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Cell Dev. Biol."],"abstract":"<jats:p>Mesenchymal stromal cell (MSC) therapy to treat neurodegenerative diseases has not been as successful as expected in some preclinical studies. Because preclinical research is so diverse, it is difficult to know whether the therapeutic outcome is due to the cell type, the type of transplant or the model of disease. Our aim here was to analyze the effect of the type of transplant on neuroprotection and axonal regeneration, so we tested MSCs from the same niche in the same model of neurodegeneration in the three transplantation settings: xenogeneic, syngeneic and allogeneic. For this, bone marrow mesenchymal stromal cells (BM-MSCs) isolated from healthy human volunteers or C57\/BL6 mice were injected into the vitreous body of C57\/BL6 mice (xenograft and syngraft) or BALB\/c mice (allograft) right after optic nerve axotomy. As controls, vehicle matched groups were done. Retinal anatomy and function were analyzed <jats:italic>in vivo<\/jats:italic> by optical coherence tomography and electroretinogram, respectively. Survival of vision forming (Brn3a<jats:sup>+<\/jats:sup>) and non-vision forming (melanopsin<jats:sup>+<\/jats:sup>) retinal ganglion cells (RGCs) was assessed at 3, 5 and 90\u00a0days after the lesion. Regenerative axons were visualized by cholera toxin \u03b2 anterograde transport. Our data show that grafted BM-MSCs did not integrate in the retina but formed a mesh on top of the ganglion cell layer. The xenotransplant caused retinal edema, detachment and folding, and a significant decrease of functionality compared to the murine transplants. RGC survival and axonal regeneration were significantly higher in the syngrafted retinas than in the other two groups or vehicle controls. Melanopsin<jats:sup>+<\/jats:sup>RGCs, but not Brn3a<jats:sup>+<\/jats:sup>RGCs, were also neuroprotected by the xenograft. In conclusion, the type of transplant has an impact on the therapeutic effect of BM-MSCs affecting not only neuronal survival but also the host tissue response. Our data indicate that syngrafts may be more beneficial than allografts and, interestingly, that the type of neuron that is rescued also plays a significant role in the successfulness of the cell therapy.<\/jats:p>","DOI":"10.3389\/fcell.2021.772223","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T07:10:58Z","timestamp":1636009858000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Neuroprotection and Axonal Regeneration Induced by Bone Marrow Mesenchymal Stromal Cells Depend on the Type of Transplant"],"prefix":"10.3389","volume":"9","author":[{"given":"Mar\u00eda","family":"Norte-Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Lucas-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gallego-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Garc\u00eda-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Valiente-Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"de la Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Vidal-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Agudo-Barriuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human Mesenchymal Stem Cells Modulate Allogeneic Immune Cell Responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/jdn.10101","article-title":"Stem Cell in Neurodegenerative Disorders; an Emerging Strategy","volume":"81","author":"Ahani\u2010Nahayati","year":"2021","journal-title":"Int. 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