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Quite uniquely, Thy-1 is capable of mediating integrin-related signaling through direct<jats:italic>trans-<\/jats:italic>and<jats:italic>cis-<\/jats:italic>interaction with integrins. Both interaction types have shown distinctive roles, even when interacting with the same type of integrin, where binding in<jats:italic>trans<\/jats:italic>or in<jats:italic>cis<\/jats:italic>often yields divergent signaling events. In this review, we will revisit recent progress and discoveries of Thy-1\u2013integrin interactions in<jats:italic>trans<\/jats:italic>and in<jats:italic>cis<\/jats:italic>, highlight their pathophysiological consequences and explore other potential binding partners of Thy-1 within the integrin regulation\/signaling paradigm.<\/jats:p>","DOI":"10.3389\/fcell.2022.928510","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T18:45:30Z","timestamp":1654541130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Thy-1-Integrin Interactions in cis and Trans Mediate Distinctive Signaling"],"prefix":"10.3389","volume":"10","author":[{"given":"Ping","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"Leyton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Hagood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/s0165-4608(02)00855-5","article-title":"THY1 Expression Is Associated with Tumor Suppression of Human Ovarian Cancer","volume":"143","author":"Abeysinghe","year":"2003","journal-title":"Cancer Genet. 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