{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:51:03Z","timestamp":1790772663480,"version":"4.1.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>TEAD4 (TEA Domain Transcription Factor 4) is well recognized as the DNA-anchor protein of YAP transcription complex, which is modulated by Hippo, a highly conserved pathway in Metazoa that controls organ size through regulating cell proliferation and apoptosis. To acquire full transcriptional activity, TEAD4 requires co-activator, YAP (Yes-associated protein) or its homolog TAZ (transcriptional coactivator with PDZ-binding motif) the signaling hub that relays the extracellular stimuli to the transcription of target genes. Growing evidence suggests that TEAD4 also exerts its function in a YAP-independent manner through other signal pathways. Although TEAD4 plays an essential role in determining that differentiation fate of the blastocyst, it also promotes tumorigenesis by enhancing metastasis, cancer stemness, and drug resistance. Upregulation of TEAD4 has been reported in several cancers, including colon cancer, gastric cancer, breast cancer, and prostate cancer and serves as a valuable prognostic marker. Recent studies show that TEAD4, but not other members of the TEAD family, engages in regulating mitochondrial dynamics and cell metabolism by modulating the expression of mitochondrial- and nuclear-encoded electron transport chain genes. TEAD4\u2019s functions including oncogenic activities are tightly controlled by its subcellular localization. As a predominantly nuclear protein, its cytoplasmic translocation is triggered by several signals, such as osmotic stress, cell confluency, and arginine availability. Intriguingly, TEAD4 is also localized in mitochondria, although the translocation mechanism remains unclear. In this report, we describe the current understanding of TEAD4 as an oncogene, epigenetic regulator and mitochondrial modulator. The contributing mechanisms will be discussed.<\/jats:p>","DOI":"10.3389\/fcell.2022.890419","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T02:40:14Z","timestamp":1651718414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["TEAD4 as an Oncogene and a Mitochondrial Modulator"],"prefix":"10.3389","volume":"10","author":[{"given":"Sheng-Chieh","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin C.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing-Jien","family":"Kung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.3390\/cells10102715","article-title":"Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine","volume":"10","author":"Barry","year":"2021","journal-title":"Cells"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1158\/1535-7163.mct-13-0918","article-title":"Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF-\u03b2, and Wnt Signaling Pathways","volume":"13","author":"Basu","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1101\/gad.176800.111","article-title":"The Transcriptional Coactivator TAZ Regulates Mesenchymal Differentiation in Malignant Glioma","volume":"25","author":"Bhat","year":"2011","journal-title":"Genes Dev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.chembiol.2018.11.010","article-title":"Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD\u22c5Yap Protein-Protein Interaction","volume":"26","author":"Bum-Erdene","year":"2019","journal-title":"Cel Chem. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1101\/gad.1978810","article-title":"The Hippo Signaling Pathway Restricts the Oncogenic Potential of an Intestinal Regeneration Program","volume":"24","author":"Cai","year":"2010","journal-title":"Genes Dev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1002\/hep.28911","article-title":"Yes-associated Protein\/TEA Domain Family Member and Hepatocyte Nuclear Factor 4-alpha (HNF4\u03b1) Repress Reciprocally to Regulate Hepatocarcinogenesis in Rats and Mice","volume":"65","author":"Cai","year":"2017","journal-title":"Hepatology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1101\/gad.1726608","article-title":"YAP Regulates Neural Progenitor Cell Number via the TEA Domain Transcription Factor","volume":"22","author":"Cao","year":"2008","journal-title":"Genes Dev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nchembio.2036","article-title":"Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of the Hippo Pathway","volume":"12","author":"Chan","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1038\/s41467-021-22652-9","article-title":"Arginine Is an Epigenetic Regulator Targeting TEAD4 to Modulate OXPHOS in Prostate Cancer Cells","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1101\/gad.1865310","article-title":"Structural Basis of YAP Recognition by TEAD4 in the Hippo Pathway","volume":"24","author":"Chen","year":"2010","journal-title":"Genes Dev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"9865","DOI":"10.2147\/ott.s266649","article-title":"Structural and Functional Overview of TEAD4 in Cancer Biology","author":"Chen","year":"2020","journal-title":"Ott"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.cub.2013.05.044","article-title":"The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification","volume":"23","author":"Cockburn","year":"2013","journal-title":"Curr. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1056\/nejmoa2024671","article-title":"Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates","volume":"383","author":"Corbett","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nn.4508","article-title":"Nusinersen, an Antisense Oligonucleotide Drug for Spinal Muscular Atrophy","volume":"20","author":"Corey","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/hep4.1656","article-title":"Transcriptional Enhancer Factor Domain Family Member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-independent Regulation of Heat Shock Protein 70 Family Members","volume":"5","author":"Coto-Llerena","year":"2021","journal-title":"Hepatol. Commun."},{"key":"B16","doi-asserted-by":"publisher","first-page":"28628","DOI":"10.18632\/oncotarget.15614","article-title":"Verteporfin Exhibits YAP-independent Anti-proliferative and Cytotoxic Effects in Endometrial Cancer Cells","volume":"8","author":"Dasari","year":"2017","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s42255-020-0172-2","article-title":"We Need to Talk about the Warburg Effect","volume":"2","author":"DeBerardinis","year":"2020","journal-title":"Nat. Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"645","DOI":"10.7150\/ijms.23460","article-title":"Verteporfin Inhibits YAP-Induced Bladder Cancer Cell Growth and Invasion via Hippo Signaling Pathway","volume":"15","author":"Dong","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"eaan4667","DOI":"10.1126\/scisignal.aan4667","article-title":"The Receptor Tyrosine Kinase EphA2 Promotes Glutamine Metabolism in Tumors by Activating the Transcriptional Coactivators YAP and TAZ","volume":"10","author":"Edwards","year":"2017","journal-title":"Sci. Signal."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e101051","DOI":"10.15252\/embj.2018101051","article-title":"Dual Function of VGLL4 in Muscle Regeneration","volume":"38","author":"Feng","year":"2019","journal-title":"EMBO J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1002\/hep.30961","article-title":"The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice","volume":"71","author":"Feng","year":"2020","journal-title":"Hepatology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"jcs225946","DOI":"10.1242\/jcs.225946","article-title":"VGLL3 Operates via TEAD1, TEAD3 and TEAD4 to Influence Myogenesis in Skeletal Muscle","volume":"132","author":"Figeac","year":"2019","journal-title":"J. Cel Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"dev179861","DOI":"10.1242\/dev.179861","article-title":"TEAD4, YAP1 and WWTR1 Prevent the Premature Onset of Pluripotency Prior to the 16-cell Stage","volume":"146","author":"Frum","year":"2019","journal-title":"Development"},{"key":"B24","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1084\/jem.20111653","article-title":"TGF-\u03b2 Synergizes with Defects in the Hippo Pathway to Stimulate Human Malignant Mesothelioma Growth","volume":"209","author":"Fujii","year":"2012","journal-title":"J. Exp. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1080\/07391102.2018.1491889","article-title":"Computational Insights into the Interaction Mechanism of Transcription Cofactor Vestigial-like Protein 4 Binding to TEA Domain Transcription Factor 4 by Molecular Dynamics Simulation and Molecular Mechanics Generalized Born\/surface Area) Calculation","volume":"37","author":"Gao","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1158\/2159-8290.cd-15-0330","article-title":"NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition","volume":"5","author":"Garcia-Rendueles","year":"2015","journal-title":"Cancer Discov."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e27529","DOI":"10.1371\/journal.pone.0027529","article-title":"Yes-associated Protein Expression in Head and Neck Squamous Cell Carcinoma Nodal Metastasis","volume":"6","author":"Ge","year":"2011","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"E7710","DOI":"10.1073\/pnas.1612335113","article-title":"Notch1 Controls Development of the Extravillous Trophoblast Lineage in the Human Placenta","volume":"113","author":"Haider","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/gcc.20550","article-title":"DNA Copy Number Alterations and Expression of Relevant Genes in Triple-Negative Breast Cancer","volume":"47","author":"Han","year":"2008","journal-title":"Genes Chromosom. Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1002\/cbic.201300163","article-title":"The TEAD4-YAP\/TAZ Protein-Protein Interaction: Expected Similarities and Unexpected Differences","volume":"14","author":"Hau","year":"2013","journal-title":"Chembiochem"},{"key":"B150","doi-asserted-by":"crossref","first-page":"17450","DOI":"10.1073\/pnas.1901765116","article-title":"ARF6 and AMAP1 are Major Targets of KRAS and TP53 Mutations to Promote Invasion, PD-L1 Dynamics, and Immune Evasion of Pancreatic Cancer","volume":"116","author":"Hashimoto","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B31","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.celrep.2019.09.001","article-title":"Activation of Oncogenic Super-enhancers Is Coupled with DNA Repair by RAD51","volume":"29","author":"Hazan","year":"2019","journal-title":"Cel Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.1158\/0008-5472.can-19-0012","article-title":"Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression","volume":"79","author":"He","year":"2019","journal-title":"Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1080\/21655979.2021.1882142","article-title":"The Interaction of TEA Domain Transcription Factor 4 (TEAD4) and Yes-Associated Protein 1 (YAP1) Promoted the Malignant Process Mediated by Serum\/glucocorticoid Regulated Kinase 1 (SGK1)","volume":"12","author":"He","year":"2021","journal-title":"Bioengineered"},{"key":"B34","doi-asserted-by":"publisher","first-page":"21507","DOI":"10.18632\/oncotarget.4242","article-title":"Combining BET and HDAC Inhibitors Synergistically Induces Apoptosis of Melanoma and Suppresses AKT and YAP Signaling","volume":"6","author":"Heinemann","year":"2015","journal-title":"Oncotarget"},{"key":"B35","doi-asserted-by":"publisher","first-page":"33899","DOI":"10.1073\/pnas.1211810109","article-title":"Tead4 Is Constitutively Nuclear, while Nuclear vs. Cytoplasmic Yap Distribution Is Regulated in Preimplantation Mouse Embryos","volume":"109","author":"Hirate","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"7362","DOI":"10.1073\/pnas.1201595109","article-title":"Altered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment","volume":"109","author":"Home","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.canlet.2020.08.034","article-title":"ARID1A-dependent Permissive Chromatin Accessibility Licenses Estrogen-Receptor Signaling to Regulate Circadian Rhythms Genes in Endometrial Cancer","volume":"492","author":"Hu","year":"2020","journal-title":"Cancer Lett."},{"key":"B151","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/cbin.11654","article-title":"The Transcription Factor TEAD4 Enhances Lung Adenocarcinoma Progression Through Enhancing PKM2 Mediated Glycolysis","volume":"45","author":"Hu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"937","DOI":"10.2147\/ott.s290425","article-title":"TEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT","author":"Huang","year":"2021","journal-title":"Ott"},{"key":"B39","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3390\/cells8060600","article-title":"Regulation of TEAD Transcription Factors in Cancer Biology","volume":"8","author":"Huh","year":"2019","journal-title":"Cells"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1002\/j.1460-2075.1993.tb05888.x","article-title":"Characterization of the Transcription Activation Function and the DNA Binding Domain of Transcriptional Enhancer Factor-1","volume":"12","author":"Hwang","year":"1993","journal-title":"EMBO J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer Analysis of Whole Genomes","volume":"578","year":"2020","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1038\/onc.2016.266","article-title":"RAC-LATS1\/2 Signaling Regulates YAP Activity by Switching between the YAP-Binding Partners TEAD4 and RUNX3","volume":"36","author":"Jang","year":"2017","journal-title":"Oncogene"},{"key":"B43","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1089\/10445490050128430","article-title":"Cooperative Binding of TEF-1 to Repeated GGAATG-Related Consensus Elements with Restricted Spatial Separation and Orientation","volume":"19","author":"Jiang","year":"2000","journal-title":"DNA Cel Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1084\/jem.20171116","article-title":"Targeting IRF3 as a YAP Agonist Therapy against Gastric Cancer","volume":"215","author":"Jiao","year":"2018","journal-title":"J. Exp. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"14058","DOI":"10.1038\/ncomms14058","article-title":"VGLL4 Targets a TCF4-TEAD4 Complex to Coregulate Wnt and Hippo Signalling in Colorectal Cancer","volume":"8","author":"Jiao","year":"2017","journal-title":"Nat. Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.ccr.2014.01.010","article-title":"A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer","volume":"25","author":"Jiao","year":"2014","journal-title":"Cancer Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3892\/or.2020.7578","article-title":"TEAD2 as a Novel Prognostic Factor for Hepatocellular Carcinoma","volume":"43","author":"Joo","year":"2020","journal-title":"Oncol. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1038\/s41598-017-02219-9","article-title":"Crystal Structure of TAZ-TEAD Complex Reveals a Distinct Interaction Mode from that of YAP-TEAD Complex","volume":"7","author":"Kaan","year":"2017","journal-title":"Sci. Rep."},{"key":"B49","first-page":"4399","article-title":"The Novel Potent TEAD Inhibitor, K-975, Inhibits YAP1\/TAZ-TEAD Protein-Protein Interactions and Exerts an Anti-tumor Effect on Malignant Pleural Mesothelioma","volume":"10","author":"Kaneda","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1242\/dev.093799","article-title":"TEAD4 Establishes the Energy Homeostasis Essential for Blastocoel Formation","volume":"140","author":"Kaneko","year":"2013","journal-title":"Development"},{"key":"B51","doi-asserted-by":"publisher","first-page":"9877","DOI":"10.1073\/pnas.1819400116","article-title":"Cell Contact and Nf2\/Merlin-dependent Regulation of TEAD Palmitoylation and Activity","volume":"116","author":"Kim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1038\/sj.bjc.6604774","article-title":"TEAD1 and C-Cbl Are Novel Prostate Basal Cell Markers that Correlate with Poor Clinical Outcome in Prostate Cancer","volume":"99","author":"Knight","year":"2008","journal-title":"Br. J. Cancer"},{"key":"B53","doi-asserted-by":"publisher","first-page":"dev162644","DOI":"10.1242\/dev.162644","article-title":"Regulation of Energy Metabolism during Early Mammalian Development: TEAD4 Controls Mitochondrial Transcription","volume":"145","author":"Kumar","year":"2018","journal-title":"Development"},{"key":"B152","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ccell.2019.12.006","article-title":"Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway","volume":"37","author":"Kurppa","year":"2020","journal-title":"Cancer Cell."},{"key":"B54","doi-asserted-by":"publisher","first-page":"E2441","DOI":"10.1073\/pnas.1212021109","article-title":"The Hippo Pathway Target, YAP, Promotes Metastasis through its TEAD-Interaction Domain","volume":"109","author":"Lamar","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"120327","DOI":"10.1016\/j.lfs.2022.120327","article-title":"Pan-cancer Analysis, Cell and Animal Experiments Revealing TEAD4 as a Tumor Promoter in ccRCC","volume":"293","author":"Li","year":"2022","journal-title":"Life Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13059-021-02272-8","article-title":"A Comprehensive Enhancer Screen Identifies TRAM2 as a Key and Novel Mediator of YAP Oncogenesis","volume":"22","author":"Li","year":"2021","journal-title":"Genome Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"82686","DOI":"10.18632\/oncotarget.12625","article-title":"The Role of Transcriptional Coactivator TAZ in Gliomas","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1042\/bcj20180225","article-title":"Structural and Ligand-Binding Analysis of the YAP-Binding Domain of Transcription Factor TEAD4","volume":"475","author":"Li","year":"2018","journal-title":"Biochem. J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/mc.23303","article-title":"YAP\/TEAD4\u2010induced KIF4A Contributes to the Progression and Worse Prognosis of Esophageal Squamous Cell Carcinoma","volume":"60","author":"Li","year":"2021","journal-title":"Mol. Carcinogenesis"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1093\/carcin\/bgt409","article-title":"Integrative Genomics Analysis Reveals the Multilevel Dysregulation and Oncogenic Characteristics of TEAD4 in Gastric Cancer","volume":"35","author":"Lim","year":"2014","journal-title":"Carcinogenesis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ncb3581","article-title":"Regulation of Hippo Pathway Transcription Factor TEAD by P38 MAPK-Induced Cytoplasmic Translocation","volume":"19","author":"Lin","year":"","journal-title":"Nat. Cel Biol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.tibs.2017.09.003","article-title":"Regulation of the Hippo Pathway Transcription Factor TEAD","volume":"42","author":"Lin","year":"","journal-title":"Trends Biochem. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/1471-2407-13-349","article-title":"Overexpression of YAP 1 Contributes to Progressive Features and Poor Prognosis of Human Urothelial Carcinoma of the Bladder","volume":"13","author":"Liu","year":"2013","journal-title":"BMC Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41419-019-1674-2","article-title":"A Novel YAP1\/SLC35B4 Regulatory axis Contributes to Proliferation and Progression of Gastric Carcinoma","volume":"10","author":"Liu","year":"2019","journal-title":"Cell Death Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.celrep.2015.12.104","article-title":"Tead and AP1 Coordinate Transcription and Motility","volume":"14","author":"Liu","year":"2016","journal-title":"Cel Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1096\/fj.10-167619","article-title":"Requirement of the Nuclear Localization of Transcription Enhancer Factor 3 for Proliferation, Migration, Tube Formation, and Angiogenesis Induced by Vascular Endothelial Growth Factor","volume":"25","author":"Liu","year":"2011","journal-title":"FASEB j."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1038\/onc.2015.342","article-title":"Increased TEAD4 Expression and Nuclear Localization in Colorectal Cancer Promote Epithelial-Mesenchymal Transition and Metastasis in a YAP-independent Manner","volume":"35","author":"Liu","year":"2016","journal-title":"Oncogene"},{"key":"B68","first-page":"3212","article-title":"A Potential Role for the Hippo Pathway Protein, YAP, in Controlling Proliferation, Cell Cycle Progression, and Autophagy in BCPAP and KI Thyroid Papillary Carcinoma Cells","volume":"9","author":"Liu","year":"2017","journal-title":"Am. J. Transl Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/pai.0000000000000544","article-title":"High Expression of Yes-Activated Protein-1 in Papillary Thyroid Carcinoma Correlates with Poor Prognosis","volume":"27","author":"Liu","year":"2019","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1101\/gad.192856.112","article-title":"Genetic and Pharmacological Disruption of the TEAD-YAP Complex Suppresses the Oncogenic Activity of YAP","volume":"26","author":"Liu-Chittenden","year":"2012","journal-title":"Genes Dev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"49502","DOI":"10.18632\/oncotarget.17738","article-title":"IKBKE Regulates Cell Proliferation and Epithelial-Mesenchymal Transition of Human Malignant Glioma via the Hippo Pathway","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"B72","doi-asserted-by":"publisher","first-page":"684424","DOI":"10.3389\/fimmu.2021.684424","article-title":"Hippo Pathway Counter-regulates Innate Immunity in Hepatitis B Virus Infection","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"e21431","DOI":"10.1371\/journal.pone.0021431","article-title":"Identification of a Classical Bipartite Nuclear Localization Signal in the Drosophila TEA\/ATTS Protein Scalloped","volume":"6","author":"Magico","year":"2011","journal-title":"PLoS One"},{"key":"B74","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1042\/bj20041434","article-title":"The Transcriptional Co-activator TAZ Interacts Differentially with Transcriptional Enhancer Factor-1 (TEF-1) Family Members","volume":"388","author":"Mahoney","year":"2005","journal-title":"Biochem. J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12964-020-00634-6","article-title":"Yes-associated Protein (YAP) Induces a Secretome Phenotype and Transcriptionally Regulates Plasminogen Activator Inhibitor-1 (PAI-1) Expression in Hepatocarcinogenesis","volume":"18","author":"Marquard","year":"2020","journal-title":"Cell Commun Signal"},{"key":"B76","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/cells10010184","article-title":"Hippo Signaling Pathway in Gliomas","volume":"10","author":"Masliantsev","year":"2021","journal-title":"Cells"},{"key":"B77","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1186\/1471-2407-11-523","article-title":"Downregulation of SAV1 Plays a Role in Pathogenesis of High-Grade clear Cell Renal Cell Carcinoma","volume":"11","author":"Matsuura","year":"2011","journal-title":"BMC Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"13562","DOI":"10.1073\/pnas.2002630117","article-title":"Pivotal Role of the Transcriptional Co-activator YAP in Trophoblast Stemness of the Developing Human Placenta","volume":"117","author":"Meinhardt","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B79","doi-asserted-by":"publisher","first-page":"e25068","DOI":"10.7554\/eLife.25068","article-title":"Dissection of the Interaction between the Intrinsically Disordered YAP Protein and the Transcription Factor TEAD","volume":"6","author":"Mesrouze","year":"2017","journal-title":"Elife"},{"key":"B80","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/cbic.201300715","article-title":"The Surprising Features of the TEAD4-Vgll1 Protein-Protein Interaction","volume":"15","author":"Mesrouze","year":"2014","journal-title":"Chembiochem"},{"key":"B81","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo-YAP\/TAZ Signalling in Organ Regeneration and Regenerative Medicine","volume":"20","author":"Moya","year":"2019","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e21570","DOI":"10.1096\/fj.202002284RR","article-title":"The Hippo Pathway: A Master Regulator of Liver Metabolism, Regeneration, and Disease","volume":"35","author":"Nguyen-Lefebvre","year":"2021","journal-title":"FASEB J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1158\/1541-7786.mcr-18-0056","article-title":"Comprehensive Genomic Profiling of Patient-Matched Head and Neck Cancer Cells: A Preclinical Pipeline for Metastatic and Recurrent Disease","volume":"16","author":"Nisa","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.devcel.2009.02.003","article-title":"The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass","volume":"16","author":"Nishioka","year":"2009","journal-title":"Develop. Cel"},{"key":"B85","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jtbi.2019.04.009","article-title":"Molecular Dynamics Simulations Study of Influence of Tyr422Ala Mutation on Transcriptional Enhancer Activation Domain 4 (TEAD4) and Transcription Co-activators Complexes","volume":"472","author":"Niu","year":"2019","journal-title":"J. Theor. Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.str.2015.11.005","article-title":"Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling","volume":"24","author":"Noland","year":"2016","journal-title":"Structure"},{"key":"B87","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1038\/onc.2017.75","article-title":"Stearoyl-CoA-desaturase 1 Regulates Lung Cancer Stemness via Stabilization and Nuclear Localization of YAP\/TAZ","volume":"36","author":"Noto","year":"2017","journal-title":"Oncogene"},{"key":"B88","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/path.2217","article-title":"DNA Profiling of Primary Serous Ovarian and Fallopian Tube Carcinomas with Array Comparative Genomic Hybridization and Multiplex Ligation-dependent Probe Amplification","volume":"213","author":"Nowee","year":"2007","journal-title":"J. Pathol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1242\/dev.139857","article-title":"Cooperative Binding of AP-1 and TEAD4 Modulates the Balance between Vascular Smooth Muscle and Hemogenic Cell Fate","volume":"143","author":"Obier","year":"2016","journal-title":"Development"},{"key":"B90","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.fob.2015.06.007","article-title":"Small Molecules Inhibiting the Nuclear Localization of YAP\/TAZ for Chemotherapeutics and Chemosensitizers against Breast Cancers","volume":"5","author":"Oku","year":"2015","journal-title":"FEBS Open Bio"},{"key":"B91","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41419-018-1249-7","article-title":"Wnt3a Disrupts GR-TEAD4-Ppar\u03b32 Positive Circuits and Cytoskeletal Rearrangement in a \u03b2-catenin-dependent Manner during Early Adipogenesis","volume":"10","author":"Park","year":"2019","journal-title":"Cel Death Dis"},{"key":"B92","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.str.2015.09.009","article-title":"Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy","volume":"23","author":"Pobbati","year":"2015","journal-title":"Structure"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1056\/nejmoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1016\/j.ymthe.2020.05.026","article-title":"Enhancer Reprogramming within Pre-existing Topologically Associated Domains Promotes TGF-\u03b2-Induced EMT and Cancer Metastasis","volume":"28","author":"Qiao","year":"2020","journal-title":"Mol. Ther."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1158\/0008-5472.can-20-2801","article-title":"YAP and \u03b2-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer","volume":"81","author":"Quinn","year":"2021","journal-title":"Cancer Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"7133","DOI":"10.2147\/ijgm.s336602","article-title":"Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma","author":"Ren","year":"2021","journal-title":"Ijgm"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1038\/modpathol.2015.102","article-title":"A Role for the Transducer of the Hippo Pathway, TAZ, in the Development of Aggressive Types of Endometrial Cancer","volume":"28","author":"Romero-P\u00e9rez","year":"2015","journal-title":"Mod. Pathol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3892\/or.2017.5642","article-title":"Overexpression of the YAP1 Oncogene in clear Cell Renal Cell Carcinoma Is Associated with Poor Outcome","volume":"38","author":"Rybarczyk","year":"2017","journal-title":"Oncol. Rep."},{"key":"B99","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/cells8040370","article-title":"The Hippo Pathway in Prostate Cancer","volume":"8","author":"Salem","year":"2019","journal-title":"Cells"},{"key":"B100","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s11060-021-03699-6","article-title":"Targeting the YAP-TEAD Interaction Interface for Therapeutic Intervention in Glioblastoma","volume":"152","author":"Saunders","year":"2021","journal-title":"J. Neurooncol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.tranon.2014.02.005","article-title":"Hippo Signaling Mediates Proliferation, Invasiveness, and Metastatic Potential of clear Cell Renal Cell Carcinoma","volume":"7","author":"Sch\u00fctte","year":"2014","journal-title":"Translational Oncol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.bbrc.2017.03.158","article-title":"Wnt Signaling Promotes Androgen-independent Prostate Cancer Cell Proliferation through Up-Regulation of the Hippo Pathway Effector YAP","volume":"486","author":"Seo","year":"2017","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B103","doi-asserted-by":"publisher","first-page":"4362","DOI":"10.1038\/onc.2017.24","article-title":"DNA-binding Mechanism of the Hippo Pathway Transcription Factor TEAD4","volume":"36","author":"Shi","year":"2017","journal-title":"Oncogene"},{"key":"B104","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12943-019-1104-1","article-title":"TEAD4 Modulated LncRNA MNX1-AS1 Contributes to Gastric Cancer Progression Partly through Suppressing BTG2 and Activating BCL2","volume":"19","author":"Shuai","year":"2020","journal-title":"Mol. Cancer"},{"key":"B105","doi-asserted-by":"publisher","first-page":"dev156273","DOI":"10.1242\/dev.156273","article-title":"Comparative Analysis of Mouse and Human Placentae across Gestation Reveals Species-specific Regulators of Placental Development","volume":"145","author":"Soncin","year":"2018","journal-title":"Development"},{"key":"B106","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1158\/1535-7163.mct-17-0560","article-title":"A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma","volume":"17","author":"Song","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"B153","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ncb2936","article-title":"Metabolic Control of YAP and TAZ by the Mevalonate Pathway","volume":"16","author":"Sorrentino","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/15384101.2017.1403687","article-title":"TEAD4 Promotes Colorectal Tumorigenesis via Transcriptionally Targeting YAP1","volume":"17","author":"Tang","year":"2018","journal-title":"Cell Cycle"},{"key":"B108","doi-asserted-by":"publisher","first-page":"13827","DOI":"10.18632\/oncotarget.7342","article-title":"Nuclear Localization of TEF3-1 Promotes Cell Cycle Progression and Angiogenesis in Cancer","volume":"7","author":"Teng","year":"2016","journal-title":"Oncotarget"},{"key":"B109","doi-asserted-by":"publisher","first-page":"5502","DOI":"10.1158\/0008-5472.can-20-0242","article-title":"YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF\/c-MET Signaling in Liver Tumorigenesis","volume":"80","author":"Thomann","year":"2020","journal-title":"Cancer Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1111\/liv.15048","article-title":"YAP\u2010induced Ccl2 Expression Is Associated with a Switch in Hepatic Macrophage Identity and Vascular Remodelling in Liver Cancer","volume":"41","author":"Thomann","year":"2021","journal-title":"Liver Int."},{"key":"B111","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ Upstream Signals and Downstream Responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cel Biol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1053\/j.gastro.2013.02.009","article-title":"Yes-associated Protein Up-Regulates Jagged-1 and Activates the Notch Pathway in Human Hepatocellular Carcinoma","volume":"144","author":"Tschaharganeh","year":"2013","journal-title":"Gastroenterology"},{"key":"B113","doi-asserted-by":"publisher","first-page":"17476","DOI":"10.1074\/jbc.m001970200","article-title":"Identification of the Functional Domain in the Transcription Factor RTEF-1 that Mediates \u03b11-Adrenergic Signaling in Hypertrophied Cardiac Myocytes","volume":"275","author":"Ueyama","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1101\/gad.888601","article-title":"TEAD\/TEF Transcription Factors Utilize the Activation Domain of YAP65, a Src\/Yes-Associated Protein Localized in the Cytoplasm","volume":"15","author":"Vassilev","year":"2001","journal-title":"Genes Dev."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1158\/1078-0432.ccr-20-0018","article-title":"YAP\/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-Mutant Glioblastoma","volume":"27","author":"Vigneswaran","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"B116","first-page":"996","article-title":"YAP\/TAZ Regulates the Insulin Signaling via IRS1\/2 in Endometrial Cancer","volume":"6","author":"Wang","year":"","journal-title":"Am. J. Cancer Res."},{"key":"B117","first-page":"27","article-title":"Verteporfin Inhibits YAP Function through Up-Regulating 14-3-3\u03c3 Sequestering YAP in the Cytoplasm","volume":"6","author":"Wang","year":"","journal-title":"Am. J. Cancer Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1158\/0008-5472.can-15-3084","article-title":"YAP\/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway","volume":"77","author":"Wang","year":"2017","journal-title":"Cancer Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"17685","DOI":"10.18632\/oncotarget.3779","article-title":"The Interplay between TEAD4 and KLF5 Promotes Breast Cancer Partially through Inhibiting the Transcription of p27Kip1","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"B120","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.canlet.2021.04.016","article-title":"KLF5-induced lncRNA IGFL2-AS1 Promotes Basal-like Breast Cancer Cell Growth and Survival by Upregulating the Expression of IGFL1","volume":"515","author":"Wang","year":"2021","journal-title":"Cancer Lett."},{"key":"B121","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1089\/dna.2021.0164","article-title":"TEAD4 Is an Immune Regulating-Related Prognostic Biomarker for Bladder Cancer and Possesses Generalization Value in Pan-Cancer","volume":"40","author":"Wang","year":"2021","journal-title":"DNA Cel Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.celrep.2015.09.014","article-title":"Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins","volume":"13","author":"Wang","year":"2015","journal-title":"Cel Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"557429","DOI":"10.3389\/fphar.2020.557429","article-title":"The Role of Photoactivated and Non-photoactivated Verteporfin on Tumor","volume":"11","author":"Wei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1053\/j.gastro.2017.02.018","article-title":"Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer","volume":"152","author":"Weiler","year":"2017","journal-title":"Gastroenterology"},{"key":"B125","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41392-020-0170-6","article-title":"p190A Inactivating Mutations Cause Aberrant RhoA Activation and Promote Malignant Transformation via the Hippo-YAP Pathway in Endometrial Cancer","volume":"5","author":"Wen","year":"2020","journal-title":"Sig Transduct Target. Ther."},{"key":"B126","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3390\/cancers10110422","article-title":"Targeting the Hippo Pathway for Breast Cancer Therapy","volume":"10","author":"Wu","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B127","doi-asserted-by":"publisher","first-page":"69823","DOI":"10.18632\/oncotarget.19310","article-title":"The Prognostic Impacts of TEA Domain (TEAD) Transcription Factor Polymorphisms in Chinese Hepatocellular Carcinoma Patients","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"B128","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcmm.13293","article-title":"Emerging Role of Hippo Signalling Pathway in Bladder Cancer","volume":"22","author":"Xia","year":"2018","journal-title":"J. Cel. Mol. Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"e91770","DOI":"10.1371\/journal.pone.0091770","article-title":"YAP Promotes Ovarian Cancer Cell Tumorigenesis and Is Indicative of a Poor Prognosis for Ovarian Cancer Patients","volume":"9","author":"Xia","year":"","journal-title":"PLoS One"},{"key":"B130","doi-asserted-by":"publisher","first-page":"e109575","DOI":"10.1371\/journal.pone.0109575","article-title":"YAP\/TEAD Co-activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells","volume":"9","author":"Xia","year":"","journal-title":"PLoS One"},{"key":"B131","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1111\/jcmm.16266","article-title":"YAP\u2010TEAD Up\u2010regulates IRS2 Expression to Induce and Deteriorate Oesophageal Cancer","volume":"25","author":"Xu","year":"2021","journal-title":"J. Cell. Mol. Medi"},{"key":"B132","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1242\/dev.010223","article-title":"Transcription Factor TEAD4 Specifies the Trophectoderm Lineage at the Beginning of Mammalian Development","volume":"134","author":"Yagi","year":"2007","journal-title":"Development"},{"key":"B133","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1146\/annurev-physiol-021014-071733","article-title":"Hippo Pathway Regulation of Gastrointestinal Tissues","volume":"77","author":"Yu","year":"2015","journal-title":"Annu. Rev. Physiol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.2147\/cmar.s260790","article-title":"Nuclear TEAD4 with SIX1 Overexpression Is an Independent Prognostic Marker in the Stage I-III Colorectal Cancer","author":"Yu","year":"2021","journal-title":"Cmar"},{"key":"B135","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1515\/biol-2021-0039","article-title":"TEAD4 Is a Novel Independent Predictor of Prognosis in LGG Patients with IDH Mutation","volume":"16","author":"Yuan","year":"2021","journal-title":"Open Life Sci."},{"key":"B149","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ijc.29429","article-title":"Genetic Variants in Hippo Pathway Genes YAP1, TEAD1 and TEAD4 are Associated With Melanoma-Specific Survival","volume":"137","author":"Yuan","year":"2015","journal-title":"Int. J. Cancer"},{"key":"B136","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the Roots of Cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1038\/ncb3216","article-title":"Genome-wide Association between YAP\/TAZ\/TEAD and AP-1 at Enhancers Drives Oncogenic Growth","volume":"17","author":"Zanconato","year":"2015","journal-title":"Nat. Cel Biol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1101\/gad.324814.119","article-title":"Dedifferentiation by Adenovirus E1A Due to Inactivation of Hippo Pathway Effectors YAP and TAZ","volume":"33","author":"Zemke","year":"2019","journal-title":"Genes Dev."},{"key":"B139","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12038-021-00238-3","article-title":"TEAD4 Overexpression Suppresses Thyroid Cancer Progression and Metastasis In Vitro by Modulating Wnt Signaling","volume":"47","author":"Zhang","year":"2022","journal-title":"J. Biosci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"15665","DOI":"10.1007\/s13277-016-5318-1","article-title":"Expression and Significance of Hippo\/YAP Signaling in Glioma Progression","volume":"37","author":"Zhang","year":"2016","journal-title":"Tumor Biol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12935-018-0675-z","article-title":"TEAD4 Overexpression Promotes Epithelial-Mesenchymal Transition and Associates with Aggressiveness and Adverse Prognosis in Head Neck Squamous Cell Carcinoma","volume":"18","author":"Zhang","year":"","journal-title":"Cancer Cel Int"},{"key":"B142","doi-asserted-by":"publisher","first-page":"17119","DOI":"10.1074\/jbc.ra118.003608","article-title":"The TEA Domain Family Transcription Factor TEAD4 Represses Murine Adipogenesis by Recruiting the Cofactors VGLL4 and CtBP2 into a Transcriptional Complex","volume":"293","author":"Zhang","year":"","journal-title":"J. Biol. Chem."},{"key":"B143","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1021\/ml500160m","article-title":"Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction","volume":"5","author":"Zhang","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"B144","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/s41388-021-02036-5","article-title":"RANBP1 Promotes Colorectal Cancer Progression by Regulating Pre-miRNA Nuclear export via a Positive Feedback Loop with YAP","volume":"41","author":"Zheng","year":"2022","journal-title":"Oncogene"},{"key":"B145","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3390\/ijms17010138","article-title":"The TEAD Family and its Oncogenic Role in Promoting Tumorigenesis","volume":"17","author":"Zhou","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.1038\/onc.2017.257","article-title":"TEAD1\/4 Exerts Oncogenic Role and Is Negatively Regulated by miR-4269 in Gastric Tumorigenesis","volume":"36","author":"Zhou","year":"2017","journal-title":"Oncogene"},{"key":"B147","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1096\/fj.14-262980","article-title":"Targeting Hippo Pathway by Specific Interruption of YAP\u2010TEAD Interaction Using Cyclic YAP\u2010like Peptides","volume":"29","author":"Zhou","year":"2015","journal-title":"FASEB j."},{"key":"B148","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.molcel.2019.06.010","article-title":"A Non-canonical Role of YAP\/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer","volume":"75","author":"Zhu","year":"2019","journal-title":"Mol. Cel"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.890419\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T02:40:22Z","timestamp":1651718422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.890419\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":153,"alternative-id":["10.3389\/fcell.2022.890419"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2022.890419","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"article-number":"890419"}}