{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:34:35Z","timestamp":1789878875299,"version":"4.0.1"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Gliomas are the most common and aggressive malignancies of the central nervous system. Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate complex cellular mechanisms that influence tumor biology and immunogenicity. However, little is known about the function of HDACs in glioma. The Oncomine, Human Protein Atlas, Gene Expression Profiling Interactive Analysis, Broad Institute Cancer Cell Line Encyclopedia, Chinese Glioma Genome Atlas, OmicShare, cBioPortal, GeneMANIA, STRING, and TIMER databases were utilized to analyze the differential expression, prognostic value, and genetic alteration of HDAC and immune cell infiltration in patients with glioma. <jats:italic>HDAC1\/2<\/jats:italic> were considerable upregulated whereas HDAC11 was significantly downregulated in cancer tissues. <jats:italic>HDAC1\/2\/3\/4\/5\/7\/8\/11<\/jats:italic> were significantly correlated with the clinical glioma stage. <jats:italic>HDAC1\/2\/3\/10<\/jats:italic> were strongly upregulated in 11 glioma cell lines. High <jats:italic>HDCA1\/3\/7<\/jats:italic> and low <jats:italic>HDAC4\/5\/11<\/jats:italic> mRNA levels were significantly associated with overall survival and disease-free survival in glioma. <jats:italic>HDAC1\/2\/3\/4\/5\/7\/9\/10\/11<\/jats:italic> are potential useful biomarkers for predicting the survival of patients with glioma. The functions of HDACs and 50 neighboring genes were primarily related to transcriptional dysregulation in cancers and the Notch, cGMP-PKG, and thyroid hormone signaling pathways. HDAC expression was significantly correlated with the infiltration of B cells, CD4<jats:sup>+<\/jats:sup> T cells, CD8<jats:sup>+<\/jats:sup> T cells, macrophages, neutrophils, and dendritic cells in glioma. Our study indicated that HDACs are putative precision therapy targets and prognostic biomarkers of survival in glioma patients.<\/jats:p>","DOI":"10.3389\/fcell.2022.840759","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T14:38:21Z","timestamp":1646923101000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma"],"prefix":"10.3389","volume":"10","author":[{"given":"Jinwei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsun","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"La","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.1038\/s41467-018-06808-8","article-title":"MiR-584-5p Potentiates Vincristine and Radiation Response by Inducing Spindle Defects and DNA Damage in Medulloblastoma","volume":"9","author":"Abdelfattah","year":"2018","journal-title":"Nat. Commun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1002\/pmic.201100504","article-title":"Antibodies for Profiling the Human Proteome-The Human Protein Atlas as a Resource for Cancer Research","volume":"12","author":"Asplund","year":"2012","journal-title":"Proteomics"},{"key":"B3","first-page":"iii53","article-title":"P11.46 Discovery of a New HDAC6 Inhibitor for the Treatment of Glioblastoma","volume-title":"Neuro Oncol.","author":"Auzmendi-Iriarte","year":"2019"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1084\/jem.20150821","article-title":"In Vivo conditional Deletion of HDAC7 Reveals its Requirement to Establish Proper B Lymphocyte Identity and Development","volume":"213","author":"Azagra","year":"2016","journal-title":"J. Exp. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2217\/epi.11.93","article-title":"Epigenetic and Epigenomic Mechanisms Shape Sarcoma and Other Mesenchymal Tumor Pathogenesis","volume":"3","author":"Bennani-Baiti","year":"2011","journal-title":"Epigenomics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.cd-12-0095","article-title":"The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"B7","doi-asserted-by":"publisher","first-page":"8777","DOI":"10.1038\/sj.onc.120812","article-title":"HDAC4 Mediates Transcriptional Repression by the Acute Promyelocytic Leukaemia-Associated Protein PLZF","volume":"23","author":"Chauchereau","year":"2004","journal-title":"Oncogene"},{"key":"B8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/ncomms1255","article-title":"The Acetylation of Tau Inhibits its Function and Promotes Pathological Tau Aggregation","volume":"2","author":"Cohen","year":"2011","journal-title":"Nat. Commun."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/1878-0261.12503","article-title":"HDAC7-mediated Control of Tumour Microenvironment Maintains Proliferative and Stemness Competence of Human Mammary Epithelial Cells","volume":"13","author":"Cutano","year":"2019","journal-title":"Mol. Oncol."},{"key":"B10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1021\/cn500021p","article-title":"Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors","volume":"5","author":"Dang","year":"2014","journal-title":"Acs Chem. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1523\/jneurosci.0037-07.2007","article-title":"Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation","volume":"27","author":"Dompierre","year":"2007","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1182\/blood-2012-07-441949","article-title":"Histone Deacetylase 1 and 2 Are Essential for normal T-Cell Development and Genomic Stability in Mice","volume":"121","author":"Dovey","year":"2013","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-generation Characterization of the Cancer Cell Line Encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","article-title":"Histone Deacetylases and Cancer","volume":"26","author":"Glozak","year":"2007","journal-title":"Oncogene"},{"key":"B15","first-page":"2085","article-title":"Comparative Gene Expression Profile Analysis of Neurofibromatosis 1-associated and Sporadic Pilocytic Astrocytomas","volume":"62","author":"Gutmann","year":"2002","journal-title":"Cancer Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many Roles of Histone Deacetylases in Development and Physiology: Implications for Disease and Therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B17","volume-title":"HDAC11 Deficiency Disrupts Oncogene-Induced Hematopoiesis in Myeloproliferative Neoplasms","year":"2020"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1182\/blood-2012-08-450916","article-title":"Dosage-dependent Tumor Suppression by Histone Deacetylases 1 and 2 through Regulation of C-Myc Collaborating Genes and P53 Function","volume":"121","author":"Heideman","year":"2013","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","first-page":"12460","DOI":"10.1021\/acs.jmedchem.0c00830","article-title":"Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight","volume":"63","author":"Ho","year":"2020","journal-title":"J. Med. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2017-03-771386","article-title":"HDAC8 Regulates Long-Term Hematopoietic Stem Cell Maintenance under Stress by Modulating P53 Activity","volume":"130","author":"Hua","year":"2017","journal-title":"Blood"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.2147\/ott.s164583","article-title":"Overexpression of HDAC9 Is Associated with Poor Prognosis and Tumor Progression of Breast Cancer in Chinese Females","author":"Huang","year":"2018","journal-title":"Ott"},{"key":"B22","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 Is a Microtubule-Associated Deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4048\/jbc.2014.17.4.323","article-title":"Expression of Histone Deacetylases HDAC1, HDAC2, HDAC3, and HDAC6 in Invasive Ductal Carcinomas of the Breast","volume":"17","author":"Jinwon","year":"2014","journal-title":"J. Breast Cancer"},{"key":"B24","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1038\/s41598-018-28265-5","article-title":"Dual Role of HDAC10 in Lysosomal Exocytosis and DNA Repair Promotes Neuroblastoma Chemoresistance","volume":"8","author":"Johannes","year":"2018","journal-title":"Scientific Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The Epigenomics of Cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e98894","DOI":"10.1371\/journal.pone.0098894","article-title":"Histone Deacetylase HDAC4 Promotes Gastric Cancer SGC-7901 Cells Progression via P21 Repression","volume":"9","author":"Kang","year":"2014","journal-title":"PLoS ONE"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2019.1711191","article-title":"Exploring Structural Requirements of Isoform Selective Histone Deacetylase Inhibitors: a Comparative In Silico Study","volume":"39","author":"Kashyap","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1038\/leu.2015.83","article-title":"Class IIa HDAC Inhibition Enhances ER Stress-Mediated Cell. Death in Multiple Myeloma","volume":"29","author":"Kikuchi","year":"2015","journal-title":"Leukemia"},{"key":"B29","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","article-title":"HDAC6 Regulates Hsp90 Acetylation and Chaperone-dependent Activation of Glucocorticoid Receptor","volume":"18","author":"Kovacs","year":"2005","journal-title":"Mol. Cel"},{"key":"B30","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ijrobp.2015.04.038","article-title":"A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients with Glioblastoma","volume":"92","author":"Krave","year":"2015","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"B31","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3892\/mmr.2019.10869","article-title":"High HDAC9 Is Associated with Poor Prognosis and Promotes Malignant Progression in Pancreatic Ductal Adenocarcinoma","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1158\/0008-5472.can-17-0307","article-title":"TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1128\/MCB.00400-15","article-title":"Histone Deacetylase 10 Regulates the Cell Cycle G2\/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway","volume":"35","author":"Li","year":"2015","journal-title":"Mol. Cel. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.molonc.2015.12.012","article-title":"Essential Role of HDAC6 in the Regulation of PD-L1 in Melanoma","volume":"10","author":"Lienlaf","year":"2016","journal-title":"Mol. Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/1878-0261.12505","article-title":"Increased Expression of the HDAC 9 Gene Is Associated with Antiestrogen Resistance of Breast Cancers","volume":"13","author":"Linares","year":"2019","journal-title":"Mol. Oncol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"vi239","DOI":"10.1093\/neuonc\/noz175.998","article-title":"STEM-25. HDAC1 IS ESSENTIAL FOR GLIOMA STEM CELL SURVIVAL","volume":"21","author":"Lo Cascio","year":"2019","journal-title":"Neuro-Oncology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"6018","DOI":"10.1093\/nar\/gkt346","article-title":"MYCN and HDAC2 Cooperate to Repress miR-183 Signaling in Neuroblastoma","volume":"41","author":"Lodrini","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1003377","DOI":"10.1371\/journal.pgen.1003377","article-title":"Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse","volume":"9","author":"Ma","year":"2013","journal-title":"Plos Genet."},{"key":"B39","first-page":"W60","article-title":"GeneMANIA Update 2018.","volume-title":"Nucl. Acids Res.","author":"Max","year":"2018"},{"key":"B40","volume-title":"The Biology and Therapeutic Implications of HDACs in the Heart, Histone Deacetylases: The Biology and Clinical Implication","author":"Mckinsey","year":"2011"},{"key":"B41","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.tips.2016.12.006","article-title":"Targeting Class I Histone Deacetylases in a \u201cComplex\u201d Environment","volume":"38","author":"Millard","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nsmb.1899","article-title":"Human HDAC1 and HDAC2 Function in the DNA-Damage Response to Promote DNA Nonhomologous End-Joining","volume":"17","author":"Miller","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3892\/or.18.4.769","article-title":"Expression Profile of Class I Histone Deacetylases in Human Cancer Tissues","volume":"18","author":"Nakagawa","year":"2007","journal-title":"Oncol. Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000529","article-title":"HDAC9 Deficiency Promotes Tumor Progression by Decreasing the CD8+ Dendritic Cell Infiltration of the Tumor Microenvironment","volume":"8","author":"Ning","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"B46","first-page":"v1","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012\u20132016","volume-title":"Neuro Oncol.","author":"Ostrom","year":"2019"},{"key":"B47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/modpathol.2011.157","article-title":"Histone Deacetylase 1 and 2 in Mesenchymal Tumors","volume":"25","author":"Pacheco","year":"2012","journal-title":"Mod. Pathol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105398","article-title":"Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43821","article-title":"HDAC3 Restrains CD8-Lineage Genes to Maintain a Bi-potential State in CD4+CD8+ Thymocytes for CD4-Lineage Commitment","volume":"8","author":"Philips","year":"2019","journal-title":"Elife"},{"key":"B50","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/415436a","article-title":"Prediction of central Nervous System Embryonal Tumour Outcome Based on Gene Expression","volume":"415","author":"Pomeroy","year":"2002","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"20047","DOI":"10.1073\/pnas.1213764109","article-title":"miR-155 Targets Histone Deacetylase 4 (HDAC4) and Impairs Transcriptional Activity of B-Cell Lymphoma 6 (BCL6) in the E\u03bc-miR-155 Transgenic Mouse Model","volume":"109","author":"Sandhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1182\/blood-2012-10-461988","article-title":"A Dual Role for Hdac1: Oncosuppressor in Tumorigenesis, Oncogene in Tumor Maintenance","volume":"121","author":"Santoro","year":"2013","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/jcb.20179","article-title":"Regulation of Histone Deacetylase Activities","volume":"93","author":"Sengupta","year":"2004","journal-title":"J. Cel. Biochem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of Histone Acetylation: the Histone Deacetylase Enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1750-1326-8-7","article-title":"HDAC6 as a Target for Neurodegenerative Diseases: what Makes it Different from the Other HDACs","volume":"8","author":"Sim\u00f5es-Pires","year":"2013","journal-title":"Mol. Neurodegeneration"},{"key":"B56","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1476-4598-13-65","article-title":"Alpha-enolase as a Potential Cancer Prognostic Marker Promotes Cell Growth, Migration, and Invasion in Glioma","volume":"13","author":"Song","year":"2014","journal-title":"Mol. Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/neuonc\/noz136","article-title":"NFAT2-HDAC1 Signaling Contributes to the Malignant Phenotype of Glioblastoma","volume":"22","author":"Song","year":"2020","journal-title":"Neuro-Oncology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1128\/mcb.00706-15","article-title":"Histone Deacetylase 3 Is Required for Efficient T Cell Development","volume":"35","author":"Stengel","year":"2015","journal-title":"Mol. Cel. Biol"},{"key":"B59","first-page":"10612","article-title":"Histone Deacetylase 3 Controls a Transcriptional Network Required for B Cell. Maturation","volume-title":"Nucleic Acids Res","author":"Stengel","year":"2019"},{"key":"B60","first-page":"D607","article-title":"STRING V11: Protein-Protein Association Networks with Increased Coverage, Supporting Functional Discovery in Genome-wide Experimental Datasets","volume-title":"Nucleic Acids Res.","author":"Szklarczyk","year":"2019"},{"key":"B61","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy Alone on Survival in Glioblastoma in a Randomised Phase III Study: 5-year Analysis of the EORTC-NCIC Trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"New Engl. J. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ccr.2006.03.003","article-title":"Neuronal and Glioma-Derived Stem Cell Factor Induces Angiogenesis within the Brain","volume":"9","author":"Sun","year":"2006","journal-title":"Cancer Cell"},{"key":"B64","first-page":"W98","article-title":"GEPIA: A Web Server for Cancer and Normal Gene Expression Profiling and Interactive Analyses","volume-title":"Nucleic Acids Res.","author":"Tang","year":"2017"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e2635","DOI":"10.1038\/cddis.2017.49","article-title":"Neuroblastoma Cells Depend on HDAC11 for Mitotic Cell Cycle Progression and Survival","volume":"8","author":"Thole","year":"2017","journal-title":"Cell Death Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1158\/1535-7163.mct-12-1242","article-title":"Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling","volume":"12","author":"Thurn","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5522","DOI":"10.1038\/s41467-020-19317-4","article-title":"An HDAC6-dependent Surveillance Mechanism Suppresses Tau-Mediated Neurodegeneration and Cognitive Decline","volume":"11","author":"Trzeciakiewicz","year":"2020","journal-title":"Nat. Commun."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115907","article-title":"NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the \u03b2-Catenin\/c-Myc\/SOX2 Pathway and Upregulating P53-Mediated MGMT Inhibition","volume":"22","author":"Tsai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"48027","DOI":"10.18632\/oncotarget.18227","article-title":"Knockdown of HDAC1 Expression Suppresses Invasion and Induces Apoptosis in Glioma Cells","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"B70","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13058-018-1018-7","article-title":"Tricho-rhino-phalangeal Syndrome 1 Protein Functions as a Scaffold Required for Ubiquitin-specific Protease 4-directed Histone Deacetylase 2 De-ubiquitination and Tumor Growth","volume":"20","author":"Wang","year":"2018","journal-title":"Breast Cancer Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2217\/epi.13.73","article-title":"HDAC4: Mechanism of Regulation and Biological Functions","volume":"6","author":"Wang","year":"2014","journal-title":"Epigenomics"},{"key":"B72","doi-asserted-by":"publisher","first-page":"4062","DOI":"10.1091\/mbc.e08-02-0139","article-title":"HDAC4 Promotes Growth of Colon Cancer Cells via Repression of P21","volume":"19","author":"Wilson","year":"2008","journal-title":"MBoC"},{"key":"B73","doi-asserted-by":"publisher","first-page":"661620","DOI":"10.3389\/fonc.2021.661620","article-title":"Insights into the Function and Clinical Application of HDAC5 in Cancer Management","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1182\/blood.2019895326","article-title":"HDAC11 Deficiency Disrupts Oncogene-Induced Hematopoiesis in Myeloproliferative Neoplasms","volume":"135","author":"Yue","year":"2020","journal-title":"Blood"},{"key":"B75","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molcel.2007.05.033","article-title":"HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cel."},{"key":"B76","volume-title":"Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data for Chinese Glioma Patients","author":"Zhao","year":"2020"},{"key":"B77","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/s1535-6108(04)00114-x","article-title":"Induction of HDAC2 Expression upon Loss of APC in Colorectal Tumorigenesis","volume":"5","author":"Zhu","year":"2004","journal-title":"Cancer Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1593\/neo.07112","article-title":"Oncomine 3.0: Genes, Pathways, and Networks in a Collection of 18,000 Cancer Gene Expression Profiles","volume":"9","author":"\u00a7","year":"2007","journal-title":"Neoplasia"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.840759\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T14:38:39Z","timestamp":1646923119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.840759\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":78,"alternative-id":["10.3389\/fcell.2022.840759"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2022.840759","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]},"article-number":"840759"}}