{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:00:00Z","timestamp":1770958800387,"version":"3.50.1"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671518"],"award-info":[{"award-number":["31671518"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Attractin (ATRN) is a widely expressed glycoprotein that is involved in energy homeostasis, neurodevelopment, and immune response. It is encoded by a gene spanning 180 kb on chromosome 20p13, a region previously implicated in schizophrenia by linkage studies. To address a possible role of <jats:italic>ATRN<\/jats:italic> in disorders of the central nervous system, we created an <jats:italic>atrn<\/jats:italic> knockout zebrafish line and performed behavioral tests. Adult <jats:italic>atrn<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> zebrafish exhibited more pronounced attack behavior relative to wild-type control zebrafish in a tracking analysis. Biochemical analysis revealed elevated testosterone levels in <jats:italic>atrn<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> zebrafish. At the gene expression level, we noted an upregulation of <jats:italic>cyp51<\/jats:italic> and <jats:italic>hsd17b7<\/jats:italic>, key proteins in testosterone synthesis in the brains of both adult and larvae of <jats:italic>atrn<jats:sup>\u2013\/\u2013<\/jats:sup><\/jats:italic> zebrafish. In order to further elucidate the relationship between testosterone and behavioral syndromes, we then compared testosterone levels of 9,008 psychiatric patients and 247 healthy controls from the same catchment area. Of all subjects examined, male subjects with schizophrenia exhibited lower testosterone levels compared with controls. In contrast, female subjects with a diagnosis of schizophrenia or bipolar disorder featured higher testosterone levels than did same sex controls. Purposeful sampling of extreme groups showed reduced <jats:italic>ATRN<\/jats:italic> expression in a subset of these subjects. Finally, we identified 14 subjects with <jats:italic>ATRN<\/jats:italic> mutations. All of whom displayed abnormal testosterone levels. In summary, the interplay of <jats:italic>ATRN<\/jats:italic> and testosterone may help to explain sexual dimorphisms in selected behavioral phenotypes.<\/jats:p>","DOI":"10.3389\/fcell.2021.755165","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T08:54:26Z","timestamp":1636620866000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Attractin Participates in Schizophrenia by Affecting Testosterone Levels"],"prefix":"10.3389","volume":"9","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijie","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqingqing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Stone","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.psyneuen.2003.11.002","article-title":"One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men.","volume":"29","author":"Almeida","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1081\/rrs-120014588","article-title":"Genetic and biochemical studies of the Agouti-attractin system.","volume":"22","author":"Barsh","year":"2002","journal-title":"J. Recept. Signal. Transduct. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1530\/acta.0.1200579","article-title":"Lack of correlation of serum estradiol with growth velocity during male pubertal growth.","volume":"120","author":"Belgorosky","year":"1989","journal-title":"Acta Endocrinol. (Copenh)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.jcyt.2018.06.011","article-title":"Pericytes reduce inflammation and collagen deposition in acute wounds.","volume":"20","author":"Bodnar","year":"2018","journal-title":"Cytotherapy"},{"key":"B5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1515\/RNS.2011.006","article-title":"Zebrafish behavioural assays of translational relevance for the study of psychiatric disease.","volume":"22","author":"Brennan","year":"2011","journal-title":"Rev. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1038\/nprot.2010.140","article-title":"Measuring behavioral and endocrine responses to novelty stress in adult zebrafish.","volume":"5","author":"Cachat","year":"2010","journal-title":"Nat. Protoc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1523\/JNEUROSCI.2706-18.2019","article-title":"Regeneration of dopaminergic neurons in adult zebrafish depends on immune system activation and differs for distinct populations.","volume":"39","author":"Caldwell","year":"2019","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.coemr.2019.03.002","article-title":"Origin and regulation of stem Leydig cells in the adult testis.","volume":"6","author":"Chen","year":"2019","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s11596-014-1346-5","article-title":"Expression of Attractin in male reproductive tract of human and mice and its correlation with male reproduction.","volume":"34","author":"Cheng","year":"2014","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.67","article-title":"Mechanisms of estradiol in fear circuitry: implications for sex differences in psychopathology.","volume":"4","author":"Cover","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.psyneuen.2008.11.007","article-title":"Amygdala activity to fear and anger in healthy young males is associated with testosterone.","volume":"34","author":"Derntl","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"11336","DOI":"10.1073\/pnas.95.19.11336","article-title":"Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions.","volume":"95","author":"Duke-Cohan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/13651501.2019.1680696","article-title":"Serum testosterone levels in bipolar and unipolar depressed female patients and the role of medication status.","volume":"24","author":"Flores-Ramos","year":"2020","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"B14","first-page":"8","article-title":"Effect of resveratrol on the testosterone production of mouse primary Leydig cell culture","author":"Forgacs","year":"2005","journal-title":"Proceedings of the 6th Slovak Conference of Animal Physiology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.yhbeh.2016.10.002","article-title":"Effects of competition outcome on testosterone concentrations in humans: an updated meta-analysis.","volume":"92","author":"Geniole","year":"2017","journal-title":"Horm. Behav."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101593","article-title":"Characterization of stem cells associated with seminiferous tubule of adult rat testis for their potential to form Leydig cells.","volume":"41","author":"Guan","year":"2019","journal-title":"Stem Cell Res."},{"key":"B17","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/genetics\/158.4.1683","article-title":"Molecular and phenotypic analysis of Attractin mutant mice.","volume":"158","author":"Gunn","year":"2001","journal-title":"Genetics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ymeth.2018.06.008","article-title":"Morphometric analysis and neuroanatomical mapping of the zebrafish brain.","volume":"150","author":"Gupta","year":"2018","journal-title":"Methods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1128\/mcb.24.7.2593-2604.2004","article-title":"Molecular mechanism of suppression of testicular steroidogenesis by proinflammatory cytokine tumor necrosis factor alpha.","volume":"24","author":"Hong","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1007\/s12031-020-01739-w","article-title":"Serum progesterone and testosterone levels in schizophrenia patients at different stages of treatment.","volume":"71","author":"Huang","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.brainres.2009.11.027","article-title":"Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat.","volume":"1312","author":"Izawa","year":"2010","journal-title":"Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.bbr.2014.05.055","article-title":"Using zebrafish to uncover the genetic and neural basis of aggression, a frequent comorbid symptom of psychiatric disorders.","volume":"276","author":"Jones","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4086","DOI":"10.1182\/blood-2007-03-080457","article-title":"Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.","volume":"110","author":"Kantari","year":"2007","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"6331","DOI":"10.1158\/1078-0432.CCR-06-1296","article-title":"Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration.","volume":"12","author":"Khwaja","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2016.10.044","article-title":"CRISPR-based technologies for the manipulation of eukaryotic genomes.","volume":"168","author":"Komor","year":"2017","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/bs.ctdb.2019.02.004","article-title":"Genetic regulation of sex determination and maintenance in zebrafish (Danio rerio).","volume":"134","author":"Kossack","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00335-001-2116-9","article-title":"Insertional mutation of the Attractin gene in the black tremor hamster.","volume":"13","author":"Kuramoto","year":"2002","journal-title":"Mamm. Genome"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1097\/01.lab.0000032375.70196.26","article-title":"The myelin vacuolation (mv) rat with a null mutation in the attractin gene.","volume":"82","author":"Kuwamura","year":"2002","journal-title":"Lab. Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s2215-0366(16)30358-3","article-title":"Why are women so vulnerable to anxiety, trauma-related and stress-related disorders? The potential role of sex hormones.","volume":"4","author":"Li","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/s0140-6736(09)60072-6","article-title":"Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study.","volume":"373","author":"Lichtenstein","year":"2009","journal-title":"Lancet"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0204-x","article-title":"CRISPR\/Cas9-induced shank3b mutant zebrafish display autism-like behaviors.","volume":"9","author":"Liu","year":"2018","journal-title":"Mol. Autism"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101545","article-title":"Zebrafish male differentiation: do all testes go through a \u201cjuvenile ovary\u201d stage?","volume":"72","author":"Luzio","year":"2021","journal-title":"Tissue Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-genom-090314-050048","article-title":"Addressing the genetics of human mental health disorders in model organisms.","volume":"16","author":"McCammon","year":"2015","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"B34","first-page":"41","author":"Metcalfe","year":"1990","journal-title":"Primary Motoneurons of the Zebrafish."},{"key":"B35","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1089\/zeb.2006.3.227","article-title":"The zebrafish as a model for behavioral studies.","volume":"3","author":"Miklosi","year":"2006","journal-title":"Zebrafish"},{"key":"B36","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1177\/1073858417699790","article-title":"The human central pattern generator for locomotion: does it exist and contribute to walking?","volume":"23","author":"Minassian","year":"2017","journal-title":"Neuroscientist"},{"key":"B37","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0079-6123(09)17911-6","article-title":"Zebrafish: a model system to examine the neurodevelopmental basis of schizophrenia.","volume":"179","author":"Morris","year":"2009","journal-title":"Prog. Brain Res"},{"key":"B38","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1523\/JNEUROSCI.06-08-02278.1986","article-title":"Development and axonal outgrowth of identified motoneurons in the zebrafish.","volume":"6","author":"Myers","year":"1986","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1080\/10253890.2017.1369523","article-title":"Hypothalamic\u2013pituitary\u2013adrenal and hypothalamic\u2013pituitary\u2013gonadal axes: sex differences in regulation of stress responsivity.","volume":"20","author":"Oyola","year":"2017","journal-title":"Stress"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1016\/j.neurobiolaging.2006.06.014","article-title":"The neuroprotective role of attractin in neurodegeneration.","volume":"28","author":"Paz","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.109780","article-title":"Long-lasting pseudo-social aggressive behavior in opiate-withdrawn mice.","volume":"97","author":"Piccin","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.aquatox.2015.10.018","article-title":"Behavioural responses of freshwater planarians after short-term exposure to the insecticide chlorantraniliprole.","volume":"170","author":"Rodrigues","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-35","article-title":"Non-cell autonomous impairment of oligodendrocyte differentiation precedes CNS degeneration in the Zitter rat: implications of macrophage\/microglial activation in the pathogenesis.","volume":"9","author":"Sakakibara","year":"2008","journal-title":"BMC Neurosci."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-015-0151-5","article-title":"Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids.","volume":"8","author":"Salilew-Wondim","year":"2015","journal-title":"J. Ovarian Res."},{"key":"B45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/26020","article-title":"Induction of the zebrafish ventral brain and floorplate requires cyclops\/nodal signalling.","volume":"395","author":"Sampath","year":"1998","journal-title":"Nature"},{"key":"B46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.maturitas.2016.09.004","article-title":"Depression in midlife women.","volume":"94","author":"Sassarini","year":"2016","journal-title":"Maturitas"},{"key":"B47","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbr.2011.05.034","article-title":"Antipsychotic drugs reverse MK-801-induced cognitive and social interaction deficits in zebrafish (Danio rerio).","volume":"224","author":"Seibt","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10048-017-0515-7","article-title":"Hypomyelinating leukodystrophy associated with a deleterious mutation in the ATRN gene.","volume":"18","author":"Shahrour","year":"2017","journal-title":"Neurogenetics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1360\/n052014-00203","article-title":"Zebrafish swimming into neuroscience research: a visible mind in a transparent brain.","volume":"45","author":"Shang","year":"2015","journal-title":"Scientia Sinica Vitae"},{"key":"B50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4088\/jcp.v66n0102","article-title":"Low testosterone levels predict incident depressive illness in older men: effects of age and medical morbidity.","volume":"66","author":"Shores","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.7150\/ijbs.19203","article-title":"Alkbh4 and Atrn act maternally to regulate zebrafish epiboly.","volume":"13","author":"Sun","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"6025","DOI":"10.1073\/pnas.110139897","article-title":"Secreted and membrane attractin result from alternative splicing of the human ATRN gene.","volume":"97","author":"Tang","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ajmg.b.30591","article-title":"Genome-wide linkage scan, fine mapping, and haplotype analysis in a large, inbred, Arab Israeli pedigree suggest a schizophrenia susceptibility locus on chromosome 20p13.","author":"Teltsh","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001162","article-title":"Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree\u2013CORRIGENDUM.","volume":"16","author":"Teltsh","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/sj.npp.2008.210.1038\/npp.2008.2","article-title":"Testosterone increases amygdala reactivity in middle-aged women to a young adulthood level.","volume":"34","author":"van Wingen","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3791\/55294","article-title":"Dissection of larval zebrafish gonadal tissue.","volume":"122","author":"Wang","year":"2017","journal-title":"J. Vis. Exp."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/0031-9384(70)90136-8","article-title":"Stimulus bound nitrogen licking evoked during electrical stimulation of the lateral hypothalamus.","volume":"5","author":"Wayner","year":"1970","journal-title":"Physiol. Behav."},{"key":"B58","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1189\/jlb.1105678","article-title":"Attractin, a dipeptidyl peptidase IV\/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function.","volume":"80","author":"Wrenger","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013553","article-title":"Mass spectrometry identification of potential biomarker proteins in the 150-kD electrophoretic band in patients with schizophrenia.","volume":"97","author":"Xu","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1074\/jbc.RA117.000414","article-title":"The transcription factor Foxc1a in zebrafish directly regulates expression of nkx2.5, encoding a transcriptional regulator of cardiac progenitor cells.","volume":"293","author":"Yue","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255640","article-title":"Sex- and context-dependent effects of acute isolation on vocal and non-vocal social behaviors in mice.","volume":"16","author":"Zhao","year":"2021","journal-title":"PLoS One"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.755165\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T08:54:36Z","timestamp":1636620876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.755165\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":61,"alternative-id":["10.3389\/fcell.2021.755165"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.755165","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]},"article-number":"755165"}}