{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:26:07Z","timestamp":1773710767820,"version":"3.50.1"},"reference-count":192,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>As an evidence-based performance, the rising incidence of various ischemic disorders has been observed across many nations. As a result, there is a growing need for the development of more effective regenerative approaches that could serve as main therapeutic strategies for the treatment of these diseases. From a cellular perspective, promoted complex inflammatory mechanisms, after inhibition of organ blood flow, can lead to cell death in all tissue types. In this case, using the stem cell technology provides a safe and regenerative approach for ischemic tissue revascularization and functional cell formation. Limb ischemia (LI) is one of the most frequent ischemic disease types and has been shown to have a promising regenerative response through stem cell therapy based on several clinical trials. Bone marrow-derived mononuclear cells (BM-MNCs), peripheral blood CD34-positive mononuclear cells (CD34<jats:sup>+<\/jats:sup> PB-MNCs), mesenchymal stem cells (MSCs), and endothelial stem\/progenitor cells (ESPCs) are the main, well-examined stem cell types in these studies. Additionally, our investigations reveal that endometrial tissue can be considered a suitable candidate for isolating new safe, effective, and feasible multipotent stem cells for limb regeneration. In addition to other teams\u2019 results, our in-depth studies on endometrial-derived stem cells (EnSCs) have shown that these cells have translational potential for limb ischemia treatment. The EnSCs are able to generate diverse types of cells which are essential for limb reconstruction, including endothelial cells, smooth muscle cells, muscle cells, and even peripheral nervous system populations. Hence, the main object of this review is to present stem cell technology and evaluate its method of regeneration in ischemic limb tissue.<\/jats:p>","DOI":"10.3389\/fcell.2022.834754","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:35:51Z","timestamp":1653284151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Stem Cell Therapy in Limb Ischemia: State-of-Art, Perspective, and Possible Impacts of Endometrial-Derived Stem Cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Saeed","family":"Khodayari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Khodayari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Ebrahimi-Barough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Khanmohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Shahidul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miko","family":"Vesovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibollah","family":"Mahmoodzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Nayernia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Aghdami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jafar","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e82085","DOI":"10.1371\/journal.pone.0082085","article-title":"Endothelial Progenitor Cells Promote Directional Three-Dimensional Endothelial Network Formation by Secreting Vascular Endothelial Growth Factor","volume":"8","author":"Abe","year":"2013","journal-title":"PloS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4236\/scd.2013.31002","article-title":"Effect of Deforolimus and VEGF on Angiogenesis in Endometrial Stromal Cells Following Three-Dimensional Culture","volume":"3","author":"Ai","year":"2013","journal-title":"Stem Cel. Discov."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4236\/scd.2013.31002","article-title":"Are Endometrial Stem Cells Novel Tools against Ischemic Heart Failure in Women? a Hypothesis","volume":"12","author":"Ai","year":"2010","journal-title":"Iranian Red Crescent Med. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"126S","DOI":"10.1016\/j.jvs.2018.01.071","article-title":"A Systematic Review and Meta-Analysis of Revascularization Outcomes of Infrainguinal Chronic Limb-Threatening Ischemia","volume":"69","author":"Almasri","year":"2019","journal-title":"J. Vasc. Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/stem.2298","article-title":"Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor\u2010KappaB Signaling","volume":"34","author":"Anderson","year":"2016","journal-title":"Stem Cells"},{"key":"B6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-61779-201-4_11","article-title":"GMP Scale-Up and Banking of Pluripotent Stem Cells for Cellular Therapy Applications","volume-title":"Human Pluripotent Stem Cells","author":"Ausubel","year":"2011"},{"key":"B7","doi-asserted-by":"publisher","first-page":"H1875","DOI":"10.1152\/ajpheart.00523.2010","article-title":"Human Cord Blood CD34+ Progenitor Cells Acquire Functional Cardiac Properties Through a Cell Fusion Process","volume":"300","author":"Avitabile","year":"2011","journal-title":"Am. J. Physiology-Heart Circulatory Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.lfs.2016.09.013","article-title":"Reactive Oxygen Species-Mediated Cardiac-Reperfusion Injury: Mechanisms and Therapies","volume":"165","author":"Bagheri","year":"2016","journal-title":"Life Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"17197","DOI":"10.1074\/jbc.m310329200","article-title":"Opening of the Mitochondrial Permeability Transition Pore Induces Reactive Oxygen Species Production at the Level of the Respiratory Chain Complex I","volume":"279","author":"Batandier","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"7170","DOI":"10.1007\/s12035-015-9574-7","article-title":"Differentiation of Human Endometrial Stem Cells into Schwann Cells in Fibrin Hydrogel as 3D Culture","volume":"53","author":"Bayat","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0118","article-title":"Potential of Mesenchymal Stem Cells as Topical Immunomodulatory Cell Therapies for Ocular Surface Inflammatory Disorders","author":"Beeken","year":"2021","journal-title":"Stem Cell Translational Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1006\/clin.1994.1003","article-title":"Phenotypic Analysis and Characterization of CD34+ Cells from Normal Human Bone Marrow, Cord Blood, Peripheral Blood, and Mobilized Peripheral Blood from Patients Undergoing Autologous Stem Cell Transplantation","volume":"70","author":"Bender","year":"1994","journal-title":"Clin. Immunol. Immunopathology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1182\/blood-2004-06-2315","article-title":"Regulator of G-Protein Signaling-5 Induction in Pericytes Coincides with Active Vessel Remodeling During Neovascularization","volume":"105","author":"Berger","year":"2005","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1089\/scd.2016.0275","article-title":"Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: a Randomized, Placebo-Controlled Comparative Study","volume":"26","author":"Bhansali","year":"2017","journal-title":"Stem Cell Dev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-11-56","article-title":"Endometrial Regenerative Cells for Treatment of Heart Failure: A New Stem Cell Enters the Clinic","volume":"11","author":"Bockeria","year":"2013","journal-title":"J. Translational Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.3389\/fcell.2021.674084","article-title":"Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration","volume":"9","author":"Bouland","year":"2021","journal-title":"Front. Cel. Developmental Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jcyt.2013.11.011","article-title":"Phase I Trial: The Use of Autologous Cultured Adipose-Derived Stroma\/Stem Cells to Treat Patients with Non-Revascularizable Critical Limb Ischemia","volume":"16","author":"Bura","year":"2014","journal-title":"Cytotherapy"},{"key":"B18","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/prs.0b013e318219c171","article-title":"The Levels of Evidence and Their Role in Evidence-Based Medicine","volume":"128","author":"Burns","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.theriogenology.2017.09.035","article-title":"Equine Mesenchymal Stem Cells Derived from Endometrial or Adipose Tissue Share Significant Biological Properties, but Have Distinctive Pattern of Surface Markers and Migration","volume":"106","author":"Cabezas","year":"2018","journal-title":"Theriogenology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1046\/j.1537-2995.1998.38111299056318.x","article-title":"Peripheral Blood CD34+ Cell Immunomagnetic Selection in Breast Cancer Patients: Effect on Hematopoietic Progenitor Content and Hematologic Recovery after High\u2010Dose Chemotherapy and Autotransplantation","volume":"38","author":"Cancelas","year":"1998","journal-title":"Transfusion"},{"key":"B21","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/molehr\/gax006","article-title":"Angiogenic Properties of Endometrial Mesenchymal Stromal Cells in Endothelial Co-Culture: an In Vitro Model of Endometriosis","volume":"23","author":"Canosa","year":"2017","journal-title":"MHR: Basic Sci. Reprod. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1095\/biolreprod.103.024109","article-title":"Clonogenicity of Human Endometrial Epithelial and Stromal Cells","volume":"70","author":"Chan","year":"2004","journal-title":"Biol. Reprod."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1210\/en.130.4.2373","article-title":"Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF), and EGF and PDGF Beta-Receptors in Human Endometrial Tissue: Localization and In Vitro Action","volume":"130","author":"Chegini","year":"1992","journal-title":"Endocrinology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.1113\/jp270650","article-title":"Reactive Oxygen\/Nitrogen Species and Contractile Function in Skeletal Muscle during Fatigue and Recovery","volume":"594","author":"Cheng","year":"2016","journal-title":"J. Physiol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4794827","article-title":"Characteristics of Human Endometrium-Derived Mesenchymal Stem Cells and Their Tropism to Endometriosis","author":"Cheng","year":"2017","journal-title":"Stem Cell Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.2337\/diabetes.54.suppl_2.s97","article-title":"Mechanisms of Pancreatic \u03b2-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities","volume":"54","author":"Cnop","year":"2005","journal-title":"Diabetes"},{"key":"B27","doi-asserted-by":"publisher","first-page":"415","DOI":"10.4155\/bio-2021-0007","article-title":"2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation (Part 3\u2013Recommendations on Immunogenicity Assay Strategies, NAb Assays, Biosimilars and FDA\/EMA Immunogenicity Guidance\/Guideline, Gene & Cell Therapy and Vaccine Assays)","volume":"13","author":"Corsaro","year":"2021","journal-title":"Bioanalysis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1089\/scd.2017.0241","article-title":"Comparison of Antibacterial and Immunological Properties of Mesenchymal Stem\/Stromal Cells from Equine Bone Marrow, Endometrium, and Adipose Tissue","volume":"27","author":"Cort\u00e9s-Araya","year":"2018","journal-title":"Stem Cell Dev."},{"key":"B29","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.3390\/ijms130910697","article-title":"Cell Signaling through Protein Kinase C Oxidation and Activation","volume":"13","author":"Cosentino-Gomes","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1091\/mbc.e06-09-0872","article-title":"Menstrual Blood-Derived Cells Confer Human Dystrophin Expression in the Murine Model of Duchenne Muscular Dystrophy via Cell Fusion and Myogenic Transdifferentiation","volume":"18","author":"Cui","year":"2007","journal-title":"Mol. Biol. Cel."},{"key":"B31","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.stem.2018.05.014","article-title":"A First-In-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury","volume":"22","author":"Curtis","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-015-0105-2","article-title":"Efficacy of Autologous Stem Cell-Based Therapy for Osteonecrosis of the Femoral Head in Sickle Cell Disease: A Five-Year Follow-Up Study","volume":"6","author":"Daltro","year":"2015","journal-title":"Stem Cel. Res. Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1007\/s00268-012-1892-6","article-title":"Intra-Arterial Allogeneic Mesenchymal Stem Cells for Critical Limb Ischemia Are Safe and Efficacious: Report of a Phase I Study","volume":"37","author":"Das","year":"2013","journal-title":"World J. Surg."},{"key":"B34","volume-title":"Guideline-Based Decision Support in Medicine","author":"De Clercq","year":"2003"},{"key":"B35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/dmrr.2399","article-title":"Both Autologous Bone Marrow Mononuclear Cell and Peripheral Blood Progenitor Cell Therapies Similarly Improve Ischaemia in Patients with Diabetic Foot in Comparison with Control Treatment","volume":"29","author":"Dubsky","year":"2013","journal-title":"Diabetes\/Metabolism Res. Rev."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1002\/jbm.a.35397","article-title":"Investigating the Neuroglial Differentiation Effect of Neuroblastoma Conditioned Medium in Human Endometrial Stem Cells Cultured on 3D Nanofibrous Scaffold","volume":"103","author":"Ebrahimi\u2010Barough","year":"2015","journal-title":"J. Biomed. Mater. Res. A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s12031-013-9957-z","article-title":"Differentiation of Human Endometrial Stromal Cells into Oligodendrocyte Progenitor Cells (OPCs)","volume":"51","author":"Ebrahimi-Barough","year":"","journal-title":"J. Mol. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12031-013-0101-x","article-title":"Derivation of Pre-Oligodendrocytes from Human Endometrial Stromal Cells by Using Overexpression of microRNA 338","volume":"51","author":"Ebrahimi-Barough","year":"","journal-title":"J. Mol. Neurosci."},{"key":"B39","first-page":"422","article-title":"Intra-Articular Injection of Autologous Mesenchymal Stem Cells in Six Patients with Knee Osteoarthritis","volume":"15","author":"Emadedin","year":"2012","journal-title":"Arch. Iranian Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.jcyt.2018.08.005","article-title":"Intra-Articular Implantation of Autologous Bone Marrow\u2013Derived Mesenchymal Stromal Cells to Treat Knee Osteoarthritis: a Randomized, Triple-Blind, Placebo-Controlled Phase 1\/2 Clinical Trial","volume":"20","author":"Emadedin","year":"2018","journal-title":"Cytotherapy"},{"key":"B41","volume-title":"Guideline on Human Cell-Based Medicinal Products","author":"Emea","year":"2008"},{"key":"B42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1600-0897.2006.00445.x","article-title":"Expression of Glycodelin and Cyclooxygenase\u20102 in Human Endometrial Tissue Following Three\u2010Dimensional Culture","volume":"57","author":"Esfandiari","year":"","journal-title":"Am. J. Reprod. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.fertnstert.2006.06.040","article-title":"Effect of a Statin on an In Vitro Model of Endometriosis","volume":"87","author":"Esfandiari","year":"","journal-title":"Fertil. Sterility"},{"key":"B44","first-page":"C664","article-title":"Angiogenesis Following Three-Dimensional Culture of Isolated Human Endometrial Stromal Cells Revascularization and Endothelial Progenitor Cells in Stroke","volume":"315","author":"Esfandiari","year":"2008","journal-title":"Am. J. Physiology-Cell Physiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"C664","DOI":"10.1152\/ajpcell.00200.2018","article-title":"Revascularization and Endothelial Progenitor Cells in Stroke","volume":"315","author":"Esquiva","year":"2018","journal-title":"Am. J. Physiology-Cell Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"PFertile Ground: Human Endometrial Programming and Lessons in Health and Disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"B47","first-page":"3992","article-title":"Evaluation of Differentiation Potential of Endometrial-Versus Bone Marrow Drived Mesenchymal Stem Cells into Myoblast-Like Cells","volume":"4","author":"Faghihi","year":"2014","journal-title":"IJCRLS"},{"key":"B48","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","article-title":"Peripheral Artery Disease: Epidemiology and Global Perspectives","volume":"14","author":"Fowkes","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1161\/01.RES.0000205765.28940.93","article-title":"CD34\u2212\/CD133+\/VEGFR-2+ Endothelial Progenitor Cell Subpopulation with Potent Vasoregenerative Capacities","volume":"98","author":"Friedrich","year":"2006","journal-title":"Circ. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","article-title":"Adult Neural Stem Cells Bridge Their Niche","volume":"10","author":"Fuentealba","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1634\/stemcells.22-4-617","article-title":"Skeletal Myogenic Differentiation of Mesenchymal Stem Cells Isolated from Human Umbilical Cord Blood","volume":"22","author":"Gang","year":"2004","journal-title":"Stem Cells"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-019-1254-5","article-title":"Autologous Stem Cell Therapy for Peripheral Arterial Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"10","author":"Gao","year":"2019","journal-title":"Stem Cel. Res. Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1095\/biolreprod.108.075226","article-title":"Isolation and Culture of Epithelial Progenitors and Mesenchymal Stem Cells from Human Endometrium","volume":"80","author":"Gargett","year":"2009","journal-title":"Biol. Reprod."},{"key":"B54","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.stemcr.2018.01.037","article-title":"Prospective Isolation of ISL1+ Cardiac Progenitors from Human ESCs for Myocardial Infarction Therapy","volume":"10","author":"Ghazizadeh","year":"2018","journal-title":"Stem Cel. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0015-0282(16)56447-4","article-title":"Growth Factors and Growth Modulators in Human Uterine Endometrium: Their Potential Relevance to Reproductive Medicine","volume":"61","author":"Giudice","year":"1994","journal-title":"Fertil. Sterility"},{"key":"B56","doi-asserted-by":"publisher","first-page":"45200","DOI":"10.18632\/oncotarget.16778","article-title":"Mesenchymal Stem Cells Release Exosomes that Transfer miRNAs to Endothelial Cells and Promote Angiogenesis","volume":"8","author":"Gong","year":"2017","journal-title":"Oncotarget"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7783","DOI":"10.1007\/s11033-020-05855-z","article-title":"Simultaneous Impact of Atorvastatin and Mesenchymal Stem Cells for Glioblastoma Multiform Suppression in Rat Glioblastoma Multiform Model","volume":"47","author":"Goodarzi","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-11-143","article-title":"A Double Blind Randomized Placebo Controlled Phase I\/II Study Assessing the Safety and Efficacy of Allogeneic Bone Marrow Derived Mesenchymal Stem Cell in Critical Limb Ischemia","volume":"11","author":"Gupta","year":"2013","journal-title":"J. Translational Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"689","DOI":"10.5966\/sctm.2016-0237","article-title":"Administration of Adult Human Bone Marrow\u2010Derived, Cultured, Pooled, Allogeneic Mesenchymal Stromal Cells in Critical Limb Ischemia Due to Buerger\u2019s Disease: Phase II Study Report Suggests Clinical Efficacy","volume":"6","author":"Gupta","year":"2017","journal-title":"Stem Cell Translational Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1056\/nejmhpr063086","article-title":"FDA Regulation of Stem-Cell-Based Therapies","volume":"355","author":"Halme","year":"2006","journal-title":"New Engl. J. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00441-017-2728-3","article-title":"Single-Cell Analysis of Diversity in Human Stem Cell-Derived Neurons","volume":"371","author":"Harbom","year":"2018","journal-title":"Cel. Tissue Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1002\/cbin.11478","article-title":"Defining the Role of 17\u03b2\u2010Estradiol in Human Endometrial Stem Cells Differentiation into Neuron\u2010Like Cells","volume":"45","author":"Hasanzadeh","year":"2021","journal-title":"Cel. Biol. Int."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-021-02165-4","article-title":"Mesenchymal Stem Cells Derived from Perinatal Tissues for Treatment of Critically Ill COVID-19-Induced ARDS Patients: A Case Series","volume":"12","author":"Hashemian","year":"2021","journal-title":"Stem Cel. Res. Ther."},{"key":"B64","doi-asserted-by":"crossref","DOI":"10.1016\/S0168-8278(18)31480-6","volume-title":"The Pathogenic Role of Stat2 in Inflammation Is Independent of Canonical Interferon Signaling and Is Mediated by TNFa","author":"Heath","year":"2018"},{"key":"B65","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1001\/jama.2013.282909","article-title":"Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy: The TAC-HFT Randomized Trial","volume":"311","author":"Heldman","year":"2014","journal-title":"Jama"},{"key":"B66","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5090\/kjtcs.2017.50.2.114","article-title":"Acute Limb Ischemia and Coronary Artery Disease in a Case of Kimura\u2019s Disease","volume":"50","author":"Heo","year":"2017","journal-title":"Korean J. Thorac. Cardiovasc. Surg."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes","volume":"19","author":"Hicks","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.bbrc.2005.03.086","article-title":"In Vitro Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells into Hepatocyte-Like Cells","volume":"330","author":"Hong","year":"2005","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/stem.1540","article-title":"HIF\u2010Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell\u2010Based Therapies for the Treatment of Critical Limb Ischemia","volume":"32","author":"Howangyin","year":"2014","journal-title":"Stem Cells"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.3892\/ol.2016.4952","article-title":"Glioblastoma Multiforme: Effect of Hypoxia and Hypoxia Inducible Factors on Therapeutic Approaches","volume":"12","author":"Huang","year":"2016","journal-title":"Oncol. Lett."},{"key":"B71","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","article-title":"Evidence of ROS Generation by Mitochondria in Cells with Impaired Electron Transport Chain and Mitochondrial DNA Damage","volume":"7","author":"Indo","year":"2007","journal-title":"Mitochondrion"},{"key":"B72","doi-asserted-by":"publisher","first-page":"8999","DOI":"10.3390\/ijms21238999","article-title":"Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia","volume":"21","author":"Jaluvka","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-60466-9","article-title":"Development of Genetic Quality Tests for Good Manufacturing Practice-Compliant Induced Pluripotent Stem Cells and Their Derivatives","volume":"10","author":"Jo","year":"2020","journal-title":"Scientific Rep."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/sctm.20-0046","article-title":"CD34+ Cell Therapy Significantly Reduces Adverse Cardiac Events, Health Care Expenditures, and Mortality in Patients with Refractory Angina","volume":"9","author":"Johnson","year":"2020","journal-title":"Stem Cell Translational Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00109-018-1729-3","article-title":"Approaches to Therapeutic Angiogenesis for Ischemic Heart Disease","volume":"97","author":"Johnson","year":"2019","journal-title":"J. Mol. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/s0140-6736(16)30513-x","article-title":"Human Neural Stem Cells in Patients with Chronic Ischaemic Stroke (PISCES): a Phase 1, First-In-Man Study","volume":"388","author":"Kalladka","year":"2016","journal-title":"The Lancet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1634\/stemcells.2004-0173a","article-title":"Roles of Stat3 and ERK in G\u2010CSF Signaling","volume":"23","author":"Kamezaki","year":"2005","journal-title":"Stem Cells"},{"key":"B78","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/genes2010107","article-title":"Prospects and Limitations of Using Endogenous Neural Stem Cells for Brain Regeneration","volume":"2","author":"Kaneko","year":"2011","journal-title":"Genes"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1002\/stem.207","article-title":"Intramuscular Transplantation of G\u2010CSF\u2010Mobilized CD34+ Cells in Patients with Critical Limb Ischemia: A Phase I\/IIa, Multicenter, Single\u2010Blinded, Dose\u2010Escalation Clinical Trial","volume":"27","author":"Kawamoto","year":"2009","journal-title":"Stem Cells"},{"key":"B80","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.stem.2012.05.015","article-title":"Mesenchymal Stromal Cells: New Directions","volume":"10","author":"Keating","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jmhi.2013.07.004","article-title":"Human Endometrial Adult Stem Cells Can Be Differentiated into Hepatocyte Cells","volume":"8","author":"Khademi","year":"2014","journal-title":"J. Med. Hypotheses Ideas"},{"key":"B82","doi-asserted-by":"publisher","first-page":"174281","DOI":"10.1016\/j.ejphar.2021.174281","article-title":"Dual Effects of Atorvastatin on Angiogenesis Pathways in the Differentiation of Mesenchymal Stem Cells","author":"Khalighfard","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1007\/s00262-021-02975-8","article-title":"Stem Cells-Derived Natural Killer Cells for Cancer Immunotherapy: Current Protocols, Feasibility, and Benefits of Ex Vivo Generated Natural Killer Cells in Treatment of Advanced Solid Tumors","volume":"70","author":"Khodayari","year":"","journal-title":"Cancer Immunol. Immunother."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-80428-5","article-title":"Gamma-Radiated Immunosuppressed Tumor Xenograft Mice Can Be a New Ideal Model in Cancer Research","volume":"11","author":"Khodayari","year":"","journal-title":"Scientific Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"887","DOI":"10.33594\/000000180","article-title":"Inflammatory Microenvironment of Acute Myocardial Infarction Prevents Regeneration of Heart with Stem Cells Therapy","volume":"53","author":"Khodayari","year":"2019","journal-title":"Cell Physiol. Biochem."},{"key":"B86","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1242\/jcs.075770","article-title":"Tnf\u03b1-Induced Noncanonical NF-\u039ab Activation Is Attenuated by RIP1 Through Stabilization of TRAF2","volume":"124","author":"Kim","year":"2011","journal-title":"J. Cel. Sci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/jocd.13063","article-title":"The Effect of Human Umbilical Cord Blood\u2013Derived Mesenchymal Stem Cell Media Containing Serum on Recovery After Laser Treatment: A Double\u2010Blinded, Randomized, Split\u2010Face Controlled Study","volume":"19","author":"Kim","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10557-018-6804-z","article-title":"Improvement in Left Ventricular Function with Intracoronary Mesenchymal Stem Cell Therapy in a Patient with Anterior Wall ST-Segment Elevation Myocardial Infarction","volume":"32","author":"Kim","year":"2018","journal-title":"Cardiovasc. Drugs Ther."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1161\/01.cir.0000124062.31102.57","article-title":"Local Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms","volume":"109","author":"Kinnaird","year":"2004","journal-title":"Circulation"},{"key":"B90","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2012.07.031","article-title":"Long-Term Clinical Outcome after Intramuscular Transplantation of Granulocyte colony Stimulating Factor-Mobilized CD34 Positive Cells in Patients with Critical Limb Ischemia","volume":"224","author":"Kinoshita","year":"2012","journal-title":"Atherosclerosis"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1111\/j.1582-4934.2008.00479.x","article-title":"CD34+ Cells Augment Endothelial Cell Differentiation of CD14+ Endothelial Progenitor Cells In Vitro","volume":"13","author":"Krenning","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"B92","first-page":"344","article-title":"Autologous Transplantation of Peripheral Blood Endothelial Progenitor Cells (CD34^ Sup+^) for Therapeutic Angiogenesis in Patients with Critical Limb Ischemia","volume":"22","author":"Kudo","year":"2003","journal-title":"Int. angiology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/joim.12102","article-title":"Medical Management of Critical Limb Ischaemia: Where Do We Stand Today?","volume":"274","author":"Lambert","year":"2013","journal-title":"J. Intern. Med."},{"key":"B94","volume-title":"Translating Regenerative Medicine to the Clinic","author":"Laurence","year":"2015"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1097\/ccm.0000000000001138","article-title":"Intracoronary Transfusion of Circulation-Derived CD34+ Cells Improves Left Ventricular Function in Patients with End-Stage Diffuse Coronary Artery Disease Unsuitable for Coronary Intervention","volume":"43","author":"Lee","year":"2015","journal-title":"Read. Online Crit. Care Med. So.y Cri.l Care Me.e"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/j.1523-1755.2004.00491.x","article-title":"Reactive Oxygen Species Amplify Protein Kinase C Signaling in High Glucose-Induced Fibronectin Expression by Human Peritoneal Mesothelial Cells","volume":"65","author":"Lee","year":"2004","journal-title":"Kidney Int."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1042\/BST0321018","article-title":"Redox Regulation of Phosphatase Function","volume":"32","author":"Leslie","year":"2004","journal-title":"Biochem. Soc. Trans."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1161\/strokeaha.119.026318","article-title":"Phase I\/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke","volume":"50","author":"Levy","year":"2019","journal-title":"Stroke"},{"key":"B99","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1160\/th05-06-0442","article-title":"Therapeutic Neovascularization by Transplantation of Mobilized Peripheral Blood Mononuclear Cells for Limb Ischemia","volume":"95","author":"Li","year":"2006","journal-title":"Thromb. Haemost."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-018-1053-4","article-title":"Safety Analysis in Patients with Autoimmune Disease Receiving Allogeneic Mesenchymal Stem Cells Infusion: A Long-Term Retrospective Study","volume":"9","author":"Liang","year":"2018","journal-title":"Stem Cel. Res. Ther."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.jvs.2016.01.022","article-title":"Autologous Bone Marrow Mononuclear Cell Therapy for Critical Limb Ischemia Is Effective and Durable","volume":"63","author":"Liang","year":"","journal-title":"J. Vasc. Surg."},{"key":"B102","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1242\/jcs.170373","article-title":"Exosomes Secreted by Mesenchymal Stem Cells Promote Endothelial Cell Angiogenesis by Transferring miR-125a","volume":"129","author":"Liang","year":"","journal-title":"J. Cel. Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1253\/circj.cj-17-0720","article-title":"Therapeutic Efficacy of Autologous Non-Mobilized Enriched Circulating Endothelial Progenitors in Patients with Critical Limb Ischemia\u2015the SCELTA Trial","volume":"82","author":"Liotta","year":"2018","journal-title":"Circ. J."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-017-1149-0","article-title":"Comparative Analysis of Curative Effect of Bone Marrow Mesenchymal Stem Cell and Bone Marrow Mononuclear Cell Transplantation for Spastic Cerebral Palsy","volume":"15","author":"Liu","year":"2017","journal-title":"J. Translational Med."},{"key":"B105","first-page":"389","article-title":"Addition of Peripheral Blood Stem Cells Collected without Mobilization Techniques to Transplanted Autologous Bone Marrow Did Not Hasten Marrow Recovery Following Myeloablative Therapy","volume":"8","author":"Lobo","year":"1991","journal-title":"Bone Marrow Transplant."},{"key":"B106","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1177\/0963689719835177","article-title":"Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes","volume":"28","author":"Lu","year":"2019","journal-title":"Cel. Transplant."},{"key":"B107","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2174\/1874325001105010253","article-title":"Suppl 2: Adult Mesenchymal Stem Cells and Cell Surface Characterization-A Systematic Review of the Literature","volume":"5","author":"Mafi","year":"2011","journal-title":"Open Orthopaedics J."},{"key":"B108","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jcyt.2018.02.368","article-title":"Bone Marrow\u2013Mesenchymal Stromal Cell Infusion in Patients with Chronic Kidney Disease: A Safety Study with 18 Months of Follow-Up","volume":"20","author":"Makhlough","year":"2018","journal-title":"Cytotherapy"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-017-0557-7","article-title":"Safety and Tolerability of Autologous Bone Marrow Mesenchymal Stromal Cells in ADPKD Patients","volume":"8","author":"Makhlough","year":"2017","journal-title":"Stem Cel. Res. Ther."},{"key":"B110","doi-asserted-by":"publisher","first-page":"101","DOI":"10.33594\/000000124","article-title":"Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function","volume":"53","author":"Mardanpour","year":"2019","journal-title":"Cel. Physiol. Biochem."},{"key":"B111","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/ma6020637","article-title":"Advanced Strategies for Articular Cartilage Defect Repair","volume":"6","author":"Matsiko","year":"2013","journal-title":"Materials"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-5-57","article-title":"Endometrial Regenerative Cells: A Novel Stem Cell Population","volume":"5","author":"Meng","year":"2007","journal-title":"J. Translational Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"4798","DOI":"10.1007\/s12035-015-9410-0","article-title":"The Differentiation of Human Endometrial Stem Cells into Neuron-Like Cells on Electrospun PAN-Derived Carbon Nanofibers with Random and Aligned Topographies","volume":"53","author":"Mirzaei","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1042\/cbr20110009","article-title":"Human Endometrial Stem Cells as a New Source for Programming to Neural Cells","volume":"19","author":"Mobarakeh","year":"2012","journal-title":"Cel. Biol. Int. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1080\/21691401.2017.1391823","article-title":"Enhanced Sciatic Nerve Regeneration by Human Endometrial Stem Cells in an Electrospun Poly (\u03b5-Caprolactone)\/Collagen\/NBG Nerve Conduit in Rat","volume":"46","author":"Mohamadi","year":"2018","journal-title":"Artif. Cell Nanomedicine, Biotechnol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5966\/sctm.2015-0004","article-title":"Intraportal Infusion of Bone Marrow Mononuclear or CD133+ Cells in Patients with Decompensated Cirrhosis: a Double\u2010blind Randomized Controlled Trial","volume":"5","author":"Mohamadnejad","year":"2016","journal-title":"Stem Cell translational Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jcyt.2020.02.007","article-title":"Autologous Bone Marrow Mesenchymal Stromal Cell Therapy for \u201cNo-option\u201d Critical Limb Ischemia Is Limited by Karyotype Abnormalities","volume":"22","author":"Mohamed","year":"2020","journal-title":"Cytotherapy"},{"key":"B118","first-page":"388","article-title":"Safety and Efficacy of Repeated Bone Marrow Mononuclear Cell Therapy in Patients with Critical Limb Ischemia in a Pilot Randomized Controlled Trial","volume":"19","author":"Molavi","year":"2016","journal-title":"Arch. Iranian Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/ijs.12520","article-title":"Intra-arterial Bone Marrow Mononuclear Cells (BM-MNCs) Transplantation in Acute Ischemic Stroke (IBIS Trial): Protocol of a Phase II, Randomized, Dose-Finding, Controlled Multicenter Trial","volume":"10","author":"Moniche","year":"2015","journal-title":"Int. J. Stroke"},{"key":"B120","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1136\/jnnp-2019-322515","article-title":"Intracerebral Implantation of Human Neural Stem Cells and Motor Recovery after Stroke: Multicentre Prospective Single-Arm Study (PISCES-2)","volume":"91","author":"Muir","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-6-45","article-title":"Allogeneic Endometrial Regenerative Cells: an\" off the Shelf Solution\" for Critical Limb Ischemia?","volume":"6","author":"Murphy","year":"2008","journal-title":"J. translational Med."},{"key":"B122","first-page":"320","article-title":"Enhancing Limb Salvage by Non-Mobilized Peripheral Blood Angiogenic Cell Precursors Therapy in Patients with Critical Limb Ischemia","volume":"92","author":"Mutirangura","year":"2009","journal-title":"J. Med. Assoc. Thai"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1016\/j.jacc.2018.08.002","article-title":"Pathology of Peripheral Artery Disease in Patients with Critical Limb Ischemia","volume":"72","author":"Narula","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1002\/jbm.a.34921","article-title":"Enhancing Neuronal Growth from Human Endometrial Stem Cells Derived Neuron\u2010Like Cells in Three\u2010Dimensional Fibrin Gel for Nerve Tissue Engineering","volume":"102","author":"Navaei\u2010Nigjeh","year":"2014","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"B125","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/sctm.18-0104","article-title":"Autologous Granulocyte Colony\u2010Stimulating Factor\u2010Mobilized Peripheral Blood CD34 Positive Cell Transplantation for Hemodialysis Patients with Critical Limb Ischemia: A Prospective Phase II Clinical Trial","volume":"7","author":"Ohtake","year":"2018","journal-title":"Stem Cell Translational Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-018-1117-5","article-title":"Predictors of Responders to Mononuclear Stem Cell-Based Therapeutic Angiogenesis for No-Option Critical Limb Ischemia","volume":"10","author":"Pan","year":"2019","journal-title":"Stem Cel. Res. Ther."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.jcyt.2013.05.013","article-title":"A Pilot Study of Autologous CD34-Depleted Bone Marrow Mononuclear Cell Transplantation via the Hepatic Artery in Five Patients with Liver Failure","volume":"15","author":"Park","year":"2013","journal-title":"Cytotherapy"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.4103\/1673-5374.139457","article-title":"Growth Factor-And Cytokine-Stimulated Endothelial Progenitor Cells in Post-Ischemic Cerebral Neovascularization","volume":"9","author":"Peplow","year":"2014","journal-title":"Neural Regen. Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4330\/wjc.v3.i6.186","article-title":"Ischemia\/Reperfusion Injury and Cardioprotective Mechanisms: Role of Mitochondria and Reactive Oxygen Species","volume":"3","author":"Perrelli","year":"2011","journal-title":"World J. Cardiol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise Review: MSC\u2010Derived Exosomes for Cell\u2010free Therapy","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/369828","article-title":"High OCT4 and Low Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells","volume":"2015","author":"Piccinato","year":"2015","journal-title":"Stem Cell Int."},{"key":"B132","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jcyt.2012.12.003","article-title":"Twenty Years of Unrestricted Hematopoietic Stem Cell Collection and Storage: Impact of Joint Accreditation Committee International Society for Cellular Therapy Europe Standards Implementation on Stem Cell Storage Policy and Resource Utilization","volume":"15","author":"Piccirillo","year":"2013","journal-title":"Cytotherapy"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1253\/circj.cj-17-0045","article-title":"Autologous Bone Marrow Mononuclear Cell Implantation and its Impact on the Outcome of Patients with Critical Limb Ischemia\u2015Results of a Randomized, Double-Blind, Placebo-Controlled Trial","volume":"81","author":"Pignon","year":"2017","journal-title":"Circ. J."},{"key":"B134","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.molmed.2020.04.005","article-title":"Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis","volume":"26","author":"Pluchino","year":"2020","journal-title":"Trends Mol. Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1158\/1078-0432.ccr-16-1518","article-title":"Neural Stem Cell\u2013Based Anticancer Gene Therapy: A First-In-Human Study in Recurrent High-Grade Glioma Patients","volume":"23","author":"Portnow","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0010-7824(78)80015-8","article-title":"On the Concept of Stem Cell and a Model of Functional-Morphological Structure of the Endometrium","volume":"18","author":"Prianishnikov","year":"1978","journal-title":"Contraception"},{"key":"B137","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/nph.15597","article-title":"DNA Damage and Reactive Oxygen Species Cause Cell Death in the rice Local Lesions 1 Mutant Under High Light and High Temperature","volume":"222","author":"Qiu","year":"2019","journal-title":"New Phytol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.expneurol.2005.10.004","article-title":"Differentiation of Human Adult CD34+ Stem Cells into Cells with a Neural Phenotype: Role of Astrocytes","volume":"197","author":"Reali","year":"2006","journal-title":"Exp. Neurol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1161\/circresaha.116.309045","article-title":"Autologous Cell Therapy for Peripheral Arterial Disease: Systematic Review and Meta-Analysis of Randomized, Nonrandomized, and Noncontrolled Studies","volume":"120","author":"Rigato","year":"2017","journal-title":"Circ. Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-017-0616-0","article-title":"Isolation and Characterization of Equine Endometrial Mesenchymal Stromal Cells","volume":"8","author":"Rink","year":"2017","journal-title":"Stem Cel. Res. Ther."},{"key":"B141","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1179\/2045772311y.0000000010","article-title":"Treatment of Pressure Ulcers with Autologous Bone Marrow Nuclear Cells in Patients with Spinal Cord Injury","volume":"34","author":"Saras\u00faa","year":"2011","journal-title":"J. Spinal Cord Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.yexcr.2014.03.003","article-title":"Defining the Role of Mesenchymal Stromal Cells on the Regulation of Matrix Metalloproteinases in Skeletal Muscle Cells","volume":"323","author":"Sassoli","year":"2014","journal-title":"Exp. Cel. Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1196\/annals.1434.014","article-title":"Stem Cells and the Pathogenesis of Endometriosis","volume":"1127","author":"Sasson","year":"2008","journal-title":"Ann. New York Acad. Sci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/circresaha.112.267054","article-title":"Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase","volume":"110","author":"Schr\u00f6der","year":"2012","journal-title":"Circ. Res."},{"key":"B145","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.cytogfr.2014.07.016","article-title":"TNF and TNF-Receptors: From Mediators of Cell Death and Inflammation to Therapeutic Giants\u2013Past, Present and Future","volume":"25","author":"Sedger","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12967-016-1066-7","article-title":"Safety and Feasibility of Cell-Based Therapy of Autologous Bone Marrow-Derived Mononuclear Cells in Plate-Stabilized Proximal Humeral Fractures in Humans","volume":"14","author":"Seebach","year":"2016","journal-title":"J. Translational Med."},{"key":"B147","first-page":"453","article-title":"Requirements for Tumor Necrosis Factor-Alpha and Interleukin-1 in Limb Ischemia\/Reperfusion Injury and Associated Lung Injury","volume":"143","author":"Seekamp","year":"1993","journal-title":"Am. J. Pathol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jmhi.2015.09.004","article-title":"Induction of Spontaneous Neo-Angiogenesis and Tube Formation in Human Endometrial Stem Cells by Bioglass","volume":"9","author":"Shamosi","year":"2015","journal-title":"J. Med. Hypotheses Ideas"},{"key":"B149","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3109\/21691401.2016.1138493","article-title":"Differentiation of Human Endometrial Stem Cells into Endothelial-Like Cells on Gelatin\/Chitosan\/Bioglass Nanofibrous Scaffolds","volume":"45","author":"Shamosi","year":"2017","journal-title":"Artif. Cell Nanomedicine, Biotechnol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"725","DOI":"10.5966\/sctm.2012-0034","article-title":"Human Mesenchymal Stem Cell Transfusion Is Safe and Improves Liver Function in Acute\u2010on\u2010Chronic Liver Failure Patients","volume":"1","author":"Shi","year":"2012","journal-title":"Stem Cell Translational Med."},{"key":"B151","doi-asserted-by":"publisher","first-page":"5278","DOI":"10.1007\/s12035-015-9442-5","article-title":"Comparison of Capability of Human Bone Marrow Mesenchymal Stem Cells and Endometrial Stem Cells to Differentiate into Motor Neurons on Electrospun Poly (\u03b5-Caprolactone) Scaffold","volume":"53","author":"Shirian","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s42155-020-00166-7","article-title":"Two Effective Cases of Additional Pedal Artery Angioplasty for Severe Lower Limb Ischemia Following Acute Thrombotic Artery Occlusion with Hypercoagulable State Diseases","volume":"3","author":"Shoji","year":"2020","journal-title":"CVIR Endovascular"},{"key":"B153","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3390\/ijms19020374","article-title":"Acute Limb Ischemia\u2014Much More Than Just a Lack of Oxygen","volume":"19","author":"Simon","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1212\/wnl.0000000000007720","article-title":"Intrathecal Administration of Autologous Mesenchymal Stem Cells in Multiple System Atrophy","volume":"93","author":"Singer","year":"2019","journal-title":"Neurology"},{"key":"B155","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1006\/excr.1998.4366","article-title":"Different Types of ROS-Scavenging Enzymes Are Expressed During Cutaneous Wound Repair","volume":"247","author":"Steiling","year":"1999","journal-title":"Exp. Cel. Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"4157213","DOI":"10.1155\/2017\/4157213","article-title":"Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide","volume":"2017","author":"Stein","year":"2017","journal-title":"Oxidative Med. Cell. Longevity"},{"key":"B157","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3390\/ijms17122101","article-title":"Peripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer","volume":"17","author":"Sullivan","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.archoralbio.2013.01.013","article-title":"Effect of Dentine Matrix Proteins on Human Endometrial Adult Stem-Like Cells: In Vitro Regeneration of Odontoblasts Cells","volume":"58","author":"Tabatabaei","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.5812\/ans.94041","article-title":"Endometrial Mesenchymal Stem Cell-Derived Exosome Promote Endothelial Cell Angiogenesis in a Dose Dependent Manner: A New Perspective on Regenerative Medicine and Cell-Free Therapy","volume":"6","author":"Taghdiri Nooshabadi","year":"2019","journal-title":"Arch. Neurosci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3727\/096368912x658007","article-title":"Autologous G-CSF-Mobilized Peripheral Blood CD34+ Cell Therapy for Diabetic Patients with Chronic Nonhealing Ulcer","volume":"23","author":"Tanaka","year":"2014","journal-title":"Cel. Transplant."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12874-016-0122-6","article-title":"Subgroup Analyses in Confirmatory Clinical Trials: Time to Be Specific About Their Purposes","volume":"16","author":"Tanniou","year":"2016","journal-title":"BMC Med. Res. Methodol."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1314709","article-title":"Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications","volume":"2016","author":"Tao","year":"2016","journal-title":"Stem Cell Int."},{"key":"B163","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/s0140-6736(02)09670-8","article-title":"Therapeutic Angiogenesis for Patients with Limb Ischaemia by Autologous Transplantation of Bone-Marrow Cells: A Pilot Study and a Randomised Controlled Trial","volume":"360","author":"Tateishi-Yuyama","year":"2002","journal-title":"The Lancet"},{"key":"B164","first-page":"659","article-title":"Effect of Dexamethasone, Insulin and EGF on the Myogenic Potential on Human Endometrial Stem Cell","volume":"13","author":"Tehrani","year":"2014","journal-title":"Iranian J. Pharm. Res. IJPR"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1093\/eurheartj\/ehp073","article-title":"Intracoronary Infusion of Bone Marrow-Derived Selected CD34+ CXCR4+ Cells and Non-Selected Mononuclear Cells in Patients with Acute STEMI and Reduced Left Ventricular Ejection Fraction: Results of Randomized, Multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial","volume":"30","author":"Tendera","year":"2009","journal-title":"Eur. Heart J."},{"key":"B166","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jvs.2020.03.055","article-title":"Risk Factors for Reamputations in Patients Amputated after Revascularization for Critical Limb-Threatening Ischemia","volume":"73","author":"Torbj\u00f6rnsson","year":"2021","journal-title":"J. Vasc. Surg."},{"key":"B167","first-page":"176","article-title":"Myogenic Transdifferentiation of Menstrual Blood-Derived Cells","volume":"26","author":"Toyoda","year":"2007","journal-title":"Acta Myologica"},{"key":"B168","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/vhrm.s125065","article-title":"Critical Limb Ischemia: Current Challenges and Future Prospects","volume":"14","author":"Uccioli","year":"2018","journal-title":"Vasc. Health Risk Manag."},{"key":"B169","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1161\/01.res.0000137877.89448.78","article-title":"Endothelial Progenitor Cells: Characterization and Role in Vascular Biology","volume":"95","author":"Urbich","year":"2004","journal-title":"Circ. Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1754-1611-8-20","article-title":"Endometrial Stem Cells in Regenerative Medicine","volume":"8","author":"Verdi","year":"2014","journal-title":"J. Biol. Eng."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3038565","article-title":"Tips and Tricks for Validation of Quality Control Analytical Methods in Good Manufacturing Practice Mesenchymal Stromal Cell Production","volume":"2018","author":"Vigan\u00f2","year":"2018","journal-title":"Stem Cell Int."},{"key":"B172","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2174\/1574888x13666180313141416","article-title":"Efficacy and Safety of Autologous Cell-Based Therapy in Patients with No-Option Critical Limb Ischaemia: A Meta-Analysis","volume":"13","author":"Wahid","year":"2018","journal-title":"Curr. Stem Cel. Res. Ther."},{"key":"B173","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1249\/mss.0000000000000563","article-title":"Reactive Oxygen Species, Mitochondria, and Endothelial Cell Death During In Vitro Simulated Dives","volume":"47","author":"Wang","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"B174","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jvs.2017.09.057","article-title":"Rationale and Design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) Trial Investigating the Therapeutic Mechanism of Mesenchymal Stromal Cells in the Treatment of Critical Limb Ischemia","volume":"68","author":"Wang","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"B175","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejvs.2015.09.010","article-title":"Quality of Life After Treatment with Autologous Bone Marrow Derived Cells in No Option Severe Limb Ischemia","volume":"51","author":"Weem","year":"2016","journal-title":"Eur. J. Vasc. Endovascular Surg."},{"key":"B176","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.jvs.2017.09.026","article-title":"Rationale and Design of the SAIL Trial for Intramuscular Injection of Allogeneic Mesenchymal Stromal Cells in No-Option Critical Limb Ischemia","volume":"67","author":"Wijnand","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"B177","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/s2213-2600(14)70291-7","article-title":"Mesenchymal Stem (Stromal) Cells for Treatment of ARDS: A Phase 1 Clinical Trial","volume":"3","author":"Wilson","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"B178","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jcyt.2013.10.004","article-title":"Autologous Bone Marrow Mononuclear Cell Infusion and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus: An Open-Label, Randomized Controlled Clinical Trial","volume":"16","author":"Wu","year":"2014","journal-title":"Cytotherapy"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.07.026","article-title":"Mesenchymal Stem Cell-Derived Exosomes Ameliorate Intervertebral Disc Degeneration via Anti-Oxidant and Anti-Inflammatory Effects","volume":"143","author":"Xia","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B180","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1177\/0963689718766279","article-title":"Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with Neuroregen Scaffolds and Mesenchymal Stem Cells","volume":"27","author":"Xiao","year":"2018","journal-title":"Cel. Transplant."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3389\/fphar.2019.01576","article-title":"Three-Dimensional Culture Promotes the Differentiation of Human Dental Pulp Mesenchymal Stem Cells into Insulin-Producing Cells for Improving the Diabetes Therapy","volume":"10","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"E192","DOI":"10.1161\/01.ATV.0000147730.78953.60","article-title":"Molecular Evaluation of Endothelial Progenitor Cells in Patients with Ischemic Limbs: Therapeutic Effect by Stem Cell Transplantation","volume":"24","author":"Yamamoto","year":"2004","journal-title":"Arteriosclerosis, Thromb. Vasc. Biol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1634\/stemcells.2006-0228","article-title":"Adipose Tissue\u2010Derived Mesenchymal Stem Cells Have In Vivo Immunosuppressive Properties Applicable for the Control of the Graft\u2010Versus\u2010Host Disease","volume":"24","author":"Ya\u00f1ez","year":"2006","journal-title":"Stem Cells"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1271\/bbb.60617","article-title":"Inhibition of P38 MAPK Reduces Tumor Conditioned Medium-Induced Angiogenesis in Co-cultured Human Umbilical Vein Endothelial Cells and Fibroblasts","volume":"71","author":"Ye","year":"2007","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B185","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/stem.3191","article-title":"Implantation of the Clinical\u2010Grade Human Neural Stem Cell Line, CTX0E03, Rescues the Behavioral and Pathological Deficits in the Quinolinic Acid\u2010Lesioned Rodent Model of Huntington's Disease","volume":"38","author":"Yoon","year":"2020","journal-title":"Stem Cells"},{"key":"B186","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/978-1-4939-7526-6_11","article-title":"A Murine Model of Hind Limb Ischemia to Study Angiogenesis and Arteriogenesis","author":"Yu","year":"2018","journal-title":"Traumatic Ischemic Inj."},{"key":"B187","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1093\/eurheartj\/ehaa226","article-title":"Clinical Effectiveness of Primary Prevention Implantable Cardioverter-Defibrillators: Results of the EU-CERT-ICD Controlled Multicentre Cohort Study","volume":"41","author":"Zabel","year":"2020","journal-title":"Eur. Heart J."},{"key":"B188","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3109\/14653240903518163","article-title":"Safety and Efficacy of Granulocyte\u2013Colony-Stimulating Factor Administration Following Autologous Intramuscular Implantation of Bone Marrow Mononuclear Cells: A Randomized Controlled Trial in Patients with Advanced Lower Limb Ischemia","volume":"12","author":"Zafarghandi","year":"2010","journal-title":"Cytotherapy"},{"key":"B189","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/jcp.21210","article-title":"Multipotential Human Adipose\u2010Derived Stromal Stem Cells Exhibit a Perivascular Phenotype In Vitro and In Vivo","volume":"214","author":"Zannettino","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1479-5876-7-15","article-title":"Feasibility Investigation of Allogeneic Endometrial Regenerative Cells","volume":"7","author":"Zhong","year":"2009","journal-title":"J. Translational Med."},{"key":"B191","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ebiom.2016.09.031","article-title":"Autologous Stem Cell Transplantation Promotes Mechanical Stretch Induced Skin Regeneration: A Randomized Phase I\/II Clinical Trial","volume":"13","author":"Zhou","year":"2016","journal-title":"EBioMedicine"},{"key":"B192","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jcyt.2016.05.006","article-title":"Safety and Efficacy of Autologous Thymosin \u03b24 Pre-Treated Endothelial Progenitor Cell Transplantation in Patients with Acute ST Segment Elevation Myocardial Infarction: A Pilot Study","volume":"18","author":"Zhu","year":"2016","journal-title":"Cytotherapy"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.834754\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:36:05Z","timestamp":1653284165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.834754\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":192,"alternative-id":["10.3389\/fcell.2022.834754"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2022.834754","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"article-number":"834754"}}