{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:46:59Z","timestamp":1779889619263,"version":"3.53.1"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The treatment of cardiovascular and cerebrovascular diseases have undergone major advances in recent decades, allowing for a more effective prevention of cardiovascular and cerebrovascular events. However, cardiac and cerebral atherothrombotic complications still account for substantial morbidity and mortality worldwide. Novel therapeutic strategies are critical to improve patient outcomes following cardiovascular diseases. miRNAs are small non-coding RNAs, that regulate gene expression. Here, we discuss the role of miR-182 in regulating myocardial proliferation, migration, hypoxia, ischemia, apoptosis and hypertrophy in atherosclerosis, CAD, MI, I\/R injury, organ transplant, cardiac hypertrophy, hypertension, heart failure, congenital heart disease and cardiotoxicity. Besides, we also summarize the current progress of miR-182 therapeutics in clinical development and discuss challenges that will need to be overcome to enter the clinic for patients with cardiac disease.<\/jats:p>","DOI":"10.3389\/fcell.2023.1181515","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T04:33:41Z","timestamp":1683606821000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of miR-182 in cardiovascular and cerebrovascular diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Gaiqin","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3682","DOI":"10.1007\/s11064-022-03718-6","article-title":"MiR-182 inhibition protects against experimental stroke in vivo and mitigates astrocyte injury and inflammation in vitro via modulation of cortactin activity","volume":"47","author":"Alhadidi","year":"2022","journal-title":"Neurochem. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00395-021-00892-6","article-title":"The miR-182\/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-\u03b2-signalling pathways in an SMC\/EC-crosstalk-associated manner","volume":"116","author":"Bai","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","article-title":"Non-coding RNAs in development and disease: Background, mechanisms, and therapeutic approaches","volume":"96","author":"Beermann","year":"2016","journal-title":"Physiol. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1128\/mcb.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1161\/circresaha.115.306361","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.hlc.2011.11.002","article-title":"A microRNA guide for clinicians and basic scientists: Background and experimental techniques","volume":"21","author":"Bernardo","year":"2012","journal-title":"Heart Lung Circ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"431","DOI":"10.2459\/JCM.0000000000000233","article-title":"The prognostic value of circulating microRNAs in heart failure: Preliminary results from a genome-wide expression study","volume":"16","author":"Cakmak","year":"2015","journal-title":"J. Cardiovasc. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1007\/s00204-016-1668-0","article-title":"MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes","volume":"90","author":"Chaudhari","year":"2016","journal-title":"Arch. Toxicol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.hlc.2022.10.008","article-title":"Clinical value and mechanism of long non-coding RNA UCA1 in acute respiratory distress syndrome induced by cardiopulmonary bypass","volume":"32","author":"Chen","year":"2022","journal-title":"Heart Lung Circ."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1097\/SCS.0b013e3182a243f3","article-title":"Analysis of microRNA expression detected by microarray of the cerebral cortex after hypoxic-ischemic brain injury","volume":"24","author":"Cui","year":"2013","journal-title":"J. craniofacial Surg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e14302","DOI":"10.1371\/journal.pone.0014302","article-title":"Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus","volume":"5","author":"Dai","year":"2010","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40659-020-00304-4","article-title":"LncRNA SNHG14 promotes OGD\/R-induced neuron injury by inducing excessive mitophagy via miR-182-5p\/BINP3 axis in HT22 mouse hippocampal neuronal cells","volume":"53","author":"Deng","year":"2020","journal-title":"Biol. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/genes12071020","article-title":"Molecular genetics and complex inheritance of congenital heart disease","volume":"12","author":"Diab","year":"2021","journal-title":"Genes (Basel)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"110047","DOI":"10.1016\/j.intimp.2023.110047","article-title":"Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p\/Rac1 pathway","volume":"118","author":"Ding","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1002\/oby.22863","article-title":"MicroRNA 182 is a novel negative regulator of adipogenesis by targeting CCAAT\/Enhancer-Binding protein \u03b1","volume":"28","author":"Dong","year":"2020","journal-title":"Obes. (Silver Spring)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13019-022-01802-0","article-title":"miR-182-5p combined with brain-derived neurotrophic factor assists the diagnosis of chronic heart failure and predicts a poor prognosis","volume":"17","author":"Fang","year":"2022","journal-title":"J. Cardiothorac. Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7915","DOI":"10.1073\/pnas.0812446106","article-title":"MicroRNAs are essential for development and function of inner ear hair cells in vertebrates","volume":"106","author":"Friedman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1741-7015-11-117","article-title":"Immunity, atherosclerosis and cardiovascular disease","volume":"11","author":"Frosteg\u00e5rd","year":"2013","journal-title":"BMC Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1523\/jneurosci.2873-12.2013","article-title":"MicroRNA-182 regulates amygdala-dependent memory formation","volume":"33","author":"Griggs","year":"2013","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1007\/s00204-022-03280-8","article-title":"microRNAs signatures as potential biomarkers of structural cardiotoxicity in human-induced pluripotent stem-cell derived cardiomyocytes","volume":"96","author":"Gryshkova","year":"2022","journal-title":"Arch. Toxicol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1146\/annurev-physiol-030212-183737","article-title":"Functions of MicroRNAs in cardiovascular biology and disease","volume":"75","author":"Hata","year":"2013","journal-title":"Annu. Rev. Physiology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/cvr\/cvt004","article-title":"Translating cardioprotection for patient benefit: Position paper from the working group of cellular biology of the heart of the European society of cardiology","volume":"98","author":"Hausenloy","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1007\/s10753-021-01525-9","article-title":"Propofol downregulates lncRNA MALAT1 to alleviate cerebral ischemia-reperfusion injury","volume":"44","author":"Hu","year":"2021","journal-title":"Inflammation"},{"key":"B26","doi-asserted-by":"publisher","first-page":"126610","DOI":"10.1016\/j.chemosphere.2020.126610","article-title":"Downregulation of miR-133a contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish","volume":"251","author":"Huang","year":"2020","journal-title":"Chemosphere"},{"key":"B27","doi-asserted-by":"publisher","first-page":"740","DOI":"10.5603\/KP.a2015.0082","article-title":"The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction","volume":"73","author":"Ikitimur","year":"2015","journal-title":"Kardiol. Pol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e2432","DOI":"10.1038\/cddis.2016.331","article-title":"Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction","volume":"7","author":"Jia","year":"2016","journal-title":"Cell Death Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"7912","DOI":"10.26355\/eurrev_202008_22446","article-title":"MiR-182-5p inhibited proliferation and migration of ovarian cancer cells by targeting BNIP3","volume":"24","author":"Jia","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1536\/ihj.19-708","article-title":"MiR-182-5p inhibits the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPPA","volume":"61","author":"Jin","year":"2020","journal-title":"Int. Heart J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.2174\/0929867325666180508100950","article-title":"Role of ox-LDL and LOX-1 in atherogenesis","volume":"26","author":"Kattoor","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1038\/srep15007","article-title":"Junb controls lymphatic vascular development in zebrafish via miR-182","volume":"5","author":"Kiesow","year":"2015","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1002\/jbmr.1604","article-title":"miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1","volume":"27","author":"Kim","year":"2012","journal-title":"J. Bone Min. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)","volume":"41","author":"Knuuti","year":"2019","journal-title":"Eur. Heart J."},{"key":"B36","doi-asserted-by":"publisher","first-page":"14035","DOI":"10.1073\/pnas.1210730109","article-title":"Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development","volume":"109","author":"Lage","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev.pathol.4.110807.092222","article-title":"MicroRNAs in cancer","volume":"4","author":"Lee","year":"2009","journal-title":"Annu. Rev. Pathol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1161\/STROKEAHA.110.579649","article-title":"MicroRNAs induced during ischemic preconditioning","volume":"41","author":"Lee","year":"2010","journal-title":"Stroke"},{"key":"B39","doi-asserted-by":"publisher","first-page":"23472","DOI":"10.1038\/srep23472","article-title":"Small molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"21228","DOI":"10.1038\/srep21228","article-title":"miR-182 modulates myocardial hypertrophic response induced by angiogenesis in heart","volume":"6","author":"Li","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e923514","DOI":"10.12659\/MSM.923514","article-title":"Identification of hub genes associated with hypertension and their interaction with miRNA based on weighted gene coexpression network analysis (WGCNA) analysis","volume":"26","author":"Li","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.omtn.2020.11.015","article-title":"SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1\/NLRP3 pathway","volume":"23","author":"Li","year":"2021","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"B43","doi-asserted-by":"publisher","first-page":"101585","DOI":"10.1016\/j.mcp.2020.101585","article-title":"Circ_002664\/miR-182-5p\/Herpud1 pathway importantly contributes to OGD\/R-induced neuronal cell apoptosis","volume":"53","author":"Liu","year":"2020","journal-title":"Mol. Cell Probes"},{"key":"B44","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1042\/cs20130079","article-title":"microRNA in the development of diabetic complications","volume":"126","author":"McClelland","year":"2014","journal-title":"Clin. Sci. (Lond)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.ijcard.2004.04.013","article-title":"Myocardial ischemia\/reperfusion-injury, a clinical view on a complex pathophysiological process","volume":"100","author":"Moens","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.trsl.2020.11.006","article-title":"Brain-derived neurotrophic factor in patients with acute coronary syndrome","volume":"231","author":"Montone","year":"2021","journal-title":"Transl. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/cir.0000000000000366","article-title":"Executive summary: Heart disease and stroke statistics--2016 update: A report from the American heart association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s00204-018-2170-7","article-title":"Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells","volume":"92","author":"Nemade","year":"2018","journal-title":"BMC Cardiovasc Disord."},{"key":"B49","doi-asserted-by":"publisher","first-page":"7018393","DOI":"10.1155\/2017\/7018393","article-title":"Ischemia\/reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists","volume":"2017","author":"Neri","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"B50","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/s0735-1097(01)01792-2","article-title":"Heart failure in pressure overload hypertrophy. The relative roles of ventricular remodeling and myocardial dysfunction","volume":"39","author":"Norton","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.3390\/cells8111400","article-title":"Identification of a diagnostic set of endomyocardial biopsy microRNAs for acute cellular rejection diagnostics in patients after heart transplantation using next-generation sequencing","volume":"8","author":"Nov\u00e1kov\u00e1","year":"2019","journal-title":"Cells"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1111\/j.1742-4658.2011.08090.x","article-title":"MicroRNAs and cardiovascular diseases","volume":"278","author":"Ono","year":"2011","journal-title":"Febs J."},{"key":"B53","first-page":"393","article-title":"MicroRNAs in health and disease--basic science and clinical applications","volume":"58","author":"Osman","year":"2012","journal-title":"Clin. Lab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1161\/circulationaha.108.825364","article-title":"Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study","volume":"119","author":"Parikh","year":"2009","journal-title":"Circulation"},{"key":"B55","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3892\/etm.2019.8227","article-title":"Expression and short-term prognostic value of miR-126 and miR-182 in patients with acute stroke","volume":"19","author":"Qi","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1213\/ANE.0000000000001633","article-title":"Lidocaine administration controls micrornas alterations observed after lung ischemia-reperfusion injury","volume":"123","author":"Rancan","year":"2016","journal-title":"Anesth. Analgesia"},{"key":"B57","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1186\/s12872-019-1122-3","article-title":"Downregulation of long non-coding RNA nuclear enriched abundant transcript 1 promotes cell proliferation and inhibits cell apoptosis by targeting miR-193a in myocardial ischemia\/reperfusion injury","volume":"19","author":"Ren","year":"2019","journal-title":"BMC Cardiovasc. Disord."},{"key":"B58","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s12098-020-03274-3","article-title":"Approach to cyanotic congenital heart disease in children","volume":"87","author":"Rohit","year":"2020","journal-title":"Indian J. Pediatr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.omtn.2018.01.005","article-title":"miR-182-5p and miR-183-5p act as GDNF mimics in dopaminergic midbrain neurons","volume":"11","author":"Roser","year":"2018","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"B60","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"B61","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: Biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"Biol. Funct. Ther. analysis methods"},{"key":"B62","doi-asserted-by":"publisher","first-page":"6975","DOI":"10.1021\/acs.jmedchem.2c00024","article-title":"The progress and promise of RNA Medicine\u2500An arsenal of targeted treatments","volume":"65","author":"Sasso","year":"2022","journal-title":"Prog. Promise RNA Medicine\u2500An Arsenal Target. Treat."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1093\/hmg\/ddq316","article-title":"Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia","volume":"19","author":"Saus","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5142381","DOI":"10.1155\/2022\/5142381","article-title":"Hsa_circRNA_0008028 deficiency ameliorates high glucose-induced proliferation, calcification, and autophagy of vascular smooth muscle cells via miR-182-5p\/TRIB3 Axis","volume":"2022","author":"Shi","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"A22","DOI":"10.1186\/cc11280","article-title":"Reperfusion injury in acute myocardial infarction","volume":"16","author":"Simonis","year":"2012","journal-title":"Crit. Care"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/ni.1945","article-title":"The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes","volume":"11","author":"Stittrich","year":"2010","journal-title":"Nat. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1161\/ATVBAHA.115.307412","article-title":"Oncological miR-182-3p, a novel smooth muscle cell phenotype modulator, evidences from model rats and patients","volume":"36","author":"Sun","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, Vasc. Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5581","DOI":"10.7150\/thno.44687","article-title":"miR-182-3p\/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4\/p21-dependent mechanism","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"B69","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/cphy.c140055","article-title":"Pathophysiology of heart failure","volume":"6","author":"Tanai","year":"2015","journal-title":"Compr. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1042\/cs20100043","article-title":"Gene expression profiling in whole blood of patients with coronary artery disease","volume":"119","author":"Taurino","year":"2010","journal-title":"Clin. Sci. (Lond)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2018.09.165","article-title":"MicroRNA-182-5p attenuates cerebral ischemia-reperfusion injury by targeting Toll-like receptor 4","volume":"505","author":"Wang","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.3892\/ijmm.2018.3370","article-title":"Differential microRNA expression profiles and bioinformatics analysis between young and aging spontaneously hypertensive rats","volume":"41","author":"Wang","year":"","journal-title":"Int. J. Mol. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1002\/cbin.11333","article-title":"Up-regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR-182-5p\/IGF1 axis","volume":"44","author":"Wang","year":"2020","journal-title":"Cell Biol. Int."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1111\/j.1600-6143.2011.03958.x","article-title":"Differential expression of microRNAs during allograft rejection","volume":"12","author":"Wei","year":"2012","journal-title":"Am. J. Transpl."},{"key":"B75","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/tp.0000000000001345","article-title":"Absence of miR-182 augments cardiac allograft survival","volume":"101","author":"Wei","year":"2017","journal-title":"Transplantation"},{"key":"B76","volume-title":"Global cardiovascular diseases report 2019","year":"2019"},{"key":"B77","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/1440-1681.12281","article-title":"MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: Potential drug targets?","volume":"41","author":"Winbanks","year":"2014","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.abb.2016.05.002","article-title":"MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP)","volume":"620","author":"Yi","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"B81","doi-asserted-by":"publisher","first-page":"317","DOI":"10.14744\/AnatolJCardiol.2019.49393","article-title":"Brain-derived neurotrophic factor in heart failure","volume":"22","author":"Y\u0131lmaz","year":"2019","journal-title":"Anatol. J. Cardiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"10356","DOI":"10.1093\/nar\/gks750","article-title":"miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury","volume":"40","author":"Yu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.gene.2013.06.006","article-title":"Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues","volume":"527","author":"Zhang","year":"2013","journal-title":"Gene"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1159\/000495053","article-title":"Ganoderic acid A protects rat H9c2 cardiomyocytes from hypoxia-induced injury via up-regulating miR-182-5p","volume":"50","author":"Zhang","year":"","journal-title":"Cell Physiol. Biochem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1139\/bcb-2017-0224","article-title":"Inhibition of miR-182-5p protects cardiomyocytes from hypoxia-induced apoptosis by targeting CIAPIN1","volume":"96","author":"Zhang","year":"","journal-title":"Biochem. Cell Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ejphar.2018.08.013","article-title":"MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1","volume":"836","author":"Zhang","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"13762","DOI":"10.1096\/fj.201903092R","article-title":"MicroRNA-182 exacerbates blood-brain barrier (BBB) disruption by downregulating the mTOR\/FOXO1 pathway in cerebral ischemia","volume":"34","author":"Zhang","year":"2020","journal-title":"Faseb J."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/cvr\/cvz040","article-title":"Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization","volume":"115","author":"Zhao","year":"2019","journal-title":"Cardiovasc Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1900023","DOI":"10.1002\/advs.201900023","article-title":"Effective delivery of hypertrophic miRNA inhibitor by cholesterol-containing nanocarriers for preventing pressure overload induced cardiac hypertrophy","volume":"6","author":"Zhi","year":"2019","journal-title":"Hypertrophy"},{"key":"B90","doi-asserted-by":"publisher","first-page":"62","DOI":"10.26442\/00403660.2019.09.000294","article-title":"Full - transcriptome analysis of miRNA expression in mononuclear cells in patients with acute decompensation of chronic heart failure of various etiologies","volume":"91","author":"Zhirov","year":"2019","journal-title":"Ter. Arkh"},{"key":"B91","doi-asserted-by":"publisher","first-page":"683707","DOI":"10.1155\/2014\/683707","article-title":"Rho\/ROCK signal cascade mediates asymmetric dimethylarginine-induced vascular smooth muscle cells migration and phenotype change","volume":"2014","author":"Zhou","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.21037\/jtd.2019.05.24","article-title":"Circulating miR-182-5p and miR-5187-5p as biomarkers for the diagnosis of unprotected left main coronary artery disease","volume":"11","author":"Zhu","year":"2019","journal-title":"J. Thorac. Dis."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1181515\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T04:33:51Z","timestamp":1683606831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1181515\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":92,"alternative-id":["10.3389\/fcell.2023.1181515"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1181515","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"article-number":"1181515"}}