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Biol."],"abstract":"<jats:p>Integrins are a family of heterodimeric receptors composed of an \u03b1- and \u03b2-subunit that mediate cell-adhesion to a number of extracellular matrix (ECM) proteins in the Trabecular Meshwork\/Schlemm\u2019s canal (TM\/SC) of the eye. Upon binding an ECM ligand, integrins transmit signals that activate a number of signaling pathways responsible for regulating actin-mediated processes (i.e phagocytosis, cell contractility, and fibronectin fibrillogenesis) that play an important role in regulating intraocular pressure (IOP) and may be involved in glaucoma. An important function of integrin-mediated signaling events is that the activity of one integrin can affect the activity of other integrins in the same cell. This creates a crosstalk that allows TM\/SC cells to respond to changes in the ECM presumably induced by the mechanical forces on the TM\/SC, aging and disease. In this review, we discuss how integrin crosstalk influences the function of the human TM\/SC pathway. In particular, we will discuss how different crosstalk pathways mediated by either the \u03b1v\u03b23 or \u03b14\u03b21 integrins can play opposing roles in the TM when active and therefore act as on\/off switches to modulate the cytoskeleton-mediated processes that regulate the outflow of aqueous humor through the TM\/SC.<\/jats:p>","DOI":"10.3389\/fcell.2022.886702","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:28:06Z","timestamp":1651213686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork\/Schlemm\u2019s Canal"],"prefix":"10.3389","volume":"10","author":[{"given":"Jennifer A.","family":"Faralli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Filla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1167\/iovs.07-1666","article-title":"Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover","volume":"49","author":"Aga","year":"2008","journal-title":"Invest. 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