{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:25:54Z","timestamp":1768623954357,"version":"3.49.0"},"reference-count":223,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Neuromuscular junctions (NMJs) are a special type of chemical synapse that transmits electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle to induce a motor response. They are an ideal model for the study of synapses, given their manageable size and easy accessibility. Alterations in their morphology or function lead to neuromuscular disorders, such as the congenital myasthenic syndromes, which are caused by mutations in proteins located in the NMJ. In this review, we highlight novel potential candidate genes that may cause or modify NMJs-related pathologies in humans by exploring the phenotypes of hundreds of mouse models available in the literature. We also underscore the fact that NMJs may differ between species, muscles or even sexes. Hence the importance of choosing a good model organism for the study of NMJ-related diseases: only taking into account the specific features of the mammalian NMJ, experimental results would be efficiently translated to the clinic.<\/jats:p>","DOI":"10.3389\/fcell.2023.1216726","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:14:36Z","timestamp":1691151276000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["NMJ-related diseases beyond the congenital myasthenic syndromes"],"prefix":"10.3389","volume":"11","author":[{"given":"Alejandra","family":"Navarro-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Vicente-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime J.","family":"Carvajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1242\/dmm.002527","article-title":"An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy","volume":"2","author":"Achilli","year":"2009","journal-title":"Dis. Model Mech."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/hmg\/dds540","article-title":"Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality","volume":"22","author":"Ackermann","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"923","DOI":"10.15252\/embr.201540434","article-title":"Presynaptic active zones in invertebrates and vertebrates","volume":"16","author":"Ackermann","year":"2015","journal-title":"EMBO Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1523\/JNEUROSCI.3408-04.2004","article-title":"Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms","volume":"24","author":"Adams","year":"2004","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1083\/jcb.150.6.1385","article-title":"Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin","volume":"150","author":"Adams","year":"2000","journal-title":"J. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"32695","DOI":"10.1074\/jbc.M109.035998","article-title":"A novel role for hGas7b in microtubular maintenance: Possible implication in tau-associated pathology in alzheimer disease","volume":"284","author":"Akiyama","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"fcab081","DOI":"10.1093\/braincomms\/fcab081","article-title":"Terminal Schwann cells at the human neuromuscular junction","volume":"3","author":"Alhindi","year":"2021","journal-title":"Brain Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1523\/JNEUROSCI.4610-11.2012","article-title":"Biglycan is an extracellular MuSK binding protein important for synapse stability","volume":"32","author":"Amenta","year":"2012","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1126\/science.aad2509","article-title":"Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure","volume":"350","author":"Amin","year":"2015","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/s0896-6273(01)80026-x","article-title":"Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity","volume":"23","author":"Arber","year":"1999","journal-title":"Neuron"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1213\/00000539-198710000-00028","article-title":"Malignant hyperthermia in a three-month-old American Indian infant","volume":"66","author":"Bailey","year":"1987","journal-title":"Anesth. Analg."},{"key":"B12","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1523\/JNEUROSCI.10-03-00894.1990","article-title":"In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse","volume":"10","author":"Balice-Gordon","year":"1990","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells10102726","article-title":"Cofilin and actin dynamics: Multiple modes of regulation and their impacts in neuronal development and degeneration","volume":"10","author":"Bamburg","year":"2021","journal-title":"Cells"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1523\/JNEUROSCI.1786-04.2005","article-title":"Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation","volume":"25","author":"Banks","year":"2005","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1523\/JNEUROSCI.21-16-06095.2001","article-title":"Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells","volume":"21","author":"Barclay","year":"2001","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1523\/JNEUROSCI.4489-07.2008","article-title":"Retrograde signaling onto Ret during motor nerve terminal maturation","volume":"28","author":"Baudet","year":"2008","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1095\/biolreprod38.4.899","article-title":"Juvenile spermatogonial depletion (jsd): A genetic defect of germ cell proliferation of male mice","volume":"38","author":"Beamer","year":"1988","journal-title":"Biol. Reprod."},{"key":"B18","doi-asserted-by":"publisher","first-page":"135163","DOI":"10.1016\/j.neulet.2020.135163","article-title":"Regulation of gene expression at the neuromuscular junction","volume":"735","author":"Belotti","year":"2020","journal-title":"Neurosci. Lett."},{"key":"B19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1097\/00001756-199210000-00009","article-title":"Different distributions of dystrophin and related proteins at nerve-muscle junctions","volume":"3","author":"Bewick","year":"1992","journal-title":"Neuroreport"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1523\/JNEUROSCI.2893-15.2016","article-title":"TMEM184b promotes axon degeneration and neuromuscular junction maintenance","volume":"36","author":"Bhattacharya","year":"2016","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"C698","DOI":"10.1152\/ajpcell.00326.2010","article-title":"Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14","volume":"302","author":"Bhattacharyya","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1113\/jphysiol.1960.sp006378","article-title":"The fine structure of the neuromuscular junction of the frog","volume":"150","author":"Birks","year":"1960","journal-title":"J. Physiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.isci.2019.11.041","article-title":"New insights into the lactate shuttle: Role of MCT4 in the modulation of the exercise capacity","volume":"22","author":"Bisetto","year":"2019","journal-title":"iScience"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1101\/gad.1592107","article-title":"The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons","volume":"21","author":"Bloom","year":"2007","journal-title":"Genes Dev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/joa.13260","article-title":"Comparative anatomy of the mammalian neuromuscular junction","volume":"237","author":"Boehm","year":"2020","journal-title":"J. Anat."},{"key":"B26","doi-asserted-by":"publisher","first-page":"eabg4982","DOI":"10.1126\/scisignal.abg4982","article-title":"The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK","volume":"15","author":"Bo\u00ebx","year":"2022","journal-title":"Sci. Signal"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e30217","DOI":"10.1371\/journal.pone.0030217","article-title":"A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes","volume":"7","author":"Bogdanik","year":"2012","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"11468","DOI":"10.1523\/JNEUROSCI.2508-08.2008","article-title":"Identification of a motif in the acetylcholine receptor \u03b2 subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization","volume":"28","author":"Borges","year":"2008","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1128\/MCB.23.3.908-915.2003","article-title":"Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality","volume":"23","author":"Buchou","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/ng0895-461","article-title":"Mutation of a new sodium channel gene, Scn8a, in the mouse mutant \u201cmotor endplate disease\u201d","volume":"10","author":"Burgess","year":"1995","journal-title":"Nat. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1128\/MCB.24.3.1096-1105.2004","article-title":"Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice","volume":"24","author":"Burgess","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"111613","DOI":"10.1016\/j.exger.2021.111613","article-title":"Variation in muscle and neuromuscular junction morphology between atrophy-resistant and atrophy-prone muscles supports failed re-innervation in aging muscle atrophy","volume":"156","author":"Burke","year":"2021","journal-title":"Exp. Gerontol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1111\/j.1460-9568.2012.08164.x","article-title":"Motor endplate disease affects neuromuscular junction maturation","volume":"36","author":"Caillol","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1242\/dmm.015222","article-title":"A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton","volume":"7","author":"Carpanini","year":"2014","journal-title":"Dis. Model Mech."},{"key":"B36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.expneurol.2015.09.014","article-title":"Altered terminal Schwann cell morphology precedes denervation in SOD1 mice","volume":"275","author":"Carrasco","year":"2016","journal-title":"Exp. Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1003550","DOI":"10.1371\/journal.pgen.1003550","article-title":"Deregulation of the protocadherin gene FAT1 alters muscle shapes: Implications for the pathogenesis of facioscapulohumeral dystrophy","volume":"9","author":"Caruso","year":"2013","journal-title":"PLoS Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.1073\/pnas.95.8.4463","article-title":"The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene","volume":"95","author":"Chambers","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B39","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.cell.2005.09.028","article-title":"Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration","volume":"123","author":"Chandra","year":"2005","journal-title":"Cell"},{"key":"B40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuron.2007.06.031","article-title":"Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction","volume":"55","author":"Chen","year":"2007","journal-title":"Neuron"},{"key":"B41","doi-asserted-by":"publisher","first-page":"17505","DOI":"10.1523\/JNEUROSCI.2922-11.2011","article-title":"Ubiquitin homeostasis is critical for synaptic development and function","volume":"31","author":"Chen","year":"2011","journal-title":"J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"10909","DOI":"10.1523\/JNEUROSCI.2635-09.2009","article-title":"The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions","volume":"29","author":"Chen","year":"2009","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1101\/gad.375206","article-title":"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction","volume":"20","author":"Cheusova","year":"2006","journal-title":"Genes Dev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e00220","DOI":"10.7554\/eLife.00220","article-title":"APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice","volume":"2","author":"Choi","year":"2013","journal-title":"Elife"},{"key":"B45","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.brainresrev.2006.12.007","article-title":"Invertebrate preparations and their contribution to neurobiology in the second half of the 20th century","volume":"54","author":"Clarac","year":"2007","journal-title":"Brain Res. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.drudis.2016.02.002","article-title":"A look into the future of ALS research","volume":"21","author":"Clerc","year":"2016","journal-title":"Drug Discov. Today"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.nmd.2021.11.004","article-title":"The 2022 version of the gene table of neuromuscular disorders (nuclear genome)","volume":"31","author":"Cohen","year":"2021","journal-title":"Neuromuscul. Disord."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1242\/dev.087106","article-title":"CLIPR-59: A protein essential for neuromuscular junction stability during mouse late embryonic development","volume":"140","author":"Couesnon","year":"2013","journal-title":"Development"},{"key":"B49","first-page":"563","article-title":"Contribution a l\u2019etude de la synapse myoneurale","volume":"6","author":"Couteaux","year":"1947","journal-title":"Rev. Canad Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0074-7696(08)60463-5","article-title":"Localization of cholinesterases at neuromuscular junctions","volume":"4","author":"Couteaux","year":"1955","journal-title":"Int. Rev. Cytol."},{"key":"B51","first-page":"147","article-title":"The action of certain esters and ethers of choline and their relation to muscarine","volume":"6","author":"Dale","year":"1914","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B52","first-page":"604","article-title":"Neuropathologic alterations in the ataxia (paralytic) mouse","volume":"80","author":"D\u2019Amato","year":"1965","journal-title":"Arch. Pathol. (Chic)"},{"key":"B53","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13287-018-1118-4","article-title":"Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes","volume":"10","author":"Daveg\u00e5rdh","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"B54","doi-asserted-by":"publisher","first-page":"107775","DOI":"10.1016\/j.celrep.2020.107775","article-title":"Synaptic vesicle precursors and lysosomes are transported by different mechanisms in the axon of mammalian neurons","volume":"31","author":"de Pace","year":"2020","journal-title":"Cell Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"e201900637","DOI":"10.26508\/lsa.201900637","article-title":"Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle","volume":"3","author":"de Paola","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"B56","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1083\/jcb.136.4.883","article-title":"Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice","volume":"136","author":"Deconinck","year":"","journal-title":"J. Cell Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/s0092-8674(00)80532-2","article-title":"Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy","volume":"90","author":"Deconinck","year":"","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/dneu.22095","article-title":"Presynaptic to postsynaptic relationships of the neuromuscular junction are held constant across age and muscle fiber type","volume":"73","author":"Deschenes","year":"2013","journal-title":"Dev. Neurobiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3390\/cells10061307","article-title":"Age-related alterations at neuromuscular junction: Role of oxidative stress and epigenetic modifications","volume":"10","author":"Dobrowolny","year":"2021","journal-title":"Cells"},{"key":"B60","doi-asserted-by":"publisher","first-page":"6528","DOI":"10.1111\/febs.12554","article-title":"In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy","volume":"280","author":"Doig","year":"2013","journal-title":"FEBS J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0960-8966(91)90050-3","article-title":"Neuromuscular disorders: Gene location","volume":"1","author":"Dubowitz","year":"1991","journal-title":"Neuromuscul. Disord."},{"key":"B62","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1136\/jnnp.33.2.238","article-title":"Hereditary motor end-plate disease in the mouse: Light and electron microscopic studies","volume":"33","author":"Duchen","year":"1970","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B63","first-page":"4","article-title":"An hereditary motor endplate disease in the mouse","volume":"189","author":"Duchen","year":"1967","journal-title":"J. Physiol. (Lond.)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1113\/jphysiol.1971.sp009340","article-title":"Electrophysiological studies of neuromuscular transmission in hereditary \u201cmotor end-plate disease\u201d of the mouse","volume":"212","author":"Duchen","year":"1971","journal-title":"J. Physiol."},{"key":"B65","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/B978-0-12-813866-3.00032-1","article-title":"Congenital myasthenic syndromes","volume-title":"Rosenberg\u2019s molecular and genetic basis of neurological and psychiatric disease","author":"Engel","year":"2020"},{"key":"B66","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/S1474-4422(14)70201-7","article-title":"Congenital myasthenic syndromes: Pathogenesis, diagnosis, and treatment","volume":"14","author":"Engel","year":"2015","journal-title":"Lancet Neurol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0072-9752(07)01503-5","article-title":"The neuromuscular junction","volume":"91","author":"Engel","year":"2008","journal-title":"Handb. Clin. Neurology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1126\/science.1108258","article-title":"Synapses form in skeletal muscles lacking neuregulin receptors","volume":"308","author":"Escher","year":"2005","journal-title":"Science"},{"key":"B69","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1113\/JPHYSIOL.1951.SP004675","article-title":"An analysis of the end-plate potential recorded with an intracellular electrode","volume":"115","author":"Fatt","year":"1951","journal-title":"J. Physiol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1113\/jphysiol.1952.sp004735","article-title":"Spontaneous subthreshold activity at motor nerve endings","volume":"117","author":"Fatt","year":"1952","journal-title":"J. Physiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1126\/science.282.5392.1321","article-title":"Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity","volume":"282","author":"Feng","year":"1998","journal-title":"Science"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1002\/lary.23218","article-title":"Differences in neuromuscular junctions of laryngeal and limb muscles in rats","volume":"122","author":"Feng","year":"2012","journal-title":"Laryngoscope"},{"key":"B73","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/s0896-6273(04)00190-4","article-title":"The synaptic vesicle protein CSP alpha prevents presynaptic degeneration","volume":"42","author":"Fern\u00e1ndez-Chac\u00f3n","year":"2004","journal-title":"Neuron"},{"key":"B74","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0896-6273(93)90153-i","article-title":"The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans","volume":"11","author":"Ferns","year":"1993","journal-title":"Neuron"},{"key":"B75","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1093\/hmg\/ddw429","article-title":"Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease","volume":"26","author":"Fil","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B76","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0896-6273(89)90029-9","article-title":"Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein","volume":"3","author":"Flucher","year":"1989","journal-title":"Neuron"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1083\/jcb.149.7.1443","article-title":"Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity","volume":"149","author":"Frey","year":"2000","journal-title":"J. Cell Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.expneurol.2009.09.007","article-title":"A role for galectin-1 in the immune response to peripheral nerve injury","volume":"220","author":"Gaudet","year":"2009","journal-title":"Exp. Neurol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1007\/s00429-014-0766-0","article-title":"Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates","volume":"220","author":"Geerts","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"B80","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/s0092-8674(00)81252-0","article-title":"Agrin acts via a MuSK receptor complex","volume":"85","author":"Glass","year":"1996","journal-title":"Cell"},{"key":"B81","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/s0896-6273(03)00673-1","article-title":"Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality","volume":"40","author":"Gomeza","year":"2003","journal-title":"Neuron"},{"key":"B82","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1101\/gr.233866.117","article-title":"Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis","volume":"29","author":"Goodwin","year":"2019","journal-title":"Genome Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/12034","article-title":"Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies","volume":"1","author":"Grady","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1083\/jcb.136.4.871","article-title":"Subtle neuromuscular defects in utrophin-deficient mice","volume":"136","author":"Grady","year":"","journal-title":"J. Cell Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/s0092-8674(00)80533-4","article-title":"Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: A model for duchenne muscular dystrophy","volume":"90","author":"Grady","year":"","journal-title":"Cell"},{"key":"B86","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/s0896-6273(00)80894-6","article-title":"Maturation and maintenance of the neuromuscular synapse: Genetic evidence for roles of the dystrophin-glycoprotein complex","volume":"25","author":"Grady","year":"2000","journal-title":"Neuron"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e3173","DOI":"10.1038\/cddis.2017.468","article-title":"The histone code reader Spin1 controls skeletal muscle development","volume":"8","author":"Greschik","year":"2017","journal-title":"Cell Death Dis."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e41917","DOI":"10.1371\/journal.pone.0041917","article-title":"Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function","volume":"7","author":"Griffiths","year":"2012","journal-title":"PLoS One"},{"key":"B89","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1128\/MCB.18.8.4761","article-title":"RhoE regulates actin cytoskeleton organization and cell migration","volume":"18","author":"Guasch","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ajhg.2017.03.008","article-title":"PLAA mutations cause a lethal infantile epileptic encephalopathy by disrupting ubiquitin-mediated endolysosomal degradation of synaptic proteins","volume":"100","author":"Hall","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/nature11923","article-title":"CLP1 links tRNA metabolism to progressive motor-neuron loss","volume":"495","author":"Hanada","year":"2013","journal-title":"Nature"},{"key":"B92","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ydbio.2014.08.026","article-title":"Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders","volume":"395","author":"Hanson","year":"2014","journal-title":"Dev. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"e2004734","DOI":"10.1371\/journal.pbio.2004734","article-title":"Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis","volume":"16","author":"Helmbacher","year":"2018","journal-title":"PLoS Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"11917","DOI":"10.1523\/JNEUROSCI.2021-10.2010","article-title":"Induced loss of ADAR2 engenders slow death of motor neurons from Q\/R site-unedited GluR2","volume":"30","author":"Hideyama","year":"2010","journal-title":"J. Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1038\/ncomms2952","article-title":"Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy","volume":"4","author":"Horstick","year":"2013","journal-title":"Nat. Commun."},{"key":"B96","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ajhg.2016.07.014","article-title":"The power of human protective modifiers: PLS3 and CORO1C unravel impaired endocytosis in spinal muscular atrophy and rescue SMA phenotype","volume":"99","author":"Hosseinibarkooie","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B97","doi-asserted-by":"publisher","first-page":"e37702","DOI":"10.1371\/journal.pone.0037702","article-title":"Gas7-deficient mouse reveals roles in motor function and muscle fiber composition during aging","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS One"},{"key":"B98","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/355696a0","article-title":"Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix","volume":"355","author":"Ibraghimov-Beskrovnaya","year":"1992","journal-title":"Nature"},{"key":"B99","doi-asserted-by":"publisher","first-page":"5040","DOI":"10.1128\/MCB.02228-06","article-title":"GA-binding protein is dispensable for neuromuscular synapse formation and synapse-specific gene expression","volume":"27","author":"Jaworski","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1016\/j.celrep.2017.11.008","article-title":"Cellular and molecular anatomy of the human neuromuscular junction","volume":"21","author":"Jones","year":"2017","journal-title":"Cell Rep."},{"key":"B101","doi-asserted-by":"publisher","first-page":"160240","DOI":"10.1098\/rsob.160240","article-title":"NMJ-morph reveals principal components of synaptic morphology influencing structure-function relationships at the neuromuscular junction","volume":"6","author":"Jones","year":"2016","journal-title":"Open Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cell.2010.12.029","article-title":"RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction","volume":"144","author":"Kaeser","year":"2011","journal-title":"Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/sj.embor.7401027","article-title":"Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1","volume":"8","author":"Kaether","year":"2007","journal-title":"EMBO Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.brainres.2007.01.063","article-title":"Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction","volume":"1143","author":"Kaja","year":"2007","journal-title":"Brain Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.1523\/JNEUROSCI.4673-13.2014","article-title":"Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury","volume":"34","author":"Kang","year":"2014","journal-title":"J. Neurosci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"22915","DOI":"10.1074\/jbc.M101011200","article-title":"Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2\/S1 protein expression in normal and wasted mice","volume":"276","author":"Khalyfa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B107","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/hmg\/ddy341","article-title":"Mice lacking \u03b1-\u03b21- and \u03b22-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle","volume":"28","author":"Kim","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"B108","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.cell.2008.10.002","article-title":"Lrp4 is a receptor for Agrin and forms a complex with MuSK","volume":"135","author":"Kim","year":"2008","journal-title":"Cell"},{"key":"B109","doi-asserted-by":"publisher","first-page":"dev200937","DOI":"10.1242\/dev.200937","article-title":"Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating development of a midbrain GABAergic neuron subtype with characteristics of REM-sleep regulatory neurons","volume":"149","author":"Kirjavainen","year":"2022","journal-title":"Development"},{"key":"B110","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nn1904","article-title":"RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels","volume":"10","author":"Kiyonaka","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1038\/s41467-022-30778-7","article-title":"Control of CRK-RAC1 activity by the miR-1\/206\/133 miRNA family is essential for neuromuscular junction function","volume":"13","author":"Klockner","year":"2022","journal-title":"Nat. Commun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"528e538","DOI":"10.1007\/BF01942820","article-title":"Die muskelspindeln","volume":"28","author":"Kuhne","year":"1863","journal-title":"Arch. fur Pathol. Anat. Physiol. fur Klin. Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.expneurol.2010.06.014","article-title":"Decreased phosphorylation of \u03b4 and \u03b5 subunits of the acetylcholine receptor coincides with delayed postsynaptic maturation in PKC \u03b8 deficient mouse","volume":"225","author":"Lanuza","year":"2010","journal-title":"Exp. Neurol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/emmm.201303275","article-title":"Compound loss of muscleblind-like function in myotonic dystrophy","volume":"5","author":"Lee","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"E270","DOI":"10.1002\/lary.26561","article-title":"Sexual dimorphism in laryngeal muscle fibers and ultrasonic vocalizations in the adult rat","volume":"127","author":"Lenell","year":"2017","journal-title":"Laryngoscope"},{"key":"B116","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/1228","article-title":"The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit","volume":"19","author":"Letts","year":"1998","journal-title":"Nat. Genet."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1242\/dev.00447","article-title":"Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development","volume":"130","author":"Leu","year":"2003","journal-title":"Development"},{"key":"B118","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.neuron.2007.09.009","article-title":"The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics","volume":"56","author":"Lewcock","year":"2007","journal-title":"Neuron"},{"key":"B119","doi-asserted-by":"publisher","first-page":"30598","DOI":"10.1074\/jbc.M110.137729","article-title":"Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis","volume":"285","author":"Li","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B120","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1523\/JNEUROSCI.3930-03.2004","article-title":"The role of the theta isoform of protein kinase C (PKC) in activity-dependent synapse elimination: Evidence from the PKC theta knock-out mouse in vivo and in vitro","volume":"24","author":"Li","year":"2004","journal-title":"J. Neurosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1523\/JNEUROSCI.5590-07.2008","article-title":"The role of nerve-versus muscle-derived factors in mammalian neuromuscular junction formation","volume":"28","author":"Lin","year":"2008","journal-title":"J. Neurosci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/35074025","article-title":"Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse","volume":"410","author":"Lin","year":"2001","journal-title":"Nature"},{"key":"B123","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.neuron.2005.04.002","article-title":"Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism","volume":"46","author":"Lin","year":"2005","journal-title":"Neuron"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1073\/pnas.97.3.1299","article-title":"Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice","volume":"97","author":"Lin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1242\/jcs.202226","article-title":"Nestin contributes to skeletal muscle homeostasis and regeneration","volume":"130","author":"Lindqvist","year":"2017","journal-title":"J. Cell Sci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.devcel.2019.06.009","article-title":"PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development","volume":"50","author":"Liu","year":"2019","journal-title":"Dev. Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1172\/JCI62656","article-title":"microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice","volume":"122","author":"Liu","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B128","doi-asserted-by":"publisher","first-page":"e1007857","DOI":"10.1371\/journal.pgen.1007857","article-title":"Blocking skeletal muscle DHPRs\/Ryr1 prevents neuromuscular synapse loss in mutant mice deficient in type III Neuregulin 1 (CRD-Nrg1)","volume":"15","author":"Liu Y","year":"2019","journal-title":"PLoS Genet."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1242\/dev.018119","article-title":"Essential roles of the acetylcholine receptor \u0263-subunit in neuromuscular synaptic patterning","volume":"135","author":"Liu","year":"2008","journal-title":"Development"},{"key":"B130","doi-asserted-by":"publisher","first-page":"135110","DOI":"10.1016\/j.neulet.2020.135110","article-title":"Crayfish and Drosophila NMJs","volume":"732","author":"Lnenicka","year":"2020","journal-title":"Neurosci. Lett."},{"key":"B131","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1016\/j.celrep.2020.02.060","article-title":"The FTLD risk factor TMEM106B regulates the transport of lysosomes at the axon initial segment of motoneurons","volume":"30","author":"L\u00fcningschr\u00f6r","year":"2020","journal-title":"Cell Rep."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/s41589-020-0598-6","article-title":"Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity","volume":"16","author":"Mabbitt","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/1471-2202-13-136","article-title":"Kalrn plays key roles within and outside of the nervous system","volume":"13","author":"Mandela","year":"2012","journal-title":"BMC Neurosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"e84042","DOI":"10.1371\/journal.pone.0084042","article-title":"Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14)","volume":"8","author":"Marshall","year":"2013","journal-title":"PLoS One"},{"key":"B135","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.1038\/s41467-020-18327-6","article-title":"NEMF mutations that impair ribosome-associated quality control are associated with neuromuscular disease","volume":"11","author":"Martin","year":"2020","journal-title":"Nat. Commun."},{"key":"B136","doi-asserted-by":"publisher","first-page":"e0132364","DOI":"10.1371\/journal.pone.0132364","article-title":"Plastin 3 expression does not modify spinal muscular atrophy severity in the \u22067 SMA mouse","volume":"10","author":"McGovern","year":"2015","journal-title":"PLoS One"},{"key":"B137","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1101\/sqb.1990.055.01.041","article-title":"The agrin hypothesis","volume":"55","author":"McMahan","year":"1990","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.1113\/jphysiol.2009.178236","article-title":"Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses","volume":"587","author":"Medrihan","year":"2009","journal-title":"J. Physiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"12251","DOI":"10.1038\/s41598-021-91094-6","article-title":"NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease","volume":"11","author":"Mejia Maza","year":"2021","journal-title":"Sci. Rep."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1242\/dev.146167","article-title":"Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways","volume":"144","author":"Mess\u00e9ant","year":"2017","journal-title":"Development"},{"key":"B141","doi-asserted-by":"publisher","first-page":"24639","DOI":"10.1073\/pnas.1911921116","article-title":"The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice","volume":"116","author":"Minis","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e19236","DOI":"10.1371\/journal.pone.0019236","article-title":"RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice","volume":"6","author":"Mochol\u00ed","year":"2011","journal-title":"PLoS One"},{"key":"B143","doi-asserted-by":"publisher","first-page":"11547","DOI":"10.1523\/JNEUROSCI.4396-10.2011","article-title":"Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions","volume":"31","author":"Mohseni","year":"2011","journal-title":"J. Neurosci."},{"key":"B144","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1016\/j.celrep.2017.03.009","article-title":"Severity of demyelinating and axonal neuropathy mouse models is modified by genes affecting structure and function of peripheral nodes","volume":"18","author":"Morelli","year":"2017","journal-title":"Cell Rep."},{"key":"B145","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/glia.20252","article-title":"Expression of Nav1.6 sodium channels by Schwann cells at neuromuscular junctions: Role in the motor endplate disease phenotype","volume":"53","author":"Musarella","year":"2006","journal-title":"Glia"},{"key":"B146","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ydbio.2014.01.016","article-title":"The c-Ski family member and transcriptional regulator Corl2\/Skor2 promotes early differentiation of cerebellar Purkinje cells","volume":"388","author":"Nakatani","year":"2014","journal-title":"Dev. Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13395-018-0152-3","article-title":"Diversification of the muscle proteome through alternative splicing","volume":"8","author":"Nakka","year":"2018","journal-title":"Skelet. Muscle"},{"key":"B148","doi-asserted-by":"publisher","first-page":"11881","DOI":"10.1073\/pnas.1310571110","article-title":"Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility","volume":"110","author":"Nelson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B149","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.semcdb.2010.08.008","article-title":"Nrg1\/ErbB signaling networks in Schwann cell development and myelination","volume":"21","author":"Newbern","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/jnen\/64.4.295","article-title":"Progressive loss of motor neuron function in wasted mice: Effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor","volume":"64","author":"Newbery","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/dvdy.21176","article-title":"Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan","volume":"236","author":"Nguyen","year":"2007","journal-title":"Dev. Dyn."},{"key":"B152","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1007\/s12035-019-1471-z","article-title":"Rab18 collaborates with Rab7 to modulate lysosomal and autophagy activities in the nervous system: An overlapping mechanism for warburg micro syndrome and charcot-marie-tooth neuropathy type 2B","volume":"56","author":"Nian","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0920-1211(90)90098-g","article-title":"Stargazer: A new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures","volume":"7","author":"Noebels","year":"1990","journal-title":"Epilepsy Res."},{"key":"B154","doi-asserted-by":"publisher","first-page":"e109598","DOI":"10.1371\/journal.pone.0109598","article-title":"The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone","volume":"9","author":"Nuytens","year":"2014","journal-title":"PLoS One"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1126\/science.1127142","article-title":"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis","volume":"312","author":"Okada","year":"2006","journal-title":"Science"},{"key":"B156","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1128\/MCB.00659-06","article-title":"Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function","volume":"27","author":"O\u2019Leary","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0092-8674(00)81073-9","article-title":"Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4","volume":"85","author":"Olson","year":"1996","journal-title":"Cell"},{"key":"B158","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1126\/science.1155085","article-title":"Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy","volume":"320","author":"Oprea","year":"2008","journal-title":"Science"},{"key":"B159","doi-asserted-by":"publisher","first-page":"e15031","DOI":"10.14814\/phy2.15031","article-title":"Sex differences in skeletal muscle revealed through fiber type, capillarity, and transcriptomics profiling in mice","volume":"9","author":"O\u2019Reilly","year":"2021","journal-title":"Physiol. Rep."},{"key":"B160","doi-asserted-by":"publisher","first-page":"6395","DOI":"10.1074\/jbc.275.9.6395","article-title":"An isoform of kalirin, a brain-specific GDP\/GTP exchange factor, is enriched in the postsynaptic density fraction","volume":"275","author":"Penzes","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B161","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/j.1471-4159.2012.07733.x","article-title":"Neuronal polarization is impaired in mice lacking RhoE expression","volume":"121","author":"Peris","year":"2012","journal-title":"J. Neurochem."},{"key":"B162","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF00300589","article-title":"The splenius capitis muscle of the rat, architecture and histochemistry, afferent and efferent innervation as compared with that of the quadriceps muscle","volume":"169","author":"Pfister","year":"1984","journal-title":"Anat. Embryol. Berl."},{"key":"B163","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1242\/dev.01264","article-title":"Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system","volume":"131","author":"Pietri","year":"2004","journal-title":"Development"},{"key":"B164","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nn1897","article-title":"Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells","volume":"10","author":"Plachta","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B165","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/nyas.13507","article-title":"Neuromuscular synapse electrophysiology in myasthenia gravis animal models","volume":"1412","author":"Plomp","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"10986","DOI":"10.1073\/pnas.1612441113","article-title":"Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation","volume":"113","author":"Polster","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B167","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/cdd.2014.14","article-title":"Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury","volume":"21","author":"Quint\u00e1","year":"2014","journal-title":"Cell Death Differ."},{"key":"B168","doi-asserted-by":"publisher","first-page":"eaav5264","DOI":"10.1126\/scitranslmed.aav5264","article-title":"Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology","volume":"11","author":"Reichenstein","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"B169","doi-asserted-by":"publisher","first-page":"e62760","DOI":"10.1371\/journal.pone.0062760","article-title":"Stac3 is a novel regulator of skeletal muscle development in mice","volume":"8","author":"Reinholt","year":"2013","journal-title":"PLoS One"},{"key":"B170","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1371\/journal.pgen.0010074","article-title":"Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss","volume":"1","author":"Richard","year":"2005","journal-title":"PLoS Genet."},{"key":"B171","doi-asserted-by":"publisher","first-page":"e24834","DOI":"10.1371\/journal.pone.0024834","article-title":"Neuropathology in mice expressing mouse alpha-synuclein","volume":"6","author":"Rieker","year":"2011","journal-title":"PLoS One"},{"key":"B172","doi-asserted-by":"publisher","first-page":"610964","DOI":"10.3389\/fnmol.2020.610964","article-title":"The neuromuscular junction in health and disease: Molecular mechanisms governing synaptic formation and homeostasis","volume":"13","author":"Rodr\u00edguez Cruz","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neuron.2012.02.019","article-title":"Motorneurons require cysteine string protein-\u03b1 to maintain the readily releasable vesicular pool and synaptic vesicle recycling","volume":"74","author":"Rozas","year":"2012","journal-title":"Neuron"},{"key":"B174","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1073\/pnas.0813112106","article-title":"Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing","volume":"106","author":"Ruggiu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B175","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1111\/j.1460-9568.2008.06301.x","article-title":"Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse","volume":"27","author":"Ruiz","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1128\/MCB.00364-09","article-title":"Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development","volume":"29","author":"Saiga","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1083\/jcb.200805150","article-title":"Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release","volume":"183","author":"Sakisaka","year":"2008","journal-title":"J. Cell Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1126\/science.276.5312.599","article-title":"Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo","volume":"276","author":"Sandrock","year":"1997","journal-title":"Science"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1002\/jnr.24231","article-title":"Clinical relevance of terminal Schwann cells: An overlooked component of the neuromuscular junction","volume":"96","author":"Santosa","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"17213","DOI":"10.1073\/pnas.1103318108","article-title":"Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition","volume":"108","author":"Schmidt","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1083\/jcb.201107083","article-title":"Neuregulin\/ErbB regulate neuromuscular junction development by phosphorylation of \u03b1-dystrobrevin","volume":"195","author":"Schmidt","year":"2011","journal-title":"J. Cell Biol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/415321a","article-title":"RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone","volume":"415","author":"Schoch","year":"2002","journal-title":"Nature"},{"key":"B183","doi-asserted-by":"publisher","first-page":"5852","DOI":"10.1038\/sj.emboj.7601425","article-title":"Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release","volume":"25","author":"Schoch","year":"2006","journal-title":"EMBO J."},{"key":"B184","doi-asserted-by":"publisher","first-page":"8181","DOI":"10.1523\/JNEUROSCI.1345-04.2004","article-title":"Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation","volume":"24","author":"Schwander","year":"2004","journal-title":"J. Neurosci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1083\/jcb.113.5.1133","article-title":"Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle","volume":"113","author":"Sealock","year":"1991","journal-title":"J. Cell Biol."},{"key":"B186","first-page":"34","volume":"27","author":"Searle","year":"1962","journal-title":"Mouse News Lett."},{"key":"B187","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.neuron.2006.08.027","article-title":"An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model","volume":"51","author":"Seburn","year":"2006","journal-title":"Neuron"},{"key":"B188","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/emboj.2011.467","article-title":"CSP\u03b1 knockout causes neurodegeneration by impairing SNAP-25 function","volume":"31","author":"Sharma","year":"2012","journal-title":"EMBO J."},{"key":"B189","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1006\/excr.2001.5435","article-title":"Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth","volume":"273","author":"She","year":"2002","journal-title":"Exp. Cell Res."},{"key":"B190","doi-asserted-by":"publisher","first-page":"e34625","DOI":"10.7554\/eLife.34625","article-title":"Motoneuron Wnts regulate neuromuscular junction development","volume":"7","author":"Shen","year":"2018","journal-title":"eLife"},{"key":"B191","doi-asserted-by":"publisher","first-page":"29395","DOI":"10.1038\/srep29395","article-title":"Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration","volume":"6","author":"Shin","year":"2016","journal-title":"Sci. Rep."},{"key":"B192","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/297402a0","article-title":"Wasted, a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia","volume":"297","author":"Shultz","year":"1982","journal-title":"Nature"},{"key":"B193","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1139\/h97-014","article-title":"Morphological adaptations of neuromuscular junctions depend on fiber type","volume":"22","author":"Sieck","year":"1997","journal-title":"Can. J. Appl. Physiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/oxfordjournals.jhered.a106505","article-title":"Ducky, a new second chromosome mutation in the mouse","volume":"46","author":"Snell","year":"1955","journal-title":"J. Hered."},{"key":"B195","doi-asserted-by":"publisher","first-page":"736978","DOI":"10.3389\/fmed.2021.736978","article-title":"Alpha-synuclein aggregation in Parkinson\u2019s disease","volume":"8","author":"Srinivasan","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"B196","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1177\/002215540004800506","article-title":"Fiber type composition of the vastus lateralis muscle of young men and women","volume":"48","author":"Staron","year":"2000","journal-title":"J. Histochem Cytochem"},{"key":"B197","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1523\/JNEUROSCI.4644-03.2004","article-title":"Neurobeachin is essential for neuromuscular synaptic transmission","volume":"24","author":"Su","year":"2004","journal-title":"J. Neurosci."},{"key":"B198","doi-asserted-by":"publisher","first-page":"6130","DOI":"10.1074\/jbc.M114.616680","article-title":"ClipR-59 interacts with Elmo2 and modulates myoblast fusion","volume":"290","author":"Sun","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B199","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1523\/JNEUROSCI.2992-16.2016","article-title":"Muscle fibers secrete FGFBP1 to slow degeneration of neuromuscular synapses during aging and progression of ALS","volume":"37","author":"Taetzsch","year":"2017","journal-title":"J. Neurosci."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1091\/mbc.12.5.1421","article-title":"Role of Rab3 GDP\/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction","volume":"12","author":"Tanaka","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"B201","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/s0896-6273(01)80027-1","article-title":"Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9","volume":"23","author":"Thaler","year":"1999","journal-title":"Neuron"},{"key":"B202","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1750-1326-10-3","article-title":"Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction","volume":"10","author":"Vaden","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B203","doi-asserted-by":"publisher","first-page":"14863","DOI":"10.1073\/pnas.1002220107","article-title":"Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise","volume":"107","author":"Valdez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B204","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1073\/pnas.1001624108","article-title":"Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits","volume":"108","author":"Valkova","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B205","doi-asserted-by":"publisher","first-page":"6021","DOI":"10.1523\/JNEUROSCI.20-16-06021.2000","article-title":"Neuropathology in mice expressing human alpha-synuclein","volume":"20","author":"van der Putten","year":"2000","journal-title":"J. Neurosci."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1023\/B:NEUR.0000021907.68461.9c","article-title":"Structural alterations at the neuromuscular junctions of matrix metalloproteinase 3 null mutant mice","volume":"32","author":"VanSaun","year":"2003","journal-title":"J. Neurocytol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/1097-4695(20000905)44:3<369:aid-neu7>3.0.co;2-z","article-title":"Matrix metalloproteinase-3 removes agrin from synaptic basal lamina","volume":"43","author":"VanSaun","year":"2000","journal-title":"J. Neurobiol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1242\/dev.067264","article-title":"Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"B209","doi-asserted-by":"publisher","first-page":"14140","DOI":"10.1073\/pnas.0704070104","article-title":"Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter","volume":"104","author":"Wang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1523\/JNEUROSCI.4660-04.2005","article-title":"Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2","volume":"25","author":"Wang","year":"2005","journal-title":"J. Neurosci."},{"key":"B211","doi-asserted-by":"publisher","first-page":"10788","DOI":"10.1523\/JNEUROSCI.2132-09.2009","article-title":"Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"B212","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.1242\/dev.02696","article-title":"LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction","volume":"133","author":"Weatherbee","year":"2006","journal-title":"Development"},{"key":"B213","doi-asserted-by":"publisher","first-page":"24849","DOI":"10.1038\/srep24849","article-title":"Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm","volume":"6","author":"Willadt","year":"2016","journal-title":"Sci. Rep."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice","volume":"326","author":"Williams","year":"2009","journal-title":"Science"},{"key":"B215","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/ng1006","article-title":"Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease","volume":"32","author":"Wilson","year":"2002","journal-title":"Nat. Genet."},{"key":"B216","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.1523\/JNEUROSCI.14-06-03688.1994","article-title":"Activity-induced changes in synaptic release sites at the crayfish neuromuscular junction","volume":"14","author":"Wojtowicz","year":"1994","journal-title":"J. Neurosci."},{"key":"B217","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/s0301-0082(00)00055-1","article-title":"Safety factor at the neuromuscular junction","volume":"64","author":"Wood","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nn.2747","article-title":"Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse","volume":"14","author":"Yang","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B219","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/s0896-6273(01)00287-2","article-title":"Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation","volume":"30","author":"Yang","year":"2001","journal-title":"Neuron"},{"key":"B220","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1242\/jcs.167544","article-title":"A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions","volume":"128","author":"Zahavi","year":"2015","journal-title":"J. Cell Sci."},{"key":"B221","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuron.2008.10.006","article-title":"LRP4 serves as a coreceptor of agrin","volume":"60","author":"Zhang","year":"2008","journal-title":"Neuron"},{"key":"B222","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neuron.2012.01.029","article-title":"Identification of CSP\u03b1 clients reveals a role in dynamin 1 regulation","volume":"74","author":"Zhang","year":"2012","journal-title":"Neuron"},{"key":"B223","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.stem.2018.02.012","article-title":"Dissecting the functional consequences of de novo DNA methylation dynamics in human motor neuron differentiation and physiology","volume":"22","author":"Ziller","year":"2018","journal-title":"Cell Stem Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1216726\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T12:14:52Z","timestamp":1691151292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1216726\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":223,"alternative-id":["10.3389\/fcell.2023.1216726"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1216726","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"article-number":"1216726"}}