{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:41Z","timestamp":1787063021831,"version":"build-2736575974"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019054","name":"Changsha Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H.pylori<\/jats:italic>\n                    ) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear. N6-methyladenosine (m6A) is the most prevalent reversible methylation modification in mammalian RNA and it plays a crucial role in controlling many biological processes. However, there are no studies reported that whether\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection impacts the m6A methylation of stomach. In this study, we measured the overall level changes of m6A methylation of RNA under\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection through\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    The total quantity of m6A was quantified in gastric tissues of clinical patients and C57 mice with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection, as well as acute infection model [\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and GES-1 cells were cocultured for 48\u00a0h at a multiplicity of infection (MOI) from of 10:1 to 50:1]. Furthermore, we performed m6A methylation sequencing and RNA-sequencing on the cell model and RNA-sequencing on animal model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Quantitative detection of RNA methylation showed that\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection group had higher m6A modification level. M6A methylation sequencing identified 2,107 significantly changed m6A methylation peaks, including 1,565 upregulated peaks and 542 downregulated peaks. A total of 2,487 mRNA was upregulated and 1,029 mRNA was downregulated. According to the comprehensive analysis of MeRIP-seq and RNA-seq, we identified 200 hypermethylation and upregulation, 129 hypermethylation but downregulation, 19 hypomethylation and downregulation and 106 hypomethylation but upregulation genes. The GO and KEGG pathway analysis of these differential methylation and regulatory genes revealed a wide range of biological functions. Moreover, combining with mice RNA-seq results, qRT- PCR showed that m6A regulators, METTL3, WTAP, FTO and ALKBH5, has significant difference; Two key genes, PTPN14 and ADAMTS1, had significant difference by qRT- PCR.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    These findings provide a basis for further investigation of the role of m6A methylation modification in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    -associated gastritis.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2023.1136096","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:22:25Z","timestamp":1686140545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Huan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1080\/14728222.2021.1971195","article-title":"Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective","volume":"25","author":"Abdi","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1158\/0008-5472.CAN-15-2272","article-title":"Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses","volume":"76","author":"Asano","year":"2016","journal-title":"Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41417-020-00222-3","article-title":"METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K\/Akt\/mTOR pathway","volume":"28","author":"Bi","year":"2021","journal-title":"Cancer Gene Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.jcmgh.2020.10.015","article-title":"Inflammation-associated senescence promotes Helicobacter pylori-induced atrophic gastritis","volume":"11","author":"Cai","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1038\/onc.2010.566","article-title":"NF-\u03baB addiction and its role in cancer: 'one size does not fit all'","volume":"30","author":"Chaturvedi","year":"2011","journal-title":"Oncogene"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1177\/0271678X20960033","article-title":"Epitranscriptomic regulation by m(6)A RNA methylation in brain development and diseases","volume":"40","author":"Chokkalla","year":"2020","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.molcel.2017.10.002","article-title":"m6A Facilitates eIF4F-Independent mRNA Translation","volume":"68","author":"Coots","year":"2017","journal-title":"Mol. Cell."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J. Dig. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1053\/j.gastro.2009.01.073","article-title":"Helicobacter pylori in health and disease","volume":"136","author":"Cover","year":"2009","journal-title":"Gastroenterology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e12768","DOI":"10.1111\/cpr.12768","article-title":"Cross talk between RNA N6-methyladenosine methyltransferase-like 3 and miR-186 regulates hepatoblastoma progression through Wnt\/\u03b2-catenin signalling pathway","volume":"53","author":"Cui","year":"2020","journal-title":"Cell. Prolif."},{"key":"B11","doi-asserted-by":"publisher","first-page":"109827","DOI":"10.1016\/j.cellsig.2020.109827","article-title":"Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity","volume":"77","author":"de Assis Lima","year":"2021","journal-title":"Cell. Signal"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1111\/j.1440-1746.2007.04912.x","article-title":"Helicobacter pylori and mitogen-activated protein kinases regulate the cell cycle, proliferation and apoptosis in gastric epithelial cells","volume":"23","author":"Ding","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e13340","DOI":"10.1111\/cpr.13340","article-title":"Effects of writers, erasers and readers within miRNA-related m6A modification in cancers","volume":"56","author":"Feng","year":"2022","journal-title":"Cell. Prolif."},{"key":"B15","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41419-020-03014-7","article-title":"PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure","volume":"11","author":"Fu","year":"2020","journal-title":"Cell. Death Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1186\/s12935-021-02318-8","article-title":"RNA m6A methylation regulators in ovarian cancer","volume":"21","author":"Guo","year":"2021","journal-title":"Cancer Cell. Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e75466","DOI":"10.7554\/eLife.75466","article-title":"YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia","volume":"11","author":"Hatterschide","year":"2022","journal-title":"Elife"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/s41419-021-04401-4","article-title":"ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN\/AKT signaling","volume":"12","author":"He","year":"2021","journal-title":"Cell. Death Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1128\/IAI.69.6.3965-3971.2001","article-title":"Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells","volume":"69","author":"Hirata","year":"2001","journal-title":"Infect. Immun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s12276-022-00897-8","article-title":"Biological roles of the RNA m(6)A modification and its implications in cancer","volume":"54","author":"Hong","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.7150\/ijbs.44365","article-title":"miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway","volume":"16","author":"Hu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/cbin.11959","article-title":"Fat mass and obesity-associated protein alleviates A\u03b21-40 induced retinal pigment epithelial cells degeneration via PKA\/CREB signaling pathway","volume":"47","author":"Hu","year":"2022","journal-title":"Cell. Biol. Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.tig.2019.10.011","article-title":"The biogenesis and precise control of RNA m(6)A methylation","volume":"36","author":"Huang","year":"2020","journal-title":"Trends Genet."},{"key":"B24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41419-020-2235-4","article-title":"YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A\/mRNA pathway","volume":"11","author":"Huang","year":"2020","journal-title":"Cell. Death Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","article-title":"Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis","volume":"29","author":"Imai","year":"2021","journal-title":"Cell. Host Microbe"},{"key":"B26","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1053\/gast.1997.v113.pm9322504","article-title":"Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells","volume":"113","author":"Keates","year":"1997","journal-title":"Gastroenterology"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101250","article-title":"The m6A(m)-independent role of FTO in regulating WNT signaling pathways","volume":"5","author":"Kim","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1053\/j.gastro.2022.01.011","article-title":"Toll-like receptor 1 locus Re-examined in a genome-wide association study update on anti-Helicobacter pylori IgG titers","volume":"162","author":"Lam","year":"2022","journal-title":"Gastroenterology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4161\/gmic.1.2.11587","article-title":"The many roads traveled by Helicobacter pylori to NF\u03baB activation","volume":"1","author":"Lamb","year":"2010","journal-title":"Gut Microbes"},{"key":"B32","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3892\/ijo.2015.3015","article-title":"miR-365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer","volume":"47","author":"Li","year":"2015","journal-title":"Int. J. Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3390\/ijms21051660","article-title":"METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export","volume":"21","author":"Li","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"144483","DOI":"10.1016\/j.gene.2020.144483","article-title":"The crosstalk between RNA m6A epitranscriptome and TGF\u03b2 signaling pathway contributes to the arrest of cell cycle","volume":"738","author":"Li","year":"2020","journal-title":"Gene"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1002\/cbin.11570","article-title":"WTAP facilitates progression of endometrial cancer via CAV-1\/NF-\u03baB axis","volume":"45","author":"Li","year":"2021","journal-title":"Cell. Biol. Int."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1055808","DOI":"10.3389\/fcell.2022.1055808","article-title":"N (6)-methyladenosine RNA methylation: From regulatory mechanisms to potential clinical applications","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell. Dev. Biol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14396","article-title":"m6 A demethylase Fto regulates the TNF-alpha-induced inflammatory response in cementoblasts","author":"Li","year":"2022","journal-title":"Oral Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.3390\/ijms23084147","article-title":"JAK-STAT1 signaling pathway is an early response to Helicobacter pylori infection and contributes to immune escape and gastric carcinogenesis","volume":"23","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbrc.2020.12.030","article-title":"PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy","volume":"550","author":"Lin","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13062-022-00347-5","article-title":"N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway","volume":"17","author":"Lin","year":"2022","journal-title":"Biol. Direct"},{"key":"B41","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s12943-022-01680-z","article-title":"Biological and pharmacological roles of m(6)A modifications in cancer drug resistance","volume":"21","author":"Liu","year":"2022","journal-title":"Mol. Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.molmed.2021.12.005","article-title":"Helicobacter pylori-induced NF-\u03baB: Trailblazer for gastric pathophysiology","volume":"28","author":"Maubach","year":"2022","journal-title":"Trends Mol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"a034728","DOI":"10.1101\/cshperspect.a034728","article-title":"What are 3' UTRs doing?","volume":"11","author":"Mayr","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N6-methyladenosine and gene expression control","volume":"15","author":"Meyer","year":"2014","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jcmgh.2019.10.007","article-title":"The hippo kinase LATS2 controls Helicobacter pylori-induced epithelial-mesenchymal transition and intestinal metaplasia in gastric mucosa","volume":"9","author":"Molina-Castro","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0006-2952(02)01030-4","article-title":"Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells","volume":"64","author":"Nozawa","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13045-018-0590-8","article-title":"Multiple functions of m(6)A RNA methylation in cancer","volume":"11","author":"Pan","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1152\/physrev.00039.2009","article-title":"Role of innate immunity in Helicobacter pylori-induced gastric malignancy","volume":"90","author":"Peek","year":"2010","journal-title":"Physiol. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s41388-021-02095-8","article-title":"RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-\u03baB and MAPK signaling pathways","volume":"41","author":"Qu","year":"2022","journal-title":"Oncogene"},{"key":"B50","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.tig.2017.04.003","article-title":"m(6 A in mRNA: An ancient mechanism for fine-tuning gene expression","volume":"33","author":"Roignant","year":"2017","journal-title":"Trends Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0099722","DOI":"10.1128\/jvi.00997-22","article-title":"WTAP targets the METTL3 m(6)a-methyltransferase complex to cytoplasmic hepatitis C virus RNA to regulate infection","volume":"96","author":"Sacco","year":"2022","journal-title":"J. Virol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/ijms22031406","article-title":"MicroRNA modulation of host immune response and inflammation triggered by Helicobacter pylori","volume":"22","author":"Sasaran","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s10495-021-01683-z","article-title":"FTO inhibits UPR(mt)-induced apoptosis by activating JAK2\/STAT3 pathway and reducing m6A level in adipocytes","volume":"26","author":"Shen","year":"2021","journal-title":"Apoptosis"},{"key":"B54","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-018-0666-1","article-title":"m(6 A facilitates hippocampus-dependent learning and memory through YTHDF1","volume":"563","author":"Shi","year":"2018","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1007\/s00394-022-02830-1","article-title":"Blueberry anthocyanin extracts protect against Helicobacter pylori-induced peptic epithelium injuries both in vitro and in vivo: The key role of MAPK\/NF-\u03baB pathway","volume":"61","author":"Shu","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"B56","doi-asserted-by":"publisher","first-page":"109176","DOI":"10.1016\/j.clim.2022.109176","article-title":"Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis","volume":"245","author":"Sun","year":"2022","journal-title":"Clin. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"E1027","DOI":"10.1152\/ajpendo.00040.2016","article-title":"Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium","volume":"310","author":"Toba","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B58","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00223-019-00654-6","article-title":"BMP2 modified by the m(6)A demethylation enzyme ALKBH5 in the ossification of the ligamentum flavum through the AKT signaling pathway","volume":"106","author":"Wang","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","article-title":"Dynamic regulation and functions of mRNA m6A modification","volume":"22","author":"Wang","year":"2022","journal-title":"Cancer Cell. Int."},{"key":"B61","doi-asserted-by":"publisher","first-page":"146125","DOI":"10.1016\/j.gene.2021.146125","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) mitigates the liver fibrosis via WTAP\/m(6)A\/Ptch1 axis through Hedgehog pathway","volume":"813","author":"Wei","year":"2022","journal-title":"Gene"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e014120","DOI":"10.1161\/JAHA.119.014120","article-title":"Helicobacter pylori infection impairs endothelial function through an exosome-mediated mechanism","volume":"9","author":"Xia","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e111364","DOI":"10.15252\/embj.2022111364","article-title":"Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development","volume":"42","author":"Xiao","year":"2022","journal-title":"EMBO J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"817584","DOI":"10.3389\/fonc.2022.817584","article-title":"Mutant NPM1-regulated FTO-mediated m(6)A demethylation promotes leukemic cell survival via PDGFRB\/ERK signaling Axis","volume":"12","author":"Xiao","year":"2022","journal-title":"Front. Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.2147\/OTT.S164749","article-title":"Helicobacter pylori promotes gastric epithelial cell survival through the PLK1\/PI3K\/Akt pathway","volume":"11","author":"Xu","year":"2018","journal-title":"Onco Targets Ther."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1111\/bph.15378","article-title":"Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP","volume":"178","author":"Yang","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"647522","DOI":"10.3389\/fcell.2021.647522","article-title":"Expression level of ADAMTS1 in granulosa cells of PCOS patients is related to granulosa cell function, oocyte quality, and embryo development","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.1096\/fj.201802644R","article-title":"METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1\/STAT5\/C\/EBP\u03b2 pathway via an m6A-YTHDF2-dependent manner","volume":"33","author":"Yao","year":"2019","journal-title":"FASEB J."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e1006663","DOI":"10.1371\/journal.pcbi.1006663","article-title":"Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods","volume":"15","author":"Zhang","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s42003-022-03878-9","article-title":"CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability","volume":"5","author":"Zhang","year":"2022","journal-title":"Commun. Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell. Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell."},{"key":"B73","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/s13046-022-02538-4","article-title":"A functional loop between YTH domain family protein YTHDF3 mediated m(6)A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinoma","volume":"41","author":"Zhou","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41420-022-01026-0","article-title":"Helicobacter pylori infection activates Wnt\/\u03b2-catenin pathway to promote the occurrence of gastritis by upregulating ASCL1 and AQP5","volume":"8","author":"Zuo","year":"2022","journal-title":"Cell. Death Discov."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1136096\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T06:54:54Z","timestamp":1686293694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1136096\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":74,"alternative-id":["10.3389\/fcell.2023.1136096"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1136096","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"article-number":"1136096"}}