{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:01:02Z","timestamp":1777896062085,"version":"3.51.4"},"reference-count":172,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Uveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, such as Vogt\u2013Koyanagi\u2013Harada (VKH) disease and Behcet\u2019s disease (BD). However, epigenetic regulation has been shown to play key roles in the immunoregulation of uveitis, and epigenetic therapies are promising treatments for intraocular inflammation. In this review, we summarize recent advances in identifying epigenetic programs that cooperate with the physiology of intraocular immune responses and the pathology of intraocular inflammation. These attempts to understand the epigenetic mechanisms of uveitis may provide hope for the future development of epigenetic therapies for these devastating intraocular inflammatory conditions.<\/jats:p>","DOI":"10.3389\/fcell.2021.758240","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:51:51Z","timestamp":1637214711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Epigenetic Modifications and Therapy in Uveitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Yanli","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hucheng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4103\/0301-4738.58468","article-title":"Current Approach in Diagnosis and Management of Anterior Uveitis","volume":"58","author":"Agrawal","year":"2010","journal-title":"Indian J. Ophthalmol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.immuni.2020.05.009","article-title":"Genetics Meets Epigenetics in Treg Cells and Autoimmunity","volume":"52","author":"Agudelo Garcia","year":"2020","journal-title":"Immunity"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1002\/jcp.27207","article-title":"Disturbed Th17\/Treg Balance, Cytokines, and miRNAs in Peripheral Blood of Patients with Behcet's Disease","volume":"234","author":"Ahmadi","year":"2019","journal-title":"J. Cel Physiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1002\/jcb.26809","article-title":"Hypermethylation of IL\u201010 Gene Is Responsible for its Low mRNA Expression in Beh\u00e7et's Disease","volume":"119","author":"Alipour","year":"2018","journal-title":"J. Cel. Biochem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.reuma.2018.06.006","article-title":"Methylation Status of Interleukin-6 Gene Promoter in Patients with Beh\u00e7et's Disease","volume":"16","author":"Alipour","year":"2020","journal-title":"Reumatolog\u00eda Cl\u00ednica"},{"key":"B6","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/1346-8138.13381","article-title":"Beh\u00e7et's Disease: A Comprehensive Review with a Focus on Epidemiology, Etiology and Clinical Features, and Management of Mucocutaneous Lesions","volume":"43","author":"Alpsoy","year":"2016","journal-title":"J. Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/s0092-8674(01)00616-x","article-title":"microRNAs","volume":"107","author":"Ambros","year":"2001","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1111\/j.1462-5822.2008.01170.x","article-title":"Immune Subversion by Chromatin Manipulation: a New Face of Hostbacterial Pathogen Interaction","volume":"10","author":"Arbibe","year":"2008","journal-title":"Cell Microbiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1167\/iovs.61.11.4","article-title":"Comprehensive miRNA Analysis Using Serum from Patients with Noninfectious Uveitis","volume":"61","author":"Asakage","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/biom10081159","article-title":"Role of microRNA\/Epithelial-To-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer","volume":"10","author":"Ashrafizadeh","year":"","journal-title":"Biomolecules"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114002","article-title":"Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance","volume":"21","author":"Ashrafizadeh","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12017-016-8422-x","article-title":"Epigenetic Modifications and Therapy in Multiple Sclerosis","volume":"19","author":"Aslani","year":"2017","journal-title":"Neuromol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1080\/1354750X.2020.1754912","article-title":"The Methylation Status of TNF-\u03b1 and SOCS3 Promoters and the Regulation of These Gene Expressions in Patients with Beh\u00e7et's Disease","volume":"25","author":"Aziz","year":"2020","journal-title":"Biomarkers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.2147\/OPTH.S94866","article-title":"Vogt\u2013Koyanagi\u2013Harada Syndrome \u2013 Current Perspectives","volume":"10","author":"Baltmr","year":"2016","journal-title":"Opth"},{"key":"B15","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nature05915","article-title":"The Complex Language of Chromatin Regulation during Transcription","volume":"447","author":"Berger","year":"2007","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s10549-009-0420-3","article-title":"Effects of a Novel DNA Methyltransferase Inhibitor Zebularine on Human Breast Cancer Cells","volume":"120","author":"Billam","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"B17","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of Epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.tig.2004.06.009","article-title":"An Integrated Epigenetic and Genetic Approach to Common Human Disease","volume":"20","author":"Bjornsson","year":"2004","journal-title":"Trends Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0014-4835(91)90044-f","article-title":"Experimental Autoimmune Anterior Uveitis (EAAU), a New Form of Experimental Uveitis. I. Induction by a Detergent-Insoluble, Intrinsic Protein Fraction of the Retinal Pigment Epithelium","volume":"52","author":"Broekhuyse","year":"1991","journal-title":"Exp. Eye Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and Autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J. Autoimmun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1177\/1352458511421055","article-title":"Methylation-dependent PAD2 Upregulation in Multiple Sclerosis Peripheral Blood","volume":"18","author":"Calabrese","year":"2012","journal-title":"Mult. Scler."},{"key":"B22","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3389\/fgene.2015.00186","article-title":"Genetic Variants in microRNA Genes: Impact on microRNA Expression, Function, and Disease","volume":"6","author":"Cammaerts","year":"2015","journal-title":"Front. Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/acr.21616","article-title":"Prevalence and Factors Associated with Uveitis in Spondylarthritis Patients in France: Results from an Observational Survey","volume":"64","author":"Canou\u00ef-Poitrine","year":"2012","journal-title":"Arthritis Care Res."},{"key":"B24","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.140.5.1490","article-title":"A New Model of Autoimmune Disease. Experimental Autoimmune Uveoretinitis Induced in Mice with Two Different Retinal Antigens","volume":"140","author":"Caspi","year":"1988","journal-title":"J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000119871","article-title":"Mouse Models of Experimental Autoimmune Uveitis","volume":"40","author":"Caspi","year":"2008","journal-title":"Ophthalmic Res."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101712","article-title":"MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions","volume":"17","author":"Catalanotto","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e14922","DOI":"10.1097\/MD.0000000000014922","article-title":"miRNAs Expression of Oral Squamous Cell Carcinoma Patients","volume":"98","author":"Chamorro Petronacci","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"B28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1076\/ocii.10.4.263.15592","article-title":"Uveitis: a Global Perspective","volume":"10","author":"Chang","year":"2002","journal-title":"Ocul. Immunol. Inflamm."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The Microbial Metabolite Butyrate Regulates Intestinal Macrophage Function via Histone Deacetylase Inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1136\/bjophthalmol-2017-311079","article-title":"MicroRNA-20a-5p Suppresses IL-17 Production by Targeting OSM and CCL1 in Patients with Vogt-Koyanagi-Harada Disease","volume":"102","author":"Chang","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1167\/iovs.07-1390","article-title":"Upregulated IL-23 and IL-17 in Behc\u0327et Patients with Active Uveitis","volume":"49","author":"Chi","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12348-021-00247-1","article-title":"\"Environmental Risk Factors Associated with Juvenile Idiopathic Arthritis Associated Uveitis: a Systematic Review of the Literature\"","volume":"11","author":"Clarke","year":"2021","journal-title":"J. Ophthal Inflamm. Infect."},{"key":"B33","first-page":"1078","article-title":"International Study Group for Behcet's Disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"B34","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3109\/08820538.2016.1170158","article-title":"Clinical Features and Complications of the HLA-B27-Associated Acute Anterior Uveitis: A Metanalysis","volume":"32","author":"D'Ambrosio","year":"2017","journal-title":"Semin. Ophthalmol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/1744666X.2016.1205486","article-title":"Behcet's Disease: Epidemiology, Clinical Manifestations, and Diagnosis","volume":"13","author":"Davatchi","year":"2017","journal-title":"Expert Rev. Clin. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","article-title":"Cancer Epigenetics: from Mechanism to Therapy","volume":"150","author":"Dawson","year":"2012","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"70","DOI":"10.5582\/irdr.2015.01007","article-title":"Cardiac Manifestations in Behcet's Disease","volume":"4","author":"Demirelli","year":"2015","journal-title":"Irdr"},{"key":"B38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41421-021-00245-6","article-title":"Identification of an Intraocular Microbiota","volume":"7","author":"Deng","year":"2021","journal-title":"Cell Discov"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.1093\/nar\/gkf509","article-title":"Dnmt3L Is a Transcriptional Repressor that Recruits Histone Deacetylase","volume":"30","author":"Deplus","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.preteyeres.2018.02.003","article-title":"The Immunopathogenesis of Chronic and Relapsing Autoimmune Uveitis - Lessons from Experimental Rat Models","volume":"65","author":"Diedrichs-M\u00f6hring","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.preteyeres.2016.02.002","article-title":"Vogt-Koyanagi-Harada Disease: Novel Insights into Pathophysiology, Diagnosis and Treatment","volume":"52","author":"Du","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1167\/iovs.13-11937","article-title":"STAT3 ActivatesmiR-155in Th17 Cells and Acts in Concert to Promote Experimental Autoimmune Uveitis","volume":"54","author":"Escobar","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/nrg2005","article-title":"Cancer Epigenomics: DNA Methylomes and Histone-Modification Maps","volume":"8","author":"Esteller","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s12017-016-8383-0","article-title":"Vorinostat Modulates the Imbalance of T Cell Subsets, Suppresses Macrophage Activity, and Ameliorates Experimental Autoimmune Uveoretinitis","volume":"18","author":"Fang","year":"2016","journal-title":"Neuromol Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"462","DOI":"10.18502\/ijaai.v18i5.1890","article-title":"Epigenetics and Beh\u00e7et's Disease: DNA Methylation Specially Highlighted","volume":"18","author":"Farhadi","year":"2019","journal-title":"Iran J. Allergy Asthma Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"6690523","DOI":"10.1155\/2021\/6690523","article-title":"The Histone Modifications of Neuronal Plasticity","volume":"2021","author":"Geng","year":"2021","journal-title":"Neural Plast."},{"key":"B47","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a Landscape Takes Shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12016-009-8169-3","article-title":"The Role of Epigenetics in Aging and Autoimmunity","volume":"39","author":"Grolleau-Julius","year":"2010","journal-title":"Clinic Rev. Allerg Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/epi.10.77","article-title":"Epigenomic Biomonitors: Global DNA Hypomethylation as a Biodosimeter of Life-Long Environmental Exposures","volume":"3","author":"Guerrero-Preston","year":"2011","journal-title":"Epigenomics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00011-015-0848-3","article-title":"Characterization of microRNA Expression Profiling in Peripheral Blood Lymphocytes in Rats with Experimental Autoimmune Uveitis","volume":"64","author":"Guo","year":"2015","journal-title":"Inflamm. Res."},{"key":"B51","first-page":"S71","article-title":"Th17 Cells in Beh\u00e7et's Disease: a New Immunoregulatory axis","volume":"29","author":"Hamzaoui","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40246-018-0163-5","article-title":"The Tale of Histone Modifications and its Role in Multiple Sclerosis","volume":"12","author":"He","year":"2018","journal-title":"Hum. Genomics"},{"key":"B53","doi-asserted-by":"publisher","first-page":"232","DOI":"10.3389\/fimmu.2019.00232","article-title":"Microbiome and Autoimmune Uveitis","volume":"10","author":"Horai","year":"2019","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"107853","DOI":"10.1016\/j.exer.2019.107853","article-title":"Uveitis Genetics","volume":"190","author":"Hou","year":"2020","journal-title":"Exp. Eye Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"20057","DOI":"10.1038\/srep20057","article-title":"miR-23a, miR-146a and miR-301a Confer Predisposition to Vogt-Koyanagi-Harada Syndrome but Not to Behcet's Disease","volume":"6","author":"Hou","year":"2016","journal-title":"Sci. Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"457835","DOI":"10.1155\/2015\/457835","article-title":"Expression of MicroRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior Uveitis","volume":"2015","author":"Hsu","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9601349","DOI":"10.1155\/2017\/9601349","article-title":"MicroRNA-146a Alleviates Experimental Autoimmune Anterior Uveitis in the Eyes of Lewis Rats","volume":"2017","author":"Hsu","year":"2017","journal-title":"Mediators Inflamm."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1002\/art.38409","article-title":"Epigenome-Wide Scan Identifies a Treatment-Responsive Pattern of Altered DNA Methylation Among Cytoskeletal Remodeling Genes in Monocytes and CD4+ T Cells from Patients with Beh\u00e7et's Disease","volume":"66","author":"Hughes","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10067-018-4191-2","article-title":"MicroRNA-146a Expression and microRNA-146a Rs2910164 Polymorphism in Behcet's Disease Patients","volume":"38","author":"Ibrahim","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1167\/iovs.10-6115","article-title":"Dynamic Changes of microRNAs in the Eye during the Development of Experimental Autoimmune Uveoretinitis","volume":"52","author":"Ishida","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.gene.2004.02.043","article-title":"Cytosine Methylation and CpG, TpG (CpA) and TpA Frequencies","volume":"333","author":"Jabbari","year":"2004","journal-title":"Gene"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.2217\/bmm-2019-0098","article-title":"Expression Levels of miR-21, miR-146b and miR-326 as Potential Biomarkers in Behcet's Disease","volume":"13","author":"Jadideslam","year":"2019","journal-title":"Biomarkers Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-981-15-3449-210.1007\/978-981-15-3449-2_2","article-title":"The Development of Epigenetics in the Study of Disease Pathogenesis","volume":"1253","author":"Jeffries","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the Histone Code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"B65","first-page":"3177","article-title":"Macrophages and Dendritic Cells in IRBP-Induced Experimental Autoimmune Uveoretinitis in B10RIII Mice","volume":"40","author":"Jiang","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The Epigenomics of Cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"key":"B67","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA Methylation: Islands, Start Sites, Gene Bodies and beyond","volume":"13","author":"Jones","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"B68","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41568-019-0109-9","article-title":"Epigenetic Therapy in Immune-Oncology","volume":"19","author":"Jones","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08820139.2021.1883647","article-title":"Role of miR-146a Rs2910164 and UTS2 Rs228648 Genetic Variants in Beh\u00e7et's Disease","author":"Kamal","year":"2021","journal-title":"Immunological Invest."},{"key":"B70","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/ng.286","article-title":"DNA Methylation Profiles in Monozygotic and Dizygotic Twins","volume":"41","author":"Kaminsky","year":"2009","journal-title":"Nat. Genet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e3234","DOI":"10.1002\/jgm.3234","article-title":"Evaluation of DNA Methylation Status of Toll-like Receptors 2 and 4 Promoters in Behcet's Disease","volume":"22","author":"Kolahi","year":"2020","journal-title":"J. Gene Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.imlet.2018.10.012","article-title":"Determination of Mir-155 and Mir-146a Expression Rates and its Association with Expression Level of TNF-\u03b1 and CTLA4 Genes in Patients with Behcet's Disease","volume":"204","author":"Kolahi","year":"2018","journal-title":"Immunol. Lett."},{"key":"B73","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin Modifications and Their Function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"8582","DOI":"10.1074\/jbc.R116.761577","article-title":"Chemical Signaling between Gut Microbiota and Host Chromatin: What Is Your Gut Really Saying?","volume":"292","author":"Krautkramer","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e133","DOI":"10.1016\/j.jfo.2019.02.002","article-title":"Eye and Beh\u00e7et's Disease","volume":"42","author":"Ksiaa","year":"2019","journal-title":"J. Fran\u00e7ais d'Ophtalmologie"},{"key":"B76","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrg2719","article-title":"Establishing, Maintaining and Modifying DNA Methylation Patterns in Plants and Animals","volume":"11","author":"Law","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.3389\/fimmu.2019.01067","article-title":"Beh\u00e7et's Disease: An Overview of Etiopathogenesis","volume":"10","author":"Leccese","year":"2019","journal-title":"Front. Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00281-014-0433-9","article-title":"Autoimmune and Autoinflammatory Mechanisms in Uveitis","volume":"36","author":"Lee","year":"2014","journal-title":"Semin. Immunopathol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.conb.2009.08.004","article-title":"Two-tier Transcriptional Control of Oligodendrocyte Differentiation","volume":"19","author":"Li","year":"2009","journal-title":"Curr. Opin. Neurobiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrd4359","article-title":"Therapeutic Targeting of microRNAs: Current Status and Future Challenges","volume":"13","author":"Li","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B81","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13075-021-02517-8","article-title":"Decreased microRNA-155 in Behcet's Disease Leads to Defective Control of Autophagy Thereby Stimulating Excessive Proinflammatory Cytokine Production","volume":"23","author":"Liang","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.2147\/OPTH.S68595","article-title":"Targeting Interleukin-6 for Noninfectious Uveitis","volume":"9","author":"Lin","year":"2015","journal-title":"Opth"},{"key":"B83","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/nrd4140","article-title":"MicroRNAs and Other Non-coding RNAs as Targets for Anticancer Drug Development","volume":"12","author":"Ling","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"B84","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.imlet.2010.10.003","article-title":"Global DNA Methylation, DNMT1, and MBD2 in Patients with Rheumatoid Arthritis","volume":"135","author":"Liu","year":"2011","journal-title":"Immunol. Lett."},{"key":"B85","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.jaut.2016.06.020","article-title":"The Critical Role of Epigenetics in Systemic Lupus Erythematosus and Autoimmunity","volume":"74","author":"Long","year":"2016","journal-title":"J. Autoimmun."},{"key":"B86","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.tips.2019.09.007","article-title":"miRNAs as Therapeutic Targets in Inflammatory Disease","volume":"40","author":"Lu","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nature07107","article-title":"Genome-scale DNA Methylation Maps of Pluripotent and Differentiated Cells","volume":"454","author":"Meissner","year":"2008","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jaut.2009.02.011","article-title":"Beh\u00e7et's Disease-Aa Contemporary Review","volume":"32","author":"Mendes","year":"2009","journal-title":"J. Autoimmun."},{"key":"B89","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/cei.12295","article-title":"Interleukin-6 Blockade in Ocular Inflammatory Diseases","volume":"176","author":"Mesquida","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"B90","first-page":"225","article-title":"The Eighth Frederick H. Verhoeff Lecture. Presented by Saiichi Mishima, MD Beh\u00e7et's Disease in Japan: Ophthalmologic Aspects","volume":"77","author":"Mishima","year":"1979","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"B91","doi-asserted-by":"publisher","first-page":"608377","DOI":"10.3389\/fimmu.2020.608377","article-title":"Immune Privilege: The Microbiome and Uveitis","volume":"11","author":"M\u00f6lzer","year":"2020","journal-title":"Front. Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/08820530701745140","article-title":"Review of Genetics in Age Related Macular Degeneration","volume":"22","author":"Montezuma","year":"2007","journal-title":"Semin. Ophthalmol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"246","DOI":"10.22045\/ibj.2016.01","article-title":"Role of Epigenetics in Biology and Human Diseases","volume":"20","author":"Moosavi","year":"2016","journal-title":"Iran Biomed. J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41571-019-0267-4","article-title":"Combining Epigenetic Drugs with Other Therapies for Solid Tumours - Past Lessons and Future Promise","volume":"17","author":"Morel","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1007\/s00464-019-07185-z","article-title":"Cartilage Oligomeric Matrix Protein (COMP) Promotes Cell Proliferation in Early-Onset colon Cancer Tumorigenesis","volume":"34","author":"Nfonsam","year":"2020","journal-title":"Surg. Endosc."},{"key":"B96","first-page":"3131","article-title":"Proctor Lecture. Experimental Autoimmune Uveitis: Mechanisms of Disease and Clinical Therapeutic Indications","volume":"32","author":"Nussenblatt","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF00163549","article-title":"The Natural History of Uveitis","volume":"14","author":"Nussenblatt","year":"1990","journal-title":"Int. Ophthalmol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1136\/bjophthalmol-2018-312885","article-title":"Novel Gene Targets for miRNA146a and miRNA155 in Anterior Uveitis","volume":"103","author":"O'Rourke","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1126\/science.1178334","article-title":"Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells","volume":"327","author":"O'Shea","year":"2010","journal-title":"Science"},{"key":"B100","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0092-8674(00)81656-6","article-title":"DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1089\/gtmb.2015.0016","article-title":"Association of Pre-miRNA-499 Rs3746444 and Pre-miRNA-146a Rs2910164 Polymorphisms and Susceptibility to Behcet's Disease","volume":"19","author":"Oner","year":"2015","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"B102","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/08923973.2018.1474921","article-title":"Curcumin Reduces the Expression of Interleukin 1\u03b2 and the Production of Interleukin 6 and Tumor Necrosis Factor Alpha by M1 Macrophages from Patients with Behcet's Disease","volume":"40","author":"Palizgir","year":"2018","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"653539","DOI":"10.1155\/2014\/653539","article-title":"Immunopathogenesis of Ocular Beh\u00e7et's Disease","volume":"2014","author":"Park","year":"2014","journal-title":"J. Immunol. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1523\/JNEUROSCI.4507-10.2011","article-title":"Changed Histone Acetylation Patterns in normal-appearing white Matter and Early Multiple Sclerosis Lesions","volume":"31","author":"Pedre","year":"2011","journal-title":"J. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207571","article-title":"From 1957 to Nowadays: A Brief History of Epigenetics","volume":"21","author":"Peixoto","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1167\/iovs.07-0251","article-title":"Characterization of IL-17+Interphotoreceptor Retinoid-Binding Protein-specific T Cells in Experimental Autoimmune Uveitis","volume":"48","author":"Peng","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/092739490500282","article-title":"Elevated Levels of Interleukin 6 in the Vitreous Fluid of Patients with Pars Planitis and Posterior Uveitis: the Massachusetts Eye & Ear Experience and Review of Previous Studies","volume":"12","author":"Perez","year":"2004","journal-title":"Ocul. Immunol. Inflamm."},{"key":"B108","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.autrev.2011.11.026","article-title":"New Insights into the Pathogenesis of Beh\u00e7et's Disease","volume":"11","author":"Pineton de Chambrun","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1016\/s0161-6420(98)99033-9","article-title":"Outcomes in Anterior Uveitis Associated with the HLA-B27 Haplotype","volume":"105","author":"Power","year":"1998","journal-title":"Ophthalmology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/17460441.2017.1295954","article-title":"Exploring the Epigenetic Drug Discovery Landscape","volume":"12","author":"Prachayasittikul","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00439-013-1346-8","article-title":"A Functional Variant of Pre-miRNA-196a2 Confers Risk for Behcet's Disease but Not for Vogt-Koyanagi-Harada Syndrome or AAU in Ankylosing Spondylitis","volume":"132","author":"Qi","year":"2013","journal-title":"Hum. Genet."},{"key":"B112","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/rheumatology\/ket438","article-title":"Increased Notch Pathway Activation in Beh\u00e7et's Disease","volume":"53","author":"Qi","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"9129163","DOI":"10.1155\/2018\/9129163","article-title":"Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice","volume":"2018","author":"Qiu","year":"2018","journal-title":"Mediators Inflamm."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/s41598-017-01249-7","article-title":"Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease","volume":"7","author":"Qiu","year":"","journal-title":"Sci. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"51277","DOI":"10.18632\/oncotarget.17235","article-title":"Ocular Behcet's Disease Is Associated with Aberrant Methylation of Interferon Regulatory Factor 8 (IRF8) in Monocyte-Derived Dendritic Cells","volume":"8","author":"Qiu","year":"","journal-title":"Oncotarget"},{"key":"B116","doi-asserted-by":"publisher","first-page":"181","DOI":"10.5114\/ceji.2019.87070","article-title":"Therapeutic Potential of Curcumin in Eye Diseases","volume":"44","author":"Radomska-Lesniewska","year":"2019","journal-title":"Cent. Eur. J. Immunol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.autrev.2019.05.012","article-title":"Targeting the Balance of T Helper Cell Responses by Curcumin in Inflammatory and Autoimmune States","volume":"18","author":"Rahimi","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"B118","doi-asserted-by":"publisher","first-page":"253","DOI":"10.4103\/0301-4738.114090","article-title":"Uveitis in Developing Countries","volume":"61","author":"Rao","year":"2013","journal-title":"Indian J. Ophthalmol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic Imprinting: Parental Influence on the Genome","volume":"2","author":"Reik","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"B120","doi-asserted-by":"publisher","first-page":"587983","DOI":"10.1155\/2015\/587983","article-title":"Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention","volume":"2015","author":"Romani","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"B121","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1097\/MAJ.0b013e3182514059","article-title":"Management of Comorbidities in Ankylosing Spondylitis","volume":"343","author":"Rosenbaum","year":"2012","journal-title":"Am. J. Med. Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10384-015-0416-y","article-title":"The Microbiome, HLA, and the Pathogenesis of Uveitis","volume":"60","author":"Rosenbaum","year":"2016","journal-title":"Jpn. J. Ophthalmol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1136\/bjo.76.3.137","article-title":"Uveitis and Systemic Disease","volume":"76","author":"Rothova","year":"1992","journal-title":"Br. J. Ophthalmol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0002-9394(14)74218-7","article-title":"Clinical Features of Acute Anterior Uveitis","volume":"103","author":"Rothova","year":"1987","journal-title":"Am. J. Ophthalmol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1750-1172-7-20","article-title":"Beh\u00e7et's Disease","volume":"7","author":"Saadoun","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"B126","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.semcdb.2019.09.008","article-title":"Epigenetics and the Developmental Origins of Health and Disease: Parental Environment Signalling to the Epigenome, Critical Time Windows and Sculpting the Adult Phenotype","volume":"97","author":"Safi-Stibler","year":"2020","journal-title":"Semin. Cel Dev. Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T Cells and Human Disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.survophthal.2010.07.003","article-title":"The Heritability of Ocular Traits","volume":"55","author":"Sanfilippo","year":"2010","journal-title":"Surv. Ophthalmol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"20110330","DOI":"10.1098\/rstb.2011.0330","article-title":"Reprogramming DNA Methylation in the Mammalian Life Cycle: Building and Breaking Epigenetic Barriers","volume":"368","author":"Seisenberger","year":"2013","journal-title":"Phil. Trans. R. Soc. B"},{"key":"B130","doi-asserted-by":"publisher","first-page":"105698","DOI":"10.1016\/j.intimp.2019.105698","article-title":"Adenovirus-mediated Down-Regulation of miR-21-5p Alleviates Experimental Autoimmune Uveoretinitis in Mice","volume":"74","author":"Shi","year":"2019","journal-title":"Int. Immunopharmacology"},{"key":"B131","doi-asserted-by":"publisher","first-page":"15170","DOI":"10.1523\/JNEUROSCI.4349-14.2015","article-title":"Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis","volume":"35","author":"Singhal","year":"2015","journal-title":"J. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T Reg Cell Homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2013.12.004","article-title":"Nature and Nurture- Genes and Environment- Predict Onset and Progression of Macular Degeneration","volume":"40","author":"Sobrin","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"2574067","DOI":"10.1155\/2018\/2574067","article-title":"Regulatory Role of Rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro","volume":"2018","author":"Sun","year":"2018","journal-title":"Mediators Inflamm."},{"key":"B135","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1136\/bjo.80.9.844","article-title":"The Possible Impact of Uveitis in Blindness: a Literature Survey","volume":"80","author":"Suttorp-Schulten","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1111\/cas.13965","article-title":"Development of Mi RNA \u2010based Therapeutic Approaches for Cancer Patients","volume":"110","author":"Takahashi","year":"2019","journal-title":"Cancer Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","article-title":"Identification of 67 Histone marks and Histone Lysine Crotonylation as a New Type of Histone Modification","volume":"146","author":"Tan","year":"2011","journal-title":"Cell"},{"key":"B138","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1242\/jeb.107151","article-title":"Twin Methodology in Epigenetic Studies","volume":"218","author":"Tan","year":"2015","journal-title":"J. Exp. Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3389\/fgene.2020.00428","article-title":"Corrigendum: Epigenetics and Metabolism in Health and Disease","volume":"11","author":"Tzika","year":"2020","journal-title":"Front. Genet."},{"key":"B140","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mrrev.2008.02.004","article-title":"Epigenetic Interplay between Histone Modifications and DNA Methylation in Gene Silencing","volume":"659","author":"Vaissi\u00e8re","year":"2008","journal-title":"Mutat. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"658514","DOI":"10.3389\/fcell.2021.658514","article-title":"miRNA Landscape in Pathogenesis and Treatment of Vogt-Koyanagi-Harada Disease","volume":"9","author":"Vega-Tapia","year":"2021","journal-title":"Front. Cel Dev. Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1167\/iovs.17-23643","article-title":"A Disease-Associated MicroRNA Cluster Links Inflammatory Pathways and an Altered Composition of Leukocyte Subsets to Noninfectious Uveitis","volume":"59","author":"Verhagen","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"20180126","DOI":"10.1098\/rstb.2018.0126","article-title":"Making Headway towards Understanding How Epigenetic Mechanisms Contribute to Early-Life Effects","volume":"374","author":"Vukic","year":"2019","journal-title":"Phil. Trans. R. Soc. B"},{"key":"B144","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/ije\/dyr184","article-title":"The Epigenotype","volume":"41","author":"Waddington","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"608134","DOI":"10.3389\/fimmu.2020.608134","article-title":"Recent Developments in HLA B27 Anterior Uveitis","volume":"11","author":"Wakefield","year":"2020","journal-title":"Front. Immunol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.iio.0000155938.83083.94","article-title":"Epidemiology of Uveitis","volume":"45","author":"Wakefield","year":"2005","journal-title":"Int. Ophthalmol. Clin."},{"key":"B147","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bj.2016.08.005","article-title":"On the Road to Epigenetic Therapy","volume":"39","author":"Walton","year":"2016","journal-title":"Biomed. J."},{"key":"B148","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1136\/bjophthalmol-2015-306924","article-title":"MicroRNAs in Retina during Development of Experimental Autoimmune Uveoretinitis in Rats","volume":"100","author":"Watanabe","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","article-title":"Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells","volume":"30","author":"Wei","year":"2009","journal-title":"Immunity"},{"key":"B150","doi-asserted-by":"publisher","first-page":"13951","DOI":"10.1096\/fj.201901446R","article-title":"miR-223-3p Promotes Autoreactive Th17 Cell Responses in Experimental Autoimmune Uveitis (EAU) by Inhibiting Transcription Factor FOXO3 Expression","volume":"33","author":"Wei","year":"2019","journal-title":"FASEB J."},{"key":"B151","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3389\/fcell.2020.00818","article-title":"MicroRNAs and Autoimmune-Mediated Eye Diseases","volume":"8","author":"Wei","year":"2020","journal-title":"Front. Cel Dev. Biol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"580636","DOI":"10.3389\/fimmu.2020.580636","article-title":"Molecular Mimicry and Uveitis","volume":"11","author":"Wildner","year":"2020","journal-title":"Front. Immunol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1093\/emboj\/17.2.520","article-title":"Distinct Requirements for Chromatin Assembly in Transcriptional Repression by Thyroid Hormone Receptor and Histone Deacetylase","volume":"17","author":"Wong","year":"1998","journal-title":"EMBO J."},{"key":"B154","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12950-016-0130-7","article-title":"MicroRNAs Differentially Expressed in Beh\u00e7et Disease Are Involved in Interleukin-6 Production","volume":"13","author":"Woo","year":"2016","journal-title":"J. Inflamm."},{"key":"B155","doi-asserted-by":"publisher","first-page":"108618","DOI":"10.1016\/j.exer.2021.108618","article-title":"The Role of the Inflammasomes in the Pathogenesis of Uveitis","volume":"208","author":"Xu","year":"2021","journal-title":"Exp. Eye Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1167\/iovs.16-21047","article-title":"miRNA Copy Number Variants Confer Susceptibility to Acute Anterior Uveitis with or without Ankylosing Spondylitis","volume":"58","author":"Yang","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical Features of Chinese Patients with Beh\u00e7et's Disease","volume":"115","author":"Yang","year":"2008","journal-title":"Ophthalmology"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.ophtha.2019.03.049","article-title":"Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt-Koyanagi-Harada Disease in Chinese Patients","volume":"126","author":"Yang","year":"2019","journal-title":"Ophthalmology"},{"key":"B159","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ophtha.2006.07.040","article-title":"Clinical Characteristics of Vogt-Koyanagi-Harada Syndrome in Chinese Patients","volume":"114","author":"Yang","year":"2007","journal-title":"Ophthalmology"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1093\/rheumatology\/kez043","article-title":"Epigenome-wide Association Study Identifies Beh\u00e7et's Disease-Associated Methylation Loci in Han Chinese","volume":"58","author":"Yu","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"B161","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s00109-014-1159-9","article-title":"Predisposition to Beh\u00e7et's Disease and VKH Syndrome by Genetic Variants of miR-182","volume":"92","author":"Yu","year":"2014","journal-title":"J. Mol. Med."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1393089","DOI":"10.1155\/2016\/1393089","article-title":"Methylation Status of Alu and LINE-1 Interspersed Repetitive Sequences in Behcet's Disease Patients","volume":"2016","author":"Y\u00fcksel","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"B163","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1136\/ard.2007.075754","article-title":"Prevalence and Characteristics of Uveitis in the Spondyloarthropathies: a Systematic Literature Review","volume":"67","author":"Zeboulon","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"B164","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s13317-016-0074-1","article-title":"Beh\u00e7et's Disease Physiopathology: a Contemporary Review","volume":"7","author":"Zeidan","year":"2016","journal-title":"Autoimmun. Highlights"},{"key":"B165","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-981-15-3449-2","article-title":"Epigenetics in Health and Disease","volume":"1253","author":"Zhang","year":"","journal-title":"Adv. Exp. Med. Biol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.bbrc.2020.06.073","article-title":"miR-182-5p Inhibits the Pathogenic Th17 Response in Experimental Autoimmune Uveitis Mice via Suppressing TAF15","volume":"529","author":"Zhang","year":"","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B167","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1136\/annrheumdis-2012-201627","article-title":"MicroRNA-146aandEts-1gene Polymorphisms in Ocular Beh\u00e7et's Disease and Vogt-Koyanagi-Harada Syndrome","volume":"73","author":"Zhou","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"B168","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1167\/iovs.12-9832","article-title":"Decreased microRNA-155 Expression in Ocular Behcet's Disease but Not in Vogt Koyanagi Harada Syndrome","volume":"53","author":"Zhou","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"64263","DOI":"10.18632\/oncotarget.19500","article-title":"Aberrant DNA Methylation of GATA Binding Protein 3 (GATA3), Interleukin-4 (IL-4), and Transforming Growth Factor-\u03b2 (TGF-\u03b2) Promoters in Behcet's Disease","volume":"8","author":"Zhu","year":"","journal-title":"Oncotarget"},{"key":"B170","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1167\/iovs.16-21188","article-title":"Promoter Hypermethylation of GATA3, IL-4, and TGF-\u03b2 Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese","volume":"58","author":"Zhu","year":"","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.3389\/fimmu.2019.01950","article-title":"The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation","volume":"10","author":"Zou","year":"2019","journal-title":"Front. Immunol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fcimb.2017.00095","article-title":"A Long Journey Ahead: Long Non-coding RNAs in Bacterial Infections","volume":"7","author":"Zur Bruegge","year":"2017","journal-title":"Front. Cel. Infect. Microbiol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.758240\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T18:58:43Z","timestamp":1673809123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.758240\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,18]]},"references-count":172,"alternative-id":["10.3389\/fcell.2021.758240"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.758240","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,18]]},"article-number":"758240"}}