{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T21:43:48Z","timestamp":1786657428330,"version":"build-2736575974"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Accumulated evidence shows that the F-box protein 3 (FBXO3) has multiple biological functions, including regulation of immune pathologies, neuropathic diseases and antiviral response. In this review article, we focus on the role of FBXO3 in inflammatory disorders and human malignancies. We also describe the substrates of FBXO3, which contribute to inflammatory disorders and cancers. We highlight that the high expression of FBXO3 is frequently observed in rheumatoid arthritis, leukemia, pituitary adenoma, and oral squamous cell carcinoma. Moreover, we discuss the regulation of FBXO3 by both carcinogens and cancer preventive agents. Our review provides a comprehensive understanding of the role of FBXO3 in various biological systems and elucidates how FBXO3 regulates substrate ubiquitination and degradation during various physiological and pathological processes. Therefore, FBXO3 can be a novel target in the treatment of human diseases including carcinomas.<\/jats:p>","DOI":"10.3389\/fcell.2021.802204","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T04:53:25Z","timestamp":1642568005000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions"],"prefix":"10.3389","volume":"9","author":[{"given":"Zhiyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penglian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The Role of the Endothelium in Severe Sepsis and Multiple Organ Dysfunction Syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12307-012-0116-9","article-title":"Role of P63 in Development, Tumorigenesis and Cancer Progression","volume":"5","author":"Bergholz","year":"2012","journal-title":"Cancer Microenvironment"},{"key":"B3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.tcb.2011.10.006","article-title":"Deconstructing P53 Transcriptional Networks in Tumor Suppression","volume":"22","author":"Bieging","year":"2012","journal-title":"Trends Cel Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"9798","DOI":"10.1128\/jvi.78.18.9798-9806.2004","article-title":"NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription","volume":"78","author":"Billecocq","year":"2004","journal-title":"J. Virol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"883","DOI":"10.2460\/javma.234.7.883","article-title":"Rift Valley Fever Virus","volume":"234","author":"Bird","year":"2009","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6098","DOI":"10.1128\/jvi.02641-10","article-title":"Rift valley Fever: Recent Insights into Pathogenesis and Prevention","volume":"85","author":"Boshra","year":"2011","journal-title":"J. Virol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1128\/jvi.75.3.1371-1377.2001","article-title":"Genetic Evidence for an Interferon-Antagonistic Function of Rift valley Fever Virus Nonstructural Protein NSs","volume":"75","author":"Bouloy","year":"2001","journal-title":"J. Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.tripleo.2010.11.020","article-title":"Genetic Alterations in Oral Squamous Cell Carcinoma Progression Detected by Combining Array-Based Comparative Genomic Hybridization and Multiplex Ligation-dependent Probe Amplification","volume":"111","author":"Cha","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.18632\/oncotarget.2167","article-title":"Regulatory Role of miR-142-3p on the Functional Hepatic Cancer Stem Cell Marker CD133","volume":"5","author":"Chai","year":"2014","journal-title":"Oncotarget"},{"key":"B10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.yjmcc.2018.11.006","article-title":"The SCFFBXO3 Ubiquitin E3 Ligase Regulates Inflammation in Atherosclerosis","volume":"126","author":"Chandra","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/ni.2565","article-title":"A Combinatorial F Box Protein Directed Pathway Controls TRAF Adaptor Stability to Regulate Inflammation","volume":"14","author":"Chen","year":"2013","journal-title":"Nat. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.imbio.2019.02.009","article-title":"Interferon-\u03b3 Upregulates \u039442PD1 Expression on Human Monocytes via the PI3K\/AKT Pathway","volume":"224","author":"Cheng","year":"2019","journal-title":"Immunobiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nrm2816","article-title":"Unleashing Formins to Remodel the Actin and Microtubule Cytoskeletons","volume":"11","author":"Chesarone","year":"2010","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/s1474-4422(17)30401-5","article-title":"Novel Genes Associated with Amyotrophic Lateral Sclerosis: Diagnostic and Clinical Implications","volume":"17","author":"Chia","year":"2018","journal-title":"Lancet Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"32756","DOI":"10.1074\/jbc.m100929200","article-title":"Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin","volume":"276","author":"Coppola","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1091\/mbc.e13-08-0482","article-title":"Essential and Nonredundant Roles for Diaphanous Formins in Cortical Microtubule Capture and Directed Cell Migration","volume":"25","author":"Daou","year":"2014","journal-title":"MBoC"},{"key":"B17","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/347558a0","article-title":"The T(15;17) Translocation of Acute Promyelocytic Leukaemia Fuses the Retinoic Acid Receptor \u03b1 Gene to a Novel Transcribed Locus","volume":"347","author":"de Th\u00e9","year":"1990","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0092-8674(91)90113-d","article-title":"The PML-Rar\u03b1 Fusion mRNA Generated by the T(15;17) Translocation in Acute Promyelocytic Leukemia Encodes a Functionally Altered RAR","volume":"66","author":"de Th\u00e9","year":"1991","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1002\/eji.200737772","article-title":"Historical Insights into Cytokines","volume":"37","author":"Dinarello","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3892\/etm.2021.9644","article-title":"miR-142-3p Reduces the Viability of Human Cervical Cancer Cells by Negatively Regulating the Cytoplasmic Localization of HMGB1","volume":"21","author":"Dong","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/abbs\/gmv076","article-title":"The NEK1 Interactor, C21ORF2, Is Required for Efficient DNA Damage Repair","volume":"47","author":"Fang","year":"2015","journal-title":"Acta Biochim. Biophys. Sin"},{"key":"B22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/ng1297-399","article-title":"An Autoimmune Disease, APECED, Caused by Mutations in a Novel Gene Featuring Two PHD-type Zinc-finger Domains","volume":"17","author":"Finnish-German","year":"1997","journal-title":"Nat. Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.semcancer.2019.12.023","article-title":"The Functions and Regulation of Smurfs in Cancers","volume":"67","author":"Fu","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1073\/pnas.0700259104","article-title":"Loss of Aire-dependent Thymic Expression of a Peripheral Tissue Antigen Renders it a Target of Autoimmunity","volume":"104","author":"Gavanescu","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"696820","DOI":"10.3389\/fcell.2021.696820","article-title":"The Impact of lncRNAs and miRNAs in Regulation of Function of Cancer Stem Cells and Progression of Cancer","volume":"9","author":"Ghafouri-Fard","year":"2021","journal-title":"Front. Cel Dev. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1126\/science.1720570","article-title":"Characterization of a Zinc finger Gene Disrupted by the T(15;17) in Acute Promyelocytic Leukemia","volume":"254","author":"Goddard","year":"1991","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41568-020-00306-0","article-title":"RNA in Cancer","volume":"21","author":"Goodall","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrm3099","article-title":"The Spatial and Temporal Organization of Ubiquitin Networks","volume":"12","author":"Grabbe","year":"2011","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"18124","DOI":"10.1074\/jbc.m115.645549","article-title":"Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase","volume":"290","author":"Han","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112767","article-title":"TGF-\u03b2-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis","volume":"20","author":"Hao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1210\/jc.2016-1307","article-title":"Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients with MissenseAIPMutations","volume":"101","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejcb.2004.12.010","article-title":"Histone Deacetylase Inhibitors and Cancer: from Cell Biology to the Clinic","volume":"84","author":"Hess-Stumpp","year":"2005","journal-title":"Eur. J. Cel Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/s0896-6273(02)00667-0","article-title":"RIM Binding Proteins (RBPs) Couple Rab3-Interacting Molecules (RIMs) to Voltage-Gated Ca2+ Channels","volume":"34","author":"Hibino","year":"2002","journal-title":"Neuron"},{"key":"B34","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3389\/fphar.2019.00583","article-title":"Targeting F-Box Protein Fbxo3 Attenuates Lung Injury Induced by Ischemia-Reperfusion in Rats","volume":"10","author":"Hung","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"14786","DOI":"10.1523\/jneurosci.4124-10.2010","article-title":"MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function","volume":"30","author":"Hussain","year":"2010","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1006\/excr.1999.4733","article-title":"Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins that Mediate Cytokine Signaling","volume":"254","author":"Inoue","year":"2000","journal-title":"Exp. Cel Res."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01977","article-title":"miR-142 Regulates the Tumorigenicity of Human Breast Cancer Stem Cells through the Canonical WNT Signaling Pathway","volume":"3","author":"Isobe","year":"2014","journal-title":"Elife"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1074\/mcp.m114.043885","article-title":"Proteomic Analyses Uncover a New Function and Mode of Action for Mouse Homolog of Diaphanous 2 (mDia2)*","volume":"14","author":"Isogai","year":"2015","journal-title":"Mol. Cell Proteomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"100683","DOI":"10.1016\/j.drup.2020.100683","article-title":"Long Non-coding RNAs as a Determinant of Cancer Drug Resistance: Towards the Overcoming of Chemoresistance via Modulation of lncRNAs","volume":"50","author":"Jiang","year":"2020","journal-title":"Drug Resist. Updates"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1056\/nejmoa061592","article-title":"NALP1in Vitiligo-Associated Multiple Autoimmune Disease","volume":"356","author":"Jin","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1128\/jvi.02914-13","article-title":"Virulence Factor NSs of Rift valley Fever Virus Recruits the F-Box Protein FBXO3 to Degrade Subunit P62 of General Transcription Factor TFIIH","volume":"88","author":"Kainulainen","year":"2014","journal-title":"J. Virol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/0092-8674(91)90112-c","article-title":"Chromosomal Translocation T(15;17) in Human Acute Promyelocytic Leukemia Fuses RAR\u03b1 with a Novel Putative Transcription Factor, PML","volume":"66","author":"Kakizuka","year":"1991","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/s41598-018-19276-3","article-title":"First Description of Behavior and Immune System Relationship in Fish","volume":"8","author":"Kirsten","year":"2018","journal-title":"Sci. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/1878-0261.12064","article-title":"Belinostat Exerts Antitumor Cytotoxicity through the Ubiquitin-Proteasome Pathway in Lung Squamous Cell Carcinoma","volume":"11","author":"Kong","year":"2017","journal-title":"Mol. Oncol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1111\/febs.13721","article-title":"Crystal Structure and Interaction Studies of the Human FBxo3 ApaG Domain","volume":"283","author":"Krzysiak","year":"2016","journal-title":"FEBS J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"9722","DOI":"10.1523\/jneurosci.1732-16.2016","article-title":"Spinal Fbxo3-dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1 Mediates Neuropathic Allodynia through CaV2.2 Activation","volume":"36","author":"Lai","year":"2016","journal-title":"J. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.bbrc.2015.02.089","article-title":"F-box Protein Fbxo3 Targets Smurf1 Ubiquitin Ligase for Ubiquitination and Degradation","volume":"458","author":"Li","year":"2015","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1016\/j.wneu.2019.12.064","article-title":"MiR-142-3p Attenuates Oxygen Glucose Deprivation\/Reoxygenation-Induced Injury by Targeting FBXO3 in Human Neuroblastoma SH-Sy5y Cells","volume":"136","author":"Li","year":"2020","journal-title":"World Neurosurg."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.4049\/jimmunol.2000305","article-title":"Zebrafish F-Box Protein Fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors Irf3 and Irf7","volume":"205","author":"Li","year":"2020","journal-title":"J.I."},{"key":"B50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.canlet.2019.09.008","article-title":"Regulation of F-Box Proteins by Noncoding RNAs in Human Cancers","volume":"466","author":"Lin","year":"2019","journal-title":"Cancer Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"16545","DOI":"10.1523\/jneurosci.2301-15.2015","article-title":"Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2\/TNIK\/GluR1 Cascade","volume":"35","author":"Lin","year":"2015","journal-title":"J. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.1158\/0008-5472.can-08-3709","article-title":"Diaphanous-related Formins Are Required for Invadopodia Formation and Invasion of Breast Tumor Cells","volume":"69","author":"Liz\u00e1rraga","year":"2009","journal-title":"Cancer Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4049\/jimmunol.1800490","article-title":"Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7","volume":"202","author":"Lu","year":"2019","journal-title":"J.I."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5247","DOI":"10.4049\/jimmunol.1300456","article-title":"Targeting F Box Protein Fbxo3 to Control Cytokine-Driven Inflammation","volume":"191","author":"Mallampalli","year":"2013","journal-title":"J.I."},{"key":"B55","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"Regulation of Inflammasome Activation","volume":"265","author":"Man","year":"2015","journal-title":"Immunol. Rev."},{"key":"B56","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/ar427","article-title":"Molecular Profile of Synovial Fibroblasts in Rheumatoid Arthritis Depends on the Stage of Proliferation","volume":"4","author":"Masuda","year":"2002","journal-title":"Arthritis Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrc1779","article-title":"Histone Deacetylase Inhibitors and the Promise of Epigenetic (And More) Treatments for Cancer","volume":"6","author":"Minucci","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ng1297-393","article-title":"Positional Cloning of the APECED Gene","volume":"17","author":"Nagamine","year":"1997","journal-title":"Nat. Genet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of Control in Inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e3001113","DOI":"10.1371\/journal.pbio.3001113","article-title":"Noncanonical TGF-\u03b2 Signaling Leads to FBXO3-Mediated Degradation of \u0394Np63\u03b1 Promoting Breast Cancer Metastasis and Poor Clinical Prognosis","volume":"19","author":"Niu","year":"2021","journal-title":"Plos Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1056\/nejmoa1606038","article-title":"Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma","volume":"375","author":"Palumbo","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.2478\/jtim-2021-0007","article-title":"The Use of Electroencephalography in Patients with Sepsis: a Review of the Literature","volume":"9","author":"Pantzaris","year":"2021","journal-title":"J. Transl Int. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1210\/jc.2005-2611","article-title":"Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy","volume":"91","author":"Perheentupa","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B64","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nri2450","article-title":"Transcriptional Regulation by AIRE: Molecular Mechanisms of central Tolerance","volume":"8","author":"Peterson","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jaut.2005.09.022","article-title":"Autoimmune Polyendocrinopathy Syndrome Type 1 (APS1) and AIRE Gene: New Views on Molecular Basis of Autoimmunity","volume":"25","author":"Peterson","year":"2005","journal-title":"J. Autoimmun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/nm.3739","article-title":"Ubiquitination in Disease Pathogenesis and Treatment","volume":"20","author":"Popovic","year":"2014","journal-title":"Nat. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jaut.2005.08.006","article-title":"Insulin Alleles and Autoimmune Regulator (AIRE) Gene Expression Both Influence Insulin Expression in the Thymus","volume":"25","author":"Sabater","year":"2005","journal-title":"J. Autoimmun."},{"key":"B68","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bbrc.2014.05.103","article-title":"N-type Voltage-dependent Ca2+ Channel in Non-excitable Microglial Cells in Mice Is Involved in the Pathophysiology of Neuropathic Pain","volume":"450","author":"Saegusa","year":"2014","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"5852","DOI":"10.1038\/sj.emboj.7601425","article-title":"Redundant Functions of RIM1\u03b1 and RIM2\u03b1 in Ca2+-Triggered Neurotransmitter Release","volume":"25","author":"Schoch","year":"2006","journal-title":"EMBO J."},{"key":"B70","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The Inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nrc.2017.105","article-title":"Ubiquitin Ligases in Oncogenic Transformation and Cancer Therapy","volume":"18","author":"Senft","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"B72","doi-asserted-by":"publisher","first-page":"17953","DOI":"10.1074\/jbc.m116.724401","article-title":"FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)","volume":"291","author":"Shao","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B73","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s00134-010-1851-3","article-title":"The Influence of Infection Sites on Development and Mortality of ARDS","volume":"36","author":"Sheu","year":"2010","journal-title":"Intensive Care Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"7126","DOI":"10.1128\/mcb.00897-08","article-title":"PML Activates Transcription by Protecting HIPK2 and P300 from SCF Fbx3 -Mediated Degradation","volume":"28","author":"Shima","year":"2008","journal-title":"Mol. Cel Biol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/dvdy.24477","article-title":"MicroRNA-142is a Multifaceted Regulator in Organogenesis, Homeostasis, and Disease","volume":"246","author":"Shrestha","year":"2017","journal-title":"Dev. Dyn."},{"key":"B76","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nrm3582","article-title":"Mechanisms and Function of Substrate Recruitment by F-Box Proteins","volume":"14","author":"Skaar","year":"2013","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nrd4432","article-title":"SCF Ubiquitin Ligase-Targeted Therapies","volume":"13","author":"Skaar","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B78","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s13287-019-1222-0","article-title":"Emerging Role of F-Box Proteins in the Regulation of Epithelial-Mesenchymal Transition and Stem Cells in Human Cancers","volume":"10","author":"Song","year":"2019","journal-title":"Stem Cel Res Ther"},{"key":"B79","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/b978-0-12-802973-2.00013-6","article-title":"The Epidemiology of Amyotrophic Lateral Sclerosis","volume":"138","author":"Talbott","year":"2016","journal-title":"Handb Clin. Neurol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2478\/jtim-2019-0026","article-title":"The Role of Calprotectin in Rheumatoid Arthritis","volume":"7","author":"Wang","year":"2019","journal-title":"J. Transl Int. Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.semcancer.2020.03.006","article-title":"NEDD4 E3 Ligase: Functions and Mechanism in Human Cancer","volume":"67","author":"Wang","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrc3700","article-title":"Roles of F-Box Proteins in Cancer","volume":"14","author":"Wang","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"B83","doi-asserted-by":"publisher","first-page":"101491","DOI":"10.1016\/j.isci.2020.101491","article-title":"An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3","volume":"23","author":"Watanabe","year":"2020","journal-title":"iScience"},{"key":"B84","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA Therapeutics - Challenges and Potential Solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/s0960-9822(00)80021-4","article-title":"A Family of Mammalian F-Box Proteins","volume":"9","author":"Winston","year":"1999","journal-title":"Curr. Biol."},{"key":"B86","first-page":"10800","article-title":"MiR-142-3p Functions as a Potential Tumor Suppressor Directly Targeting HMGB1 in Non-small-cell Lung Carcinoma","volume":"8","author":"Xiao","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"4928","DOI":"10.1002\/jcp.29372","article-title":"MiR\u2010142\u20103p Functions as a Tumor Suppressor by Targeting RAC1\/PAK1 Pathway in Breast Cancer","volume":"235","author":"Xu","year":"2020","journal-title":"J. Cel Physiol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"100673","DOI":"10.1016\/j.drup.2019.100673","article-title":"Emerging Roles of F-Box Proteins in Cancer Drug Resistance","volume":"49","author":"Yan","year":"2020","journal-title":"Drug Resist. Updates"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.802204\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T04:53:28Z","timestamp":1642568008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2021.802204\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,19]]},"references-count":88,"alternative-id":["10.3389\/fcell.2021.802204"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2021.802204","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,19]]},"article-number":"802204"}}