{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:55Z","timestamp":1787237215640,"version":"build-2736575974"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba\n                    <jats:italic>Dictyostelium discoideum<\/jats:italic>\n                    is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologs of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi Anemia DNA inter-strand crosslink and DNA strand break repair pathways. Loss of function of these not only results in malignancy, but also neurodegeneration, immune-deficiencies and congenital abnormalities. Additionally,\n                    <jats:italic>D. discoideum<\/jats:italic>\n                    displays remarkable conservations of DNA repair factors that are targets in cancer and other therapies, including poly(ADP-ribose) polymerases that are targeted to treat breast and ovarian cancers. This, taken together with the genetic tractability of\n                    <jats:italic>D. discoideum<\/jats:italic>\n                    , make it an attractive model to assess the mechanistic basis of DNA repair to provide novel insights into how these pathways can be targeted to treat a variety of pathologies. Here we describe progress in understanding the mechanisms of DNA repair in\n                    <jats:italic>D. discoideum<\/jats:italic>\n                    , and how these impact on genome stability with implications for understanding development of malignancy.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2021.752175","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:35:29Z","timestamp":1633739729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair"],"prefix":"10.3389","volume":"9","author":[{"given":"Catherine J.","family":"Pears","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Brustel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Lakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.molcel.2010.06.026","article-title":"Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.","volume":"39","author":"Adamo","year":"2010","journal-title":"Mol. 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