{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:40:19Z","timestamp":1790300419143,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Adverse environmental factors in early life result in fetal metabolic programming and increased risk of adult diseases. Birth weight is an indirect marker of the intrauterine environment, modulated by nutrient availability and placental transport capacity. However, studies of placental transporters in idiopathic birth weight alterations and in maternal obesity in relation to neonatal metabolic outcomes are scarce. We aimed to analyze the placental nutrient transporter protein expression in small (SGA, n = 14), adequate (AGA, n = 18), and large (LGA n = 10) gestational age term for newborns from healthy or obese mothers (LGA-OB, n = 9) and their association with maternal fatty acids, metabolic status, placental triglycerides, and neonatal outcomes. The transporter expression was determined by Western blot. The fatty acid profile was evaluated by gas chromatography, and placental triglycerides were quantified by an enzymatic colorimetric method. GLUT1 was higher in LGA and lower in SGA and positively correlated with maternal HbA1c and placental weight (PW). SNAT2 was lower in SGA, while SNAT4 was lower in LGA-OB. FATP1 was lower in SGA and higher in LGA. SNAT4 correlated negatively and FATP1 correlated positively with the PW and birth anthropometry (BA). Placental triglycerides were higher in LGA and LGA-OB and correlated with pregestational BMI, maternal insulin, and BA. Maternal docosahexaenoic acid (DHA) was higher in SGA, specifically in male placentas, correlating negatively with maternal triglycerides, PW, cord glucose, and abdominal perimeter. Palmitic acid (PA) correlated positively with FATP4 and cord insulin, linoleic acid correlated negatively with PA and maternal cholesterol, and arachidonic acid correlated inversely with maternal TG and directly with FATP4. Our study highlights the importance of placental programming in birth weight both in healthy and obese pregnancies.<\/jats:p>","DOI":"10.3389\/fcell.2022.822527","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:22:32Z","timestamp":1648578152000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity"],"prefix":"10.3389","volume":"10","author":[{"given":"Juan-Antonio","family":"Garcia-Santillan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luisa","family":"Lazo-de-la-Vega-Monroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria-Celina","family":"Rodriguez-Salda\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel-Angel","family":"Solis-Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Angelica","family":"Corona-Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha-Isabel","family":"Gonzalez-Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector-Manuel","family":"Gomez-Zapata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Manuel","family":"Malacara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Barbosa-Sabanero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ajog.2014.08.009","article-title":"Increased Glucose and Placental GLUT-1 in Large Infants of Obese Nondiabetic Mothers","volume":"212","author":"Acosta","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"285S","DOI":"10.1093\/ajcn\/71.1.285s","article-title":"Long-chain Polyunsaturated Fatty Acids, Pregnancy, and Pregnancy Outcome","volume":"71","author":"Al","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"272S","DOI":"10.1042\/bst022272s","article-title":"Immunolocalization of GLUT1 and GLUT3 Glucose Transporters in Human Placenta","volume":"22","author":"Arnott","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"B4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/1477-7827-9-105","article-title":"Altered Placental Development in Undernourished Rats: Role of Maternal Glucocorticoids","volume":"9","author":"Belkacemi","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/1933719110380276","article-title":"Asymmetric Syncytial Expression of GLUT9 Splice Variants in Human Term Placenta and Alterations in Diabetic Pregnancies","volume":"18","author":"Bibee","year":"2011","journal-title":"Reprod. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1042\/cs20150511","article-title":"Increased Ubiquitination and Reduced Plasma Membrane Trafficking of Placental Amino Acid Transporter SNAT-2 in Human IUGR","volume":"129","author":"Chen","year":"2015","journal-title":"Clin. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"36300","DOI":"10.1074\/jbc.274.51.36300","article-title":"The Fatty Acid Transport Protein (FATP1) Is a Very Long Chain Acyl-CoA Synthetase","volume":"274","author":"Coe","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.pcl.2004.01.004","article-title":"Abnormal Fetal Growth: Intrauterine Growth Retardation, Small for Gestational Age, Large for Gestational Age","volume":"51","author":"Das","year":"2004","journal-title":"Pediatr. Clin. North America"},{"key":"B9","doi-asserted-by":"publisher","first-page":"25867","DOI":"10.1038\/srep25867","article-title":"Associations between Whole Peripheral Blood Fatty Acids and DNA Methylation in Humans","volume":"6","author":"De La Rocha","year":"2016","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ogc.2021.02.001","article-title":"Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction","volume":"48","author":"Dumolt","year":"2021","journal-title":"Obstet. Gynecol. Clin. North America"},{"key":"B11","doi-asserted-by":"publisher","first-page":"102080","DOI":"10.1016\/j.plefa.2020.102080","article-title":"Maternal Dietary Fatty Acids and Their Roles in Human Placental Development","volume":"155","author":"Duttaroy","year":"2020","journal-title":"Prostaglandins, Leukot. Essent. Fatty Acids"},{"key":"B12","doi-asserted-by":"publisher","first-page":"20180123","DOI":"10.1098\/rstb.2018.0123","article-title":"Metabolic Programming in Early Life in Humans","volume":"374","author":"Fall","year":"2019","journal-title":"Phil. Trans. R. Soc. B"},{"key":"B13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.placenta.2010.06.006","article-title":"Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity","volume":"31","author":"Farley","year":"2010","journal-title":"Placenta"},{"key":"B14","first-page":"30","article-title":"Birth weight of male and female infants born in hospitals affiliated with the Instituto Mexicano del Seguro Social","volume":"69","author":"Flores-Huerta","year":"2012","journal-title":"Bol Med. Hosp. Infant Mex"},{"key":"B15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12958-015-0054-8","article-title":"Expression and Functional Characterisation of System L Amino Acid Transporters in the Human Term Placenta","volume":"13","author":"Gaccioli","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00726-007-0006-5","article-title":"Transport of Amino Acids through the Placenta and Their Role","volume":"34","author":"Grillo","year":"2008","journal-title":"Amino Acids"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/sj.ejcn.1602016","article-title":"Effect of Placental Function on Fatty Acid Requirements during Pregnancy","volume":"58","author":"Haggarty","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"11948","DOI":"10.1074\/jbc.m412629200","article-title":"Enzymatic Properties of Purified Murine Fatty Acid Transport Protein 4 and Analysis of Acyl-CoA Synthetase Activities in Tissues from FATP4 Null Mice","volume":"280","author":"Hall","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/s0005-2736(00)00390-4","article-title":"Evidence for the Transport of Neutral as Well as Cationic Amino Acids by ATA3, a Novel and Liver-specific Subtype of Amino Acid Transport System A","volume":"1510","author":"Hatanaka","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"B20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fphys.2016.00028","article-title":"Placental Adaptation: What Can We Learn from Birthweight:Placental Weight Ratio?","volume":"7","author":"Hayward","year":"2016","journal-title":"Front. Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/ijo.2016.188","article-title":"Maternal Obesity Modulates Intracellular Lipid Turnover in the Human Term Placenta","volume":"41","author":"Hirschmugl","year":"2017","journal-title":"Int. J. Obes."},{"key":"B22","doi-asserted-by":"publisher","first-page":"14114","DOI":"10.1038\/s41598-019-50626-x","article-title":"The Effect of High Glucose on Lipid Metabolism in the Human Placenta","volume":"9","author":"Hulme","year":"2019","journal-title":"Sci. Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1053\/plac.1999.0448","article-title":"CURRENT TOPIC: Glucose Transporters in the Human Placenta","volume":"21","author":"Illsley","year":"2000","journal-title":"Placenta"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02778","article-title":"Insulin Stimulates GLUT4 Trafficking to the Syncytiotrophoblast Basal Plasma Membrane in the Human Placenta","author":"James-Allan","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1007\/s43032-020-00173-y","article-title":"Changes in Placental Nutrient Transporter Protein Expression and Activity across Gestation in Normal and Obese Women","volume":"27","author":"James-Allan","year":"2020","journal-title":"Reprod. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1210\/jc.2012-2667","article-title":"Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies","volume":"98","author":"Jansson","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B27","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1016\/j.placenta.2005.11.010","article-title":"IFPA 2005 Award in Placentology Lecture. Human Placental Transport in Altered Fetal Growth: Does the Placenta Function as a Nutrient Sensor? -- a Review","volume":"27","author":"Jansson","year":"2006","journal-title":"Placenta"},{"key":"B28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/s0002-9378(99)70169-9","article-title":"Placental Glucose Transport and GLUT 1 Expression in Insulin-dependent Diabetes","volume":"180","author":"Jansson","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1067\/mob.2001.108075","article-title":"Placental Glucose Transport in Gestational Diabetes Mellitus","volume":"184","author":"Jansson","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1210\/jcem.77.6.8263141","article-title":"Glucose Transporter Protein Expression in Human Placenta throughout Gestation and in Intrauterine Growth Retardation","volume":"77","author":"Jansson","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.placenta.2013.08.010","article-title":"Placental Glucose Transporter 3 (GLUT3) Is Up-Regulated in Human Pregnancies Complicated by Late-Onset Intrauterine Growth Restriction","volume":"34","author":"Janzen","year":"2013","journal-title":"Placenta"},{"key":"B32","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.placenta.2007.05.002","article-title":"Regulation of Placental Nutrient Transport-Aa Review","volume":"28","author":"Jones","year":"2007","journal-title":"Placenta"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-021-00699-9","volume-title":"Role of Placental Glucose Transporters in Determining Fetal Growth","author":"Joshi","year":"2021"},{"key":"B34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000291493","article-title":"Placental Glucose Transporters in Fetal Intrauterine Growth Retardation and Macrosomia","volume":"44","author":"Kainulainen","year":"1997","journal-title":"Gynecol. Obstet. Invest."},{"key":"B35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.placenta.2016.12.008","article-title":"Review: Sexual Dimorphism in the Formation, Function and Adaptation of the Placenta","volume":"54","author":"Kalisch-Smith","year":"2017","journal-title":"Placenta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1096\/fj.13-242271","article-title":"Down-regulation of Placental mTOR, Insulin\/IGF-I Signaling, and Nutrient Transporters in Response to Maternal Nutrient Restriction in the Baboon","volume":"28","author":"Kavitha","year":"2013","journal-title":"FASEB J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1210\/jc.2014-1896","article-title":"Association between Expression of FABPpm in Skeletal Muscle and Insulin Sensitivity in Intramyocellular Lipid-Accumulated Nonobese Men","volume":"99","author":"Kawaguchi","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B38","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1201\/9781315152950-23","article-title":"Fetal Origins of Obesity, Cardiovascular Disease, and Type 2 Diabetes","volume-title":"The Biology of the First 1,000 Days","author":"Kruger","year":"2017"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1908S","DOI":"10.3945\/ajcn.110.001230","article-title":"Placental Transfer of Fatty Acids and Fetal Implications","volume":"94","author":"Larqu\u00e9","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/ajcn\/84.4.853","article-title":"Docosahexaenoic Acid Supply in Pregnancy Affects Placental Expression of Fatty Acid Transport Proteins","volume":"84","author":"Larqu\u00e9","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1530\/rep-20-0186","article-title":"Association of Placental Nutrient Sensing Pathways with Birth Weight","volume":"160","author":"Lazo-de-la-Vega-Monroy","year":"2020","journal-title":"Reproduction"},{"key":"B42","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.placenta.2017.04.023","article-title":"Placental Glucose Transporter (GLUT)-1 Is Down-Regulated in Preeclampsia","volume":"55","author":"L\u00fcscher","year":"2017","journal-title":"Placenta"},{"key":"B43","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/pr.2013.83","article-title":"SNAT2 Expression and Regulation in Human Growth-Restricted Placentas","volume":"74","author":"Mand\u00f2","year":"2013","journal-title":"Pediatr. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"21047","DOI":"10.1073\/pnas.1907884116","article-title":"Paternal Knockout of Slc38a4\/SNAT4 Causes Placental Hypoplasia Associated with Intrauterine Growth Restriction in Mice","volume":"116","author":"Matoba","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B45","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1095\/biolreprod.112.102152","article-title":"The Role of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in the Regulation of Bovine Endometrial Cell Functions","volume":"87","author":"Mishra","year":"2012","journal-title":"Biol. Reprod."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051271","article-title":"Elevated Glucose and Insulin Levels Decrease DHA Transfer across Human Trophoblasts via SIRT1-dependent Mechanism","volume":"12","author":"Mishra","year":"2020","journal-title":"Nutrients"},{"key":"B47","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1467-789x.2010.00735.x","article-title":"Early-life Determinants of Overweight and Obesity: a Review of Systematic Reviews","volume":"11","author":"Monasta","year":"2010","journal-title":"Obes. Rev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.mam.2012.07.001","article-title":"The SLC2 (GLUT) Family of Membrane Transporters","volume":"34","author":"Mueckler","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"B49","volume-title":"Atenci\u00f3n de la mujer durante el embarazo, parto y puerperio y del reci\u00e9n nacido","author":"Norma Oficial Mexicana Nom-007-Ssa2-1993","year":"1993"},{"key":"B50","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1095\/biolreprod.116.141085","article-title":"Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons","volume":"95","author":"Pantham","year":"2016","journal-title":"Biol. Reprod."},{"key":"B51","doi-asserted-by":"publisher","first-page":"158861","DOI":"10.1016\/j.bbalip.2020.158861","article-title":"Sex-specific Responses in Placental Fatty Acid Oxidation, Esterification and Transfer Capacity to Maternal Obesity","volume":"1866","author":"Powell","year":"2021","journal-title":"Biochim. Biophys. Acta (Bba) - Mol. Cel Biol. Lipids"},{"key":"B52","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1053\/plac.1999.0419","article-title":"Glucose Production by the Human Placenta In Vivo","volume":"20","author":"Prendergast","year":"1999","journal-title":"Placenta"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082892","article-title":"Reduction of In Vivo Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in the Non-human Primate","volume":"13","author":"Rosario","year":"2021","journal-title":"Nutrients"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1038\/s41598-017-03888-2","article-title":"Maternal Folate Deficiency Causes Inhibition of mTOR Signaling, Down-Regulation of Placental Amino Acid Transporters and Fetal Growth Restriction in Mice","volume":"7","author":"Rosario","year":"2017","journal-title":"Sci. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1042\/cs20150554","article-title":"Regulation of Amino Acid Transporter Trafficking by mTORC1 in Primary Human Trophoblast Cells Is Mediated by the Ubiquitin Ligase Nedd4-2","volume":"130","author":"Rosario","year":"2016","journal-title":"Clin. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1210\/en.2010-1153","article-title":"Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters","volume":"152","author":"Rosario","year":"2011","journal-title":"Endocrinology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/oby.21165","article-title":"Increased Placental Nutrient Transport in a Novel Mouse Model of Maternal Obesity with Fetal Overgrowth","volume":"23","author":"Rosario","year":"2015","journal-title":"Obesity"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4267","DOI":"10.1210\/jc.2004-2265","article-title":"Peroxisome Proliferator-Activated Receptor-\u03b3 and Retinoid X Receptor Signaling Regulate Fatty Acid Uptake by Primary Human Placental Trophoblasts","volume":"90","author":"Schaiff","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1194\/jlr.d700017-jlr200","article-title":"A Simple and Rapid Method to Assay Triacylglycerol in Cells and Tissues","volume":"48","author":"Schwartz","year":"2007","journal-title":"J. Lipid Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.placenta.2017.07.001","article-title":"Maternal BMI and Gestational Diabetes Alter Placental Lipid Transporters and Fatty Acid Composition","volume":"57","author":"Segura","year":"2017","journal-title":"Placenta"},{"key":"B61","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1017\/s2040174419000631","article-title":"Birth Size and Cancer Prognosis: a Systematic Review and Meta-Analysis","volume":"11","author":"Sharma","year":"2020","journal-title":"J. Dev. Orig Health Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.placenta.2008.07.001","article-title":"Placental System A Amino Acid Transport Is Reduced in Pregnancies with Small for Gestational Age (SGA) Infants but Not in Preeclampsia with SGA Infants","volume":"29","author":"Shibata","year":"2008","journal-title":"Placenta"},{"key":"B63","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1177\/1933719107306895","article-title":"System A Amino Acid Transporter Activity in Term Placenta Is Substrate Specific and Inversely Related to Amino Acid Concentration","volume":"14","author":"Snook Parrott","year":"2007","journal-title":"Reprod. Sci."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245833","article-title":"Differential Expression of Glucose Transporter Proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the Placenta of Macrosomic, Small-For-Gestational-Age and Growth-Restricted Foetuses","volume":"10","author":"Stanirowski","year":"2021","journal-title":"J. Clin. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jcjd.2017.04.008","article-title":"Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus","volume":"42","author":"Stanirowski","year":"2018","journal-title":"Can. J. Diabetes"},{"key":"B66","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00726-017-2384-7","article-title":"Contributions of System A Subtypes to \u03b1-methylaminoisobutyric Acid Uptake by Placental Microvillous Membranes of Human and Rat","volume":"49","author":"Takahashi","year":"2017","journal-title":"Amino Acids"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1042\/cs20210575","article-title":"Placenta-specific Slc38a2\/SNAT2 Knockdown Causes Fetal Growth Restriction in Mice","volume":"135","author":"Vaughan","year":"2021","journal-title":"Clin. Sci. (Lond)."},{"key":"B68","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/bs.pmbts.2016.12.008","article-title":"Regulation of Placental Amino Acid Transport and Fetal Growth","volume":"145","author":"Vaughan","year":"2017","journal-title":"Prog. Mol. Biol. Transl Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.plefa.2012.12.002","article-title":"Maternal Micronutrients and omega 3 Fatty Acids Affect Placental Fatty Acid Desaturases and Transport Proteins in Wistar Rats","volume":"88","author":"Wadhwani","year":"2013","journal-title":"Prostaglandins, Leukot. Essent. Fatty Acids"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.1210\/jc.2019-00166","article-title":"Use of Glucose, Glutamine and Fatty Acids for Trophoblast Respiration in Lean, Obese and Gestational Diabetic Women","volume":"104","author":"Wang","year":"2019","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"B71","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.diabres.2016.07.003","article-title":"Expression and Correlation of Sex Hormone-Binding Globulin and Insulin Signal Transduction and Glucose Transporter Proteins in Gestational Diabetes Mellitus Placental Tissue","volume":"119","author":"Zhang","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B72","doi-asserted-by":"publisher","first-page":"R1224","DOI":"10.1152\/ajpregu.00309.2010","article-title":"Maternal Obesity Markedly Increases Placental Fatty Acid Transporter Expression and Fetal Blood Triglycerides at Midgestation in the Ewe","volume":"299","author":"Zhu","year":"2010","journal-title":"Am. J. Physiology-Regulatory, Integr. Comp. Physiol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.822527\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T18:22:41Z","timestamp":1648578161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.822527\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":72,"alternative-id":["10.3389\/fcell.2022.822527"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2022.822527","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"article-number":"822527"}}