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Unfortunately, there is so far no effective interventions to delay the progression and development of KOA. There is a pressing need for explorations and developments of new effective interventions. Photobiomodulation therapy (PBMT), also known as low-level light therapy (LLLT), has attracted widespread attention in treating KOA because it is drug-free, non-invasive, safe and useful with rarely reported side effects. It provides the biological stimulatory effects primarily by enhancing the activity of mitochondrial cytochrome c oxidase. This stimulation, in turn, fosters cell proliferation and tissue regeneration. In addition to this, the paper provides a concise overview of the light parameters and the effectiveness of PBMT when applied in the treatment of KOA patients in clinical settings. It also delves into the experimental evidence supporting the modulatory effects of PBMT and its potential underlying mechanisms in addressing synovitis, cartilage degeneration, and pain resolution.<\/jats:p>","DOI":"10.3389\/fcell.2023.1286025","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T18:30:42Z","timestamp":1700159442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Current advances of photobiomodulation therapy in treating knee osteoarthritis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yanlei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanbo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.physio.2021.03.011","article-title":"Effects of low-level and high-intensity laser therapy as adjunctive to rehabilitation exercise on pain, stiffness and function in knee osteoarthritis: a systematic review and meta-analysis","volume":"114","author":"Ahmad","year":"2022","journal-title":"Physiotherapy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.3390\/life13071519","article-title":"Comparison between low-level and high-intensity laser therapy as an adjunctive treatment for knee osteoarthritis: a randomized, double-blind clinical trial","volume":"13","author":"Ahmad","year":"2023","journal-title":"Life (Basel)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1177\/0269215511425962","article-title":"Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study","volume":"26","author":"Alfredo","year":"2012","journal-title":"Clin. 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