significance of Dendritic Swelling after Loud Sounds in the Guinea Pig Cochlea","volume":"9","author":"Robertson","year":"1983","journal-title":"Hearing Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.otc.2010.05.007","article-title":"Endolymphatic Hydrops: Pathophysiology and Experimental Models","volume":"43","author":"Salt","year":"2010","journal-title":"Otolaryngologic Clin. North America"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0378-5955(01)00224-6","article-title":"Differential Vulnerability of Basal and Apical Hair Cells Is Based on Intrinsic Susceptibility to Free Radicals","volume":"155","author":"Sha","year":"2001","journal-title":"Hearing Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3109\/00016487109125346","article-title":"Primary Structural Changes in the Organ of Corti after Acoustic Overstimulation","volume":"71","author":"Spoendlin","year":"1971","journal-title":"Acta Oto-Laryngologica"},{"key":"B55","doi-asserted-by":"publisher","first-page":"24907","DOI":"10.1038\/srep24907","article-title":"Round-Window Delivery of Neurotrophin 3 Regenerates Cochlear Synapses after Acoustic Overexposure","volume":"6","author":"Suzuki","year":"2016","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"108099","DOI":"10.1016\/j.heares.2020.108099","article-title":"Is Cochlear Synapse Loss an Origin of Low-Frequency Hearing Loss Associated with Endolymphatic Hydrops?","volume":"398","author":"Valenzuela","year":"2020","journal-title":"Hearing Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.heares.2017.07.003","article-title":"Noise-induced Cochlear Synaptopathy in Rhesus Monkeys ( Macaca mulatta )","volume":"353","author":"Valero","year":"2017","journal-title":"Hearing Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.heares.2018.03.012","article-title":"Effects of Cochlear Synaptopathy on Middle-Ear Muscle Reflexes in Unanesthetized Mice","volume":"363","author":"Valero","year":"2018","journal-title":"Hearing Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.heares.2015.04.014","article-title":"Cochlear Neuropathy in Human Presbycusis: Confocal Analysis of Hidden Hearing Loss in post-mortem Tissue","volume":"327","author":"Viana","year":"2015","journal-title":"Hearing Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2004.04.016","article-title":"The Guide to Plotting a Cochleogram","volume":"197","author":"Viberg","year":"2004","journal-title":"Hearing Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0378-5955(02)00279-4","article-title":"K+ Cycling and the Endocochlear Potential","volume":"165","author":"Wangemann","year":"2002","journal-title":"Hearing Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"ENEURO.0363-17.2017","DOI":"10.1523\/ENEURO.0363-17.2017","article-title":"Weak Middle-Ear-Muscle Reflex in Humans with Noise-Induced Tinnitus and Normal Hearing May Reflect Cochlear Synaptopathy","volume":"4","author":"Wojtczak","year":"2017","journal-title":"eNeuro"},{"key":"B63","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10162-020-00777-w","article-title":"Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea","volume":"22","author":"Wood","year":"2021","journal-title":"Jaro"},{"key":"B64","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1242\/dmm.004135","article-title":"Deficient Forward Transduction and Enhanced Reverse Transduction in the Alpha Tectorin C1509G Human Hearing Loss Mutation","volume":"3","author":"Xia","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e82602","DOI":"10.1371\/journal.pone.0082602","article-title":"Prestin Regulation and Function in Residual Outer Hair Cells after Noise-Induced Hearing Loss","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1152\/physiol.00018.2009","article-title":"Potassium Ion Movement in the Inner Ear: Insights from Genetic Disease and Mouse Models","volume":"24","author":"Zdebik","year":"2009","journal-title":"Physiology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s42003-020-01532-w","article-title":"Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration","volume":"4","author":"Zhao","year":"2021","journal-title":"Commun. Biol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.747870\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T07:58:48Z","timestamp":1636099128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.747870\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":68,"alternative-id":["10.3389\/fcell.2021.747870"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.747870","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"article-number":"747870"}}