{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:56:39Z","timestamp":1792202199670,"version":"4.4.0"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Somitogenesis refers to the segmentation of the paraxial mesoderm, a tissue located on the back of the embryo, into regularly spaced and sized pieces, i.e., the somites. This periodicity is important to assure, for example, the formation of a functional vertebral column. Prevailing models of somitogenesis are based on the existence of a gene regulatory network capable of generating a striped pattern of gene expression, which is subsequently translated into periodic tissue boundaries. An alternative view is that the pre-pattern that guides somitogenesis is not chemical, but of a mechanical origin. A striped pattern of mechanical strain can be formed in physically connected tissues expanding at different rates, as it occurs in the embryo. Here we argue that both molecular and mechanical cues could drive somite periodicity and suggest how they could be integrated.<\/jats:p>","DOI":"10.3389\/fcell.2021.753446","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T09:16:59Z","timestamp":1638350219000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular and Mechanical Cues for Somite Periodicity"],"prefix":"10.3389","volume":"9","author":[{"given":"Marta","family":"Linde-Medina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoor H.","family":"Smit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102317","article-title":"A mechanical model of early somite segmentation.","volume":"24","author":"Adhyapok","year":"2021","journal-title":"iScience."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1242\/dev.098905","article-title":"An anterior limit of FGF\/Erk signal activity marks the earliest future somite boundary in zebrafish.","volume":"141","author":"Akiyama","year":"2014","journal-title":"Development"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.105.208001","article-title":"Softening induced instability of a stretched cohesive granular layer.","volume":"105","author":"Alarc\u00f3n","year":"2010","journal-title":"Phys. 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