{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:06:23Z","timestamp":1782187583897,"version":"3.54.5"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2020\/11667-0"],"award-info":[{"award-number":["#2020\/11667-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS100947 R61NS124923"],"award-info":[{"award-number":["R01NS100947 R61NS124923"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>It is well established that temporal lobe epilepsy (TLE) is often related to oxidative stress and neuroinflammation. Both processes subserve alterations observed in epileptogenesis and ultimately involve distinct classes of cells, including astrocytes, microglia, and specific neural subtypes. For this reason, molecules associated with oxidative stress response and neuroinflammation have been proposed as potential targets for therapeutic strategies. However, these molecules can participate in distinct intracellular pathways depending on the cell type. To illustrate this, we reviewed the potential role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) and myeloid differentiation primary response 88 (MyD88) in astrocytes, microglia, and neurons in epileptogenesis. Furthermore, we presented approaches to study genes in different cells, employing single-cell RNA-sequencing (scRNAseq) transcriptomic analyses, transgenic technologies and viral serotypes carrying vectors with specific promoters. We discussed the importance of identifying particular roles of molecules depending on the cell type, endowing more effective therapeutic strategies to treat TLE.<\/jats:p>","DOI":"10.3389\/fcell.2022.926776","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T08:24:16Z","timestamp":1656923056000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Distinct Cell-specific Roles of NOX2 and MyD88 in Epileptogenesis"],"prefix":"10.3389","volume":"10","author":[{"given":"Cayo","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan Paschoalino","family":"Pongilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia In\u00eas","family":"M\u00f3vio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Shigueto Vilar","family":"Higa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Ribeiro","family":"Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Reime","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Hiroaki","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e76310","DOI":"10.1371\/journal.pone.0076310","article-title":"Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain","volume":"8","author":"Aschauer","year":"2013","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.2174\/18715273113129990064","article-title":"Astrocyte-microglia Cooperation in the Expression of a Pro-inflammatory Phenotype","volume":"12","author":"Barbierato","year":"2013","journal-title":"Cnsnddt"},{"key":"B3","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4137\/JEN.S39887","article-title":"Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity","volume":"10","author":"Beckhauser","year":"2016","journal-title":"J. Exp. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3389\/fncel.2020.00209","article-title":"Glia Crosstalk in Neuroinflammatory Diseases","volume":"14","author":"Bernaus","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1007\/s43440-020-00143-w","article-title":"Role of Oxidative Stress in Epileptogenesis and Potential Implications for Therapy","volume":"72","author":"Borowicz-Reutt","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/1742-2094-9-229","article-title":"Expression of Myeloid Differentiation Factor 88 in Neurons Is Not Requisite for the Induction of Sickness Behavior by Interleukin-1\u03b2","volume":"9","author":"Braun","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nn.2334","article-title":"NADPH Oxidase Is the Primary Source of Superoxide Induced by NMDA Receptor Activation","volume":"12","author":"Brennan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.neuint.2011.09.002","article-title":"Detailed Analysis of Inflammatory and Neuromodulatory Cytokine Secretion from Human NT2 Astrocytes Using Multiplex Bead Array","volume":"60","author":"Burkert","year":"2012","journal-title":"Neurochem. Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1177\/0271678x17738701","article-title":"A Combination Antioxidant Therapy to Inhibit NOX2 and Activate Nrf2 Decreases Secondary Brain Damage and Improves Functional Recovery after Traumatic Brain Injury","volume":"38","author":"Chandran","year":"2018","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbi.2013.02.005","article-title":"Characterization of Phenotype Markers and Neuronotoxic Potential of Polarised Primary Microglia In Vitro","volume":"32","author":"Chhor","year":"2013","journal-title":"Brain, Behav. Immun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0151569","DOI":"10.1371\/journal.pone.0151569","article-title":"Microglia-Derived Cytokines\/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice","volume":"11","author":"Chien","year":"2016","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"109229","DOI":"10.1016\/j.celrep.2021.109229","article-title":"Sublayer- and Cell-type-specific Neurodegenerative Transcriptional Trajectories in Hippocampal Sclerosis","volume":"35","author":"Cid","year":"2021","journal-title":"Cell Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.omtm.2017.11.007","article-title":"Emerging Issues in AAV-Mediated In Vivo Gene Therapy","volume":"8","author":"Colella","year":"2018","journal-title":"Mol. Ther. - Methods & Clin. Dev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1101\/gad.1821209","article-title":"Sequence, Biogenesis, and Function of Diverse Small RNA Classes Bound to the Piwi Family Proteins of Tetrahymena Thermophila","volume":"23","author":"Couvillion","year":"2009","journal-title":"Genes. Dev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/s0304-3940(00)01409-9","article-title":"Lipid Peroxidation in hippocampus Early and Late after Status Epilepticus Induced by Pilocarpine or Kainic Acid in Wistar Rats","volume":"291","author":"Dal-Pizzol","year":"2000","journal-title":"Neurosci. Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1128\/cmr.00008-08","article-title":"Gene Therapy Using Adeno-Associated Virus Vectors","volume":"21","author":"Daya","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1074\/jbc.m111.293696","article-title":"NADPH Oxidase Is Internalized by Clathrin-Coated Pits and Localizes to a Rab27A\/B GTPase-Regulated Secretory Compartment in Activated Macrophages","volume":"287","author":"Ejlerskov","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1016\/j.ymthe.2021.04.005","article-title":"Best of Most Possible Worlds: Hybrid Gene Therapy Vectors Based on Parvoviruses and Heterologous Viruses","volume":"29","author":"Fakhiri","year":"2021","journal-title":"Mol. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0040-1718719","article-title":"Epilepsy-Definition, Classification, Pathophysiology, and Epidemiology","volume":"40","author":"Falco-Walter","year":"2020","journal-title":"Semin. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3389\/fncel.2018.00329","article-title":"Role of Microglia TLRs in Neurodegeneration","volume":"12","author":"Fiebich","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"5649","DOI":"10.1523\/jneurosci.2617-17.2018","article-title":"Metaplasticity in the Visual Cortex: Crosstalk between Visual Experience and Reactive Oxygen Species","volume":"38","author":"Francis-Oliveira","year":"2018","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41434-019-0075-6","article-title":"Astrocyte-selective AAV Gene Therapy through the Endogenous GFAP Promoter Results in Robust Transduction in the Rat Spinal Cord Following Injury","volume":"26","author":"Griffin","year":"2019","journal-title":"Gene Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1590\/s1676-26492006000200003","article-title":"Plasticidade neuronal associada \u00e0 epilepsia Do lobo temporal mesial: insights a partir de estudos em humanos e em modelos animais","volume":"12","author":"Guedes","year":"2006","journal-title":"J. epilepsy Clin. Neurophysiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1097\/nen.0b013e3182358e4e","article-title":"Activation of NOX2 by the Stimulation of Ionotropic and Metabotropic Glutamate Receptors Contributes to Glutamate Neurotoxicity In Vivo through the Production of Reactive Oxygen Species and Calpain Activation","volume":"70","author":"Guemez-Gamboa","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1084\/jem.20180200","article-title":"Astrocytes and Microglia: Models and Tools","volume":"216","author":"Guttenplan","year":"2019","journal-title":"J. Exp. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0188830","DOI":"10.1371\/journal.pone.0188830","article-title":"Cellular Selectivity of AAV Serotypes for Gene Delivery in Neurons and Astrocytes by Neonatal Intracerebroventricular Injection","volume":"12","author":"Hammond","year":"2017","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1111\/bph.13425","article-title":"NADPH Oxidases in Oxidant Production by Microglia: Activating Receptors, Pharmacology and Association with Disease","volume":"174","author":"Haslund-Vinding","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1083\/jcb.201611078","article-title":"Astrocytic TLR4 at the Crossroads of Inflammation and Seizure Susceptibility","volume":"215","author":"Henneberger","year":"2016","journal-title":"J. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1152\/physiol.00038.2015","article-title":"Calcium, Reactive Oxygen Species, and Synaptic Plasticity","volume":"31","author":"Hidalgo","year":"2016","journal-title":"Physiology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1161\/01.atv.0000187472.55437.af","article-title":"IQGAP1 Regulates Reactive Oxygen Species-dependent Endothelial Cell Migration through Interacting with Nox2","volume":"25","author":"Ikeda","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuropharm.2019.02.011","article-title":"Suppressing Pro-inflammatory Prostaglandin Signaling Attenuates Excitotoxicity-Associated Neuronal Inflammation and Injury","volume":"149","author":"Jiang","year":"2019","journal-title":"Neuropharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5625\/lar.2018.34.4.147","article-title":"Mouse Cre-LoxP System: General Principles to Determine Tissue-specific Roles of Target Genes","volume":"34","author":"Kim","year":"2018","journal-title":"Lab. Anim. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"20969","DOI":"10.1038\/srep20969","article-title":"Pilocarpine-induced Seizures Trigger Differential Regulation of microRNA-Stability Related Genes in Rat Hippocampal Neurons","volume":"6","author":"Kinjo","year":"2016","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1007\/s12035-017-0623-2","article-title":"New Insights on Temporal Lobe Epilepsy Based on Plasticity-Related Network Changes and High-Order Statistics","volume":"55","author":"Kinjo","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.4103\/1673-5374.300976","article-title":"Pro- and Anti-epileptic Roles of Microglia","volume":"16","author":"Kinoshita","year":"2021","journal-title":"Neural Regen. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1007\/s13311-018-0653-0","article-title":"Inhibition of MyD88 Signaling Skews Microglia\/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus after Status Epilepticus in Mice","volume":"15","author":"Liu","year":"2018","journal-title":"Neurotherapeutics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.bbi.2020.10.007","article-title":"Role of Astroglial Toll-like Receptors (TLRs) in Central Nervous System Infections, Injury and Neurodegenerative Diseases","volume":"91","author":"Lun Li","year":"2021","journal-title":"Brain, Behav. Immun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/glia.23018","article-title":"Microglia Engulf Viable Newborn Cells in the Epileptic Dentate Gyrus","volume":"64","author":"Luo","year":"2016","journal-title":"Glia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1089\/ars.2013.5293","article-title":"The Use of the Cre\/loxPSystem to Study Oxidative Stress in Tissue-Specific Manganese Superoxide Dismutase Knockout Models","volume":"20","author":"Marecki","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"B42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2017.08.009","article-title":"Scavenging Reactive Oxygen Species Inhibits Status Epilepticus-Induced Neuroinflammation","volume":"298","author":"Mcelroy","year":"2017","journal-title":"Exp. Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1007\/s11064-020-03000-7","article-title":"Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus","volume":"45","author":"Mcnair","year":"2020","journal-title":"Neurochem. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s42494-020-00024-y","article-title":"The Role of Inflammation in Epileptogenesis","volume":"2","author":"Meng","year":"2020","journal-title":"Acta Epileptol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1093\/brain\/awy276","article-title":"Microglial Phenotypes in the Human Epileptic Temporal Lobe","volume":"141","author":"Morin-Brureau","year":"2018","journal-title":"Brain"},{"key":"B46","doi-asserted-by":"publisher","first-page":"107504","DOI":"10.1016\/j.pharmthera.2020.107504","article-title":"Targeting Prostaglandin Receptor EP2 for Adjunctive Treatment of Status Epilepticus","volume":"209","author":"Nagib","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e57","DOI":"10.1002\/cpmb.57","article-title":"Introduction to Single-Cell RNA Sequencing","volume":"122","author":"Olsen","year":"2018","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"B48","volume-title":"Epilepsy: A Public Health Imperative","year":"2019"},{"key":"B49","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1042\/bj20061184","article-title":"Cross-talk between IRAK-4 and the NADPH Oxidase","volume":"403","author":"Pacquelet","year":"2007","journal-title":"Biochem. J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3390\/antiox11020261","article-title":"LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain","volume":"11","author":"Park","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1007\/s12035-015-9142-1","article-title":"Interplay between Exosomes, microRNAs and Toll-like Receptors in Brain Disorders","volume":"53","author":"Paschon","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.seizure.2013.04.023","article-title":"TLR4, ATF-3 and IL8 Inflammation Mediator Expression Correlates with Seizure Frequency in Human Epileptic Brain Tissue","volume":"22","author":"Pernhorst","year":"2013","journal-title":"Seizure"},{"key":"B53","doi-asserted-by":"publisher","first-page":"a022822","DOI":"10.1101\/cshperspect.a022822","article-title":"Epileptogenesis","volume":"5","author":"Pitk\u00e4nen","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"745613","DOI":"10.1155\/2015\/745613","article-title":"Seizure-induced Oxidative Stress in Temporal Lobe Epilepsy","volume":"2015","author":"Puttachary","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"B55","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1189\/jlb.0404216","article-title":"Structure and Regulation of the Neutrophil Respiratory Burst Oxidase: Comparison with Nonphagocyte Oxidases","volume":"76","author":"Quinn","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neulet.2015.05.041","article-title":"Microglial ROS Production in an Electrical Rat Post-status Epilepticus Model of Epileptogenesis","volume":"599","author":"Rettenbeck","year":"2015","journal-title":"Neurosci. Lett."},{"key":"B57","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bbi.2018.11.010","article-title":"Removal of Microglial-specific MyD88 Signaling Alters Dentate Gyrus Doublecortin and Enhances Opioid Addiction-like Behaviors","volume":"76","author":"Rivera","year":"2019","journal-title":"Brain, Behav. Immun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"16026","DOI":"10.1038\/mtm.2016.26","article-title":"Microglia-specific Targeting by Novel Capsid-Modified AAV6 Vectors","volume":"3","author":"Rosario","year":"2016","journal-title":"Mol. Ther. - Methods & Clin. Dev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"113213","DOI":"10.1016\/j.expneurol.2020.113213","article-title":"Ryanodine Receptors Drive Neuronal Loss and Regulate Synaptic Proteins during Epileptogenesis","volume":"327","author":"Royero","year":"2020","journal-title":"Exp. Neurol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.nbd.2013.12.006","article-title":"Temporal and Spatial Increase of Reactive Nitrogen Species in the Kainate Model of Temporal Lobe Epilepsy","volume":"64","author":"Ryan","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/jnr.22581","article-title":"Superoxide Dismutase Deficiency Enhances Superoxide Levels in Brain Tissues during Oxygenation and Hypoxia-Reoxygenation","volume":"89","author":"Sasaki","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1006\/meth.1998.0593","article-title":"Inducible Gene Targeting in Mice Using the Cre\/loxSystem","volume":"14","author":"Sauer","year":"1998","journal-title":"Methods"},{"key":"B63","doi-asserted-by":"publisher","first-page":"14850","DOI":"10.1523\/jneurosci.3922-11.2011","article-title":"Ablation of Cyclooxygenase-2 in Forebrain Neurons Is Neuroprotective and Dampens Brain Inflammation after Status Epilepticus","volume":"31","author":"Serrano","year":"2011","journal-title":"J. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"106410","DOI":"10.1016\/j.yebeh.2019.07.011","article-title":"Reactive Oxygen Species in Status Epilepticus","volume":"101","author":"Shekh-Ahmad","year":"2019","journal-title":"Epilepsy & Behav."},{"key":"B65","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1083\/jcb.201605046","article-title":"Postnatal Activation of TLR4 in Astrocytes Promotes Excitatory Synaptogenesis in Hippocampal Neurons","volume":"215","author":"Shen","year":"2016","journal-title":"J. Cell Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuint.2005.10.002","article-title":"Depletion of Reduced Glutathione Precedes Inactivation of Mitochondrial Enzymes Following Limbic Status Epilepticus in the Rat hippocampus","volume":"48","author":"Sleven","year":"2006","journal-title":"Neurochem. Int."},{"key":"B67","doi-asserted-by":"publisher","first-page":"11816","DOI":"10.1021\/acs.jmedchem.1c00816","article-title":"EP2 Antagonists (2011-2021): A Decade's Journey from Discovery to Therapeutics","volume":"64","author":"Sluter","year":"2021","journal-title":"J. Med. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/jnc.13081","article-title":"Recombinant Adeno-Associated Viral (rAAV) Vectors Mediate Efficient Gene Transduction in Cultured Neonatal and Adult Microglia","volume":"136","author":"Su","year":"2016","journal-title":"J. Neurochem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1523\/jneurosci.2040-20.2020","article-title":"Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus","volume":"41","author":"Varvel","year":"2021","journal-title":"J. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3390\/antiox10060890","article-title":"NADPH Oxidases (NOX): An Overview from Discovery,Molecular Mechanisms to Physiology and Pathology","volume":"10","author":"Vermot","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuropharm.2012.04.004","article-title":"The Role of Inflammation in Epileptogenesis","volume":"69","author":"Vezzani","year":"2013","journal-title":"Neuropharmacology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.freeradbiomed.2013.08.166","article-title":"NOX2 Deficiency Ameliorates Cerebral Injury through Reduction of Complexin II-Mediated Glutamate Excitotoxicity in Experimental Stroke","volume":"65","author":"Wang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.expneurol.2017.05.008","article-title":"Myeloid Differentiation Factor 88 Is Up-Regulated in Epileptic Brain and Contributes to Experimental Seizures in Rats","volume":"295","author":"Wang","year":"2017","journal-title":"Exp. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1016\/j.jid.2016.06.003","article-title":"Research Techniques Made Simple: Methodology and Clinical Applications of RNA Sequencing","volume":"136","author":"Whitley","year":"2016","journal-title":"J. Investigative Dermatology"},{"key":"B75","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s10616-019-00324-3","article-title":"MiR-206 Inhibits Epilepsy and Seizure-Induced Brain Injury by Targeting CCL2","volume":"71","author":"Wu","year":"2019","journal-title":"Cytotechnology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"627557","DOI":"10.3389\/fphar.2021.627557","article-title":"Agmatine Alleviates Epileptic Seizures and Hippocampal Neuronal Damage by Inhibiting Gasdermin D-Mediated Pyroptosis","volume":"12","author":"Xueying Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.2147\/dddt.s314076","article-title":"Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-epileptic Effects through Activating TLR4\/MYD88\/Caspase-3 Pathway in Rats","volume":"15","author":"Yang","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"B78","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1080\/10715762.2017.1311015","article-title":"Involvement of Nox2 and Nox4 NADPH Oxidases in Early Brain Injury after Subarachnoid Hemorrhage","volume":"51","author":"Zhang","year":"2017","journal-title":"Free Radic. Res."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.926776\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T08:24:19Z","timestamp":1656923059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2022.926776\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":78,"alternative-id":["10.3389\/fcell.2022.926776"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2022.926776","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,4]]},"article-number":"926776"}}