{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:16:12Z","timestamp":1790957772124,"version":"4.1.0"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome characterized by the excessive accumulation of fat within liver cells, which can progress to end-stage liver disease in severe cases, posing a threat to life. Pyroptosis is a distinct, pro-inflammatory form of cell death, differing from traditional apoptosis. In recent years, there has been growing research interest in the association between pyroptosis and NAFLD, encompassing the mechanisms and functions of pyroptosis in the progression of NAFLD, as well as potential therapeutic targets. Controlled pyroptosis can activate immune cells, eliciting host immune responses to shield the body from harm. However, undue activation of pyroptosis may worsen inflammatory responses, induce cellular or tissue damage, disrupt immune responses, and potentially impact liver function. This review elucidates the involvement of pyroptosis and key molecular players, including NOD-like receptor thermal protein domain associated protein 3(NLRP3) inflammasome, gasdermin D (GSDMD), and the caspase family, in the pathogenesis and progression of NAFLD. It emphasizes the promising prospects of targeting pyroptosis as a therapeutic approach for NAFLD and offers valuable insights into future directions in the field of NAFLD treatment.<\/jats:p>","DOI":"10.3389\/fcell.2024.1407738","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:54:58Z","timestamp":1719982498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (NAFLD)"],"prefix":"10.3389","volume":"12","author":[{"given":"Shu-Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Bu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B2","doi-asserted-by":"publisher","first-page":"170375","DOI":"10.1016\/j.peptides.2020.170375","article-title":"Liraglutide ameliorates lipotoxicity-induced inflammation through the mTORC1 signalling pathway","volume":"133","author":"Ao","year":"2020","journal-title":"Peptides"},{"key":"B3","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/S0140-6736(15)00803-X","article-title":"Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study","volume":"387","author":"Armstrong","year":"2016","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.3389\/fimmu.2019.01309","article-title":"Gal-3 deficiency suppresses novosphyngobium aromaticivorans inflammasome activation and IL-17 driven autoimmune cholangitis in mice","volume":"10","author":"Arsenijevic","year":"2019","journal-title":"Front. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0234038","DOI":"10.1371\/journal.pone.0234038","article-title":"Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis","volume":"15","author":"Baeza-Raja","year":"2020","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"558525","DOI":"10.3389\/fphar.2020.558525","article-title":"Inulin exerts beneficial effects on non-alcoholic fatty liver disease via modulating gut microbiome and suppressing the lipopolysaccharide-toll-like receptor 4-m\u03c8-nuclear factor-\u03bab-nod-like receptor protein 3 pathway via gut-liver Axis in mice","volume":"11","author":"Bao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.immuni.2020.02.012","article-title":"Mitochondrial GSDMD pores DAMPen pyroptosis","volume":"52","author":"Barnett","year":"2020","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e48235","DOI":"10.15252\/embr.201948235","article-title":"A genome\u2010wide screen identifies IRF2 as a key regulator of caspase\u20104 in human cells","volume":"20","author":"Benaoudia","year":"2019","journal-title":"EMBO Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"877924","DOI":"10.3389\/fphar.2022.877924","article-title":"Protective effect of danshen zexie decoction against non-alcoholic fatty liver disease through inhibition of ROS\/NLRP3\/IL-1\u03b2 pathway by Nrf2 signaling activation","volume":"13","author":"Biao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s10753-017-0628-z","article-title":"NLRP3 deletion inhibits the non-alcoholic steatohepatitis development and inflammation in kupffer cells induced by palmitic acid","volume":"40","author":"Cai","year":"2017","journal-title":"Inflammation"},{"key":"B11","doi-asserted-by":"publisher","first-page":"114941","DOI":"10.1016\/j.taap.2020.114941","article-title":"Benzyl isothiocyanate ameliorates high-fat\/cholesterol\/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells","volume":"393","author":"Chen","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/s41418-023-01183-4","article-title":"GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p\/MARCH7\/NLRP3 axis-mediated pyroptosis","volume":"30","author":"Chen","year":"2023","journal-title":"Cell. Death Differ."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2901871","DOI":"10.1155\/2018\/2901871","article-title":"NLRP3 inflammasome formation and activation in nonalcoholic steatohepatitis: therapeutic target for antimetabolic syndrome remedy FTZ","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1002\/j.1460-2075.1996.tb00759.x","article-title":"A bacterial invasin induces macrophage apoptosis by binding directly to ICE","volume":"15","author":"Chen","year":"1996","journal-title":"EMBO J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/hep.22404","article-title":"Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes","volume":"48","author":"Cl\u00e9ment","year":"2008","journal-title":"Hepatology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/03602532.2017.1293683","article-title":"Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters","volume":"49","author":"Cobbina","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0966-842x(00)01936-3","article-title":"Pro-inflammatory programmed cell death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/hep.24341","article-title":"Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells","volume":"54","author":"Csak","year":"2011","journal-title":"Hepatology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev-pathmechdis-032521-102529","article-title":"Role of the inflammasome in liver disease","volume":"17","author":"de Carvalho Ribeiro","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1053\/j.gastro.2005.09.004","article-title":"NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis","volume":"129","author":"Dela Pe\u00f1a","year":"2005","journal-title":"Gastroenterology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.3389\/fimmu.2019.02926","article-title":"Absence of the caspases 1\/11 modulates liver global lipid profile and gut microbiota in high-fat-diet-induced obese mice","volume":"10","author":"De Sant Ana","year":"2020","journal-title":"Front. Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"154299","DOI":"10.1016\/j.metabol.2020.154299","article-title":"Metabolic liver disease in diabetes \u2013 from mechanisms to clinical trials","volume":"111","author":"Dewidar","year":"2020","journal-title":"Metabolism"},{"key":"B24","doi-asserted-by":"publisher","first-page":"28734","DOI":"10.1038\/srep28734","article-title":"New insights into salvianolic acid A action: regulation of the TXNIP\/NLRP3 and TXNIP\/ChREBP pathways ameliorates HFD-induced NAFLD in rats","volume":"6","author":"Ding","year":"2016","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1113883","DOI":"10.3389\/fimmu.2023.1113883","article-title":"Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages","volume":"14","author":"Drummer","year":"2023","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/s0966-842x(00)01945-4","article-title":"Dismantling the cryptococcus coat","volume":"9","author":"D Souza","year":"2001","journal-title":"Trends Microbiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"880298","DOI":"10.3389\/fimmu.2022.880298","article-title":"Association of inflammatory cytokines with non-alcoholic fatty liver disease","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00210-019-01773-5","article-title":"NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway","volume":"393","author":"Dwivedi","year":"2020","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"44292","DOI":"10.1007\/s11356-023-25258-4","article-title":"Association between perfluoroalkyl substances exposure and the prevalence of nonalcoholic fatty liver disease in the different sexes: a study from the National Health and Nutrition Examination Survey 2005-2018","volume":"30","author":"E","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-981-10-8684-7_3","article-title":"Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease","volume":"1061","author":"Farrell","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1186\/s12967-022-03692-1","article-title":"The p-STAT3\/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis","volume":"20","author":"Feng","year":"2022","journal-title":"J. Transl. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"28263","DOI":"10.1073\/pnas.2000466117","article-title":"Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP\/NF-\u03baB\/NLRP3 inflammasome circuit","volume":"117","author":"Flores-Costa","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"101270","DOI":"10.1016\/j.molmet.2021.101270","article-title":"Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH","volume":"53","author":"Fredrickson","year":"2021","journal-title":"Mol. Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.3390\/cells9102148","article-title":"The absence of NLRP3-inflammasome modulates hepatic fibrosis progression, lipid metabolism, and inflammation in KO NLRP3 mice during aging","volume":"9","author":"Gallego","year":"2020","journal-title":"Cells"},{"key":"B36","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell. Death Differ."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1120254","DOI":"10.3389\/fnut.2023.1120254","article-title":"Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-\u03baB\/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet","volume":"10","author":"Gao","year":"2023","journal-title":"Front. Nutr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J. Hepatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3892\/etm.2018.6300","article-title":"2,3,5,4\u2019-tetrahydroxy-stilbene-2-O-\u03b2-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease","volume":"16","author":"Han","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/hep4.1801","article-title":"Role of cholesterol-associated steatohepatitis in the development of NASH","volume":"6","author":"Horn","year":"2022","journal-title":"Hepatol. Commun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e0045","DOI":"10.1097\/HC9.0000000000000045","article-title":"Canagliflozin ameliorates the development of NAFLD by preventing NLRP3-mediated pyroptosis through FGF21-ERK1\/2 pathway","volume":"7","author":"Huang","year":"2023","journal-title":"Hepatol. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"154797","DOI":"10.1016\/j.metabol.2021.154797","article-title":"A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage","volume":"120","author":"Huang","year":"2021","journal-title":"Metabolism"},{"key":"B45","doi-asserted-by":"publisher","first-page":"21224","DOI":"10.1002\/jcp.28728","article-title":"Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high\u2010fat high cholesterol diet via regulating NF\u2010\u03baB and NLRP3 inflammasome pathway","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/antiox9111040","article-title":"Auranofin attenuates non-alcoholic fatty liver disease by suppressing lipid accumulation and NLRP3 inflammasome-mediated hepatic inflammation in vivo and in vitro","volume":"9","author":"Hwangbo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J. Exp. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"3711371","DOI":"10.1155\/2022\/3711371","article-title":"Dietary fatty acid regulation of the NLRP3 inflammasome via the TLR4\/NF-\u03baB signaling pathway affects chondrocyte pyroptosis","volume":"2022","author":"Jin","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"eaax4917","DOI":"10.1126\/scisignal.aax4917","article-title":"IRF2 transcriptionally induces GSDMD expression for pyroptosis","volume":"12","author":"Kayagaki","year":"2019","journal-title":"Sci. Signal."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1136\/gutjnl-2020-322509","article-title":"Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis","volume":"70","author":"Koh","year":"2021","journal-title":"Gut"},{"key":"B51","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41598-022-26896-3","article-title":"IL-1\u03b2 neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH","volume":"13","author":"Kucsera","year":"2023","journal-title":"Sci. Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1053\/jhep.2003.50316","article-title":"Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E","volume":"38","author":"Kugelmas","year":"2003","journal-title":"Hepatology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3390\/antiox9100924","article-title":"Involvement of HO-1 and autophagy in the protective effect of magnolol in hepatic steatosis-induced NLRP3 inflammasome activation in vivo and in vitro","volume":"9","author":"Kuo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"175091","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"13065","DOI":"10.3390\/ijms241713065","article-title":"Research progress of pyroptosis in fatty liver disease","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41420-022-00859-z","article-title":"Downregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI","volume":"8","author":"Li","year":"","journal-title":"Cell. Death Discov."},{"key":"B57","doi-asserted-by":"publisher","first-page":"110542","DOI":"10.1016\/j.biopha.2020.110542","article-title":"Role of the NLRP3 inflammasome in autoimmune diseases","volume":"130","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B58","doi-asserted-by":"publisher","first-page":"9390786","DOI":"10.1155\/2018\/9390786","article-title":"Chaihu-shugan-san decoction modulates intestinal microbe dysbiosis and alleviates chronic metabolic inflammation in NAFLD rats via the NLRP3 inflammasome pathway","volume":"2018","author":"Liang","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3390\/cells9041041","article-title":"The emerging role of MicroRNAs in NAFLD: highlight of MicroRNA-29a in modulating oxidative stress, inflammation, and beyond","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"B60","doi-asserted-by":"publisher","first-page":"8158","DOI":"10.26355\/eurrev_201909_19036","article-title":"Cardiolipin inhibitor ameliorates the non-alcoholic steatohepatitis through suppressing NLRP3 inflammasome activation","volume":"23","author":"Liu","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3389\/fphar.2017.00975","article-title":"Scutellarin suppresses NLRP3 inflammasome activation in macrophages and protects mice against bacterial sepsis","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"116424","DOI":"10.1016\/j.taap.2023.116424","article-title":"Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis","volume":"462","author":"Lo","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell."},{"key":"B64","doi-asserted-by":"publisher","first-page":"4","DOI":"10.22034\/IJI.2022.90579.2016","article-title":"LPS activated macrophages induced hepatocyte pyroptosis via P2X7R activation of NLRP3 in mice","volume":"19","author":"Luo","year":"2022","journal-title":"Iran. J. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jnutbio.2019.05.015","article-title":"Apigenin ameliorates HFD-induced NAFLD through regulation of the XO\/NLRP3 pathways","volume":"71","author":"Lv","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3760\/cma.j.cn501113-20200326-00142","article-title":"Study of the effect of liraglutide on the correlation between NLRP3 inflammasome and non-alcoholic fatty liver disease","volume":"30","author":"Ma","year":"2022","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"B67","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fphar.2020.00185","article-title":"Berberine inhibits nod-like receptor family pyrin domain containing 3 inflammasome activation and pyroptosis in nonalcoholic steatohepatitis via the ROS\/TXNIP Axis","volume":"11","author":"Mai","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J. Hepatol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1038\/ijo.2016.74","article-title":"Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-\/-.Leiden mice","volume":"40","author":"Morrison","year":"2016","journal-title":"Int. J. Obes. (Lond)"},{"key":"B70","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell. Metab."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.3390\/ijms22136969","article-title":"Fructose and the liver","volume":"22","author":"Muriel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3390\/biom12060824","article-title":"NAFLD: mechanisms, treatments, and biomarkers","volume":"12","author":"Nassir","year":"2022","journal-title":"Biomolecules"},{"key":"B74","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3390\/md19060318","article-title":"Attenuating effects of dieckol on high-fat diet-induced nonalcoholic fatty liver disease by decreasing the NLRP3 inflammasome and pyroptosis","volume":"19","author":"Oh","year":"2021","journal-title":"Mar. Drugs"},{"key":"B75","doi-asserted-by":"publisher","first-page":"101122","DOI":"10.1016\/j.molmet.2020.101122","article-title":"Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans","volume":"50","author":"Pafili","year":"2021","journal-title":"Mol. Metab."},{"key":"B76","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cellimm.2018.08.006","article-title":"Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release","volume":"332","author":"Pan","year":"2018","journal-title":"Cell. Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/met.2022.0006","article-title":"Nonalcoholic fatty liver disease patients exhibit reduced CD47 and increased sphingosine, cholesterol, and monocyte chemoattractant protein-1 levels in the erythrocyte membranes","volume":"20","author":"Papadopoulos","year":"2022","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"B78","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jhep.2022.08.022","article-title":"IL-6\/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease","volume":"78","author":"Park","year":"2023","journal-title":"J. Hepatol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1194\/jlr.M085613","article-title":"Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression","volume":"59","author":"Peng","year":"2018","journal-title":"J. Lipid Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"12200","DOI":"10.1038\/s41598-017-11744-6","article-title":"Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD","volume":"7","author":"Pierantonelli","year":"2017","journal-title":"Sci. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41419-018-1004-0","article-title":"Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway","volume":"9","author":"Qiu","year":"2018","journal-title":"Cell. Death Dis."},{"key":"B82","doi-asserted-by":"publisher","first-page":"115861","DOI":"10.1016\/j.bcp.2023.115861","article-title":"NLRP3 inflammasome in hepatic diseases: a pharmacological target","volume":"217","author":"Ramos-Tovar","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7447","DOI":"10.3390\/ijms23137447","article-title":"The P2x7r-NLRP3 and AIM2 inflammasome platforms mark the complexity\/severity of viral or metabolic liver damage","volume":"23","author":"Rossi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jhep.2021.11.009","article-title":"A new perspective on NAFLD: focusing on lipid droplets","volume":"76","author":"Scorletti","year":"2022","journal-title":"J. Hepatol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1864307","DOI":"10.1155\/2018\/1864307","article-title":"Exenatide delays the progression of nonalcoholic fatty liver disease in C57bl\/6 mice, which may involve inhibition of the NLRP3 inflammasome through the mitophagy pathway","volume":"2018","author":"Shao","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"B86","doi-asserted-by":"publisher","first-page":"669202","DOI":"10.3389\/fphys.2021.669202","article-title":"Gardenoside hinders caspase-1-mediated hepatocyte pyroptosis through the CTCF\/DPP4 signaling pathway","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Physiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"175270","DOI":"10.1016\/j.ejphar.2022.175270","article-title":"Baicalin improved hepatic injury of NASH by regulating NRF2\/HO-1\/NRLP3 pathway","volume":"934","author":"Shi","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"106195","DOI":"10.1016\/j.intimp.2020.106195","article-title":"Baicalin attenuates hepatic injury in non-alcoholic steatohepatitis cell model by suppressing inflammasome-dependent GSDMD-mediated cell pyroptosis","volume":"81","author":"Shi","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1186\/s12967-023-04380-4","article-title":"Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase","volume":"21","author":"Shi","year":"2023","journal-title":"J. Transl. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jhep.2023.03.038","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","volume":"79","author":"Tacke","year":"2023","journal-title":"J. Hepatol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1053\/j.gastro.2011.06.040","article-title":"Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis","volume":"141","author":"Van Rooyen","year":"2011","journal-title":"Gastroenterology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jhep.2015.11.022","article-title":"Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism","volume":"64","author":"Wan","year":"2016","journal-title":"J. Hepatol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3390\/nu13030856","article-title":"Ginseng saponin enriched in Rh1 and Rg2 ameliorates nonalcoholic fatty liver disease by inhibiting inflammasome activation","volume":"13","author":"Wang","year":"","journal-title":"Nutrients"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1111\/bph.14938","article-title":"Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3\/NF-\u03baB pathway in mice","volume":"177","author":"Wang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.bbrc.2020.11.009","article-title":"NLRP3 inflammasome inhibitor CY-09 reduces hepatic steatosis in experimental NAFLD mice","volume":"534","author":"Wang","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"B99","doi-asserted-by":"publisher","first-page":"115655","DOI":"10.1016\/j.envpol.2020.115655","article-title":"Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes","volume":"267","author":"Weng","year":"2020","journal-title":"Environ. Pollut."},{"key":"B100","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"","journal-title":"Hepatology"},{"key":"B101","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/hep.29523","article-title":"NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice","volume":"67","author":"Wree","year":"2018","journal-title":"Hepatology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s00109-014-1170-1","article-title":"NLRP3 inflammasome activation is required for fibrosis development in NAFLD","volume":"92","author":"Wree","year":"","journal-title":"J. Mol. Med. Berl."},{"key":"B103","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1038\/s41586-021-03478-3","article-title":"Gasdermin D pore structure reveals preferential release of mature interleukin-1","volume":"593","author":"Xia","year":"2021","journal-title":"Nature"},{"key":"B104","doi-asserted-by":"publisher","first-page":"7885","DOI":"10.1002\/jcp.27909","article-title":"What role does pyroptosis play in microbial infection?","volume":"234","author":"Xia","year":"2019","journal-title":"J. Cell. Physiology"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.ijbiomac.2018.09.151","article-title":"Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3\/6 pathways in a methionine choline deficient diet steatohepatitis mouse model","volume":"120","author":"Xiao","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1007\/s10792-022-02506-z","article-title":"GSDMD-mediated pyroptosis in retinal vascular inflammatory diseases: a review","volume":"43","author":"Xiaodong","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","article-title":"Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice","volume":"68","author":"Xu","year":"2018","journal-title":"J. Hepatol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.jhep.2015.01.019","article-title":"Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: one stone hits two birds","volume":"62","author":"Xu","year":"2015","journal-title":"J. Hepatol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1124\/dmd.118.082008","article-title":"Glycyrrhizin alleviates nonalcoholic steatohepatitis via modulating bile acids and meta-inflammation","volume":"46","author":"Yan","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"B110","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.3390\/ijms21082790","article-title":"Sweroside prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome","volume":"21","author":"Yang","year":"2020","journal-title":"IJMS"},{"key":"B111","doi-asserted-by":"publisher","first-page":"24399","DOI":"10.1038\/srep24399","article-title":"A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"B112","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.metabol.2014.02.003","article-title":"Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation","volume":"63","author":"Yang","year":"2014","journal-title":"Metabolism"},{"key":"B113","doi-asserted-by":"publisher","first-page":"115457","DOI":"10.1016\/j.jep.2022.115457","article-title":"Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis","volume":"296","author":"Ye","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1142\/S0192415X20500937","article-title":"Antrodia cinnamomea attenuates non-alcoholic steatohepatitis by suppressing NLRP3 inflammasome activation in vitro and in vivo","volume":"48","author":"Yen","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"111504","DOI":"10.1016\/j.biopha.2021.111504","article-title":"4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation","volume":"138","author":"Yen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B116","doi-asserted-by":"publisher","first-page":"9963534","DOI":"10.1155\/2021\/9963534","article-title":"Jiangzhi ligan decoction inhibits GSDMD-mediated canonical\/noncanonical pyroptosis pathways and alleviates high-fat diet-induced nonalcoholic fatty liver disease","volume":"2021","author":"Yin","year":"2021","journal-title":"Dis. Markers"},{"key":"B117","doi-asserted-by":"publisher","first-page":"6659445","DOI":"10.1155\/2021\/6659445","article-title":"Gegen qinlian decoction ameliorates nonalcoholic fatty liver disease in rats via oxidative stress, inflammation, and the NLRP3 signal Axis","volume":"2021","author":"Ying","year":"2021","journal-title":"Evidence-Based Complementary Altern. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"B119","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B120","doi-asserted-by":"publisher","first-page":"172715","DOI":"10.1016\/j.ejphar.2019.172715","article-title":"Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy","volume":"864","author":"Yu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","article-title":"Pharmacological inhibitors of the NLRP3 inflammasome","volume":"10","author":"Zahid","year":"2019","journal-title":"Front. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1096\/fj.201700602R","article-title":"Silybin inhibits NLRP3 inflammasome assembly through the NAD+\/SIRT2 pathway in mice with nonalcoholic fatty liver disease","volume":"32","author":"Zhang","year":"","journal-title":"FASEB J."},{"key":"B123","doi-asserted-by":"publisher","first-page":"110616","DOI":"10.1016\/j.intimp.2023.110616","article-title":"MiR-223-3p attenuates radiation-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages","volume":"122","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/s41374-018-0177-6","article-title":"Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis","volume":"99","author":"Zhang","year":"2019","journal-title":"Lab. Investig."},{"key":"B125","doi-asserted-by":"publisher","first-page":"643149","DOI":"10.3389\/fimmu.2021.643149","article-title":"Inflammasomes and fibrosis","volume":"12","author":"Zhang","year":"","journal-title":"Front. Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"108894","DOI":"10.1016\/j.abb.2021.108894","article-title":"Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats","volume":"705","author":"Zhang","year":"","journal-title":"Arch. Biochem. Biophys."},{"key":"B127","doi-asserted-by":"publisher","first-page":"4862","DOI":"10.1021\/acs.jafc.8b00944","article-title":"Amelioration of alcoholic liver steatosis by dihydroquercetin through the modulation of AMPK-dependent lipogenesis mediated by P2x7r-NLRP3-inflammasome activation","volume":"66","author":"Zhang","year":"","journal-title":"J. Agric. Food Chem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"119778","DOI":"10.1016\/j.lfs.2021.119778","article-title":"Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice","volume":"281","author":"Zhang","year":"","journal-title":"Life Sci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"8786424","DOI":"10.1155\/2020\/8786424","article-title":"Si-Wu-Tang alleviates nonalcoholic fatty liver disease via blocking TLR4-JNK and caspase-8-GSDMD signaling pathways","volume":"2020","author":"Zhang","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B130","doi-asserted-by":"publisher","first-page":"175291","DOI":"10.1016\/j.ejphar.2022.175291","article-title":"Trilobatin alleviates non-alcoholic fatty liver disease in high-fat diet plus streptozotocin-induced diabetic mice by suppressing NLRP3 inflammasome activation","volume":"933","author":"Zhang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"8597897","DOI":"10.1155\/2018\/8597897","article-title":"Salidroside attenuates high-fat diet-induced nonalcoholic fatty liver disease via AMPK-dependent TXNIP\/NLRP3 pathway","volume":"2018","author":"Zheng","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B132","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3389\/fendo.2018.00640","article-title":"Verapamil ameliorates hepatic metaflammation by inhibiting thioredoxin-interacting protein\/NLRP3 pathways","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B133","doi-asserted-by":"publisher","first-page":"e24940","DOI":"10.1097\/MD.0000000000024940","article-title":"Prevalence and risk factor analysis for the nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus","volume":"100","author":"Zhou","year":"2021","journal-title":"Med. Baltim."},{"key":"B134","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jcmgh.2021.04.009","article-title":"Caspase-11-Mediated hepatocytic pyroptosis promotes the progression of nonalcoholic steatohepatitis","volume":"12","author":"Zhu","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/358167a0","article-title":"Shigella flexneri induces apoptosis in infected macrophages","volume":"358","author":"Zychlinsky","year":"1992","journal-title":"Nature"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2024.1407738\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T04:55:06Z","timestamp":1719982506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2024.1407738\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":135,"alternative-id":["10.3389\/fcell.2024.1407738"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2024.1407738","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"article-number":"1407738"}}