{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:09:38Z","timestamp":1785409778832,"version":"3.56.0"},"reference-count":210,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress environment of tumors. Here, we discuss the mutual influences between glucose deprivation and other features of the tumor microenvironment, such as hypoxia, immune escape, low pH, and oxidative stress. In the face of a series of stress responses brought by glucose deficiency, different types of tumors have different coping mechanisms. We summarize the tumor studies on glucose deficiency in the last decade and review the genes and pathways that determine the fate of tumors under harsh conditions. It turns out that most of these genes help tumor cells survive in glucose-deprivation conditions. The development of related inhibitors may bring new opportunities for the treatment of tumors.<\/jats:p>","DOI":"10.3389\/fcell.2023.1275543","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:19:06Z","timestamp":1698823146000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade"],"prefix":"10.3389","volume":"11","author":[{"given":"Yingnan","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.1074\/jbc.M411662200","article-title":"Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells","volume":"280","author":"Ahmad","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1073\/pnas.0913860107","article-title":"ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS","volume":"107","author":"Alexander","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fcell.2019.00004","article-title":"Hypoxia-Modified cancer cell metabolism","volume":"7","author":"Al Tameemi","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3802","DOI":"10.3390\/cancers12123802","article-title":"Characteristics of the tumor microenvironment that influence immune cell functions: hypoxia, oxidative stress, metabolic alterations","volume":"12","author":"Augustin","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3390\/cells9051249","article-title":"A new pathway promotes adaptation of human glioblastoma cells to glucose starvation","volume":"9","author":"Azzalin","year":"2020","journal-title":"Cells"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1038\/s41467-021-23004-3","article-title":"ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer","volume":"12","author":"Baik","year":"2021","journal-title":"Nat. Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1080\/15548627.2021.1886767","article-title":"PRKAA\/AMPK\u03b1 phosphorylation switches the role of RASAL2 from a suppressor to an activator of autophagy","volume":"17","author":"Bao","year":"2021","journal-title":"Autophagy"},{"key":"B8","doi-asserted-by":"publisher","first-page":"R187","DOI":"10.1530\/erc-12-0085","article-title":"The reactive stroma microenvironment and prostate cancer progression","volume":"19","author":"Barron","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1158\/2159-8290.cd-20-1808","article-title":"Therapeutic targeting of the tumor microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.3390\/cells11111800","article-title":"AMPK modulates the metabolic adaptation of C6 glioma cells in glucose-deprived conditions without affecting glutamate transport","volume":"11","author":"Belo do Nascimento","year":"2022","journal-title":"Cells"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1097\/CCM.0b013e318174de32","article-title":"Treating hyperglycemia improves skeletal muscle protein metabolism in cancer patients after major surgery","volume":"36","author":"Biolo","year":"2008","journal-title":"Crit. Care Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/s0891-5849(98)00217-2","article-title":"Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells","volume":"26","author":"Blackburn","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.1158\/1078-0432.ccr-16-2410","article-title":"LKB1 expression Correlates with increased survival in patients with advanced non-small cell lung cancer treated with chemotherapy and bevacizumab","volume":"23","author":"Bonanno","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13046-023-02779-x","article-title":"Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts","volume":"42","author":"Boso","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00109-007-0281-3","article-title":"Hypoxia and cancer","volume":"85","author":"Brahimi-Horn","year":"2007","journal-title":"J. Mol. Med. Berl."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.3892\/ijo.2016.3760","article-title":"FOXO3a orchestrates glioma cell responses to starvation conditions and promotes hypoxia-induced cell death","volume":"49","author":"Brucker","year":"2016","journal-title":"Int. J. Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1016\/j.molcel.2021.06.021","article-title":"SnapShot: cancer metabolism","volume":"81","author":"Brunner","year":"2021","journal-title":"Mol. Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.tem.2018.01.008","article-title":"Starvation, stress resistance, and cancer","volume":"29","author":"Buono","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"B19","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.ccell.2016.06.023","article-title":"Regulation of OGT by URI in response to glucose confers c-MYC-dependent survival mechanisms","volume":"30","author":"Bur\u00e9n","year":"2016","journal-title":"Cancer Cell"},{"key":"B20","first-page":"14383","article-title":"HRP-3 protects the hepatoma cells from glucose deprivation-induced apoptosis","volume":"8","author":"Cai","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e2448","DOI":"10.1038\/cddis.2016.355","article-title":"Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells","volume":"7","author":"Cai","year":"2016","journal-title":"Cell Death Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1002\/bies.201670911","article-title":"The hypoxic microenvironment: a determinant of cancer stem cell evolution","volume":"38","author":"Carnero","year":"2016","journal-title":"Bioessays"},{"key":"B23","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/ijms21010157","article-title":"Tumor microenvironment: a metabolic player that Shapes the immune response","volume":"21","author":"Cassim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1002\/eji.200838289","article-title":"Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells","volume":"38","author":"Cham","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.4049\/jimmunol.174.8.4670","article-title":"Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells","volume":"174","author":"Cham","year":"2005","journal-title":"J. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e15691","DOI":"10.7554\/eLife.15691","article-title":"A nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosis","volume":"5","author":"Chao","year":"2016","journal-title":"Elife"},{"key":"B28","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41421-022-00406-1","article-title":"PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation","volume":"8","author":"Chen","year":"","journal-title":"Cell Discov."},{"key":"B29","doi-asserted-by":"publisher","first-page":"jcs259609","DOI":"10.1242\/jcs.259609","article-title":"AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation","volume":"135","author":"Chen","year":"","journal-title":"J. Cell Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.3390\/cells9071598","article-title":"ROS mediate xCT-dependent cell death in human breast cancer cells under glucose deprivation","volume":"9","author":"Chen","year":"2020","journal-title":"Cells"},{"key":"B31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41568-020-00312-2","article-title":"Endoplasmic reticulum stress signals in the tumour and its microenvironment","volume":"21","author":"Chen","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/s41467-018-04815-3","article-title":"Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1158\/0008-5472.can-15-2921","article-title":"Metabolic stress-induced phosphorylation of KAP1 Ser473 blocks mitochondrial Fusion in breast cancer cells","volume":"76","author":"Cheng","year":"2016","journal-title":"Cancer Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.bbrc.2013.01.074","article-title":"Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells","volume":"432","author":"Choi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s10792-022-02492-2","article-title":"A relatively low glucose promotes the proliferation of vascular endothelial cells by suppressing VEGFR2 O-GlcNAcylation and its proteasome degradation","volume":"43","author":"Deng","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e2020215118","DOI":"10.1073\/pnas.2020215118","article-title":"Selective autophagy of AKAP11 activates cAMP\/PKA to fuel mitochondrial metabolism and tumor cell growth","volume":"118","author":"Deng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","author":"Denko","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.mito.2023.02.011","article-title":"The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells","volume":"69","author":"Dharaskar","year":"2023","journal-title":"Mitochondrion"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.celrep.2017.01.051","article-title":"The mTOR and PP2A pathways regulate PHD2 phosphorylation to Fine-Tune HIF1\u03b1 levels and colorectal cancer cell survival under hypoxia","volume":"18","author":"Di Conza","year":"","journal-title":"Cell Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/j.celrep.2017.02.081","article-title":"PHD2 targeting overcomes breast cancer cell death upon glucose starvation in a PP2A\/B55\u03b1-mediated manner","volume":"18","author":"Di Conza","year":"","journal-title":"Cell Rep."},{"key":"B41","doi-asserted-by":"publisher","first-page":"22538","DOI":"10.1038\/srep22538","article-title":"Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death","volume":"6","author":"Ding","year":"2016","journal-title":"Sci. Rep."},{"key":"B42","doi-asserted-by":"publisher","first-page":"7291","DOI":"10.1093\/nar\/gks452","article-title":"Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation","volume":"40","author":"Druz","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/j.bpj.2016.03.040","article-title":"Interstitial pressure in pancreatic ductal adenocarcinoma is Dominated by a Gel-Fluid Phase","volume":"110","author":"DuFort","year":"2016","journal-title":"Biophys. J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"10122","DOI":"10.1038\/s41598-018-28074-w","article-title":"Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells","volume":"8","author":"Endo","year":"2018","journal-title":"Sci. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1158\/0008-5472.can-12-2796","article-title":"Acidity generated by the tumor microenvironment drives local invasion","volume":"73","author":"Estrella","year":"2013","journal-title":"Cancer Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"510","DOI":"10.7150\/ijms.39557","article-title":"Enhanced expression of asparagine synthetase under glucose-deprived conditions promotes esophageal squamous cell carcinoma development","volume":"17","author":"Fang","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.yexcr.2017.11.028","article-title":"Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer","volume":"362","author":"Fang","year":"2018","journal-title":"Exp. Cell Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"17815","DOI":"10.18632\/oncotarget.7404","article-title":"AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation","volume":"7","author":"Ferretti","year":"2016","journal-title":"Oncotarget"},{"key":"B49","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/b978-0-12-397927-8.00009-9","article-title":"Targeting the tumor stroma as a novel therapeutic approach for prostate cancer","volume":"65","author":"Franco","year":"2012","journal-title":"Adv. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/onc.2017.345","article-title":"Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms","volume":"37","author":"Fu","year":"2018","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0282223","DOI":"10.1371\/journal.pone.0282223","article-title":"Acss2\/HIF-2 signaling facilitates colon cancer growth and metastasis","volume":"18","author":"Garcia","year":"2023","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.redox.2018.03.017","article-title":"GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress","volume":"17","author":"Gonzalez-Menendez","year":"2018","journal-title":"Redox Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.semcancer.2012.02.009","article-title":"Tumor metabolism as modulator of immune response and tumor progression","volume":"22","author":"Gottfried","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11427-019-1562-y","article-title":"Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival","volume":"63","author":"Guo","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s11658-018-0088-y","article-title":"Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis","volume":"23","author":"Gwangwa","year":"2018","journal-title":"Cell Mol. Biol. Lett."},{"key":"B56","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.cell.2015.08.012","article-title":"Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses","volume":"162","author":"Ho","year":"2015","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.1038\/onc.2015.415","article-title":"NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer","volume":"35","author":"Hong","year":"2016","journal-title":"Oncogene"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1158\/0008-5472.can-11-3831","article-title":"Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma","volume":"72","author":"Hu","year":"2012","journal-title":"Cancer Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"6235","DOI":"10.3748\/wjg.v22.i27.6235","article-title":"Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression","volume":"22","author":"Hu","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/s41419-022-05177-x","article-title":"Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells","volume":"13","author":"Hyro\u0161\u0161ov\u00e1","year":"2022","journal-title":"Cell Death Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1111\/cas.13086","article-title":"Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine","volume":"107","author":"Ikeda","year":"2016","journal-title":"Cancer Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e96168","DOI":"10.1371\/journal.pone.0096168","article-title":"Glucose deprivation induces G2\/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells","volume":"9","author":"Isono","year":"2014","journal-title":"PLoS One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e00479-16","DOI":"10.1128\/mcb.00479-16","article-title":"Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors","volume":"37","author":"Iurlaro","year":"2017","journal-title":"Mol. Cell Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-bioeng-071813-105259","article-title":"The role of Mechanical forces in tumor growth and therapy","volume":"16","author":"Jain","year":"2014","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"B66","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1042\/ebc20190041","article-title":"Metabolism","volume":"64","author":"Judge","year":"2020","journal-title":"Essays Biochem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"6666","DOI":"10.1002\/jcp.30329","article-title":"Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity","volume":"236","author":"Kalimuthu","year":"2021","journal-title":"J. Cell Physiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"B69","first-page":"526","article-title":"Energy stress-induced lncRNA HAND2-AS1 represses HIF1\u03b1-mediated energy metabolism and inhibits osteosarcoma progression","volume":"8","author":"Kang","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"26200","DOI":"10.18632\/oncotarget.15429","article-title":"Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT","volume":"8","author":"Kanska","year":"2017","journal-title":"Oncotarget"},{"key":"B71","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3390\/cancers11030316","article-title":"Tumor Neovascularization and developments in therapeutics","volume":"11","author":"Katayama","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1038\/s41467-019-10015-4","article-title":"Competition for nutrients and its role in controlling immune responses","volume":"10","author":"Kedia-Mehta","year":"2019","journal-title":"Nat. Commun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1126\/science.1224409","article-title":"SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions","volume":"338","author":"Keller","year":"2012","journal-title":"Science"},{"key":"B74","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.15252\/embj.201696239","article-title":"The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation","volume":"36","author":"Khan","year":"2017","journal-title":"Embo J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1113\/jp280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"175","DOI":"10.18632\/genesandcancer.17","article-title":"NDRG2 overexpression enhances glucose deprivation-mediated apoptosis in breast cancer cells via inhibition of the LKB1-AMPK pathway","volume":"5","author":"Kim","year":"2014","journal-title":"Genes Cancer"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.cmet.2017.04.004","article-title":"Autophagy and tumor metabolism","volume":"25","author":"Kimmelman","year":"2017","journal-title":"Cell Metab."},{"key":"B78","doi-asserted-by":"publisher","first-page":"102649","DOI":"10.1016\/j.isci.2021.102649","article-title":"KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition","volume":"24","author":"Koppula","year":"2021","journal-title":"iScience"},{"key":"B79","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1158\/1541-7786.mcr-06-0150","article-title":"Translating\" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways","volume":"4","author":"Koumenis","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"167","DOI":"10.18388\/abp.2013_1967","article-title":"Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells","volume":"60","author":"Kr\u0119towski","year":"2013","journal-title":"Acta Biochim. Pol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1111\/febs.14406","article-title":"Sestrin2 facilitates glutamine-dependent transcription of PGC-1\u03b1 and survival of liver cancer cells under glucose limitation","volume":"285","author":"Kumar","year":"2018","journal-title":"Febs J."},{"key":"B82","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2021.01.010","article-title":"The hexosamine biosynthetic pathway and cancer: current knowledge and future therapeutic strategies","volume":"503","author":"Lam","year":"2021","journal-title":"Cancer Lett."},{"key":"B83","doi-asserted-by":"publisher","first-page":"476","DOI":"10.14348\/molcells.2023.0011","article-title":"Stem cell properties of gastric cancer stem-like cells under stress conditions are regulated via the c-Fos\/UCH-L3\/\u03b2-Catenin Axis","volume":"46","author":"Lee","year":"2023","journal-title":"Mol. Cells"},{"key":"B84","doi-asserted-by":"publisher","first-page":"jcs259090","DOI":"10.1242\/jcs.259090","article-title":"Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells","volume":"135","author":"Lee","year":"2022","journal-title":"J. Cell Sci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41420-023-01411-3","article-title":"Sestrin2-mediated disassembly of stress granules dampens aerobic glycolysis to overcome glucose starvation","volume":"9","author":"Li","year":"","journal-title":"Cell Death Discov."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1002\/hep.31641","article-title":"Ras Homolog family member F, Filopodia associated promotes hepatocellular carcinoma metastasis by altering the metabolic Status of cancer cells through RAB3D","volume":"73","author":"Li","year":"","journal-title":"Hepatology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"114865","DOI":"10.1016\/j.biopha.2023.114865","article-title":"Combination of niclosamide and quinacrine inactivates Akt\/HK2\/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation","volume":"163","author":"Li","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B88","doi-asserted-by":"publisher","first-page":"jcs255273","DOI":"10.1242\/jcs.255273","article-title":"AKR1B10 negatively regulates autophagy through reducing GAPDH upon glucose starvation in colon cancer","volume":"134","author":"Li","year":"","journal-title":"J. Cell Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41419-017-0158-5","article-title":"The responsively decreased PKM2 facilitates the survival of pancreatic cancer cells in hypoglucose","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis."},{"key":"B90","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","article-title":"Autophagy and autophagy-related proteins in cancer","volume":"19","author":"Li","year":"","journal-title":"Mol. Cancer"},{"key":"B91","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.canlet.2020.03.007","article-title":"AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation","volume":"478","author":"Li","year":"","journal-title":"Cancer Lett."},{"key":"B92","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.bbrc.2023.07.029","article-title":"Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response","volume":"675","author":"Li","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2353115","DOI":"10.1155\/2022\/2353115","article-title":"Energy-stress-mediated AMPK activation promotes GPX4-dependent ferroptosis through the JAK2\/STAT3\/P53 Axis in renal cancer","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B94","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12935-015-0164-6","article-title":"The association between Salt-inducible kinase 2 (SIK2) and gamma isoform of the regulatory subunit B55 of PP2A (B55gamma) contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K","volume":"15","author":"Li","year":"2015","journal-title":"Cancer Cell Int."},{"key":"B95","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00018-015-2070-4","article-title":"Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression","volume":"73","author":"Li","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"857968","DOI":"10.3389\/fonc.2022.857968","article-title":"Mitochondrion-localized SND1 promotes Mitophagy and liver cancer progression through PGAM5","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Oncol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1038\/onc.2014.204","article-title":"MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect","volume":"34","author":"Lin","year":"2015","journal-title":"Oncogene"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.7150\/thno.29538","article-title":"Gastric cancer cells escape metabolic stress via the DLC3\/MACC1 axis","volume":"9","author":"Lin","year":"2019","journal-title":"Theranostics"},{"key":"B99","first-page":"87","article-title":"HSF1 promotes the inhibition of EMT-associated migration by low glucose via directly regulating Snail1 expression in HCC cells","volume":"22","author":"Liu","year":"2016","journal-title":"Discov. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"617","DOI":"10.7150\/ijbs.29689","article-title":"Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2","volume":"15","author":"Liu","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1582-4934.2003.tb00202.x","article-title":"Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line","volume":"7","author":"Liu","year":"2003","journal-title":"J. Cell Mol. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/s41419-021-04212-7","article-title":"Tumor-suppressive function of EZH2 is through inhibiting glutaminase","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e143377","DOI":"10.1172\/jci143377","article-title":"Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma","volume":"131","author":"Loong","year":"2021","journal-title":"J. Clin. Invest"},{"key":"B105","doi-asserted-by":"publisher","first-page":"5539","DOI":"10.7150\/ijbs.71809","article-title":"Thioredoxin 1 supports colorectal cancer cell survival and promotes migration and invasion under glucose deprivation through interaction with G6PD","volume":"18","author":"Lu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"4650","DOI":"10.1038\/s41388-020-1305-5","article-title":"SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle","volume":"39","author":"Lu","year":"2020","journal-title":"Oncogene"},{"key":"B107","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41420-022-00987-6","article-title":"MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer","volume":"8","author":"Luo","year":"2022","journal-title":"Cell Death Discov."},{"key":"B108","doi-asserted-by":"publisher","first-page":"15795","DOI":"10.1007\/s13277-016-5382-6","article-title":"An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism","volume":"37","author":"Luo","year":"2016","journal-title":"Tumour Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic interactions in the tumor microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/cas.15168","article-title":"P90 ribosomal S6 kinase confers cancer cell survival by mediating checkpoint kinase 1 degradation in response to glucose stress","volume":"113","author":"Ma","year":"2022","journal-title":"Cancer Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/1878-0261.12403","article-title":"SCF\u03b2-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation","volume":"13","author":"Ma","year":"2019","journal-title":"Mol. Oncol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13046-023-02723-z","article-title":"Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing","volume":"42","author":"Ma","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1038\/s41598-020-57657-9","article-title":"Activation of pH-Sensing receptor OGR1 (GPR68) induces ER stress via the IRE1\u03b1\/JNK pathway in an Intestinal epithelial cell Model","volume":"10","author":"Maeyashiki","year":"2020","journal-title":"Sci. Rep."},{"key":"B114","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.bbadis.2010.02.002","article-title":"Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes","volume":"1802","author":"Marambio","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/sj.onc.1208325","article-title":"Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer","volume":"24","author":"May","year":"2005","journal-title":"Oncogene"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/s41419-018-1244-z","article-title":"GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation","volume":"9","author":"Meng","year":"2018","journal-title":"Cell Death Dis."},{"key":"B117","doi-asserted-by":"publisher","first-page":"e27713","DOI":"10.7554\/eLife.27713","article-title":"Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition","volume":"6","author":"Muir","year":"2017","journal-title":"Elife"},{"key":"B118","doi-asserted-by":"publisher","first-page":"e329","DOI":"10.1038\/oncsis.2017.34","article-title":"Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions","volume":"6","author":"Murai","year":"2017","journal-title":"Oncogenesis"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.3390\/ijms20112761","article-title":"Quercetin regulates the integrated stress response to improve memory","volume":"20","author":"Nakagawa","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.3892\/ijo.2014.2367","article-title":"HIF-1\u03b1 activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells","volume":"44","author":"Nishimoto","year":"2014","journal-title":"Int. J. Oncol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/cells10051188","article-title":"Extracellular acidification induces Lysosomal Dysregulation","volume":"10","author":"Ordway","year":"2021","journal-title":"Cells"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e56628","DOI":"10.1371\/journal.pone.0056628","article-title":"Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation","volume":"8","author":"Owada","year":"2013","journal-title":"PLoS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"e1005931","DOI":"10.1371\/journal.pgen.1005931","article-title":"Protein kinase A activation promotes cancer cell resistance to glucose starvation and Anoikis","volume":"12","author":"Palorini","year":"2016","journal-title":"PLoS Genet."},{"key":"B124","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.bbrc.2017.01.018","article-title":"NDRG2 overexpression suppresses hepatoma cells survival during metabolic stress through disturbing the activation of fatty acid oxidation","volume":"483","author":"Pan","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B125","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12916-023-02727-8","article-title":"PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models","volume":"21","author":"Park","year":"2023","journal-title":"BMC Med."},{"key":"B126","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s13258-021-01196-8","article-title":"Ezh2 promotes TR\u03b2 lysine methylation-mediated degradation in hepatocellular carcinoma","volume":"44","author":"Park","year":"2022","journal-title":"Genes Genomics"},{"key":"B127","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1093\/carcin\/bgw058","article-title":"\u03b2III-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells","volume":"37","author":"Parker","year":"2016","journal-title":"Carcinogenesis"},{"key":"B128","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.canlet.2021.07.027","article-title":"HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways","volume":"518","author":"Penugurti","year":"2021","journal-title":"Cancer Lett."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1093\/annonc\/mdw168","article-title":"Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy","volume":"27","author":"Pitt","year":"2016","journal-title":"Ann. Oncol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s11033-022-08090-w","article-title":"Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer","volume":"50","author":"Qu","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.freeradbiomed.2019.09.020","article-title":"Glucose starvation-induced oxidative stress causes mitochondrial dysfunction and apoptosis via Prohibitin 1 upregulation in human breast cancer cells","volume":"145","author":"Raut","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.freeradbiomed.2021.02.018","article-title":"Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation","volume":"166","author":"Ren","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"101154","DOI":"10.1016\/j.redox.2019.101154","article-title":"Critical role of AMPK in redox regulation under glucose starvation","volume":"25","author":"Ren","year":"2019","journal-title":"Redox Biol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/cvr\/cvq045","article-title":"Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling","volume":"86","author":"Rey","year":"2010","journal-title":"Cardiovasc Res."},{"key":"B135","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1038\/s41388-020-1260-1","article-title":"Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation","volume":"39","author":"Ricciardiello","year":"2020","journal-title":"Oncogene"},{"key":"B136","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.molcel.2013.12.019","article-title":"Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition","volume":"53","author":"Roberts","year":"2014","journal-title":"Mol. Cell"},{"key":"B137","doi-asserted-by":"publisher","first-page":"12252","DOI":"10.1038\/s41598-018-29708-9","article-title":"Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer","volume":"8","author":"Romero-Cordoba","year":"2018","journal-title":"Sci. Rep."},{"key":"B138","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1172\/jci40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J. Clin. Invest"},{"key":"B140","doi-asserted-by":"publisher","first-page":"2023.01.30.526207","DOI":"10.1101\/2023.01.30.526207","article-title":"Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma","author":"Saggese","year":"2023","journal-title":"bioRxiv"},{"key":"B141","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","article-title":"ER stress-induced cell death mechanisms","volume":"1833","author":"Sano","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B142","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ccell.2014.12.002","article-title":"Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress","volume":"27","author":"Schug","year":"2015","journal-title":"Cancer Cell"},{"key":"B143","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/onc.2009.441","article-title":"Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics","volume":"29","author":"Semenza","year":"2010","journal-title":"Oncogene"},{"key":"B144","doi-asserted-by":"publisher","first-page":"360","DOI":"10.14348\/molcells.2022.2242","article-title":"SKP2 contributes to AKT activation by ubiquitination degradation of PHLPP1, Impedes autophagy, and facilitates the survival of thyroid carcinoma","volume":"46","author":"Shao","year":"2023","journal-title":"Mol. Cells"},{"key":"B145","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00441-016-2389-7","article-title":"Mesenchymal-epithelial signalling in tumour microenvironment: role of high-mobility group Box 1","volume":"365","author":"Sharma","year":"2016","journal-title":"Cell Tissue Res."},{"key":"B146","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ceb.2006.10.005","article-title":"Glucose metabolism and cancer","volume":"18","author":"Shaw","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"4767","DOI":"10.1074\/jbc.M117.816785","article-title":"Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells","volume":"293","author":"Sheikh","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1089\/ars.2009.2501","article-title":"Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species","volume":"11","author":"Shimizu","year":"2009","journal-title":"Antioxid. Redox Signal"},{"key":"B149","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.4103\/0973-1482.55133","article-title":"Glucose deprivation-induced metabolic oxidative stress and cancer therapy","volume":"5","author":"Simons","year":"2009","journal-title":"J. Cancer Res. Ther."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1034205","DOI":"10.3389\/fonc.2023.1034205","article-title":"Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival","volume":"13","author":"Singh","year":"2023","journal-title":"Front. Oncol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"e0171940","DOI":"10.1371\/journal.pone.0171940","article-title":"Oxidative stress-mediated NF\u03baB phosphorylation upregulates p62\/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy","volume":"12","author":"Song","year":"2017","journal-title":"PLoS One"},{"key":"B152","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1749-6632.2000.tb06199.x","article-title":"Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism?","volume":"899","author":"Spitz","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.3390\/ijms24043356","article-title":"The Interleukin-11\/IL-11 receptor promotes glioblastoma survival and invasion under glucose-starved conditions through enhanced glutaminolysis","volume":"24","author":"Stuart","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"74299","DOI":"10.18632\/oncotarget.19402","article-title":"Effect of p53 on pancreatic cancer-glucose tolerance abnormalities by regulating transglutaminase 2 in resistance to glucose metabolic stress","volume":"8","author":"Su","year":"2017","journal-title":"Oncotarget"},{"key":"B155","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.bbrc.2016.02.064","article-title":"AKT-p53 axis protect cancer cells from autophagic cell death during nutrition deprivation","volume":"471","author":"Sudhagar","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B156","doi-asserted-by":"publisher","first-page":"e44235","DOI":"10.7554\/eLife.44235","article-title":"Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability","volume":"8","author":"Sullivan","year":"2019","journal-title":"Elife"},{"key":"B157","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/cr.2015.33","article-title":"cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions","volume":"25","author":"Sun","year":"2015","journal-title":"Cell Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.bbcan.2018.06.005","article-title":"Metabolic reprogramming for cancer cells and their microenvironment: beyond the Warburg Effect","volume":"1870","author":"Sun","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"B159","doi-asserted-by":"publisher","first-page":"13561","DOI":"10.1073\/pnas.1121572109","article-title":"Keap1 degradation by autophagy for the maintenance of redox homeostasis","volume":"109","author":"Taguchi","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B160","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bbrc.2020.12.079","article-title":"LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway","volume":"537","author":"Takahashi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B161","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.7150\/thno.38087","article-title":"JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy","volume":"10","author":"Tan","year":"2020","journal-title":"Theranostics"},{"key":"B162","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1038\/s41467-019-11447-8","article-title":"LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc","volume":"10","author":"Tang","year":"2019","journal-title":"Nat. Commun."},{"key":"B163","doi-asserted-by":"publisher","first-page":"109329","DOI":"10.1016\/j.cellsig.2019.05.014","article-title":"The cystine\/glutamate antiporter xCT is a key regulator of EphA2 S897 phosphorylation under glucose-limited conditions","volume":"62","author":"Teramoto","year":"2019","journal-title":"Cell Signal"},{"key":"B164","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2199-14-27","article-title":"An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2","volume":"14","author":"Terashima","year":"2013","journal-title":"BMC Mol. Biol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"146446","DOI":"10.1016\/j.gene.2022.146446","article-title":"The absence of cellular glucose triggers oncogene AEG-1 that instigates VEGFC in HCC: a possible genetic root cause of angiogenesis","volume":"826","author":"Umapathy","year":"2022","journal-title":"Gene"},{"key":"B166","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1186\/s12967-023-04440-9","article-title":"SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism","volume":"21","author":"Varghese","year":"2023","journal-title":"J. Transl. Med."},{"key":"B167","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s43018-022-00393-y","article-title":"Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors","volume":"3","author":"Vaziri-Gohar","year":"2022","journal-title":"Nat. Cancer"},{"key":"B168","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.1038\/s41467-023-38921-8","article-title":"Increased glucose availability sensitizes pancreatic cancer to chemotherapy","volume":"14","author":"Vaziri-Gohar","year":"2023","journal-title":"Nat. Commun."},{"key":"B169","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3389\/fonc.2018.00617","article-title":"Metabolic Dependencies in pancreatic cancer","volume":"8","author":"Vaziri-Gohar","year":"2018","journal-title":"Front. Oncol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.freeradbiomed.2018.04.009","article-title":"Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation","volume":"120","author":"Walker","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"B171","doi-asserted-by":"publisher","first-page":"109923","DOI":"10.1016\/j.cellsig.2021.109923","article-title":"Phosphorylation at Ser10 triggered p27 degradation and promoted gallbladder carcinoma cell migration and invasion by regulating stathmin1 under glucose deficiency","volume":"80","author":"Wang","year":"2021","journal-title":"Cell Signal"},{"key":"B172","doi-asserted-by":"publisher","first-page":"6711","DOI":"10.18632\/oncotarget.6817","article-title":"HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress","volume":"7","author":"Wang","year":"","journal-title":"Oncotarget"},{"key":"B173","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.7150\/jca.21148","article-title":"Cpt1c regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions","volume":"8","author":"Wang","year":"2017","journal-title":"J. Cancer"},{"key":"B174","doi-asserted-by":"publisher","first-page":"e232","DOI":"10.1038\/oncsis.2016.41","article-title":"PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions","volume":"5","author":"Wang","year":"","journal-title":"Oncogenesis"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/s41419-022-05466-5","article-title":"4EBP1 senses extracellular glucose deprivation and initiates cell death signaling in lung cancer","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"B176","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the Origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"B177","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41421-022-00423-0","article-title":"GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation","volume":"8","author":"Wei","year":"2022","journal-title":"Cell Discov."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1159\/000491622","article-title":"SKP2 promotes hepatocellular carcinoma progression through nuclear AMPK-SKP2-CARM1 signaling transcriptionally regulating nutrient-deprived autophagy induction","volume":"47","author":"Wei","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.7150\/ijbs.76704","article-title":"SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma","volume":"19","author":"Wei","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41568-021-00344-2","article-title":"Autophagy in tumour immunity and therapy","volume":"21","author":"Xia","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"B181","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41419-022-04801-0","article-title":"Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex","volume":"13","author":"Xia","year":"2022","journal-title":"Cell Death Dis."},{"key":"B182","doi-asserted-by":"publisher","first-page":"e144703","DOI":"10.1172\/jci144703","article-title":"Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation","volume":"131","author":"Xiang","year":"2021","journal-title":"J. Clin. Invest"},{"key":"B183","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.taap.2019.04.017","article-title":"HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator","volume":"373","author":"Xiao","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"107753","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B185","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.1074\/jbc.RA119.012213","article-title":"High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine\/glutamate transporter xCT (SLC7A11)","volume":"295","author":"Yamaguchi","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B186","doi-asserted-by":"publisher","first-page":"109874","DOI":"10.1016\/j.cellsig.2020.109874","article-title":"Epidermal growth factor promotes glioblastoma cell death under glucose deprivation via upregulation of xCT (SLC7A11)","volume":"78","author":"Yamamoto","year":"2021","journal-title":"Cell Signal"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3390\/cancers11101460","article-title":"Glucose metabolism in pancreatic cancer","volume":"11","author":"Yan","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B188","first-page":"3896","article-title":"MOB1A regulates glucose deprivation-induced autophagy via IL6-STAT3 pathway in gallbladder carcinoma","volume":"10","author":"Yang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"B189","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.1038\/s41388-019-0764-z","article-title":"Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma","volume":"38","author":"Yang","year":"2019","journal-title":"Oncogene"},{"key":"B190","doi-asserted-by":"publisher","first-page":"e00207","DOI":"10.1042\/bsr20150090","article-title":"Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death","volume":"35","author":"Yang","year":"2015","journal-title":"Biosci. Rep."},{"key":"B191","doi-asserted-by":"publisher","first-page":"5877","DOI":"10.5483\/bmbrep.2023-0029","article-title":"Regulation of glucose and glutamine metabolism to overcome cisplatin resistance in intrahepatic cholangiocarcinoma","author":"Yang","year":"2023","journal-title":"BMB Rep."},{"key":"B192","doi-asserted-by":"publisher","first-page":"39694","DOI":"10.18632\/oncotarget.9233","article-title":"Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"B193","doi-asserted-by":"publisher","first-page":"102065","DOI":"10.1016\/j.redox.2021.102065","article-title":"Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions","volume":"46","author":"Ying","year":"2021","journal-title":"Redox Biol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.3390\/cancers11121993","article-title":"Glucose depletion enhances the stem cell phenotype and gemcitabine resistance of cholangiocarcinoma Organoids through AKT phosphorylation and reactive oxygen species","volume":"11","author":"Yoshikawa","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1533033819870781","DOI":"10.1177\/1533033819870781","article-title":"Curcumin regulates the progression of colorectal cancer via LncRNA NBR2\/AMPK pathway","volume":"18","author":"Yu","year":"2019","journal-title":"Technol. Cancer Res. Treat."},{"key":"B196","doi-asserted-by":"publisher","first-page":"9570","DOI":"10.1039\/d1nr02159a","article-title":"Supramolecular nanovesicles for synergistic glucose starvation and hypoxia-activated gene therapy of cancer","volume":"13","author":"Yue","year":"2021","journal-title":"Nanoscale"},{"key":"B197","doi-asserted-by":"publisher","first-page":"e2201210","DOI":"10.1002\/advs.202201210","article-title":"Vanguard is a glucose deprivation-Responsive long non-Coding RNA essential for Chromatin Remodeling-Reliant DNA Repair","volume":"9","author":"Zhang","year":"","journal-title":"Adv. Sci. (Weinh)"},{"key":"B198","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jcmgh.2022.03.009","article-title":"Targeting USP9X-AMPK Axis in ARID1A-deficient hepatocellular carcinoma","volume":"14","author":"Zhang","year":"","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1038\/s41388-021-01749-x","article-title":"Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis","volume":"40","author":"Zhang","year":"2021","journal-title":"Oncogene"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2016.11.023","article-title":"Blocking preferential glucose uptake sensitizes liver tumor-initiating cells to glucose restriction and sorafenib treatment","volume":"388","author":"Zhang","year":"","journal-title":"Cancer Lett."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1111\/cas.13562","article-title":"Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect","volume":"109","author":"Zhang","year":"2018","journal-title":"Cancer Sci."},{"key":"B202","doi-asserted-by":"publisher","first-page":"e2615","DOI":"10.1038\/cddis.2017.14","article-title":"ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function","volume":"8","author":"Zhang","year":"","journal-title":"Cell Death Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"9854904","DOI":"10.34133\/2022\/9854904","article-title":"lncRNA HITT inhibits lactate production by Repressing PKM2 Oligomerization to reduce tumor growth and macrophage Polarization","volume":"2022","author":"Zhao","year":"2022","journal-title":"Res. (Wash D C)"},{"key":"B204","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1186\/s12935-021-02416-7","article-title":"Glucose starvation suppresses gastric cancer through targeting miR-216a-5p\/Farnesyl-Diphosphate Farnesyltransferase 1 axis","volume":"21","author":"Zhao","year":"2021","journal-title":"Cancer Cell Int."},{"key":"B205","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1016\/j.celrep.2018.08.066","article-title":"CARM1 Methylates GAPDH to regulate glucose metabolism and is suppressed in liver cancer","volume":"24","author":"Zhong","year":"2018","journal-title":"Cell Rep."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.7150\/jca.64195","article-title":"Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation","volume":"13","author":"Zhou","year":"2022","journal-title":"J. Cancer"},{"key":"B207","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/15384101.2021.1885236","article-title":"LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22\/TCF7 axis","volume":"20","author":"Zhu","year":"2021","journal-title":"Cell Cycle"},{"key":"B208","doi-asserted-by":"publisher","first-page":"1175151","DOI":"10.3389\/fonc.2023.1175151","article-title":"SIRT1 mediated gastric cancer progression under glucose deprivation through the FoxO1-Rab7-autophagy axis","volume":"13","author":"Zhu","year":"2023","journal-title":"Front. Oncol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1158\/0008-5472.can-21-1179","article-title":"Low glucose-induced overexpression of HOXC-AS3 promotes metabolic reprogramming of breast cancer","volume":"82","author":"Zhu","year":"2022","journal-title":"Cancer Res."},{"key":"B210","doi-asserted-by":"publisher","first-page":"3623","DOI":"10.1111\/cas.15905","article-title":"Metabolic stress-induced reciprocal loop of long noncoding RNA ZFAS1 and ZEB1 promotes epithelial-mesenchymal transition and metastasis of pancreatic cancer cells","volume":"114","author":"Zhuo","year":"2023","journal-title":"Cancer Sci."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1275543\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:19:12Z","timestamp":1698823152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2023.1275543\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":210,"alternative-id":["10.3389\/fcell.2023.1275543"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2023.1275543","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"article-number":"1275543"}}