{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:47:08Z","timestamp":1792180028876,"version":"4.4.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Iron deficiency anemia can be treated with oral or intravenous Fe supplementation. Such supplementation has considerable effects on the human microbiome, and on opportunistic pathogenic micro-organisms. Molecular understanding of the control and regulation of Fe availability at the host-microbe interface is crucial to interpreting the side effects of Fe supplementation. Here, we provide a concise overview of the regulation of Fe by the opportunistic pathogen <jats:italic>Staphylococcus aureus<\/jats:italic>. Ferric uptake regulator (Fur) plays a central role in controlling Fe uptake, utilization and storage in order to maintain a required value. The micro-organism has a strong preference for heme iron as an Fe source, which is enabled by the Iron-regulated surface determinant (Isd) system. The strategies it employs to overcome Fe restriction imposed by the host include: hijacking host proteins, replacing metal cofactors, and replacing functions by non-metal dependent enzymes. We propose that integrated omics approaches, which include metalloproteomics, are necessary to provide a comprehensive understanding of the metal tug of war at the host-microbe interface down to the molecular level.<\/jats:p>","DOI":"10.3389\/fcell.2022.857237","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:20:53Z","timestamp":1648513253000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host\u2014Microbe Interface"],"prefix":"10.3389","volume":"10","author":[{"given":"Madeleine C.","family":"van Dijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"de Kruijff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter-Leon","family":"Hagedoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e342","DOI":"10.1016\/S2352-3026(19)30264-9","article-title":"Intravenous Iron: A Framework for Changing the Management of Iron Deficiency","volume":"7","author":"Auerbach","year":"2020","journal-title":"Lancet Haematol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.1259329","article-title":"Escape from Bacterial Iron Piracy through Rapid Evolution of Transferrin","volume":"346","author":"Barber","year":"2014","journal-title":"Science"},{"key":"B3","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1159\/000094343","article-title":"Non-Transferrin-Bound Iron Is Associated with Enhanced Staphylococcus aureus Growth in Hemodialysis Patients Receiving Intravenous Iron Sucrose","volume":"26","author":"Barton Pai","year":"2006","journal-title":"Am. 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