{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:02:57Z","timestamp":1769076177337,"version":"3.49.0"},"reference-count":143,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fcell.2023.1112751","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T10:07:15Z","timestamp":1675418835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications"],"prefix":"10.3389","volume":"11","author":[{"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanliang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuju","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1021\/acscentsci.9b00284","article-title":"Design of safe nanotherapeutics for the excretion of excess systemic toxic iron","volume":"5","author":"Abbina","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.arcmed.2015.08.006","article-title":"Effects of coenzyme Q10 supplementation on inflammatory cytokines (TNF-alpha, IL-6) and oxidative stress in rheumatoid arthritis patients: A randomized controlled trial","volume":"46","author":"Abdollahzad","year":"2015","journal-title":"Arch. Med. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5155","DOI":"10.1038\/s41598-018-23408-0","article-title":"Modeling the effects of lipid peroxidation during ferroptosis on membrane properties","volume":"8","author":"Agmon","year":"2018","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"102272","DOI":"10.1016\/j.redox.2022.102272","article-title":"UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death","volume":"51","author":"Arslanbaeva","year":"2022","journal-title":"Redox Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"817104","DOI":"10.3389\/fcell.2021.817104","article-title":"Interplay between iron overload and osteoarthritis: Clinical significance and cellular mechanisms","volume":"9","author":"Cai","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3390\/antiox9121275","article-title":"Associations between coenzyme Q10 status, oxidative stress, and muscle strength and endurance in patients with osteoarthritis","volume":"9","author":"Chang","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"955069","DOI":"10.3389\/fimmu.2022.955069","article-title":"Ferroptosis in inflammatory arthritis: A promising future","volume":"13","author":"Chang","year":"2022","journal-title":"Front. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1038\/s41467-021-23902-6","article-title":"iPLA2\u03b2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4","volume":"12","author":"Chen","year":"","journal-title":"Nat. Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"6993","DOI":"10.2147\/JIR.S340351","article-title":"iTRAQ and PRM-based proteomic analysis provides new insights into mechanisms of response to triple therapy in patients with rheumatoid arthritis","volume":"14","author":"Chen","year":"","journal-title":"J. Inflamm. Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.3390\/cells11213508","article-title":"Targeting ferroptosis holds potential for intervertebral disc degeneration therapy","volume":"11","author":"Chen","year":"","journal-title":"Cells"},{"key":"B12","doi-asserted-by":"publisher","first-page":"108557","DOI":"10.1016\/j.intimp.2022.108557","article-title":"7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2\/ARE signaling","volume":"107","author":"Chen","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bbrc.2021.02.137","article-title":"KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma","volume":"550","author":"Chen","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"590226","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/ijc.32496","article-title":"Targeting ferroptosis in rhabdomyosarcoma cells","volume":"146","author":"Dachert","year":"2020","journal-title":"Int. J. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.bbrc.2020.01.066","article-title":"AIFM2 blocks ferroptosis independent of ubiquinol metabolism","volume":"523","author":"Dai","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1210\/endrev\/bnab028","article-title":"Secondary osteoporosis","volume":"43","author":"Ebeling","year":"2022","journal-title":"Endocr. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e001369","DOI":"10.1136\/jitc-2020-001369","article-title":"Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity","volume":"8","author":"Efimova","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"k1036","DOI":"10.1136\/bmj.k1036","article-title":"Increased cardiovascular risk in rheumatoid arthritis: Mechanisms and implications","volume":"361","author":"England","year":"2018","journal-title":"BMJ"},{"key":"B22","doi-asserted-by":"publisher","first-page":"628988","DOI":"10.3389\/fphar.2021.628988","article-title":"Baicalin prevents myocardial ischemia\/reperfusion injury through inhibiting ACSL4 mediated ferroptosis","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.3390\/molecules27133970","article-title":"Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines","volume":"27","author":"Fernandez-Acosta","year":"2022","journal-title":"Molecules"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"120537","DOI":"10.1016\/j.biomaterials.2020.120537","article-title":"Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors","volume":"268","author":"Fu","year":"2021","journal-title":"Biomaterials"},{"key":"B26","doi-asserted-by":"publisher","first-page":"101670","DOI":"10.1016\/j.redox.2020.101670","article-title":"Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis","volume":"36","author":"Fuhrmann","year":"2020","journal-title":"Redox Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"111836","DOI":"10.1016\/j.exger.2022.111836","article-title":"Ferroptosis - a new target of osteoporosis","volume":"165","author":"Gao","year":"2022","journal-title":"Exp. Gerontol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41574-018-0096-z","article-title":"The role of hypoxia-inducible factors in metabolic diseases","volume":"15","author":"Gonzalez","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"791376","DOI":"10.3389\/fphar.2022.791376","article-title":"Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","article-title":"SnapShot: Ferroptosis","volume":"181","author":"Hadian","year":"2020","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8966368","DOI":"10.1155\/2022\/8966368","article-title":"Theaflavin-3,3'-Digallate plays a ROS-mediated dual role in ferroptosis and apoptosis via the MAPK pathway in human osteosarcoma cell lines and xenografts","volume":"2022","author":"He","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1158\/2159-8290.CD-19-1500","article-title":"The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis","volume":"11","author":"Hong","year":"2021","journal-title":"Cancer Discov."},{"key":"B35","doi-asserted-by":"publisher","first-page":"920273","DOI":"10.3389\/fgene.2022.920273","article-title":"p53: A regulator of ferroptosis induced by galectin-1 derived peptide 3 in MH7A cells","volume":"13","author":"Hu","year":"","journal-title":"Front. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"810327","DOI":"10.3389\/fcell.2022.810327","article-title":"Blockade of GCH1\/BH4 Axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis","volume":"10","author":"Hu","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e0241080","DOI":"10.1371\/journal.pone.0241080","article-title":"Liposome\/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3\/Th17 targeting","volume":"15","author":"Jhun","year":"2020","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s12276-022-00756-6","article-title":"Dynamic synovial fibroblasts are modulated by NBCn1 as a potential target in rheumatoid arthritis","volume":"54","author":"Ji","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/iub.2656","article-title":"Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"key":"B42","doi-asserted-by":"publisher","first-page":"594509","DOI":"10.3389\/fcell.2020.594509","article-title":"Iron overload is associated with accelerated progression of osteoarthritis: The role of DMT1 mediated iron homeostasis","volume":"8","author":"Jing","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"628079","DOI":"10.3389\/fendo.2020.628079","article-title":"Redox epiphospholipidome in programmed cell death signaling: Catalytic mechanisms and regulation","volume":"11","author":"Kagan","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1021\/acschembio.0c00086","article-title":"Blockade of the lysophosphatidylserine lipase ABHD12 potentiates ferroptosis in cancer cells","volume":"15","author":"Kathman","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1038\/s41598-021-81741-3","article-title":"An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo","volume":"11","author":"Keuters","year":"2021","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.bbrc.2020.02.093","article-title":"Down-regulation of IDH2 sensitizes cancer cells to erastin-induced ferroptosis","volume":"525","author":"Kim","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"586578","DOI":"10.3389\/fcell.2020.586578","article-title":"Oxidative damage and antioxidant defense in ferroptosis","volume":"8","author":"Kuang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system x(c)(-) in health and disease: From molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"111202","DOI":"10.1016\/j.biopha.2020.111202","article-title":"EF24 induces ferroptosis in osteosarcoma cells through HMOX1","volume":"136","author":"Lin","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B53","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.3390\/cancers13184576","article-title":"The evolving role of ferroptosis in breast cancer: Translational implications present and future","volume":"13","author":"Lin","year":"","journal-title":"Cancers (Basel)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e22147","DOI":"10.1096\/fj.202101610R","article-title":"Activation of osteoblast ferroptosis via the METTL3\/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss","volume":"36","author":"Lin","year":"2022","journal-title":"FASEB J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1093\/rheumatology\/keac069","article-title":"Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis","volume":"61","author":"Ling","year":"2022","journal-title":"Rheumatol. Oxf."},{"key":"B56","doi-asserted-by":"publisher","first-page":"mfac027","DOI":"10.1093\/mtomcs\/mfac027","article-title":"Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blockage in K7M2 osteosarcoma cells","volume":"14","author":"Liu","year":"","journal-title":"Metallomics"},{"key":"B57","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41416-019-0660-x","article-title":"Activation of the reverse transsulfuration pathway through NRF2\/CBS confers erastin-induced ferroptosis resistance","volume":"122","author":"Liu","year":"2020","journal-title":"Br. J. Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2634431","DOI":"10.1155\/2022\/2634431","article-title":"Ferroptosis: A new regulatory mechanism in osteoporosis","volume":"2022","author":"Liu","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1002\/cbin.11121","article-title":"The induction of ferroptosis by impairing STAT3\/Nrf2\/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin","volume":"43","author":"Liu","year":"2019","journal-title":"Cell Biol. Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1031779","DOI":"10.3389\/fonc.2022.1031779","article-title":"Ferroptosis in osteosarcoma: A promising future","volume":"12","author":"Liu","year":"","journal-title":"Front. Oncol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jconrel.2018.05.025","article-title":"ROS-triggered degradable iron-chelating nanogels: Safely improving iron elimination in vivo","volume":"283","author":"Liu","year":"2018","journal-title":"J. Control Release"},{"key":"B62","doi-asserted-by":"publisher","first-page":"16130","DOI":"10.1038\/s41598-019-52513-x","article-title":"Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence","volume":"9","author":"Lu","year":"2019","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"6670497","DOI":"10.1155\/2021\/6670497","article-title":"Ferroportin-dependent iron homeostasis protects against oxidative stress-induced nucleus pulposus cell ferroptosis and ameliorates intervertebral disc degeneration in vivo","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3109\/10715762.2015.1112901","article-title":"The onset of lipid peroxidation in rheumatoid arthritis: Consequences and monitoring","volume":"50","author":"Luczaj","year":"2016","journal-title":"Free Radic. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2022.06.236","article-title":"Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation","volume":"188","author":"Luo","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3892\/etm.2020.9504","article-title":"Icariin enhances cell survival in lipopolysaccharide-induced synoviocytes by suppressing ferroptosis via the Xc-\/GPX4 axis","volume":"21","author":"Luo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1783485","DOI":"10.1155\/2021\/1783485","article-title":"Bavachin induces ferroptosis through the STAT3\/P53\/slc7a11 Axis in osteosarcoma cells","volume":"2021","author":"Luo","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00011-022-01547-5","article-title":"The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes","volume":"71","author":"Lv","year":"2022","journal-title":"Inflamm. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"9067610","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"4594606","DOI":"10.1155\/2020\/4594606","article-title":"Identification, expression, and roles of the cystine\/glutamate antiporter in ocular tissues","volume":"2020","author":"Martis","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-011-0864-8","article-title":"The transsulfuration pathway: A source of cysteine for glutathione in astrocytes","volume":"42","author":"McBean","year":"2012","journal-title":"Amino Acids"},{"key":"B72","doi-asserted-by":"publisher","first-page":"103847","DOI":"10.1016\/j.ebiom.2022.103847","article-title":"Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression","volume":"76","author":"Miao","year":"2022","journal-title":"EBioMedicine"},{"key":"B73","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"Ni","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.3390\/ijms18122656","article-title":"Icariin regulates cellular functions and gene expression of osteoarthritis patient-derived human fibroblast-like synoviocytes","volume":"18","author":"Pan","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"651552","DOI":"10.3389\/fmed.2021.651552","article-title":"The role of ferroptosis in acute respiratory distress syndrome","volume":"8","author":"Qu","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41556-020-0565-1","article-title":"Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture","volume":"22","author":"Riegman","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nm.2146","article-title":"Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development","volume":"16","author":"Saito","year":"2010","journal-title":"Nat. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"834247","DOI":"10.3389\/fimmu.2022.834247","article-title":"New druggable targets for rheumatoid arthritis based on insights from synovial Biology","volume":"13","author":"Sandhu","year":"2022","journal-title":"Front. Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-030-62026-4_4","article-title":"The role of NCOA4-mediated ferritinophagy in ferroptosis","volume":"1301","author":"Santana-Codina","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/ph11040114","article-title":"The role of NCOA4-mediated ferritinophagy in health and disease","volume":"11","author":"Santana-Codina","year":"2018","journal-title":"Pharm. (Basel)"},{"key":"B81","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/fonc.2015.00131","article-title":"Oncogenic RAS mutants confer resistance of RMS13 rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death","volume":"5","author":"Schott","year":"2015","journal-title":"Front. Oncol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bbrc.2021.06.036","article-title":"Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis","volume":"567","author":"Shi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.21037\/atm-21-5086","article-title":"Identification of a novel iron zinc finger protein 36 (ZFP36) for predicting the overall survival of osteosarcoma based on the Gene Expression Omnibus (GEO) database","volume":"9","author":"Song","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/imr.12839","article-title":"Inflammasomes contributing to inflammation in arthritis","volume":"294","author":"Spel","year":"2020","journal-title":"Immunol. Rev."},{"key":"B87","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox Biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B88","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.canlet.2020.02.015","article-title":"Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs","volume":"483","author":"Su","year":"2020","journal-title":"Cancer Lett."},{"key":"B89","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.bbrc.2022.02.112","article-title":"Dexamethasone induces ferroptosis via P53\/SLC7A11\/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head","volume":"602","author":"Sun","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41419-018-0794-4","article-title":"Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"B91","doi-asserted-by":"publisher","first-page":"24142","DOI":"10.1074\/jbc.274.34.24142","article-title":"Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation","volume":"274","author":"Tacchini","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"","journal-title":"Cell Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"5192271","DOI":"10.1155\/2021\/5192271","article-title":"The synergistic reducing drug resistance effect of cisplatin and ursolic acid on osteosarcoma through a multistep mechanism involving ferritinophagy","volume":"2021","author":"Tang","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1053\/j.gastro.2011.03.007","article-title":"Hypoxia-inducible factor-2\u03b1 mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice","volume":"140","author":"Taylor","year":"2011","journal-title":"Gastroenterology"},{"key":"B95","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1042\/BJ20150658","article-title":"An essential role for functional lysosomes in ferroptosis of cancer cells","volume":"473","author":"Torii","year":"2016","journal-title":"Biochem. J."},{"key":"B96","doi-asserted-by":"publisher","first-page":"6343","DOI":"10.1038\/s41467-020-20164-6","article-title":"D-mannose suppresses macrophage IL-1\u03b2 production","volume":"11","author":"Torretta","year":"2020","journal-title":"Nat. Commun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.3390\/nu7042324","article-title":"Chronic iron deficiency as an emerging risk factor for osteoporosis: A hypothesis","volume":"7","author":"Toxqui","year":"2015","journal-title":"Nutrients"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1045885","DOI":"10.3389\/fmolb.2022.1045885","article-title":"Indocyanine green as a near-infrared theranostic agent for ferroptosis and apoptosis-based, photothermal, and photodynamic cancer therapy","volume":"9","author":"Tseng","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s40425-019-0826-3","article-title":"Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine","volume":"7","author":"Turubanova","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"B100","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.bbi.2022.06.016","article-title":"Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice","volume":"105","author":"Vancassel","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/ars.2021.0136","article-title":"Tetrahydrobiopterin in cell function and death mechanisms","volume":"37","author":"Vasquez-Vivar","year":"2022","journal-title":"Antioxid. Redox Signal"},{"key":"B103","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41419-021-03725-5","article-title":"Mitochondrial ferritin attenuates cerebral ischaemia\/reperfusion injury by inhibiting ferroptosis","volume":"12","author":"Wang","year":"","journal-title":"Cell Death Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2022.08.018","article-title":"Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes","volume":"190","author":"Wang","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12011-021-02627-z","article-title":"Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis","volume":"200","author":"Wang","year":"","journal-title":"Biol. Trace Elem. Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"735965","DOI":"10.3389\/fphar.2021.735965","article-title":"Ferroptosis-inducing nanomedicine for cancer therapy","volume":"12","author":"Wang","year":"","journal-title":"Front. Pharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12951-021-01201-y","article-title":"Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms","volume":"20","author":"Wang","year":"","journal-title":"J. Nanobiotechnology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"102262","DOI":"10.1016\/j.redox.2022.102262","article-title":"ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury","volume":"51","author":"Wang","year":"","journal-title":"Redox Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"8832043","DOI":"10.1155\/2020\/8832043","article-title":"Posttranslational modifications in ferroptosis","volume":"2020","author":"Wei","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"B110","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","article-title":"The release and activity of HMGB1 in ferroptosis","volume":"510","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B111","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41467-021-27948-4","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10753-020-01338-2","article-title":"ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: A covert clue for potential therapy","volume":"44","author":"Xie","year":"2021","journal-title":"Inflammation"},{"key":"B113","doi-asserted-by":"publisher","first-page":"996244","DOI":"10.3389\/fendo.2022.996244","article-title":"No genetic causal association between iron status and osteoporosis: A two-sample mendelian randomization","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B114","first-page":"598","article-title":"Regulation of iron metabolism by hypoxia-inducible factors","volume":"69","author":"Xu","year":"2017","journal-title":"Sheng Li Xue Bao"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1080\/10715762.2021.2024816","article-title":"MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4","volume":"55","author":"Xu","year":"2021","journal-title":"Free Radic. Res."},{"key":"B116","doi-asserted-by":"publisher","first-page":"7168","DOI":"10.3390\/ijms22137168","article-title":"Iron chelator induces apoptosis in osteosarcoma cells by disrupting intracellular iron homeostasis and activating the MAPK pathway","volume":"22","author":"Xue","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"910675","DOI":"10.3389\/fpubh.2022.910675","article-title":"Research progress of ferroptosis regulatory network and bone remodeling in osteoporosis","volume":"10","author":"Yan","year":"2022","journal-title":"Front. Public Health"},{"key":"B118","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2018.10.185","article-title":"The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia","volume":"507","author":"Yang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-022-04924-4","article-title":"Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis","volume":"13","author":"Yang","year":"","journal-title":"Cell Death Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"6691","DOI":"10.1002\/jcp.30331","article-title":"Exosomes derived from vascular endothelial cells antagonize glucocorticoid-induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell Physiol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"B122","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1136\/annrheumdis-2013-204355","article-title":"NAMPT (visfatin), a direct target of hypoxia-inducible factor-2\u03b1, is an essential catabolic regulator of osteoarthritis","volume":"74","author":"Yang","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"B123","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B124","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B125","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41413-022-00198-w","article-title":"Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis","volume":"10","author":"Yang","year":"","journal-title":"Bone Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte ferroptosis contribute to the progression of osteoarthritis","volume":"27","author":"Yao","year":"2021","journal-title":"J. Orthop. Transl."},{"key":"B127","doi-asserted-by":"publisher","first-page":"114861","DOI":"10.1016\/j.ejmech.2022.114861","article-title":"Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications","volume":"244","author":"Yin","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","article-title":"Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis","volume":"10","author":"Yoshida","year":"2019","journal-title":"Nat. Commun."},{"key":"B129","doi-asserted-by":"publisher","first-page":"112672","DOI":"10.1016\/j.fct.2021.112672","article-title":"Downregulation of Cx43 reduces cisplatin-induced acute renal injury by inhibiting ferroptosis","volume":"158","author":"Yu","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.2019002907","article-title":"Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis","volume":"136","author":"Yu","year":"2020","journal-title":"Blood"},{"key":"B131","doi-asserted-by":"publisher","first-page":"102964","DOI":"10.1016\/j.pdpdt.2022.102964","article-title":"YAP knockdown in combination with ferroptosis induction increases the sensitivity of HOS human osteosarcoma cells to pyropheophorbide-alpha methyl ester-mediated photodynamic therapy","volume":"39","author":"Zhan","year":"2022","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"B132","doi-asserted-by":"publisher","first-page":"936233","DOI":"10.3389\/fphar.2022.936233","article-title":"Discovering the potential value of coenzyme Q10 in oxidative stress: Enlightenment from a synthesis of clinical evidence based on various population","volume":"13","author":"Zhang","year":"","journal-title":"Front. Pharmacol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"972753","DOI":"10.3389\/fimmu.2022.972753","article-title":"Ferroptosis and musculoskeletal diseases: \"Iron maiden\" cell death may be a promising therapeutic target","volume":"13","author":"Zhang","year":"","journal-title":"Front. Immunol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"B135","doi-asserted-by":"publisher","first-page":"809806","DOI":"10.3389\/fimmu.2021.809806","article-title":"Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis","volume":"12","author":"Zhao","year":"","journal-title":"Front. Immunol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"100380","DOI":"10.1016\/j.jbo.2021.100380","article-title":"Targeting ferroptosis in osteosarcoma","volume":"30","author":"Zhao","year":"","journal-title":"J. Bone Oncol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"779585","DOI":"10.3389\/fimmu.2022.779585","article-title":"Ferroptosis in rheumatoid arthritis: A potential therapeutic strategy","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"Onco Targets Ther."},{"key":"B139","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab."},{"key":"B140","doi-asserted-by":"publisher","first-page":"7846","DOI":"10.1039\/d2sc02297d","article-title":"Ambient synthesis of an iminium-linked covalent organic framework for synergetic RNA interference and metabolic therapy of fibrosarcoma","volume":"13","author":"Zhou","year":"2022","journal-title":"Chem. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"e13134","DOI":"10.1111\/cpr.13134","article-title":"D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2\u03b1-dependent manner","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif."},{"key":"B142","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41589-020-0472-6","article-title":"Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis","volume":"16","author":"Zou","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1112751\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T10:07:20Z","timestamp":1675418840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1112751\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":143,"alternative-id":["10.3389\/fcell.2023.1112751"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1112751","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,3]]},"article-number":"1112751"}}