{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:28:28Z","timestamp":1777379308313,"version":"3.51.4"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871681"],"award-info":[{"award-number":["81871681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1161962"],"award-info":[{"award-number":["OPP1161962"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M642171"],"award-info":[{"award-number":["2018M642171"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2018K236C"],"award-info":[{"award-number":["2018K236C"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p><jats:italic>Plasmodium vivax<\/jats:italic>\u2013infected erythrocytes can enter the spleen and evade spleen clearance to establish chronic infections. However, the mechanism underlying <jats:italic>P. vivax<\/jats:italic> immune evasion in the spleen is still unclear. Human splenic fibroblasts (HSF), also known as barrier cells, play an essential role in the immune function of spleen. A hypothesis holds that <jats:italic>P. vivax<\/jats:italic>\u2014infected erythrocytes induce spleen structural remodeling to form barrier cells. Subsequently, these infected erythrocytes can selectively cytoadhere to these barrier cells to escape spleen clearance. In this work, we found that <jats:italic>P. vivax<\/jats:italic> surface-related antigen (PvSRA; PlasmoDB ID: PVX_084970), an exported protein on infected erythrocyte membrane, could bind with HSF. Considering the above hypothesis, we speculated that PvSRA might be involved in <jats:italic>P. vivax<\/jats:italic> immune evasion by changing HSF cell performance. To investigate this speculation, RNA sequencing, protein microarray, and bioinformatics analysis technologies were applied, and <jats:italic>in vitro<\/jats:italic> validations were further performed. The results showed that the recombinant PvSRA attracted HSF migration and interacted with HSF by targeting integrin \u03b21 (ITGB1) along with changes in HSF cell performance, such as focal adhesion, extracellular matrix, actin cytoskeleton, and cell cycle. This study indicated that PvSRA might indeed participate in the immune evasion of <jats:italic>P. vivax<\/jats:italic> in the spleen by changing HSF function through PvSRA\u2013ITGB1 axis.<\/jats:p>","DOI":"10.3389\/fcell.2021.764109","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T07:12:04Z","timestamp":1638774724000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of the Recombinant Plasmodium vivax Surface-Related Antigen as a Possible Immune Evasion Factor Against Human Splenic Fibroblasts by Targeting ITGB1"],"prefix":"10.3389","volume":"9","author":[{"given":"Haitian","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feihu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokouvi","family":"Kassegne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Taek","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1182\/blood.v97.9.2872","article-title":"Glycophorin A Dimerization and Band 3 Interaction during Erythroid Membrane Biogenesis: In Vivo Studies in Human Glycophorin A Transgenic Mice","volume":"97","author":"Auffray","year":"2001","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nm0111-48","article-title":"Defying Malaria: Fathoming Severe Plasmodium Vivax Disease","volume":"17","author":"Bassat","year":"2011","journal-title":"Nat. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1093\/bioinformatics\/btp465","article-title":"Network Analyses in Systems Pharmacology","volume":"25","author":"Berger","year":"2009","journal-title":"Bioinformatics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"16290","DOI":"10.1073\/pnas.0807404105","article-title":"The Transcriptome of Plasmodium Vivax Reveals Divergence and Diversity of Transcriptional Regulation in Malaria Parasites","volume":"105","author":"Bozdech","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/1933719112466303","article-title":"Integrin Upregulation and Localization to Focal Adhesion Sites in Pregnant Human Myometrium","volume":"20","author":"Burkin","year":"2013","journal-title":"Reprod. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1086\/654815","article-title":"On the Cytoadhesion ofPlasmodium Vivax-Infected Erythrocytes","volume":"202","author":"Carvalho","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-2141.2006.06120.x","article-title":"Role of Dystrophins and Utrophins in Platelet Adhesion Process","volume":"134","author":"Cerecedo","year":"2006","journal-title":"Br. J. Haematol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"6479","DOI":"10.1021\/pr100705g","article-title":"Immunoproteomics Profiling of Blood Stage Plasmodium Vivax Infection by High-Throughput Screening Assays","volume":"9","author":"Chen","year":"","journal-title":"J. Proteome Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s10585-010-9306-3","article-title":"FAK Is Involved in Invasion and Metastasis of Hepatocellular Carcinoma","volume":"27","author":"Chen","year":"","journal-title":"Clin. Exp. Metastasis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1084\/jem.192.1.1","article-title":"The Semiconserved Head Structure of Plasmodium Falciparum Erythrocyte Membrane Protein 1 Mediates Binding to Multiple Independent Host Receptors","volume":"192","author":"Chen","year":"2000","journal-title":"J. Exp. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S1473-3099(18)30596-6","article-title":"Risk of Plasmodium Vivax Parasitaemia after Plasmodium Falciparum Infection: a Systematic Review and Meta-Analysis","volume":"19","author":"Commons","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.ijpara.2004.10.012","article-title":"Variant Genes and the Spleen in Plasmodium Vivax Malaria","volume":"34","author":"del Portillo","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1001575","DOI":"10.1371\/journal.pmed.1001575","article-title":"Major burden of Severe Anemia from Non-falciparum Malaria Species in Southern Papua: a Hospital-Based Surveillance Study","volume":"10","author":"Douglas","year":"2013","journal-title":"Plos Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/s0003-9861(03)00332-1","article-title":"Molecular Cloning, Expression, and Characterization of Bovine Tissue Factor Pathway Inhibitor-2","volume":"417","author":"Du","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"B16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12936-018-2228-2","article-title":"Sudden Spleen Rupture in a Plasmodium Vivax-Infected Patient Undergoing Malaria Treatment","volume":"17","author":"Elizalde-Torrent","year":"2018","journal-title":"Malar. J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"13056","DOI":"10.1073\/pnas.1920596117","article-title":"Plasmodium Vivaxspleen-dependent Genes Encode Antigens Associated with Cytoadhesion and Clinical protection","volume":"117","author":"Fernandez-Becerra","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pt.2008.09.012","article-title":"Plasmodium Vivax and the Importance of the Subtelomeric Multigene Vir Superfamily","volume":"25","author":"Fernandez-Becerra","year":"2009","journal-title":"Trends Parasitol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"12862","DOI":"10.1038\/srep12862","article-title":"Leishmania Infection Modulates Beta-1 Integrin Activation and Alters the Kinetics of Monocyte Spreading over Fibronectin","volume":"5","author":"Figueira","year":"2015","journal-title":"Sci. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"rs7","DOI":"10.1126\/scisignal.2005473","article-title":"E-cadherin Interactome Complexity and Robustness Resolved by Quantitative Proteomics","volume":"7","author":"Guo","year":"2014","journal-title":"Sci. Signal."},{"key":"B21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1086\/596048","article-title":"High Deformability ofPlasmodium Vivax-Infected Red Blood Cells under Microfluidic Conditions","volume":"199","author":"Handayani","year":"2009","journal-title":"J. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"43250","DOI":"10.1074\/jbc.M111.234716","article-title":"Enhanced Activity of Transforming Growth Factor \u03b21 (TGF-\u03921) Bound to Cartilage Oligomeric Matrix Protein","volume":"286","author":"Haudenschild","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0197937","DOI":"10.1371\/journal.pone.0197937","article-title":"Role of Integrin Alpha8 in Murine Model of Lung Fibrosis","volume":"13","author":"Hung","year":"2018","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12936-017-1684-4","article-title":"Severe Plasmodium Vivax Infection in Korea","volume":"16","author":"Im","year":"2017","journal-title":"Malar. J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1128\/MCB.00064-09","article-title":"Fas-mediated Apoptosis Is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) In Vitro and In Vivo","volume":"29","author":"Juric","year":"2009","journal-title":"Mol. Cell Biol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cid\/ciy403","article-title":"High Risk of Plasmodium Vivax Malaria Following Splenectomy in Papua, Indonesia","volume":"68","author":"Kho","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/age.12421","article-title":"Identification of Genes in Longissimus Dorsi Muscle Differentially Expressed between Wannanhua and Yorkshire Pigs Using RNA-Sequencing","volume":"47","author":"Li","year":"2016","journal-title":"Anim. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jprot.2014.02.029","article-title":"Profiling the Humoral Immune Responses to Plasmodium Vivax Infection and Identification of Candidate Immunogenic Rhoptry-Associated Membrane Antigen (RAMA)","volume":"102","author":"Lu","year":"2014","journal-title":"J. Proteomics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/ni.2112","article-title":"Regulated Release of Nitric Oxide by Nonhematopoietic Stroma Controls Expansion of the Activated T Cell Pool in Lymph Nodes","volume":"12","author":"Lukacs-Kornek","year":"2011","journal-title":"Nat. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e1934","DOI":"10.1371\/journal.pntd.0001934","article-title":"Spleen Rupture in a Case of Untreated Plasmodium Vivax Infection","volume":"6","author":"Machado Siqueira","year":"2012","journal-title":"Plos Negl. Trop. Dis."},{"key":"B31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cell.2008.04.051","article-title":"Exported Proteins Required for Virulence and Rigidity of Plasmodium Falciparum-Infected Human Erythrocytes","volume":"134","author":"Maier","year":"2008","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.devcel.2014.09.009","article-title":"DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis","volume":"31","author":"Marchesi","year":"2014","journal-title":"Dev. Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1462-5822.2010.01523.x","article-title":"Strain-specific Spleen Remodelling in Plasmodium Yoelii Infections in Balb\/c Mice Facilitates Adherence and Spleen Macrophage-Clearance Escape","volume":"13","author":"Martin-Jaular","year":"2011","journal-title":"Cell Microbiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"G1257","DOI":"10.1152\/ajpgi.00266.2007","article-title":"CCL25 and CCL28 Promote \u03b14\u03b27-integrin-dependent Adhesion of Lymphocytes to MAdCAM-1 under Shear Flow","volume":"294","author":"Miles","year":"2008","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal Adhesion Kinase: in Command and Control of Cell Motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1182\/blood-2002-11-3462","article-title":"JAML, a Novel Protein with Characteristics of a Junctional Adhesion Molecule, Is Induced during Differentiation of Myeloid Leukemia Cells","volume":"102","author":"Moog-Lutz","year":"2003","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"24947","DOI":"10.1074\/jbc.274.35.24947","article-title":"A Novel Protease-Docking Function of Integrin at Invadopodia","volume":"274","author":"Mueller","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"15430","DOI":"10.1073\/pnas.0702579104","article-title":"Viral Targeting of Fibroblastic Reticular Cells Contributes to Immunosuppression and Persistence during Chronic Infection","volume":"104","author":"Mueller","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1083\/jcb.138.5.1139","article-title":"Nuclear-cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: a Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus","volume":"138","author":"Nix","year":"1997","journal-title":"J. Cell Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/jcs.230920","article-title":"Correction: TIMP-1 Promotes Hypermigration of Toxoplasma-Infected Primary Dendritic Cells via CD63-ITGB1-FAK Signaling","volume":"132","author":"\u00d3lafsson","year":"2019","journal-title":"J. Cell Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1513\/pats.200601-012TK","article-title":"Matrix Metalloproteases in Aberrant Fibrotic Tissue Remodeling","volume":"3","author":"Pardo","year":"2006","journal-title":"Proc. Am. Thorac. Soc."},{"key":"B42","doi-asserted-by":"publisher","first-page":"8943","DOI":"10.1038\/s41598-019-45228-6","article-title":"Complement Receptor 1 Availability on Red Blood Cell Surface Modulates Plasmodium Vivax Invasion of Human Reticulocytes","volume":"9","author":"Prajapati","year":"2019","journal-title":"Sci. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1242\/bio.017558","article-title":"Focal Adhesion Kinase Is Required for Actin Polymerization and Remodeling of the Cytoskeleton during Sperm Capacitation","volume":"5","author":"Roa-Espitia","year":"2016","journal-title":"Biol. Open"},{"key":"B44","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12936-015-0815-z","article-title":"Improvement of Culture Conditions for Long-Term In Vitro Culture of Plasmodium Vivax","volume":"14","author":"Roobsoong","year":"2015","journal-title":"Malar. J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/b0-12-370879-6\/00013-2","article-title":"ADHESION, CELL-MATRIX | Focal Contacts and Signaling","volume":"1","author":"Rosen","year":"2006","journal-title":"Encyclopedia Respir. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1074\/jbc.M112.435156","article-title":"Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-Induced Inflammation","volume":"289","author":"Roy","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.sbi.2005.06.001","article-title":"Protein-protein Interactions in Human Disease","volume":"15","author":"Ryan","year":"2005","journal-title":"Curr. Opin. Struct. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1242\/jcs.045112","article-title":"Cellular Functions of FAK Kinases: Insight into Molecular Mechanisms and Novel Functions","volume":"123","author":"Schaller","year":"2010","journal-title":"J. Cell Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.3390\/ijms21072514","article-title":"Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers","volume":"21","author":"Simeone","year":"2020","journal-title":"Ijms"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1096\/fj.13-247767","article-title":"Citrullination of Collagen II Affects Integrin\u2010mediated Cell Adhesion in a Receptor\u2010specific Manner","volume":"28","author":"Sipil\u00e4","year":"2014","journal-title":"FASEB J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"a018267","DOI":"10.1101\/cshperspect.a018267","article-title":"The Actin Cytoskeleton and Actin-Based Motility","volume":"10","author":"Svitkina","year":"2018","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular Matrix Structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1038\/s41467-020-16337-y","article-title":"Plasma-derived Extracellular Vesicles from Plasmodium Vivax Patients Signal Spleen Fibroblasts via NF-kB Facilitating Parasite Cytoadherence","volume":"11","author":"Toda","year":"2020","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe Malaria Is Associated with Parasite Binding to Endothelial Protein C Receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.medcli.2020.05.010","article-title":"Update on Malaria","volume":"155","author":"Varo","year":"2020","journal-title":"Medicina Cl\u00ednica"},{"key":"B56","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ygyno.2018.10.002","article-title":"RNA Sequencing (RNA-Seq) and its Application in Ovarian Cancer","volume":"152","author":"Wang","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-seq: a Revolutionary Tool for Transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/0167-5699(91)90108-6","article-title":"Barrier Cells in the Spleen","volume":"12","author":"Weiss","year":"1991","journal-title":"Immunol. Today"},{"key":"B59","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4269\/ajtmh.1989.41.144","article-title":"Mechanisms of Splenic Control of Murine Malaria: Cellular Reactions of the Spleen in Lethal (Strain 17XL) Plasmodium Yoelii Malaria in BALB\/c Mice, and the Consequences of Pre-infective Splenectomy","volume":"41","author":"Weiss","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B60","unstructured":"World Malaria Report2020"},{"key":"B61","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.fsi.2010.04.019","article-title":"A Novel CD29-like Protein Expressed in Japanese Lamprey (Lethenteron Japonicum) and Involved in Immune Response","volume":"29","author":"Wu","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.pt.2016.12.012","article-title":"Three Is a Crowd - New Insights into Rosetting in Plasmodium Falciparum","volume":"33","author":"Yam","year":"2017","journal-title":"Trends Parasitol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s12943-018-0864-3","article-title":"Biomarkers for Predicting Efficacy of PD-1\/pd-L1 Inhibitors","volume":"17","author":"Yi","year":"2018","journal-title":"Mol. Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"19276","DOI":"10.1038\/srep19276","article-title":"Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin Beta-1 and Plays a Central Role in Fibrosis","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.764109\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T07:12:10Z","timestamp":1638774730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.764109\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,6]]},"references-count":63,"alternative-id":["10.3389\/fcell.2021.764109"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.764109","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,6]]},"article-number":"764109"}}