{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:30:31Z","timestamp":1791995431260,"version":"4.4.0"},"reference-count":169,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6\u00a0months and 5\u00a0years old. FSs not only endanger children\u2019s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and \u03b3-aminobutyric acid (GABA) system are currently well studied.<\/jats:p>","DOI":"10.3389\/fcell.2023.1186050","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T05:03:07Z","timestamp":1684990987000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms"],"prefix":"10.3389","volume":"11","author":[{"given":"You","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wei-wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0225034","DOI":"10.1371\/journal.pone.0225034","article-title":"Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure","volume":"14","author":"Alese","year":"2019","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.brainresbull.2019.11.021","article-title":"Prolonged febrile seizure history exacerbates seizure severity in a pentylenetetrazole rat model of epilepsy","volume":"155","author":"Alese","year":"2020","journal-title":"Brain Res. Bull."},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jphs.2020.09.003","article-title":"Microglia modulate the structure and function of the hippocampus after early-life seizures","volume":"144","author":"Andoh","year":"2020","journal-title":"J. Pharmacol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e2022058167","DOI":"10.1542\/peds.2022-058167","article-title":"COVID-19 and acute neurologic complications in children","volume":"150","author":"Antoon","year":"2022","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"5880","DOI":"10.1111\/ejn.14969","article-title":"The effects of microglia- and astrocyte-derived factors on neurogenesis in health and disease","volume":"54","author":"Araki","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1055\/s-0040-1715992","article-title":"Zinc status and febrile seizures: Results from a cross-sectional study","volume":"11","author":"Arul","year":"2020","journal-title":"J. Neurosci. Rural. Pract."},{"key":"B7","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s11011-019-00492-3","article-title":"Effect of a novel prolonged febrile seizure model on GABA associated ion channels","volume":"35","author":"Asisipo","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1212\/01.wnl.0000080362.55784.1c","article-title":"A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy","volume":"61","author":"Audenaert","year":"2003","journal-title":"Neurology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1212\/01.wnl.0000230145.73496.a2","article-title":"A novel GABRG2 mutation associated with febrile seizures","volume":"67","author":"Audenaert","year":"2006","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1111\/j.1528-1167.2008.01679.x","article-title":"History of simple febrile seizures is associated with hippocampal abnormalities in adults","volume":"49","author":"Auer","year":"2008","journal-title":"Epilepsia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1136\/jnnp.63.4.461","article-title":"Bilateral reductions in hippocampal volume in adults with epilepsy and a history of febrile seizures","volume":"63","author":"Barr","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.nbd.2018.08.004","article-title":"Vagal TRPV1 activation exacerbates thermal hyperpnea and increases susceptibility to experimental febrile seizures in immature rats","volume":"119","author":"Barrett","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"450","DOI":"10.2174\/1871527320666211004123731","article-title":"Role of SCN2A c.56G\/A gene polymorphism in Egyptian children with genetic epilepsy with febrile seizure plus","volume":"21","author":"Berseem","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e20154654","DOI":"10.1542\/peds.2015-4654","article-title":"Childhood epilepsy, febrile seizures, and subsequent risk of ADHD","volume":"138","author":"Bertelsen","year":"2016","journal-title":"Pediatrics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/ajm.ajm_57_19","article-title":"Status of 25-hydroxy vitamin D level in simple febrile seizures and its correlation with recurrence of seizures","volume":"10","author":"Bhat","year":"2020","journal-title":"Avicenna J. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s004010050952","article-title":"An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy","volume":"97","author":"Blumcke","year":"1999","journal-title":"Acta Neuropathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.3390\/ijms23105526","article-title":"Modulation of endocannabinoid system components in depression: Pre-clinical and clinical evidence","volume":"23","author":"Bright","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.5114\/aoms.2016.63739","article-title":"GABRG2 C588T gene polymorphisms might be a predictive genetic marker of febrile seizures and generalized recurrent seizures: A case-control study in a Romanian pediatric population","volume":"14","author":"Butila","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/19418744221123208","article-title":"Impact of the COVID-19 pandemic on diagnostic frequency of febrile seizures: An electronic health record database observational study","volume":"13","author":"Cadet","year":"2023","journal-title":"Neurohospitalist"},{"key":"B20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.braindev.2017.12.004","article-title":"Predictive value of EEG for febrile seizure recurrence","volume":"40","author":"Cappellari","year":"2018","journal-title":"Brain Dev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e2003912","DOI":"10.1002\/adma.202003912","article-title":"Time-gated FRET nanoprobes for autofluorescence-free long-term in vivo imaging of developing zebrafish","volume":"32","author":"Cardoso Dos Santos","year":"2020","journal-title":"Adv. Mater"},{"key":"B22","doi-asserted-by":"publisher","first-page":"594","DOI":"10.24953\/turkjped.2021.04.006","article-title":"Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure","volume":"63","author":"Carman","year":"2021","journal-title":"Turk J. Pediatr."},{"key":"B23","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1002\/ana.10789","article-title":"Febrile seizures impair memory and cAMP response-element binding protein activation","volume":"54","author":"Chang","year":"2003","journal-title":"Ann. Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.nbd.2004.12.012","article-title":"Repetitive febrile seizures in rat pups cause long-lasting deficits in synaptic plasticity and NR2A tyrosine phosphorylation","volume":"18","author":"Chang","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.expneurol.2016.05.034","article-title":"Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window","volume":"283","author":"Chen","year":"2016","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/85480","article-title":"Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability","volume":"7","author":"Chen","year":"2001","journal-title":"Nat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/11330","article-title":"Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits","volume":"5","author":"Chen","year":"1999","journal-title":"Nat. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/s0896-6273(03)00499-9","article-title":"Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures","volume":"39","author":"Chen","year":"2003","journal-title":"Neuron"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e17167","DOI":"10.1097\/MD.0000000000017167","article-title":"Association between interleukin-6 gene polymorphisms and febrile seizure risk: A meta-analysis","volume":"98","author":"Chen","year":"2019","journal-title":"Med. Baltim."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1038\/ncomms5486","article-title":"Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.braindev.2018.05.006","article-title":"Association of developing childhood epilepsy subsequent to febrile seizure: A population-based cohort study","volume":"40","author":"Chiang","year":"2018","journal-title":"Brain Dev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1742-2094-8-135","article-title":"Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures","volume":"8","author":"Choi","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.euroneuro.2017.05.005","article-title":"Cannabinoids in attention-deficit\/hyperactivity disorder: A randomised-controlled trial","volume":"27","author":"Cooper","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ejphar.2018.01.023","article-title":"Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation","volume":"822","author":"Crespo","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/cns.13088","article-title":"Prolonged febrile seizures induce inheritable memory deficits in rats through DNA methylation","volume":"25","author":"Dai","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s12264-014-1482-8","article-title":"Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures","volume":"30","author":"Dai","year":"2014","journal-title":"Neurosci. Bull."},{"key":"B37","doi-asserted-by":"publisher","first-page":"ENEURO.0394","DOI":"10.1523\/ENEURO.0394-20.2021","article-title":"Interneuron dysfunction in a new mouse model of SCN1A GEFS+","volume":"8","author":"Das","year":"2021","journal-title":"eNeuro"},{"key":"B38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13148-019-0721-2","article-title":"DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures","volume":"11","author":"de Nijs","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1001\/jamapediatrics.2019.3343","article-title":"Evaluation of long-term risk of epilepsy, psychiatric disorders, and mortality among children with recurrent febrile seizures: A national cohort study in Denmark","volume":"173","author":"Dreier","year":"2019","journal-title":"JAMA Pediatr."},{"key":"B40","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1001\/jamapediatrics.2020.0046","article-title":"Limited clinical application and concerns of bias in long-term risk of epilepsy, psychiatric disorders, and mortality following febrile seizures-reply","volume":"174","author":"Dreier","year":"2020","journal-title":"JAMA Pediatr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/1531-8249(200003)47:3<336::aid-ana9>3.0.co;2-w","article-title":"Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term","volume":"47","author":"Dube","year":"2000","journal-title":"Ann. Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.expneurol.2008.10.003","article-title":"Cognitive dysfunction after experimental febrile seizures","volume":"215","author":"Dube","year":"2009","journal-title":"Exp. Neurol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/brain\/awl018","article-title":"Temporal lobe epilepsy after experimental prolonged febrile seizures: Prospective analysis","volume":"129","author":"Dube","year":"2006","journal-title":"Brain"},{"key":"B44","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.expneurol.2017.03.026","article-title":"Early-life febrile seizures worsen adult phenotypes in Scn1a mutants","volume":"293","author":"Dutton","year":"2017","journal-title":"Exp. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.nut.2015.05.024","article-title":"Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial","volume":"31","author":"Fallah","year":"2015","journal-title":"Nutrition"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.3129","article-title":"Common variants associated with general and MMR vaccine-related febrile seizures","volume":"46","author":"Feenstra","year":"2014","journal-title":"Nat. Genet."},{"key":"B47","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1038\/srep21931","article-title":"Transient increase of interleukin-1\u03b2 after prolonged febrile seizures promotes adult epileptogenesis through long-lasting upregulating endocannabinoid signaling","volume":"6","author":"Feng","year":"2016","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s12264-014-1524-2","article-title":"Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats","volume":"31","author":"Feng","year":"2015","journal-title":"Neurosci. Bull."},{"key":"B49","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/j.1528-1167.2010.02928.x","article-title":"Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures","volume":"52","author":"Finegersh","year":"2011","journal-title":"Epilepsia"},{"key":"B50","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s11011-014-9648-7","article-title":"Postnatal interleukin-1\u03b2 administration after experimental prolonged febrile seizures enhances epileptogenesis in adulthood","volume":"30","author":"Fukuda","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1111\/epi.13750","article-title":"Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury","volume":"58","author":"Gallentine","year":"2017","journal-title":"Epilepsia"},{"key":"B52","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1136\/jnnp.71.5.638","article-title":"A magnetic resonance study of complicated early childhood convulsion","volume":"71","author":"Grunewald","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.annemergmed.2016.11.024","article-title":"Do all children who present with a complex febrile seizure need a lumbar puncture?","volume":"70","author":"Guedj","year":"2017","journal-title":"Ann. Emerg. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.26355\/eurrev_202111_27261","article-title":"Evaluation of risk factors associated with first episode febrile seizure","volume":"25","author":"Gunes","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"5457","DOI":"10.1007\/s12035-015-9457-y","article-title":"Contribution of GABRG2 polymorphisms to risk of epilepsy and febrile seizure: A multicenter cohort study and meta-analysis","volume":"53","author":"Haerian","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/ejhg.2012.92","article-title":"Haploinsufficiency of CELF4 at 18q12.2 is associated with developmental and behavioral disorders, seizures, eye manifestations, and obesity","volume":"20","author":"Halgren","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.nbd.2014.05.025","article-title":"Long-term modifications of epileptogenesis and hippocampal rhythms after prolonged hyperthermic seizures in the mouse","volume":"69","author":"Hamelin","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/children7090144","article-title":"Identification of missense ADGRV1 mutation as a candidate genetic cause of familial febrile seizure 4","volume":"7","author":"Han","year":"2020","journal-title":"Child. (Basel)"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1016\/j.lfs.2005.11.023","article-title":"Successive alterations of hippocampal gamma-aminobutyric acid B receptor subunits in a rat model of febrile seizure","volume":"78","author":"Han","year":"2006","journal-title":"Life Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/PEC.0000000000002935","article-title":"The association between COVID-19 and febrile seizure: A retrospective case-control study","volume":"39","author":"Hanlon","year":"2023","journal-title":"Pediatr. Emerg. Care"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1111\/epi.17371","article-title":"Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits","volume":"63","author":"Harris","year":"2022","journal-title":"Epilepsia"},{"key":"B62","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3109\/00207454.2015.1018385","article-title":"Long-term metabolic alterations in a febrile seizure model","volume":"126","author":"Heng","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/acn3.48","article-title":"Identification of Srp9 as a febrile seizure susceptibility gene","volume":"1","author":"Hessel","year":"2014","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.bbi.2015.01.017","article-title":"TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain","volume":"48","author":"Huang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/BF02072115","article-title":"Serum sodium levels and probability of recurrent febrile convulsions","volume":"154","author":"Hugen","year":"1995","journal-title":"Eur. J. Pediatr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1093\/jpids\/piac085","article-title":"Change in seizure incidence in febrile children with COVID-19 in the era of omicron variant of concern","volume":"11","author":"Iijima","year":"2022","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"B67","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.nbd.2008.07.010","article-title":"Short- and long-term limbic abnormalities after experimental febrile seizures","volume":"32","author":"Jansen","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e0145247","DOI":"10.1371\/journal.pone.0145247","article-title":"Expression profiling after prolonged experimental febrile seizures in mice suggests structural remodeling in the Hippocampus","volume":"10","author":"Jongbloets","year":"2015","journal-title":"PLoS One"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.3346\/jkms.2023.38.e18","article-title":"The impact of omicron wave on pediatric febrile seizure","volume":"38","author":"Joung","year":"2023","journal-title":"J. Korean Med. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1528-1167.2010.02916.x","article-title":"Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin","volume":"52","author":"Jung","year":"2011","journal-title":"Epilepsia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1111\/j.1460-9568.2006.04732.x","article-title":"Persistent changes in action potential broadening and the slow afterhyperpolarization in rat CA1 pyramidal cells after febrile seizures","volume":"23","author":"Kamal","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1093\/brain\/awt233","article-title":"Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A","volume":"136","author":"Kasperaviciute","year":"2013","journal-title":"Brain"},{"key":"B73","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1177\/0883073818787064","article-title":"Predictive value of epileptiform discharges for subsequent epilepsy after febrile seizures","volume":"33","author":"Kavcic","year":"2018","journal-title":"J. Child. Neurol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e00403","DOI":"10.1002\/brb3.403","article-title":"A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers","volume":"5","author":"Kim","year":"2015","journal-title":"Brain Behav."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1097\/00001756-200110290-00020","article-title":"The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures","volume":"12","author":"Kim","year":"2001","journal-title":"Neuroreport"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/j.1651-2227.1995.tb13571.x","article-title":"Low sodium levels in serum are associated with subsequent febrile seizures","volume":"84","author":"Kiviranta","year":"1995","journal-title":"Acta Paediatr."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23541","article-title":"Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures","author":"Kloc","year":"2023","journal-title":"Hippocampus"},{"key":"B78","doi-asserted-by":"publisher","first-page":"108430","DOI":"10.1016\/j.yebeh.2021.108430","article-title":"Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration","volume":"126","author":"Kloc","year":"2022","journal-title":"Epilepsy Behav."},{"key":"B79","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.yebeh.2013.10.022","article-title":"Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice","volume":"31","author":"Kong","year":"2014","journal-title":"Epilepsy Behav."},{"key":"B80","doi-asserted-by":"publisher","first-page":"442","DOI":"10.3389\/fncel.2019.00442","article-title":"Activation of TRPV1 contributes to recurrent febrile seizures via inhibiting the microglial M2 phenotype in the immature brain","volume":"13","author":"Kong","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1038\/nm.2850","article-title":"GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy","volume":"18","author":"Koyama","year":"2012","journal-title":"Nat. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1136\/archdischild-2013-304647","article-title":"Risk of subsequent attention deficit-hyperactivity disorder in children with febrile seizures","volume":"99","author":"Ku","year":"2014","journal-title":"Arch. Dis. Child."},{"key":"B83","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.braindev.2021.03.002","article-title":"Body temperature predicts recurrent febrile seizures in the same febrile illness","volume":"43","author":"Kubota","year":"2021","journal-title":"Brain Dev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/aian.AIAN_472_17","article-title":"Risk factors of recurrence of febrile seizures in children in a tertiary care hospital in kanpur: A one year follow up study","volume":"22","author":"Kumar","year":"2019","journal-title":"Ann. Indian Acad. Neurol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2008.04.026","article-title":"Hyperthermic seizure induces persistent alteration in excitability of the dentate gyrus in immature rats","volume":"1216","author":"Kwak","year":"2008","journal-title":"Brain Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.seizure.2018.04.023","article-title":"Cytokine levels in febrile seizure patients: A systematic review and meta-analysis","volume":"59","author":"Kwon","year":"2018","journal-title":"Seizure"},{"key":"B87","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.yebeh.2013.03.034","article-title":"Longitudinal assessment of skill development in children with first febrile seizure","volume":"28","author":"Leaffer","year":"2013","journal-title":"Epilepsy Behav."},{"key":"B88","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3343\/alm.2012.32.3.190","article-title":"Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures","volume":"32","author":"Lee","year":"2012","journal-title":"Ann. Lab. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/jnc.13130","article-title":"Hyperthermia-induced seizures alter adenosine A1 and A2A receptors and 5'-nucleotidase activity in rat cerebral cortex","volume":"134","author":"Leon-Navarro","year":"2015","journal-title":"J. Neurochem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3390\/life11080854","article-title":"Is preterm birth a risk factor for subsequent autism spectrum disorder and attention deficit hyperactivity disorder in children with febrile seizure?-A retrospective study","volume":"11","author":"Lin","year":"2021","journal-title":"Life (Basel)"},{"key":"B91","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1073\/pnas.1713895115","article-title":"Visualizing long-term single-molecule dynamics in vivo by stochastic protein labeling","volume":"115","author":"Liu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1093\/brain\/aww167","article-title":"The superficial white matter in temporal lobe epilepsy: A key link between structural and functional network disruptions","volume":"139","author":"Liu","year":"2016","journal-title":"Brain"},{"key":"B93","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1136\/ebm.15.1.15","article-title":"Antipyretic drugs do not reduce recurrences of febrile seizures in children with previous febrile seizure","volume":"15","author":"Lux","year":"2010","journal-title":"Evid. Based Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.1093\/brain\/aws213","article-title":"Recognition memory is impaired in children after prolonged febrile seizures","volume":"135","author":"Martinos","year":"2012","journal-title":"Brain"},{"key":"B95","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00431-008-0776-0","article-title":"Development of hippocampal sclerosis after a complex febrile seizure","volume":"168","author":"Merkenschlager","year":"2009","journal-title":"Eur. J. Pediatr."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e24398","DOI":"10.7759\/cureus.24398","article-title":"Hyponatremia and recurrent febrile seizures during febrile episodes: A meta-analysis","volume":"14","author":"Miyagi","year":"2022","journal-title":"Cureus"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/j.bbadis.2017.05.024","article-title":"Electroencephalographic and biochemical long-lasting abnormalities in animal model of febrile seizure","volume":"1863","author":"Mohammed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1212\/WNL.0000000000003565","article-title":"Mutations in GABRB3: From febrile seizures to epileptic encephalopathies","volume":"88","author":"Moller","year":"2017","journal-title":"Neurology"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1016\/0024-3205(96)00218-4","article-title":"The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups","volume":"58","author":"Nagaki","year":"1996","journal-title":"Life Sci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fpsyt.2020.00315","article-title":"Endocannabinoid system components as potential biomarkers in psychiatry","volume":"11","author":"Navarrete","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1007\/s00381-012-1817-6","article-title":"Neuronal injury and cytogenesis after simple febrile seizures in the hippocampal dentate gyrus of juvenile rat","volume":"28","author":"Nazem","year":"2012","journal-title":"Childs Nerv. Syst."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1212\/WNL.0b013e31824f807a","article-title":"Long-term risk of developing epilepsy after febrile seizures: A prospective cohort study","volume":"78","author":"Neligan","year":"2012","journal-title":"Neurology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1111\/apa.14716","article-title":"Neurodevelopmental problems should be considered in children with febrile seizures","volume":"108","author":"Nilsson","year":"2019","journal-title":"Acta Paediatr."},{"key":"B104","doi-asserted-by":"publisher","first-page":"CD003031","DOI":"10.1002\/14651858.CD003031.pub3","article-title":"Prophylactic drug management for febrile seizures in children","volume":"2","author":"Offringa","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"CD003031","DOI":"10.1002\/14651858.CD003031.pub3","article-title":"Prophylactic drug management for febrile seizures in children","volume":"6","author":"Offringa","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"B106","doi-asserted-by":"publisher","first-page":"12900","DOI":"10.3390\/ijms232112900","article-title":"A complex genomic rearrangement resulting in loss of function of SCN1A and SCN2A in a patient with severe developmental and epileptic encephalopathy","volume":"23","author":"Orlando","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ajp.2012.08.010","article-title":"BDNF-TrkB signaling and neuroprotection in schizophrenia","volume":"6","author":"Pandya","year":"2013","journal-title":"Asian J. Psychiatr."},{"key":"B108","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ejpn.2015.05.009","article-title":"Association between iron deficiency and febrile seizures","volume":"19","author":"Papageorgiou","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"h4240","DOI":"10.1136\/bmj.h4240","article-title":"Febrile seizures","volume":"351","author":"Patel","year":"2015","journal-title":"BMJ"},{"key":"B111","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1523\/JNEUROSCI.3748-16.2017","article-title":"Enduring memory impairments provoked by developmental febrile seizures are mediated by functional and structural effects of neuronal restrictive silencing factor","volume":"37","author":"Patterson","year":"2017","journal-title":"J. Neurosci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.eplepsyres.2021.106848","article-title":"Febrile seizures reduce hippocampal subfield volumes but not cortical thickness in children with focal onset seizures","volume":"179","author":"Peng","year":"2021","journal-title":"Epilepsy Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"8218","DOI":"10.3390\/ijms22158218","article-title":"Early life febrile seizures impair hippocampal synaptic plasticity in young rats","volume":"22","author":"Postnikova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B114","first-page":"32","article-title":"Clinical update: Assessment and management of febrile children","volume":"89","author":"Printz","year":"2016","journal-title":"Community Pract."},{"key":"B115","doi-asserted-by":"publisher","first-page":"976","DOI":"10.2214\/AJR.07.2407","article-title":"Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis","volume":"190","author":"Provenzale","year":"2008","journal-title":"AJR Am. J. Roentgenol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/epi.13724","article-title":"Long-term white matter tract reorganization following prolonged febrile seizures","volume":"58","author":"Pujar","year":"2017","journal-title":"Epilepsia"},{"key":"B117","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/epi.13357","article-title":"Experimental febrile seizures increase dendritic complexity of newborn dentate granule cells","volume":"57","author":"Raijmakers","year":"2016","journal-title":"Epilepsia"},{"key":"B118","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ijdevneu.2014.01.001","article-title":"Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat","volume":"34","author":"Rajab","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2004226","DOI":"10.1002\/advs.202004226","article-title":"Long-term imaging of wound angiogenesis with large scale optoacoustic microscopy","volume":"8","author":"Rebling","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.nbd.2011.10.013","article-title":"A prolonged experimental febrile seizure results in motor map reorganization in adulthood","volume":"45","author":"Reid","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B121","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1111\/epi.12061","article-title":"Increased excitability and molecular changes in adult rats after a febrile seizure","volume":"54","author":"Reid","year":"2013","journal-title":"Epilepsia"},{"key":"B122","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/PEC.0000000000001173","article-title":"Evaluation of patients with febrile seizure: Risk factors, reccurence, treatment and prognosis","volume":"36","author":"Renda","year":"2020","journal-title":"Pediatr. Emerg. Care"},{"key":"B123","doi-asserted-by":"publisher","first-page":"ENEURO.0002","DOI":"10.1523\/ENEURO.0002-21.2021","article-title":"Seizure phenotype and underlying cellular defects in Drosophila knock-in models of DS (R1648C) and GEFS+ (R1648H) SCN1A epilepsy","volume":"8","author":"Roemmich","year":"2021","journal-title":"eNeuro"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.eplepsyres.2015.08.001","article-title":"Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures","volume":"117","author":"Saitoh","year":"2015","journal-title":"Epilepsy Res."},{"key":"B125","first-page":"56","article-title":"Comparison of relation between attention deficit hyperactivity disorder in children with and without simple febrile seizure admitted in arak central Iran","volume":"10","author":"Salehi","year":"2016","journal-title":"Iran. J. Child. Neurol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1111\/epi.13898","article-title":"Alterations in the \u03b12 \u03b4 ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic\/genetic generalized epilepsies","volume":"58","author":"Santolini","year":"2017","journal-title":"Epilepsia"},{"key":"B127","doi-asserted-by":"publisher","first-page":"102083","DOI":"10.1016\/j.scr.2020.102083","article-title":"Generation of iPSC lines from two patients affected by febrile seizure due to inherited missense mutation in SCN1A gene","volume":"49","author":"Scalise","year":"2020","journal-title":"Stem Cell Res."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3390\/biomedicines10051075","article-title":"Human iPSC modeling of genetic febrile seizure reveals aberrant molecular and physiological features underlying an impaired neuronal activity","volume":"10","author":"Scalise","year":"2022","journal-title":"Biomedicines"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/ng.3130","article-title":"Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes","volume":"46","author":"Schubert","year":"2014","journal-title":"Nat. Genet."},{"key":"B130","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/nm1422","article-title":"Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis","volume":"12","author":"Schuchmann","year":"2006","journal-title":"Nat. Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"e15461","DOI":"10.1111\/ped.15461","article-title":"Comparison of febrile seizures in children with or without coronavirus disease-2019: A single-center observational study","volume":"65","author":"Seo","year":"2023","journal-title":"Pediatr. Int."},{"key":"B132","first-page":"354","article-title":"Association of the single nucleotide polymorphisms of the genes encoding IL-2 and IFN-gamma with febrile seizure","volume":"55","author":"Shahrokhi","year":"2017","journal-title":"Acta Med. Iran."},{"key":"B133","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.braindev.2011.09.016","article-title":"Clinical spectrum of SCN2A mutations","volume":"34","author":"Shi","year":"2012","journal-title":"Brain Dev."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/ng.3150","article-title":"Feverish prospects for seizure genetics","volume":"46","author":"Sisodiya","year":"2014","journal-title":"Nat. Genet."},{"key":"B135","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/brain\/awab260","article-title":"Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes","volume":"145","author":"Skotte","year":"2022","journal-title":"Brain"},{"key":"B136","first-page":"445","article-title":"Febrile seizures: Risks, evaluation, and prognosis","volume":"99","author":"Smith","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"B137","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s1059-1311(02)00195-4","article-title":"From swelling to sclerosis: Acute change in mesial hippocampus after prolonged febrile seizure","volume":"12","author":"Sokol","year":"2003","journal-title":"Seizure"},{"key":"B138","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nrn1388","article-title":"Genetic mechanisms that underlie epilepsy","volume":"5","author":"Steinlein","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s10571-018-0586-5","article-title":"Canonical transient receptor potential channel 3 contributes to febrile seizure inducing neuronal cell death and neuroinflammation","volume":"38","author":"Sun","year":"2018","journal-title":"Cell Mol. Neurobiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"112998","DOI":"10.1016\/j.jep.2020.112998","article-title":"Anti-convulsant effects of cultures bear bile powder in febrile seizure via regulation of neurotransmission and inhibition of neuroinflammation","volume":"262","author":"Sun","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1111\/j.1528-1167.2012.03694.x","article-title":"Experimental early-life febrile seizures induce changes in GABA(A) R-mediated neurotransmission in the dentate gyrus","volume":"53","author":"Swijsen","year":"","journal-title":"Epilepsia"},{"key":"B142","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1002\/dneu.22016","article-title":"Long-lasting enhancement of GABA(A) receptor expression in newborn dentate granule cells after early-life febrile seizures","volume":"72","author":"Swijsen","year":"","journal-title":"Dev. Neurobiol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1212\/01.wnl.0000210487.36667.a5","article-title":"Diffusion MRI abnormalities after prolonged febrile seizures with encephalopathy","volume":"66","author":"Takanashi","year":"2006","journal-title":"Neurology"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1111\/epi.17271","article-title":"Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures","volume":"63","author":"Tanaka","year":"2022","journal-title":"Epilepsia"},{"key":"B145","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1111\/bph.15076","article-title":"Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility","volume":"177","author":"Tang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1002\/ana.21712","article-title":"Heat opens axon initial segment sodium channels: A febrile seizure mechanism?","volume":"66","author":"Thomas","year":"2009","journal-title":"Ann. Neurol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.nbd.2014.05.013","article-title":"GABAA receptor biogenesis is impaired by the \u03b32 subunit febrile seizure-associated mutation, GABRG2(R177G)","volume":"69","author":"Todd","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B148","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0896-6273(02)00748-1","article-title":"Cadherin regulates dendritic spine morphogenesis","volume":"35","author":"Togashi","year":"2002","journal-title":"Neuron"},{"key":"B149","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.seizure.2018.08.019","article-title":"Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study","volume":"61","author":"Tsai","year":"2018","journal-title":"Seizure"},{"key":"B150","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.yebeh.2015.04.067","article-title":"Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children","volume":"47","author":"Tsai","year":"2015","journal-title":"Epilepsy Behav."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1111\/j.1528-1167.2009.02054.x","article-title":"Hippocampal distribution of vesicular glutamate transporter 1 in patients with temporal lobe epilepsy","volume":"50","author":"van der Hel","year":"2009","journal-title":"Epilepsia"},{"key":"B152","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s13312-010-0080-8","article-title":"Iron deficiency as a risk factor for first febrile seizure","volume":"47","author":"Vaswani","year":"2010","journal-title":"Indian Pediatr."},{"key":"B153","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/aje\/kwk086","article-title":"The long-term risk of epilepsy after febrile seizures in susceptible subgroups","volume":"165","author":"Vestergaard","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0140-6736(08)61198-8","article-title":"Death in children with febrile seizures: A population-based cohort study","volume":"372","author":"Vestergaard","year":"2008","journal-title":"Lancet"},{"key":"B155","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41582-019-0217-x","article-title":"Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy","volume":"15","author":"Vezzani","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1469-8749.2012.04405.x","article-title":"Febrile seizures and behavioural and cognitive outcomes in preschool children: The generation R study","volume":"54","author":"Visser","year":"2012","journal-title":"Dev. Med. Child. Neurol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/1252","article-title":"Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B","volume":"19","author":"Wallace","year":"1998","journal-title":"Nat. Genet."},{"key":"B158","doi-asserted-by":"publisher","first-page":"108346","DOI":"10.1016\/j.celrep.2020.108346","article-title":"Microglial displacement of GABAergic synapses is a protective event during complex febrile seizures","volume":"33","author":"Wan","year":"2020","journal-title":"Cell Rep."},{"key":"B159","doi-asserted-by":"publisher","first-page":"173","DOI":"10.31083\/j.jin.2019.02.145","article-title":"Protein kinase C-\u03b5 contributes to a chronic inhibitory effect of IL-1\u03b2 on voltage-gated sodium channels in mice with febrile seizure","volume":"18","author":"Wang","year":"2019","journal-title":"J. Integr. Neurosci."},{"key":"B160","first-page":"1008","article-title":"Serum zinc level in children presenting with febrile seizures","volume":"29","author":"Waqar Rabbani","year":"2013","journal-title":"Pak J. Med. Sci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"626704","DOI":"10.3389\/fcell.2021.626704","article-title":"Heat-shock induces granule cell dispersion and microgliosis in hippocampal slice cultures","volume":"9","author":"Weninger","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B162","article-title":"Febrile seizure","volume-title":"StatPearls","author":"Xixis","year":"2022"},{"key":"B163","doi-asserted-by":"publisher","first-page":"924303","DOI":"10.1155\/2015\/924303","article-title":"Hyperthermia-induced febrile seizures have moderate and transient effects on spatial learning in immature rats","volume":"2015","author":"Yagoubi","year":"2015","journal-title":"Behav. Neurol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"14514","DOI":"10.1021\/acs.analchem.8b04355","article-title":"Visualizing endogenous sulfur dioxide derivatives in febrile-seizure-induced hippocampal damage by a two-photon energy transfer cassette","volume":"90","author":"Yang","year":"2018","journal-title":"Anal. Chem."},{"key":"B165","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-019-1487-3","article-title":"TRPV1 mediates astrocyte activation and interleukin-1\u03b2 release induced by hypoxic ischemia (HI)","volume":"16","author":"Yang","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/epi.16059","article-title":"Hippocampal diffusion abnormality after febrile status epilepticus is related to subsequent epilepsy","volume":"60","author":"Yokoi","year":"2019","journal-title":"Epilepsia"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1111\/j.1528-1167.2010.02587.x","article-title":"Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy","volume":"51","author":"Zhang","year":"2010","journal-title":"Epilepsia"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/s41419-021-04450-9","article-title":"TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"B169","doi-asserted-by":"publisher","first-page":"864074","DOI":"10.3389\/fnmol.2022.864074","article-title":"ADGRV1 variants in febrile seizures\/epilepsy with antecedent febrile seizures and their associations with audio-visual abnormalities","volume":"15","author":"Zhou","year":"2022","journal-title":"Front. Mol. Neurosci."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1186050\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T05:03:19Z","timestamp":1684990999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1186050\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":169,"alternative-id":["10.3389\/fcell.2023.1186050"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1186050","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]},"article-number":"1186050"}}