{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:03:47Z","timestamp":1791608627869,"version":"4.3.4"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>This paper confirms the damaging effects produced by MP and Cd on testicular activity in the rat. Oral treatment with both chemicals resulted in testicular damage, documented by biomolecular and histological alterations, particularly by impaired morphometric parameters, increased apoptosis, reduced testosterone synthesis, and downregulation of the steroidogenic enzyme 3\u03b2-HSD. We also demonstrated, for the first time, that both MP and Cd can affect the protein level of PTMA, a small peptide that regulates germ cell proliferation and differentiation. Interestingly, the cytoarchitecture of testicular cells was also altered by the treatments, as evidenced by the impaired expression and localization of DAAM1 and PREP, two proteins involved in actin- and microtubule-associated processes, respectively, during germ cells differentiation into spermatozoa, impairing normal spermatogenesis. Finally, we showed that the effect of simultaneous treatment with MP and Cd were more severe than those produced by MP alone and less harmful than those of Cd alone. This could be due to the different ways of exposure of the two substances to rats (in drinking water for Cd and in oral gavage for MP), since being the first contact in the animals\u2019 gastrointestinal tract, MP can adsorb Cd, reducing its bioavailability through the Trojan-horse effect.<\/jats:p>","DOI":"10.3389\/fcell.2023.1145702","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:12:04Z","timestamp":1678320724000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP"],"prefix":"10.3389","volume":"11","author":[{"given":"Massimo","family":"Venditti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majida","family":"Ben Hadj Hassine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imed","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Minucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jchemneu.2010.03.002","article-title":"Prolyl endopeptidase mRNA expression in the central nervous system during rat development","volume":"40","author":"Agirregoitia","year":"2010","journal-title":"J. Chem. Neuroanat."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.3390\/cells11223601","article-title":"Mechanisms of cadmium-induced testicular injury: A risk to male fertility","volume":"11","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"B3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.toxicon.2022.02.011","article-title":"Potential protective effect of lactic acid bacteria against zearalenone causing reprotoxicity in male mice","volume":"209","author":"Belgacem","year":"2022","journal-title":"Toxicon"},{"key":"B5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000056980","article-title":"Prothymosin alpha, a mammalian c-myc-regulated acidic nuclear protein, provokes the decondensation of human chromosomes in vitro","volume":"93","author":"Bo\u00e1n","year":"2001","journal-title":"Cytogenet. Cell Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/jcp.25923","article-title":"Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity","volume":"233","author":"Chemek","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"76983","DOI":"10.1007\/s11356-022-20983-8","article-title":"Bioaccessibility of microplastic-associated heavy metals using an in vitro digestion model and its implications for human health risk assessment","volume":"29","author":"Chen","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"46687","DOI":"10.1038\/srep46687","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"R53","DOI":"10.1530\/REP-18-0457","article-title":"The cytoskeleton in spermatogenesis","volume":"157","author":"Dunleavy","year":"2019","journal-title":"Reproduction"},{"key":"B10","article-title":"Statement on the presence of microplastics and nanoplastics in food, with particular focus on seafood","volume":"14","year":"2016","journal-title":"EFSA J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/mrd.23307","article-title":"Study of expression of genes potentially responsible for reduced fitness in patients with myotonic dystrophy type 1 and identification of new biomarkers of testicular function","volume":"87","author":"Ergoli","year":"2020","journal-title":"Mol. Reprod. Dev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/jcp.22131","article-title":"Expression of prothymosin alpha in meiotic and post-meiotic germ cells during the first wave of rat spermatogenesis","volume":"224","author":"Ferrara","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1002\/jcp.24332","article-title":"First evidence of prothymosin \u03b1 localization in the acrosome of mammalian male gametes","volume":"228","author":"Ferrara","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"800327","DOI":"10.3389\/fendo.2021.800327","article-title":"Signaling proteins that regulate spermatogenesis are the emerging target of toxicant-induced male reproductive dysfunction","volume":"12","author":"Gao","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"34594","DOI":"10.1007\/s11356-021-18218-3","article-title":"Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat","volume":"29","author":"Haddadi","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000322082","article-title":"Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain","volume":"33","author":"Hannula","year":"2011","journal-title":"Dev. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"143986","DOI":"10.1016\/j.scitotenv.2020.143986","article-title":"Enhanced toxicity of triphenyl phosphate to zebrafish in the presence of micro- and nano-plastics","volume":"756","author":"He","year":"2021","journal-title":"Sci. Total. Environ."},{"key":"B18","doi-asserted-by":"publisher","first-page":"100035","DOI":"10.1016\/j.hazl.2021.100035","article-title":"Microplastics as a Trojan horse for trace metals","volume":"2","author":"Hildebrandt","year":"2021","journal-title":"J. Hazard. Mat. Lett."},{"key":"B19","doi-asserted-by":"publisher","first-page":"124028","DOI":"10.1016\/j.jhazmat.2020.124028","article-title":"Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice","volume":"405","author":"Hou","year":"2021","journal-title":"J. Hazard. Mat."},{"key":"B20","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1530\/EJE-18-0396","article-title":"Mechanisms in Endocrinology: Hormonal regulation of spermatogenesis: Mutant mice challenging old paradigms","volume":"179","author":"Huhtaniemi","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e2022015","DOI":"10.5620\/eaht.2022015","article-title":"Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats","volume":"37","author":"Ilechukwu","year":"2022","journal-title":"Environ. Anal. Health. Toxicol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"123430","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J. Hazard. Mat."},{"key":"B23","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12989-022-00453-2","article-title":"Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR\/cAMP\/PKA\/StAR pathway","volume":"19","author":"Jin","year":"2022","journal-title":"Part. Fibre. Toxicol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4840","DOI":"10.2174\/0929867326666190807145212","article-title":"In vitro immunodetection of prothymosin alpha in normal and pathological conditions","volume":"27","author":"Karachaliou","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"116056","DOI":"10.1016\/j.envpol.2020.116056","article-title":"First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary via the mTOR pathway","volume":"270","author":"Kechiche","year":"2021","journal-title":"Environ. Pollut."},{"key":"B26","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1177\/153537020122600615","article-title":"Cadmium effects on hypothalamic-pituitary-testicular axis in male rats","volume":"226","author":"Lafuente","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0278-6915(00)00077-6","article-title":"Pubertal and postpubertal cadmium exposure differentially affects the hypothalamic\u2013pituitary\u2013testicular axis function in the rat","volume":"38","author":"Lafuente","year":"2000","journal-title":"Food Chem. Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1021\/acs.est.8b05512","article-title":"Emergence of nanoplastic in the environment and possible impact on human health","volume":"53","author":"Lehner","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"dmac035","DOI":"10.1093\/humupd\/dmac035","article-title":"Temporal trends in sperm count: A systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries","author":"Levine","year":"2022","journal-title":"Hum. Reprod. Update dmac035"},{"key":"B30","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1093\/humupd\/dmx022","article-title":"Temporal trends in sperm count: A systematic review and meta-regression analysis","volume":"23","author":"Levine","year":"2017","journal-title":"Hum. Reprod. Update"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.12688\/f1000research.11421.1","article-title":"Cell polarity, cell adhesion, and spermatogenesis: Role of cytoskeletons","volume":"6","author":"Li","year":"2017","journal-title":"F1000Research"},{"key":"B32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.semcdb.2016.01.003","article-title":"Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?","volume":"59","author":"Li","year":"2016","journal-title":"Semin. Cell. Dev. Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"47921","DOI":"10.1007\/s11356-021-13911-9","article-title":"Polystyrene microplastics induce blood-testis barrier disruption regulated by the MAPK-Nrf2 signaling pathway in rats","volume":"28","author":"Li","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B34","doi-asserted-by":"publisher","first-page":"114498","DOI":"10.1016\/j.envpol.2020.114498","article-title":"Do polystyrene nanoplastics affect the toxicity of cadmium to wheat (Triticum aestivum L.)?","volume":"263","author":"Lian","year":"2020","journal-title":"Environ. Pollut."},{"key":"B35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.2478\/aiht-2021-72-3510","article-title":"Environmental and occupational exposures associated with male infertility","volume":"72","author":"Mari\u0107","year":"2021","journal-title":"Arh. Hig. Rada. Toksikol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.3390\/ijms23095128","article-title":"New insight on the in vitro effects of melatonin in preserving human sperm quality","volume":"23","author":"Minucci","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s00418-021-02071-z","article-title":"Microenvironment for spermatogenesis and sperm maturation","volume":"157","author":"Miyaso","year":"2022","journal-title":"Histochem. Cell. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1002\/jcp.25330","article-title":"First evidence of DAAM1 localization during the post-natal development of rat testis and in mammalian sperm","volume":"231","author":"Pariante","year":"","journal-title":"J. Cell. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1017\/S0967199415000568","article-title":"Prothymosin alpha expression and localization during the spermatogenesis of Danio rerio","volume":"24","author":"Pariante","year":"","journal-title":"Zygote"},{"key":"B41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/bdr2.1133","article-title":"Comparative aspects of pre- and postnatal development of the male reproductive system","volume":"110","author":"Picut","year":"2018","journal-title":"Birth Defects Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/REP-19-0204","article-title":"D-Asp upregulates PREP and GluA2\/3 expressions and induces p-ERK1\/2 and p-Akt in rat testis","volume":"158","author":"Santillo","year":"2019","journal-title":"Reproduction"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e13646","DOI":"10.1111\/and.13646","article-title":"Environmental contaminants and male infertility: Effects and mechanisms","volume":"53","author":"Selvaraju","year":"2021","journal-title":"Andrologia"},{"key":"B44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3390\/biology11050659","article-title":"Sperm phosphoproteome: Unraveling male infertility","volume":"11","author":"Serrano","year":"2022","journal-title":"Biol. (Basel)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: Definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1017\/S0967199419000194","article-title":"Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis","volume":"27","author":"Venditti","year":"2019","journal-title":"Zygote"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.3390\/biom12091210","article-title":"First evidence of the expression and localization of prothymosin \u03b1 in human testis and its involvement in testicular cancers","volume":"12","author":"Venditti","year":"2022","journal-title":"Biomolecules"},{"key":"B48","doi-asserted-by":"publisher","first-page":"8094","DOI":"10.3390\/ijms22158094","article-title":"Preliminary investigation on the involvement of cytoskeleton-related proteins, DAAM1 and PREP, in human testicular disorders","volume":"22","author":"Venditti","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3390\/genes12071016","article-title":"Altered expression of DAAM1 and PREP induced by cadmium toxicity is counteracted by melatonin in the rat testis","volume":"12","author":"Venditti","year":"","journal-title":"Genes (Basel)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"112878","DOI":"10.1016\/j.ecoenv.2021.112878","article-title":"Evidence of melatonin ameliorative effects on the blood-testis barrier and sperm quality alterations induced by cadmium in the rat testis","volume":"226","author":"Venditti","year":"","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B51","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/mrd.23345","article-title":"Cadmium-induced toxicity increases prolyl endopeptidase (PREP) expression in the rat testis","volume":"87","author":"Venditti","year":"","journal-title":"Mol. Reprod. Dev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1017\/S0967199420000301","article-title":"EH domain binding protein 1-like 1 (EHBP1L1), a protein with calponin homology domain, is expressed in the rat testis","volume":"28","author":"Venditti","year":"","journal-title":"Zygote"},{"key":"B53","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1071\/RD19172","article-title":"DAAM1 and PREP are involved in human spermatogenesis","volume":"32","author":"Venditti","year":"","journal-title":"Reprod. Fertil. Dev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.crvi.2018.03.001","article-title":"First evidence of DAAM1 localization in mouse seminal vesicles and its possible involvement during regulated exocytosis","volume":"341","author":"Venditti","year":"2018","journal-title":"C. R. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3390\/biomedicines10010181","article-title":"Differential expression and localization of EHBP1L1 during the first wave of rat spermatogenesis suggest its involvement in acrosome biogenesis","volume":"10","author":"Venditti","year":"2022","journal-title":"Biomedicines"},{"key":"B56","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1017\/S096719941700065X","article-title":"Prothymosin alpha expression in the vertebrate testis: A comparative review","volume":"25","author":"Venditti","year":"2017","journal-title":"Zygote"},{"key":"B57","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1369\/0022155418810064","article-title":"Subcellular localization of prolyl endopeptidase during the first wave of rat spermatogenesis and in rat and human sperm","volume":"67","author":"Venditti","year":"2019","journal-title":"J. Histochem. Cytochem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/ani11010133","article-title":"Preliminary investigation on the ameliorative role exerted by D-aspartic acid in counteracting ethane dimethane sulfonate (EDS) toxicity in the rat testis","volume":"11","author":"Venditti","year":"","journal-title":"Toxic. Rat Testis Animals (Basel)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/biom10050677","article-title":"D-aspartate upregulates DAAM1 protein levels in the rat testis and induces its localization in spermatogonia nucleus","volume":"10","author":"Venditti","year":"","journal-title":"Biomolecules"},{"key":"B60","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/cells11040591","article-title":"Cell-cell interaction-mediated signaling in the testis induces reproductive dysfunction\u2014lesson from the toxicant\/pharmaceutical models","volume":"11","author":"Wang","year":"","journal-title":"Cells"},{"key":"B61","doi-asserted-by":"publisher","first-page":"135714","DOI":"10.1016\/j.chemosphere.2022.135714","article-title":"Antagonistic effect of polystyrene nanoplastics on cadmium toxicity to maize (Zea mays L.)","volume":"307","author":"Wang","year":"","journal-title":"Chemosphere"},{"key":"B62","doi-asserted-by":"publisher","first-page":"135942","DOI":"10.1016\/j.chemosphere.2022.135942","article-title":"Distinct adverse outcomes and lipid profiles of erythrocytes upon single and combined exposure to cadmium and microplastics","volume":"307","author":"Wang","year":"","journal-title":"Chemosphere"},{"key":"B63","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/toxsci\/kfaa109","article-title":"Microtubule cytoskeleton and spermatogenesis-lesson from studies of toxicant models","volume":"177","author":"Wang","year":"","journal-title":"Toxicol. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.reprotox.2020.05.017","article-title":"Actin binding proteins, actin cytoskeleton and spermatogenesis - lesson from toxicant models","volume":"96","author":"Wang","year":"","journal-title":"Reprod. Toxicol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1007\/s12011-021-02917-6","article-title":"Single and combined effects of microplastics and cadmium on the cadmium accumulation and biochemical and immunity of Channa argus","volume":"200","author":"Wang","year":"","journal-title":"Biol. Trace. Elem. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"117904","DOI":"10.1016\/j.envpol.2021.117904","article-title":"Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2","volume":"289","author":"Wei","year":"2021","journal-title":"Environ. Pollut."},{"key":"B67","doi-asserted-by":"publisher","first-page":"153059","DOI":"10.1016\/j.tox.2021.153059","article-title":"Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice","volume":"465","author":"Wei","year":"2022","journal-title":"Toxicology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"113577","DOI":"10.1016\/j.fct.2022.113577","article-title":"Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway","volume":"172","author":"Wen","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"B69","volume-title":"WHO laboratory manual for the examination and processing of human semen","year":"2021"},{"key":"B70","doi-asserted-by":"publisher","first-page":"106259","DOI":"10.1016\/j.aquatox.2022.106259","article-title":"Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish","volume":"250","author":"Yang","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"B71","first-page":"4867","article-title":"Increased expression of prothymosin-\u03b1, independently or combined with TP53, correlates with poor prognosis in colorectal cancer","volume":"7","author":"Zhang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"158353","DOI":"10.1016\/j.scitotenv.2022.158353","article-title":"Microplastics addition reduced the toxicity and uptake of cadmium to Brassica chinensis L","volume":"852","author":"Zhang","year":"2022","journal-title":"Sci. Total. Environ."},{"key":"B73","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3389\/fgene.2020.00527","article-title":"Toxicological effects of cadmium on mammalian testis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Genet."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1145702\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:12:09Z","timestamp":1678320729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1145702\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,9]]},"references-count":72,"alternative-id":["10.3389\/fcell.2023.1145702"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1145702","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,9]]},"article-number":"1145702"}}