{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:14:49Z","timestamp":1791360889618,"version":"4.3.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The Hippo\/YAP pathway is a signaling pathway that plays an important role in cell proliferation, survival, differentiation, cell fate determination, organ size, and tissue homeostasis. Lens epithelial cells (LECs), located on the anterior surface of the lens, are the parental cells responsible for growth and development of the transparent ocular lens. During lens development, LECs undergo a process of differentiation where they exit the cell cycle and transform into lens fiber cells (LFCs), which constitute the majority of the lens structure. YAP is involved in the proliferation and differentiation of LECs, the maintenance of nuclear morphology, cell polarity, cell apical polarity complex, and connexin morphology. The role of the ordered arrangement of LFCs has been demonstrated in several animal studies, and <jats:italic>Yap1<\/jats:italic> heterozygous deletion mice exhibit cataracts. The mechanism of the Hippo\/YAP pathway in the physiological activities and lesions of LECs is complex, which is of great significance to understanding the development of the lens and the pathogenesis of lens-related diseases.<\/jats:p>","DOI":"10.3389\/fcell.2025.1524814","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T08:53:07Z","timestamp":1742806387000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of the Hippo\/YAP pathway in the physiological activities and lesions of lens epithelial cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Shumei","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.cobme.2018.03.003","article-title":"New developments in mechanotransduction: cross talk of the Wnt, TGF-\u03b2 and Notch signalling pathways in reaction to shear stress","volume":"5","author":"Abuammah","year":"2018","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2633004020938061","DOI":"10.1177\/2633004020938061","article-title":"Congenital cataract: a guide to genetic and clinical management","volume":"1","author":"Bell","year":"2020","journal-title":"Ther. Adv. Rare Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41420-023-01791-6","article-title":"Uveitic glaucoma-like features in Yap conditional knockout mice","volume":"10","author":"Bitard","year":"2024","journal-title":"Cell Death Discov."},{"key":"B4","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s42255-021-00362-2","article-title":"STK3\/STK4 signalling in adipocytes regulates mitophagy and energy expenditure","volume":"3","author":"Cho","year":"2021","journal-title":"Nat. Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.3390\/cells10112925","article-title":"The multiple interactions of RUNX with the hippo\u2013YAP pathway","volume":"10","author":"Chuang","year":"2021","journal-title":"Cells"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1242\/dev.107953","article-title":"The cellular and molecular mechanisms of vertebrate lens development","volume":"141","author":"Cvekl","year":"2014","journal-title":"Development"},{"key":"B7","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.exer.2018.01.014","article-title":"A role for Hippo\/YAP-signaling in FGF-induced lens epithelial cell proliferation and fibre differentiation","volume":"169","author":"Dawes","year":"2018","journal-title":"Exp. Eye Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4103\/ijo.IJO_940_18","article-title":"Triangle sign in Morgagnian cataract","volume":"67","author":"Deshmukh","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41580-023-00644-5","article-title":"Control of stem cell renewal and fate by YAP and TAZ","volume":"24","author":"Driskill","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.1158\/0008-5472.CAN-23-2994","article-title":"TEAD inhibition overcomes YAP1\/TAZ-driven primary and acquired resistance to KRASG12C inhibitors","volume":"83","author":"Edwards","year":"2023","journal-title":"Cancer Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1093\/hmg\/ddh106","article-title":"A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)","volume":"13","author":"Fossdal","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.ophtha.2018.04.013","article-title":"Global prevalence of presbyopia and vision impairment from uncorrected presbyopia: systematic review, meta-analysis, and modelling","volume":"125","author":"Fricke","year":"2018","journal-title":"Ophthalmology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"818649","DOI":"10.3389\/fphys.2021.818649","article-title":"Physiological mechanisms regulating lens transport","volume":"12","author":"Giannone","year":"2021","journal-title":"Front. Physiology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/CMR.0000000000000911","article-title":"Combined Mcl-1 and YAP1\/TAZ inhibition for treatment of metastatic uveal melanoma","volume":"33","author":"Glinkina","year":"2023","journal-title":"Melanoma Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tcb.2015.05.002","article-title":"YAP and TAZ: a nexus for Hippo signaling and beyond","volume":"25","author":"Hansen","year":"2015","journal-title":"Trends Cell Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12906-017-1678-3","article-title":"The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy","volume":"17","author":"Hao","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.14336\/AD.2018.0910","article-title":"Deficiency of yes-associated protein induces cataract in mice","volume":"10","author":"He","year":"2019","journal-title":"Aging Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e23832","DOI":"10.1096\/fj.202400848R","article-title":"A role for YAP\/FOXM1\/Nrf2 axis in oxidative stress and apoptosis of cataract induced by UVB irradiation","volume":"38","author":"Hong","year":"2024","journal-title":"FASEB J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"663","DOI":"10.5483\/BMBRep.2023-0127","article-title":"C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1\/2-YAP signaling in cardiomyocytes","volume":"56","author":"Jin","year":"2023","journal-title":"BMB Rep."},{"key":"B21","first-page":"2654","article-title":"Parkin-directed mitophagy is required for lens cell survival upon exposure to cataract-associated environmental insults","volume":"56","author":"Kantorow","year":"2015","journal-title":"Investigative Ophthalmol. and Vis. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.2147\/OPTH.S259011","article-title":"Presbyopia - a review of current treatment options and emerging therapies","volume":"15","author":"Katz","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3485","DOI":"10.1038\/s41598-018-21828-6","article-title":"Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ","volume":"8","author":"Khanal","year":"2018","journal-title":"Sci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.4103\/ijo.IJO_1023_17","article-title":"Pediatric cataract","volume":"65","author":"Khokhar","year":"2017","journal-title":"Indian J. Ophthalmol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ydbio.2016.09.001","article-title":"Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye","volume":"419","author":"Kim","year":"2016","journal-title":"Dev. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.freeradbiomed.2016.07.016","article-title":"Mitochondrial oxygen metabolism in primary human lens epithelial cells: association with age, diabetes and glaucoma","volume":"97","author":"Kubota","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1167\/iovs.19-26893","article-title":"Lens stretching modulates lens epithelial cell proliferation via YAP regulation","volume":"60","author":"Kumar","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/dvdy.24628","article-title":"Hippo-yap signaling in ocular development and disease","volume":"247","author":"Lee","year":"2018","journal-title":"Dev. Dyn."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1016\/j.celrep.2019.03.021","article-title":"YAP\/TAZ activation drives uveal melanoma initiation and progression","volume":"29","author":"Li","year":"2019","journal-title":"Cell Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e22783","DOI":"10.1096\/fj.202201187RR","article-title":"Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1\u2010YAP\u2010PROX1 axis","volume":"37","author":"Li","year":"2023","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41536-021-00126-2","article-title":"The common YAP activation mediates corneal epithelial regeneration and repair with different-sized wounds","volume":"6","author":"Li","year":"2021","journal-title":"npj Regen. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1060","DOI":"10.1002\/iid3.1060","article-title":"TGF-\u03b2\/Smads signaling pathway, Hippo-YAP\/TAZ signaling pathway, and VEGF: their mechanisms and roles in vascular remodeling related diseases","volume":"11","author":"Liu","year":"","journal-title":"Immun. Inflamm. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"109255","DOI":"10.1016\/j.abb.2022.109255","article-title":"High MST2 expression regulates lens epithelial cell apoptosis in age-related cataracts through YAP1 targeting GLUT1","volume":"723","author":"Liu","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"key":"B34","doi-asserted-by":"publisher","first-page":"101112","DOI":"10.1016\/j.preteyeres.2022.101112","article-title":"The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens","volume":"92","author":"Liu","year":"","journal-title":"Prog. Retin. Eye Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/iovs.61.12.21","article-title":"Heterozygous loss of Yap1 in mice causes progressive cataracts","volume":"61","author":"Lu","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","article-title":"The Hippo pathway: Biology and pathophysiology","volume":"88","author":"Ma","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/s41598-020-58189-y","article-title":"Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap\/Taz transcriptional activation in lens epithelial cells and explants","volume":"10","author":"Maddala","year":"2020","journal-title":"Sci. Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e1269","DOI":"10.1038\/cddis.2014.218","article-title":"Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment","volume":"5","author":"Matsumoto","year":"2014","journal-title":"Cell Death Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6109","DOI":"10.1167\/iovs.11-8702","article-title":"Elastic properties of human lens zonules as a function of age in presbyopes","volume":"53","author":"Michael","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"101184","DOI":"10.1016\/j.isci.2020.101184","article-title":"A CTGF-YAP regulatory pathway is essential for angiogenesis and barriergenesis in the retina","volume":"23","author":"Moon","year":"2020","journal-title":"iScience"},{"key":"B41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-031-68453-1_9","article-title":"Ophthalmological pathology and medical and surgical management in eye disease cataract","volume-title":"Clinical ophthalmology: a guide to diagnosis and treatment","author":"Munteanu","year":"2024"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1111\/cas.15352","article-title":"Physiological and pathological roles of the Hippo-YAP\/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis","volume":"113","author":"Nishina","year":"2022","journal-title":"Cancer Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/j.1365-2443.2009.01292.x","article-title":"Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif","volume":"14","author":"Oka","year":"2009","journal-title":"Genes Cells"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1038\/s41388-023-02810-7","article-title":"AXL activates YAP through the EGFR-LATS1\/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma","volume":"42","author":"Okamoto","year":"2023","journal-title":"Oncogene"},{"key":"B45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bbrc.2019.01.065","article-title":"Low shear stress induces ERK nuclear localization and YAP activation to control the proliferation of breast cancer cells","volume":"510","author":"Qin","year":"2019","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1167\/iovs.12-11007","article-title":"Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ","volume":"54","author":"Raghunathan","year":"2013","journal-title":"Investigative Ophthalmol. and Vis. Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/cdd.2016.2","article-title":"Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation","volume":"23","author":"Rauch","year":"2016","journal-title":"Cell Death Differ."},{"key":"B48","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/02713683.2022.2088797","article-title":"A review of lens biomechanical contributions to presbyopia","volume":"48","author":"Rich","year":"2023","journal-title":"Curr. Eye Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","article-title":"\u03b2-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis","volume":"151","author":"Rosenbluh","year":"2012","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/jcp.28971","article-title":"Mst1 deletion reduces septic cardiomyopathy via activating Parkin-related mitophagy","volume":"235","author":"Shang","year":"2020","journal-title":"J. Cell Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ydbio.2013.12.037","article-title":"Dual function of Yap in the regulation of lens progenitor cells and cellular polarity","volume":"386","author":"Song","year":"2014","journal-title":"Dev. Biol."},{"key":"B52","first-page":"1162","article-title":"Age-related changes in human ciliary muscle and lens: a magnetic resonance imaging study","volume":"40","author":"Strenk","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ydbio.2020.12.018","article-title":"YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance","volume":"475","author":"Szulzewsky","year":"2021","journal-title":"Dev. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.3390\/biom13121767","article-title":"Understanding the role of yes-associated protein (YAP) signaling in the transformation of lens epithelial cells (EMT) and fibrosis","volume":"13","author":"Taiyab","year":"2023","journal-title":"Biomolecules"},{"key":"B55","doi-asserted-by":"publisher","first-page":"S27-S28","DOI":"10.1016\/j.ophtha.2019.12.029","article-title":"Elimination of posterior capsule opacification","volume":"127","author":"Tassignon","year":"2020","journal-title":"Ophthalmology"},{"key":"B56","first-page":"654","article-title":"The lens-corneal separation requires precision control of Hippo-Yap signaling","volume":"63","author":"Wang","year":"","journal-title":"Investigative Ophthalmol. Vis. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"188787","DOI":"10.1016\/j.bbcan.2022.188787","article-title":"Recent insight into the role and therapeutic potential of YAP\/TAZ in gastrointestinal cancers","volume":"1877","author":"Wang","year":"","journal-title":"Biochimica Biophysica Acta (BBA) - Rev. Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12974-023-02855-1","article-title":"ATP-P2X7R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension","volume":"20","author":"Wei","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1167\/iovs.09-4371","article-title":"The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens","volume":"51","author":"Wiley","year":"2010","journal-title":"Investigative Ophthalmol. and Vis. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.preteyeres.2018.09.004","article-title":"Presbyopia: effectiveness of correction strategies","volume":"68","author":"Wolffsohn","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.exer.2015.04.021","article-title":"Experimental models for posterior capsule opacification research","volume":"142","author":"Wormstone","year":"2016","journal-title":"Exp. Eye Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12964-023-01073-9","article-title":"ATXN3 promotes prostate cancer progression by stabilizing YAP","volume":"21","author":"Wu","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"B63","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.toxlet.2020.05.015","article-title":"Enhanced mitophagy mediated by the YAP\/Parkin pathway protects against DOX-induced cardiotoxicity","volume":"330","author":"Xiao","year":"2020","journal-title":"Toxicol. Lett."},{"key":"B64","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.bbrc.2013.08.071","article-title":"Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer","volume":"439","author":"Xiao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2023.01.039","article-title":"Cell response to mechanical microenvironment cues via Rho signaling: from mechanobiology to mechanomedicine","volume":"159","author":"Xie","year":"2023","journal-title":"Acta Biomater."},{"key":"B66","first-page":"83","article-title":"Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation","volume":"24","author":"Yan","year":"2018","journal-title":"Mol. Vis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1002\/jcp.30757","article-title":"Specific ablation of Hippo signalling component Yap1 in retinal progenitors and M\u00fcller cells results in late onset retinal degeneration","volume":"237","author":"Yang","year":"2022","journal-title":"J. Cell. Physiology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"107208","DOI":"10.1016\/j.jbc.2024.107208","article-title":"Upregulation of CYR61 by TGF-\u03b2 and YAP signaling exerts a counter-suppression of hepatocellular carcinoma","volume":"300","author":"Zhang","year":"","journal-title":"J. Biol. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1167\/iovs.63.8.24","article-title":"EGF receptor signaling modulates YAP activation and promotes experimental proliferative vitreoretinopathy","volume":"63","author":"Zhang","year":"2022","journal-title":"Investigative Ophthalmol. and Vis. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"116885","DOI":"10.1016\/j.taap.2024.116885","article-title":"Role of MST2\/YAP1 signaling pathway in retinal cells apoptosis and diabetic retinopathy","volume":"484","author":"Zhang","year":"","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s13000-015-0415-9","article-title":"High expression of TAZ indicates a poor prognosis in retinoblastoma","volume":"10","author":"Zhang","year":"2015","journal-title":"Diagn Pathol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.yexcr.2018.10.007","article-title":"YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells","volume":"373","author":"Zhu","year":"2018","journal-title":"Exp. Cell Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"856041","DOI":"10.3389\/fcvm.2022.856041","article-title":"Receptor-Interacting protein kinase 3 suppresses mitophagy activation via the yes-associated protein\/transcription factor EB pathways in septic cardiomyopathy","volume":"9","author":"Zhu","year":"2022","journal-title":"Front. Cardiovasc Med."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1524814\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T08:53:16Z","timestamp":1742806396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1524814\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":73,"alternative-id":["10.3389\/fcell.2025.1524814"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1524814","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"article-number":"1524814"}}