{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:17:20Z","timestamp":1790029040692,"version":"4.0.1"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    <jats:italic>CTNND2<\/jats:italic>\n                    gene is located on the short arm of human chromosome 5 and encodes \u03b4-catenin protein, which interacts with different proteins and plays different cell functions. Studies have demonstrated that \u03b4-catenin plays an important role in regulating synaptic maturation and neuronal integrity. The\n                    <jats:italic>CTNND2<\/jats:italic>\n                    gene is closely associated with a variety of neurological diseases, including Cri-du-Chat syndrome, Autism spectrum disorders, Alzheimer\u2019s disease, and Epilepsy. Furthermore, an increasing number of studies have demonstrated that\n                    <jats:italic>CTNND2<\/jats:italic>\n                    is involved in various cancers and may serve as a novel biomarker for the diagnosis and treatment for these diseases. In this review, we will focus on the signaling regulatory functions of\n                    <jats:italic>CTNND2<\/jats:italic>\n                    and its encoded protein \u03b4-catenin in neuro-related diseases and cancers, and discuss the limitations of previous investigative studies and the challenges of the future researches on\n                    <jats:italic>CTNND2<\/jats:italic>\n                    and \u03b4-catenin signaling.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2025.1559059","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T19:59:46Z","timestamp":1743105586000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Roles and regulation of \u03b4-catenin in tumorigenesis and neuronal diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100007","DOI":"10.1016\/j.xhgg.2020.100007","article-title":"Disruption of CTNND2, encoding delta-catenin, causes a penetrant attention deficit disorder and myopia","volume":"1","author":"Adegbola","year":"2020","journal-title":"Hum. 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