{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:39:49Z","timestamp":1793911189865,"version":"4.8.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Adipose tissue-derived mesenchymal stem cells are promising contributors to regenerative medicine, exhibiting the ability to regenerate tissues and modulate the immune system, which is particularly beneficial for addressing chronic inflammatory ulcers and wounds. Despite their inherent capabilities, research suggests that pretreatment amplifies therapeutic effectiveness.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Our experimental design exposed adipose-derived mesenchymal stem cells to six inflammatory factors for 24\u00a0h. We subsequently evaluated gene expression and proteome profile alterations and observed the wound closure rate post-treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Specific pretreatments, such as IL\u20101\u03b2, notably demonstrated an accelerated wound\u2010healing process. Analysis of gene and protein expression profiles revealed alterations in pathways associated with tissue regeneration.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> This suggests that licensed cells exhibit potentially higher therapeutic efficiency than untreated cells, shedding light on optimizing regenerative strategies using adipose tissue-derived stem cells.<\/jats:p>","DOI":"10.3389\/fcell.2024.1367242","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:37:49Z","timestamp":1711600669000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Licensing effects of inflammatory factors and TLR ligands on the regenerative capacity of adipose-derived mesenchymal stem cells"],"prefix":"10.3389","volume":"12","author":[{"given":"Di\u00e1na","family":"Sz\u0171cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Monostori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Mikl\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n G.","family":"P\u00e1hi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szil\u00e1rd","family":"P\u00f3liska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Ver\u00e9b","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"1054","author":"Aggarwal Sp","year":"2005","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1152\/physiol.00021.2019","article-title":"Adipose tissue-derived stem cells: immunomodulatory effects and therapeutic potential","volume":"352","author":"Al-Ghadban","year":"2020","journal-title":"Physiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e35036","DOI":"10.1371\/journal.pone.0035036","article-title":"Macrophage-associated mesenchymal stem cells assume an activated, migratory, pro-inflammatory phenotype with increased IL-6 and CXCL10 secretion","volume":"74","author":"Anton","year":"2012","journal-title":"Plos One"},{"key":"B4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/s0301-472x(01)00769-x","article-title":"Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo","volume":"301","author":"Bartholomew","year":"2002","journal-title":"Exp. Hematol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/stcltm\/szac081","article-title":"Adipose-derived stromal cells for chronic wounds: scientific evidence and roadmap toward clinical practice","volume":"121","author":"Brembilla","year":"2023","journal-title":"Stem Cell Transl. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13040-019-0204-1","article-title":"ViSEAGO: a Bioconductor package for clustering biological functions using Gene Ontology and semantic similarity","volume":"12","author":"Brionne","year":"2019","journal-title":"BioData Min."},{"key":"B7","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.3390\/cells10123433","article-title":"Adipose tissue-derived mesenchymal stem cells","volume":"10","author":"Bunnell Ba","year":"2021","journal-title":"Cells"},{"key":"B8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.imlet.2015.06.003","article-title":"Mesenchymal stem cells and adaptive immune responses","volume":"1682","author":"Cao","year":"2015","journal-title":"Immunol. Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3390\/ijms19010267","article-title":"Mechanical activation of adipose tissue and derived mesenchymal stem cells: novel anti-inflammatory properties","volume":"191","author":"Carelli","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cytogfr.2019.05.006","article-title":"Mesenchymal stem cells immunomodulation: the road to IFN-gamma licensing and the path ahead","volume":"47","author":"Carvalho","year":"2019","journal-title":"Cytokine and growth factor Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for treatment of infected diabetic foot ulcers","volume":"545","author":"Chang","year":"2021","journal-title":"Accounts Chem. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.2353\/ajpath.2009.080879","article-title":"Immunoglobulin expression in non-lymphoid lineage and neoplastic cells","volume":"1744","author":"Chen","year":"2009","journal-title":"Am. J. pathology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1111813","DOI":"10.3389\/fimmu.2023.1111813","article-title":"Toward transplantation tolerance with adipose tissue-derived therapeutics","volume":"14","author":"Cheng","year":"2023","journal-title":"Front. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1182\/bloodadvances.2017006205","article-title":"Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFN\u03b3 priming","volume":"111","author":"Chinnadurai","year":"2017","journal-title":"Blood Adv."},{"key":"B15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/jir.2006.0037","article-title":"Human mesenchymal stem cells constitutively express chemokines and chemokine receptors that can be upregulated by cytokines, IFN-beta, and Copaxone","volume":"271","author":"Croitoru-Lamoury","year":"2007","journal-title":"J. Interferon Cytokine Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/j.1365-2249.2010.04256.x","article-title":"Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells","volume":"1623","author":"Crop","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"865601","DOI":"10.1155\/2010\/865601","article-title":"Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential","volume":"2010","author":"DelaRosa","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jdiacomp.2018.05.009","article-title":"Osteopontin levels in plasma, muscles, and bone in patient with non-healing diabetic foot ulcers: a new player in wound healing process?","volume":"328","author":"Feldbrin","year":"2018","journal-title":"J. Diabetes Complicat"},{"key":"B19","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/mt.2011.189","article-title":"Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation","volume":"201","author":"Fran\u00e7ois","year":"2012","journal-title":"Mol. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1524-475X.2009.00454.x","article-title":"Migration of bone marrow-derived mesenchymal stem cells induced by tumor necrosis factor-alpha and its possible role in wound healing","volume":"172","author":"Fu","year":"2009","journal-title":"Wound repair Regen."},{"key":"B21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.jcyt.2016.02.002","article-title":"Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model","volume":"185","author":"Fuenzalida","year":"2016","journal-title":"Cytotherapy"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.5966\/sctm.2015-0285","article-title":"Mesenchymal stem cell-derived exosomes promote fracture healing in a mouse model","volume":"512","author":"Furuta","year":"2016","journal-title":"Stem Cell Transl. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/scrt2","article-title":"Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications","volume":"11","author":"Ghannam","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"3218","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1387\/ijdb.180074pf","article-title":"Plasticity of human adipose-derived stem cells - relevance to tissue repair","volume":"62","author":"Guasti","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/eji.201948336","article-title":"TNF-\u03b1 and IL-1\u03b2 sensitize human MSC for IFN-\u03b3 signaling and enhance neutrophil recruitment","volume":"512","author":"Hackel","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/jid.2011.64","article-title":"Tumor necrosis factor-alpha-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms","volume":"1317","author":"Heo","year":"2011","journal-title":"J. investigative dermatology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1111\/jcmm.13492","article-title":"Preconditioning influences mesenchymal stem cell properties in vitro and in vivo","volume":"223","author":"Hu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1113982","DOI":"10.3389\/fcvm.2023.1113982","article-title":"Mesenchymal stem cell-based therapy for non-healing wounds due to chronic limb-threatening ischemia: a review of preclinical and clinical studies","volume":"10","author":"Huerta","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/dgd.12049","article-title":"Adipose-derived mesenchymal stem cells and regenerative medicine","volume":"553","author":"Konno","year":"2013","journal-title":"Dev. Growth Differ."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/060012","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"B32","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"242","author":"Krampera","year":"2006","journal-title":"Stem Cells"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.stem.2021.09.006","article-title":"Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy","volume":"2810","author":"Krampera","year":"2021","journal-title":"Cell stem Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.3390\/Ijms23052425","article-title":"Adipose tissue-derived mesenchymal stem\/stromal cells and their contribution to angiogenic processes in tissue regeneration","volume":"23","author":"Krawczenko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"963689720945682","DOI":"10.1177\/0963689720945682","article-title":"Modulation of T-cell activation markers expression by the adipose tissue-derived mesenchymal stem cells of patients with rheumatic diseases","volume":"29","author":"Kuca-Warnawin","year":"2020","journal-title":"Cell Transplant."},{"key":"B36","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s13287-020-01840-2","article-title":"Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE","volume":"111","author":"Kurte","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1021\/pr900898n","article-title":"Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells","volume":"94","author":"Lee","year":"2010","journal-title":"J. Proteome Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00018-017-2473-5","article-title":"Interactions between mesenchymal stem cells and the immune system","volume":"7413","author":"Li","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/cdd.2012.26","article-title":"Mesenchymal stem cells: a double-edged sword in regulating immune responses","volume":"199","author":"Li","year":"2012","journal-title":"Cell death Differ."},{"key":"B40","doi-asserted-by":"publisher","first-page":"145347","DOI":"10.1016\/j.gene.2020.145347","article-title":"Single-cell profiles of human bone marrow-derived mesenchymal stromal cells after IFN-\u03b3 and TNF-\u03b1 licensing","volume":"771","author":"Lu","year":"2021","journal-title":"Gene"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/Ijms21041306","article-title":"Hopes and limits of adipose-derived stem cells (ADSCs) and mesenchymal stem cells (MSCs) in wound healing","volume":"214","author":"Mazini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1182\/blood-2003-11-3909","article-title":"Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation","volume":"10312","author":"Meisel","year":"2004","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e48777","DOI":"10.15252\/embr.201948777","article-title":"TLR4-dependent shaping of the wound site by MSCs accelerates wound healing","volume":"215","author":"Munir","year":"2020","journal-title":"Embo Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/cyto.a.23242","article-title":"Isolation, cultivation, and characterization of human mesenchymal stem cells","author":"Mushahary","year":"2018","journal-title":"Cytom. Part A"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1007\/s00018-019-03125-1","article-title":"Biological functions of mesenchymal stem cells and clinical implications","volume":"7617","author":"Naji","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1634\/stemcells.22-3-405","article-title":"Functional expression of HGF and HGF receptor\/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing","volume":"223","author":"Neuss","year":"2004","journal-title":"Stem Cells"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5124","DOI":"10.1111\/jcmm.16501","article-title":"Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration","volume":"2511","author":"Nieto-Nicolau","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"23103","DOI":"10.1038\/srep23103","article-title":"TLR3-\/4-Priming differentially promotes Ca(2+) signaling and cytokine expression and Ca(2+)-dependently augments cytokine release in hMSCs","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.cellimm.2017.11.010","article-title":"Tissue regeneration: the crosstalk between mesenchymal stem cells and immune response","volume":"326","author":"Qi","year":"2018","journal-title":"Cell. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1016\/j.transproceed.2009.06.119","article-title":"Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function","volume":"416","author":"Renner","year":"2009","journal-title":"Transplant. Proc."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.3390\/Ijms19103217","article-title":"The role of chemokines in wound healing","volume":"1910","author":"Ridiandries","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jtos.2019.01.006","article-title":"The therapeutic application of mesenchymal stem cells at the ocular surface","volume":"172","author":"Sahu","year":"2019","journal-title":"ocular Surf."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3924858","DOI":"10.1155\/2016\/3924858","article-title":"Preconditioning of human mesenchymal stem cells to enhance their regulation of the immune response","volume":"2016","author":"Saparov","year":"2016","journal-title":"Stem Cells Int."},{"key":"B55","doi-asserted-by":"publisher","first-page":"512","DOI":"10.18632\/oncotarget.13473","article-title":"Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation","volume":"81","author":"Shin","year":"2017","journal-title":"Oncotarget"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3109\/14653249.2012.706705","article-title":"Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms","volume":"1410","author":"Shohara","year":"2012","journal-title":"Cytotherapy"},{"key":"B57","doi-asserted-by":"publisher","first-page":"874698","DOI":"10.3389\/Fimmu.2022.874698","article-title":"Enhancing mesenchymal stromal cell potency: inflammatory licensing via mechanotransduction","volume":"13","author":"Skibber","year":"2022","journal-title":"Front. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"419","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.3390\/cells12151966","article-title":"Effect of inflammatory microenvironment on the regenerative capacity of adipose-derived mesenchymal stem cells","volume":"1215","author":"Szucs","year":"2023","journal-title":"Cells"},{"key":"B60","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s12967-015-0642-6","article-title":"LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b","volume":"13","author":"Ti","year":"2015","journal-title":"J. Transl. Med."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083987","article-title":"Inflammatory regulation by TNF-alpha-activated adipose-derived stem cells in the human bladder cancer microenvironment","volume":"228","author":"Ting","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3109\/13813455.2010.535835","article-title":"Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose\/muscle cross-talk","volume":"1172","author":"Trayhurn","year":"2011","journal-title":"Archives physiology Biochem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1089\/scd.2009.0418","article-title":"Mesenchymal stem cells inhibit complement activation by secreting factor H","volume":"1911","author":"Tu","year":"2010","journal-title":"Stem Cells Dev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"8847038","DOI":"10.1155\/2020\/8847038","article-title":"Vessel wall-derived mesenchymal stromal cells share similar differentiation potential and immunomodulatory properties with bone marrow-derived stromal cells","volume":"2020","author":"Vereb","year":"2020","journal-title":"Stem Cells Int."},{"key":"B65","doi-asserted-by":"publisher","first-page":"26227","DOI":"10.1038\/srep26227","article-title":"Role of human corneal stroma-derived mesenchymal-like stem cells in corneal immunity and wound healing","volume":"6","author":"Vereb","year":"2016","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1016\/j.injury.2022.09.041","article-title":"LPS-pretreatment adipose-derived mesenchymal stromal cells promote wound healing in diabetic rats by improving angiogenesis","volume":"53","author":"Wang","year":"2022","journal-title":"Injury"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ni.3002","article-title":"Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications","volume":"1511","author":"Wang","year":"2014","journal-title":"Nat. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e10088","DOI":"10.1371\/journal.pone.0010088","article-title":"A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype","volume":"54","author":"Waterman","year":"2010","journal-title":"Plos One"},{"key":"B69","doi-asserted-by":"publisher","first-page":"917790","DOI":"10.3389\/fimmu.2022.917790","article-title":"Cytokine activation reveals tissue-imprinted gene profiles of mesenchymal stromal cells","volume":"13","author":"Wiese","year":"2022","journal-title":"Front. Immunol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1002\/jcp.24255","article-title":"Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: perspectives from stem cell biology and molecular medicine","volume":"2285","author":"Wu","year":"2013","journal-title":"J. Cell. physiology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41419-020-03034-3","article-title":"Mesenchymal stem cells reverse EMT process through blocking the activation of NF-kappaB and Hedgehog pathways in LPS-induced acute lung injury","volume":"1110","author":"Xiao","year":"2020","journal-title":"Cell death Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3727\/096368910X508942","article-title":"Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn","volume":"196","author":"Yagi","year":"2010","journal-title":"Cell Transplant."},{"key":"B73","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","article-title":"GOSemSim: an R package for measuring semantic similarity among GO terms and gene products","volume":"267","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"B74","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41420-021-00550-9","article-title":"Current insights into the expression and functions of tumor-derived immunoglobulins","volume":"7","author":"Zhao","year":"2021","journal-title":"Cell Death Discov."},{"key":"B75","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","article-title":"Anatomical, physiological, and functional diversity of adipose tissue","volume":"271","author":"Zwick","year":"2018","journal-title":"Cell metab."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2024.1367242\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:38:24Z","timestamp":1711600704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2024.1367242\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":75,"alternative-id":["10.3389\/fcell.2024.1367242"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2024.1367242","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"article-number":"1367242"}}