{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:37:34Z","timestamp":1792622254011,"version":"4.5.0"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>T cells play a central role in anti-tumor immunity, yet their function is often compromised within the immunosuppressive tumor microenvironment, leading to cancer progression and resistance to immunotherapies. T-cell activation and differentiation require dynamic metabolic shifts, with mitochondrial metabolism playing a crucial role in sustaining their function. Research in cancer immunometabolism has revealed key mitochondrial abnormalities in tumor-infiltrating lymphocytes, including reduced mitochondrial capacity, depolarization, structural defects, and elevated reactive oxygen species. While these mitochondrial disruptions are well-characterized in solid tumors and linked to T-cell exhaustion, their impact on T-cell immunity in lymphoproliferative disorders remains underexplored. Chronic lymphocytic leukemia (CLL), the most prevalent chronic adult leukemia, is marked by profound T-cell dysfunction that limits the success of adoptive cell therapies. Emerging studies are shedding light on the role of mitochondrial disturbances in CLL-related T-cell dysfunction, but significant knowledge gaps remain. This review explores mitochondrial metabolism in T-cell exhaustion, emphasizing recent findings in CLL. We also discuss therapeutic strategies to restore T-cell mitochondrial function and identify key research gaps.<\/jats:p>","DOI":"10.3389\/fcell.2025.1577081","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:23:32Z","timestamp":1744867412000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of mitochondrial metabolism on T-cell dysfunction in chronic lymphocytic leukemia"],"prefix":"10.3389","volume":"13","author":[{"given":"Wael","family":"Gamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Mediavilla-Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishaal","family":"Kunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sahakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pinilla-Ibarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/s41590-021-00975-5","article-title":"Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation","volume":"22","author":"Abdel-Hakeem","year":"2021","journal-title":"Nat. Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/bjh.12401","article-title":"Enhancement of CD 154\/IL 4 proliferation by the T follicular helper (T fh) cytokine, IL 21 and increased numbers of circulating cells resembling T fh cells in chronic lymphocytic leukaemia","volume":"162","author":"Ahearne","year":"2013","journal-title":"Br. J. Haematol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.31083\/j.fbl2911398","article-title":"Interplay of reactive oxygen species (ROS) and epigenetic Remodelling in Cardiovascular diseases pathogenesis: a Contemporary perspective","volume":"29","author":"Al-Awar","year":"2024","journal-title":"FBL"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1172\/JCI46102","article-title":"Exhaustion of tumor-specific CD8\u207a T cells in metastases from melanoma patients","volume":"121","author":"Baitsch","year":"2011","journal-title":"J. Clin. Investigation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/emboj.2011.25","article-title":"The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse","volume":"30","author":"Baixauli","year":"2011","journal-title":"Embo J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2018.02.012","article-title":"Mitochondria-endoplasmic Reticulum contact sites function as immunometabolic Hubs that Orchestrate the rapid Recall response of memory CD8+ T cells","volume":"48","author":"Bantug","year":"2018","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/s41590-022-01224-z","article-title":"Epigenetic regulation of T cell exhaustion","volume":"23","author":"Belk","year":"2022","journal-title":"Nat. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","article-title":"Developmental relationships of Four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms","volume":"52","author":"Beltra","year":"2020","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.immuni.2016.07.008","article-title":"Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8+ T cell exhaustion","volume":"45","author":"Bengsch","year":"2016","journal-title":"Immunity"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1182\/blood-2005-02-0642","article-title":"Reduced frequencies and suppressive function of CD4+ CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine","volume":"106","author":"Beyer","year":"2005","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/modpathol.2011.164","article-title":"Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia","volume":"25","author":"Biancotto","year":"2012","journal-title":"Mod. Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"6955","DOI":"10.1073\/pnas.102181599","article-title":"Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression","volume":"99","author":"Bichi","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1432328","DOI":"10.1080\/2162402X.2018.1432328","article-title":"Restricted T cell receptor repertoire in CLL-like monoclonal B cell lymphocytosis and early stage CLL","volume":"7","author":"Blanco","year":"2018","journal-title":"Oncoimmunology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The Putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3324\/haematol.2012.077537","article-title":"The PD-1\/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia","volume":"98","author":"Brusa","year":"2013","journal-title":"haematologica"},{"key":"B17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through metabolic programming","volume":"166","author":"Buck Michael","year":"2016","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.4049\/jimmunol.1401350","article-title":"Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell\u2013derived IFN-\u03b3 by a T-bet\u2013dependent mechanism","volume":"194","author":"B\u00fcrgler","year":"2015","journal-title":"J. Immunol."},{"key":"B19","first-page":"1","article-title":"The concept of immunological Surveillance","volume-title":"Immunological aspects of Neoplasia","author":"Burnet","year":"1970"},{"key":"B20","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/s0140-6736(74)90944-1","article-title":"Clinical significance of t-cells in chronic lymphocytic leukaemia","volume":"304","author":"Catovsky","year":"1974","journal-title":"Lancet"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1007\/s13277-013-0937-2","article-title":"Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia","volume":"34","author":"Cha","year":"2013","journal-title":"Tumor Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41586-024-07242-1","article-title":"FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy","volume":"629","author":"Chan","year":"2024","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic Competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets Immunology: the cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3836","DOI":"10.1182\/blood-2010-07-299321","article-title":"Definition and characterization of the systemic T-cell dysregulation in untreated indolent B-cell lymphoma and very early CLL","volume":"117","author":"Christopoulos","year":"2011","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae Shape determines respiratory chain Supercomplexes Assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12943-021-01464-x","article-title":"Epigenetic modulation of antitumor immunity for improved cancer immunotherapy","volume":"20","author":"Dai","year":"2021","journal-title":"Mol. Cancer"},{"key":"B29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.leukres.2010.08.010","article-title":"Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease","volume":"35","author":"D\u2019Arena","year":"2011","journal-title":"Leukemia Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.molimm.2015.07.026","article-title":"Feeding an army: the metabolism of T cells in activation, anergy, and exhaustion","volume":"68","author":"Delgoffe","year":"2015","journal-title":"Mol. Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1186\/s12967-018-1545-0","article-title":"Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients","volume":"16","author":"De Matteis","year":"2018","journal-title":"J. Transl. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1182\/bloodadvances.2019000360","article-title":"Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment","volume":"3","author":"de Weerdt","year":"2019","journal-title":"Blood Adv."},{"key":"B33","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-024-07300-8","article-title":"FOXO1 is a master regulator of memory programming in CAR T cells","volume":"629","author":"Doan","year":"2024","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.1076514","article-title":"Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes","volume":"298","author":"Dudley","year":"2002","journal-title":"Science"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1038\/s41423-020-0365-3","article-title":"Enforced PGC-1\u03b1 expression promotes CD8 T cell fitness, memory formation and antitumor immunity","volume":"18","author":"Dumauthioz","year":"2021","journal-title":"Cell Mol. Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/bjh.16260","article-title":"Increased frequency of CD4(+) PD-1(+) HLA-DR(+) T cells is associated with disease progression in CLL","volume":"188","author":"Elston","year":"2020","journal-title":"Br. J. Haematol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"884S","DOI":"10.3945\/ajcn.110.001917","article-title":"Regulation of PGC-1\u03b1, a nodal regulator of mitochondrial biogenesis","volume":"93","author":"Fernandez-Marcos","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1172\/JCI27794","article-title":"PGC-1 coactivators: inducible regulators of energy metabolism in health and disease","volume":"116","author":"Finck","year":"2006","journal-title":"J. Clin. Investigation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/nm.4275","article-title":"Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B","volume":"23","author":"Fisicaro","year":"2017","journal-title":"Nat. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1182\/blood-2015-03-567388","article-title":"Perturbation of the normal immune system in patients with CLL","volume":"126","author":"Forconi","year":"2015","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/s41591-018-0010-1","article-title":"Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia","volume":"24","author":"Fraietta","year":"2018","journal-title":"Nat. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s42255-020-00280-9","article-title":"Metabolic and epigenetic regulation of T-cell exhaustion","volume":"2","author":"Franco","year":"2020","journal-title":"Nat. Metab."},{"key":"B43","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1182\/blood.2021011597","article-title":"PI3K\u03b4\/\u03b3 inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity","volume":"139","author":"Funk","year":"2022","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2024014822","DOI":"10.1182\/bloodadvances.2024014822","article-title":"Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: Evaluation in an immunocompetent model","author":"Gamal","year":"2025","journal-title":"Blood Adv."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1182\/bloodadvances.2022008985","article-title":"The role of Th17 cells in chronic lymphocytic leukemia: friend or foe?","volume":"7","author":"Gamal","year":"2023","journal-title":"Blood Adv."},{"key":"B46","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cell.2017.06.007","article-title":"De novo epigenetic Programs Inhibit PD-1 blockade-mediated T cell Rejuvenation","volume":"170","author":"Ghoneim","year":"2017","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/sj.leu.2404869","article-title":"The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with thalidomide","volume":"22","author":"Giannopoulos","year":"2008","journal-title":"Leukemia"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1570774","DOI":"10.1080\/2162402X.2019.1570774","article-title":"Multiparametric analysis of CD8(+) T cell compartment phenotype in chronic lymphocytic leukemia reveals a signature associated with progression toward therapy","volume":"8","author":"Gonnord","year":"2019","journal-title":"Oncoimmunology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1172\/JCI24176","article-title":"Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells","volume":"115","author":"G\u00f6rg\u00fcn","year":"2005","journal-title":"J. Clin. investigation"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6250","DOI":"10.1073\/pnas.0901166106","article-title":"E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction","volume":"106","author":"Gorgun","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s00262-013-1473-z","article-title":"Expanded CD8+ T cells of murine and human CLL are driven into a senescent KLRG1+ effector memory phenotype","volume":"62","author":"G\u00f6thert","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1182\/bloodadvances.2020003482","article-title":"Chimeric antigen receptor T-cell therapy in adults with B-cell acute lymphoblastic leukemia","volume":"6","author":"Grover","year":"2022","journal-title":"Blood Adv."},{"key":"B53","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3389\/fgene.2019.00435","article-title":"Regulation of mitochondrial biogenesis as a way for active Longevity: interaction between the Nrf2 and PGC-1\u03b1 signaling pathways","volume":"10","author":"Gureev","year":"2019","journal-title":"Front. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/ajh.25595","article-title":"Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment","volume":"94","author":"Hallek","year":"2019","journal-title":"Am. J. Hematol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s12276-022-00739-7","article-title":"Sirtuins are crucial regulators of T cell metabolism and functions","volume":"54","author":"Hamaidi","year":"2022","journal-title":"Exp. and Mol. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1016\/j.immuni.2021.11.004","article-title":"Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity","volume":"54","author":"Hanna","year":"2021","journal-title":"Immunity"},{"key":"B57","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41375-018-0250-6","article-title":"Control of chronic lymphocytic leukemia development by clonally-expanded CD8(+) T-cells that undergo functional exhaustion in secondary lymphoid tissues","volume":"33","author":"Hanna","year":"2019","journal-title":"Leukemia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e938","DOI":"10.1097\/HS9.0000000000000938","article-title":"In vitro 3D Spheroid culture system displays sustained T cell-dependent CLL proliferation and survival","volume":"7","author":"Haselager","year":"2023","journal-title":"HemaSphere"},{"key":"B59","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nri.2017.146","article-title":"Epigenetic control of CD8+ T cell differentiation","volume":"18","author":"Henning","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1182\/blood-2011-01-328484","article-title":"Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765","volume":"117","author":"Herman","year":"2011","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1182\/blood-2010-02-271171","article-title":"Phosphatidylinositol 3-kinase-\u03b4 inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals","volume":"116","author":"Herman","year":"2010","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1073\/pnas.1920413117","article-title":"Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity","volume":"117","author":"Hermans","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1038\/leu.2017.11","article-title":"Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood","volume":"31","author":"Herndon","year":"2017","journal-title":"Leukemia"},{"key":"B64","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"eado3032","DOI":"10.1126\/sciimmunol.ado3032","article-title":"Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate","volume":"10","author":"Huang","year":"2025","journal-title":"Sci. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"eabg4544","DOI":"10.1126\/sciadv.abg4544","article-title":"AMPK\/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy","volume":"7","author":"Hung","year":"2021","journal-title":"Sci. Adv."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e78091","DOI":"10.1371\/journal.pone.0078091","article-title":"Th17\/IL-17A might play a protective role in chronic lymphocytic leukemia immunity","volume":"8","author":"Hus","year":"2013","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","article-title":"Immune evasion through mitochondrial transfer in the tumour microenvironment","volume":"638","author":"Ikeda","year":"2025","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01262-1","article-title":"Cholesterol homeostasis and lipid raft dynamics at the basis of tumor-induced immune dysfunction in chronic lymphocytic leukemia","author":"Jacobs","year":"2025","journal-title":"Cell. and Mol. Immunol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s13277-012-0628-4","article-title":"Downregulation of IL-17-producing T cells is associated with regulatory T cell expansion and disease progression in chronic lymphocytic leukemia","volume":"34","author":"Jadidi-Niaragh","year":"2013","journal-title":"Tumor Biol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.4049\/jimmunol.0901662","article-title":"Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of Ciprofloxacin-mediated immunosuppression","volume":"184","author":"Kami\u0144ski","year":"2010","journal-title":"J. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/ejh.14076","article-title":"CAR-T cell therapy in hematological malignancies: where are we now and where are we heading for?","volume":"112","author":"Khan","year":"2024","journal-title":"Eur. J. Haematol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000533610","article-title":"Chronic lymphocytic leukemia: disease biology","volume":"147","author":"Koehrer","year":"2023","journal-title":"Acta Haematol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"E166","DOI":"10.1073\/pnas.1416389112","article-title":"HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL)","volume":"112","author":"Kowalewski","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3109\/10428194.2012.728287","article-title":"Regulatory T-cells in B-cell chronic lymphocytic leukemia: their role in disease progression and autoimmune cytopenias","volume":"54","author":"Lad","year":"2013","journal-title":"Leukemia and lymphoma"},{"key":"B76","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41467-017-00520-9","article-title":"Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy","volume":"8","author":"Laker","year":"2017","journal-title":"Nat. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.it.2021.12.004","article-title":"Tumor microenvironment metabolites directing T cell differentiation and function","volume":"43","author":"Liu","year":"2022","journal-title":"Trends Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1038\/s41375-021-01198-1","article-title":"EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia","volume":"35","author":"Lla\u00f3-Cid","year":"2021","journal-title":"Leukemia"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e006522","DOI":"10.1136\/jitc-2022-006522","article-title":"Metabolic reprogramming via an engineered PGC-1\u03b1 improves human chimeric antigen receptor T-cell therapy against solid tumors","volume":"11","author":"Lontos","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"B80","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.coi.2017.04.004","article-title":"The role of AMPK in T cell metabolism and function","volume":"46","author":"Ma","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41590-023-01738-0","article-title":"Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria","volume":"25","author":"Ma","year":"2024","journal-title":"Nat. Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1182\/blood-2003-01-0182","article-title":"Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia","volume":"102","author":"Mackus","year":"2003","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/s41375-023-01817-z","article-title":"Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors","volume":"37","author":"Martens","year":"2023","journal-title":"Leukemia"},{"key":"B84","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.tcb.2017.02.004","article-title":"Mitochondria and epigenetics \u2013 crosstalk in homeostasis and stress","volume":"27","author":"Matilainen","year":"2017","journal-title":"Trends Cell Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1182\/blood-2015-02-626754","article-title":"Mechanisms of PD-L1\/PD-1\u2013mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the E\u00b5-TCL1 CLL mouse model","volume":"126","author":"McClanahan","year":"2015","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-021-04390-6","article-title":"Decade-long leukaemia remissions with persistence of CD4+ CAR T cells","volume":"602","author":"Melenhorst","year":"2022","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6540","DOI":"10.1182\/bloodadvances.2023010305","article-title":"T-cell dysfunction by pseudohypoxia and autocrine purinergic signaling in chronic lymphocytic leukemia","volume":"7","author":"Montironi","year":"2023","journal-title":"Blood Adv."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1038\/sj.leu.2403907","article-title":"Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia","volume":"19","author":"Motta","year":"2005","journal-title":"Leukemia"},{"key":"B89","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1111\/cas.13827","article-title":"Reinforce the antitumor activity of CD8+ T cells via glutamine restriction","volume":"109","author":"Nabe","year":"2018","journal-title":"Cancer Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e124989","DOI":"10.1172\/jci.insight.124989","article-title":"Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma","volume":"4","author":"Najjar","year":"2019","journal-title":"JCI Insight"},{"key":"B91","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.celrep.2013.07.011","article-title":"Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells","volume":"4","author":"Os","year":"2013","journal-title":"Cell Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.immuni.2014.06.005","article-title":"Memory CD8+ T cells Use cell-intrinsic Lipolysis to support the metabolic programming necessary for development","volume":"41","author":"O\u2019Sullivan","year":"2014","journal-title":"Immunity"},{"key":"B93","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.immuni.2008.03.004","article-title":"The biological functions of T helper 17 cell effector cytokines in inflammation","volume":"28","author":"Ouyang","year":"2008","journal-title":"Immunity"},{"key":"B94","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3324\/haematol.2016.151100","article-title":"T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers","volume":"102","author":"Palma","year":"2017","journal-title":"Haematologica"},{"key":"B95","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1182\/blood-2012-11-467670","article-title":"IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells","volume":"122","author":"Pascutti","year":"2013","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature08097","article-title":"Enhancing CD8 T-cell memory by modulating fatty acid metabolism","volume":"460","author":"Pearce","year":"2009","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"B98","first-page":"49","article-title":"Malignant lymphomas in transplantation patients: a review of the world experience","volume":"3","author":"Penn","year":"1970","journal-title":"Int. Z Klin. Pharmakol Ther. Toxikol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1038\/s41590-024-01999-3","article-title":"Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism","volume":"25","author":"Peralta","year":"2024","journal-title":"Nat. Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1365-2249.2011.04466.x","article-title":"Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells","volume":"166","author":"Piper","year":"2011","journal-title":"Clin. and Exp. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3234","DOI":"10.1182\/blood-2024-200177","article-title":"A novel 3D Hydrogel culture system mimics the lymph node and induces CLL survival and proliferation","volume":"144","author":"Play\u00e0-Albinyana","year":"2024","journal-title":"Blood"},{"key":"B102","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/s0145-2126(01)00194-1","article-title":"T type 1\/type 2 subsets balance in B-cell chronic lymphocytic leukemia\u2014the three-color flow cytometry analysis","volume":"26","author":"Podhorecka","year":"2002","journal-title":"Leukemia Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1056\/NEJMoa1103849","article-title":"Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia","volume":"365","author":"Porter","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.celrep.2019.04.022","article-title":"Acetate promotes T cell effector function during glucose restriction","volume":"27","author":"Qiu","year":"2019","journal-title":"Cell Rep."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","article-title":"Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes","volume":"186","author":"Rahim","year":"2023","journal-title":"Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1182\/blood-2012-02-411678","article-title":"Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer","volume":"120","author":"Ramsay","year":"2012","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1172\/JCI35017","article-title":"Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug","volume":"118","author":"Ramsay","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B108","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1158\/0008-5472.can-23-0801","article-title":"Progressively enhancing stemness of adoptively transferred T cells with PI3K\u03b4 blockade improves metabolism and anti-tumor immunity","volume":"84","author":"Rangel Rivera","year":"2023","journal-title":"Cancer Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.cmet.2018.06.002","article-title":"Etomoxir Actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation","volume":"28","author":"Raud","year":"2018","journal-title":"Cell Metab."},{"key":"B110","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/s41577-021-00537-8","article-title":"CD8+ T cell metabolism in infection and cancer","volume":"21","author":"Reina-Campos","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1182\/blood-2012-09-457531","article-title":"T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production","volume":"121","author":"Riches","year":"2013","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/bjh.16316","article-title":"TBET\u2010expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in E\u00b5\u2010TCL1 mice","volume":"189","author":"Roessner","year":"2020","journal-title":"Br. J. Haematol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1038\/s41375-020-0873-2","article-title":"T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?","volume":"34","author":"Roessner","year":"2020","journal-title":"Leukemia"},{"key":"B114","doi-asserted-by":"publisher","first-page":"e2317735121","DOI":"10.1073\/pnas.2317735121","article-title":"Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with \u0394133p53\u03b1","volume":"121","author":"Roselle","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1034\/j.1600-0609.2002.01612.x","article-title":"Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B\u2010CLL)","volume":"68","author":"Rossmann","year":"2002","journal-title":"Eur. J. Haematol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/bf01655298","article-title":"Cancer after transplantation","volume":"10","author":"Ross Sheil","year":"1986","journal-title":"World J. Surg."},{"key":"B117","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1158\/2326-6066.CIR-21-0110","article-title":"Mitochondria as Playmakers of CAR T-cell fate and Longevity","volume":"9","author":"Rostamian","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","article-title":"Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells","volume":"17","author":"Saha","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.immuni.2016.08.009","article-title":"The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction","volume":"45","author":"Scharping","year":"2016","journal-title":"Immunity"},{"key":"B120","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41590-020-00834-9","article-title":"Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion","volume":"22","author":"Scharping","year":"2021","journal-title":"Nat. Immunol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.celrep.2016.06.078","article-title":"Distinct metabolic Requirements of exhausted and functional Virus-specific CD8 T cells in the Same Host","volume":"16","author":"Schurich","year":"2016","journal-title":"Cell Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena Laura","year":"2013","journal-title":"Immunity"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.4049\/jimmunol.158.3.1482","article-title":"Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia","volume":"158","author":"Serrano","year":"1997","journal-title":"J. Immunol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.aaa8172","article-title":"The future of immune checkpoint therapy","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"B125","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cmet.2023.12.010","article-title":"Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation","volume":"36","author":"Si","year":"2024","journal-title":"Cell Metab."},{"key":"B126","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1182\/blood-2023-179529","article-title":"Lisocabtagene maraleucel (liso-cel) in R\/R CLL\/SLL: 24-Month median follow-up of TRANSCEND CLL 004","volume":"142","author":"Siddiqi","year":"2023","journal-title":"Blood"},{"key":"B127","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.immuni.2018.12.021","article-title":"Intratumoral Tcf1+PD-1+CD8+ T cells with stem-like properties promote tumor control in response to Vaccination and checkpoint blockade immunotherapy","volume":"50","author":"Siddiqui","year":"2019","journal-title":"Immunity"},{"key":"B128","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1016\/j.celrep.2018.11.018","article-title":"Drp1 controls effective T cell immune-Surveillance by regulating T cell migration, proliferation, and cMyc-dependent metabolic reprogramming","volume":"25","author":"Simula","year":"2018","journal-title":"Cell Rep."},{"key":"B129","doi-asserted-by":"publisher","first-page":"e93411","DOI":"10.1172\/jci.insight.93411","article-title":"Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma","volume":"2","author":"Siska","year":"2017","journal-title":"JCI Insight"},{"key":"B131","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nm.3048","article-title":"ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets","volume":"19","author":"Souers","year":"2013","journal-title":"Nat. Med."},{"key":"B132","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nm1551","article-title":"A brief history of TH17, the first major revision in the TH1\/TH2 hypothesis of T cell\u2013mediated tissue damage","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cmet.2015.11.002","article-title":"Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy","volume":"23","author":"Sukumar","year":"2016","journal-title":"Cell Metab."},{"key":"B134","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/intimm\/dxw025","article-title":"Roles of regulatory T cells in cancer immunity","volume":"28","author":"Takeuchi","year":"2016","journal-title":"Int. Immunol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"1354825","DOI":"10.3389\/fimmu.2024.1354825","article-title":"Revolutionizing cancer treatment: enhancing CAR-T cell therapy with CRISPR\/Cas9 gene editing technology","volume":"15","author":"Tao","year":"2024","journal-title":"Front. Immunol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.3109\/10428194.2012.673224","article-title":"Expansion of effector T cells associated with decreased PD-1 expression in patients with indolent B cell lymphomas and chronic lymphocytic leukemia","volume":"53","author":"Tonino","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"B137","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1182\/blood.v74.2.786.786","article-title":"T-cell activation and subset Patterns are altered in B-CLL and correlate with the stage of the disease","volume":"74","author":"T\u00f6tterman","year":"1989","journal-title":"Blood"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/s41375-022-01519-y","article-title":"Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures","volume":"36","author":"Vaca","year":"2022","journal-title":"Leukemia"},{"key":"B139","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1182\/blood.2018885863","article-title":"Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy","volume":"134","author":"van Bruggen","year":"2019","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1182\/bloodadvances.2022007034","article-title":"Depletion of CLL cells by venetoclax treatment reverses oxidative stress and impaired glycolysis in CD4 T cells","volume":"6","author":"van Bruggen","year":"2022","journal-title":"Blood Adv."},{"key":"B141","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-065X.2012.01150.x","article-title":"Metabolic switching and fuel choice during T-cell differentiation and memory development","volume":"249","author":"van der Windt","year":"2012","journal-title":"Immunol. Rev."},{"key":"B142","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt Gerritje","year":"2012","journal-title":"Immunity"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/s41590-020-0725-2","article-title":"Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen","volume":"21","author":"Vardhana","year":"2020","journal-title":"Nat. Immunol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1158\/1078-0432.CCR-14-3017","article-title":"Antigen selection Shapes the T-cell repertoire in chronic lymphocytic leukemia","volume":"22","author":"Vardi","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"B145","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/leu.2016.362","article-title":"Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements","volume":"31","author":"Vardi","year":"2017","journal-title":"Leukemia"},{"key":"B146","doi-asserted-by":"publisher","first-page":"612244","DOI":"10.3389\/fimmu.2020.612244","article-title":"T cells in chronic lymphocytic leukemia: a two-Edged Sword","volume":"11","author":"Vlachonikola","year":"2021","journal-title":"Front. Immunol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the Origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"B148","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.cmet.2022.03.013","article-title":"The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function","volume":"34","author":"Wenes","year":"2022","journal-title":"Cell Metab."},{"key":"B149","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"12","DOI":"10.6004\/jnccn.2019.0002","article-title":"NCCN guidelines insights: chronic lymphocytic leukemia\/small lymphocytic lymphoma, version 2.2019","volume":"17","author":"Wierda","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"B151","doi-asserted-by":"publisher","first-page":"e1465167","DOI":"10.1080\/2162402X.2018.1465167","article-title":"High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia","volume":"7","author":"Wierz","year":"2018","journal-title":"Oncoimmunology"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1056\/NEJMoa1400029","article-title":"Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib","volume":"370","author":"Woyach","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"6858","DOI":"10.1038\/s41467-023-42634-3","article-title":"Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1\u03b1-mediated glycolytic reprogramming","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"B154","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.tem.2018.06.002","article-title":"Sink into the epigenome: Histones as Repositories that influence cellular metabolism","volume":"29","author":"Ye","year":"2018","journal-title":"Trends Endocrinol. and Metabolism"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-020-0793-3","article-title":"Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion","volume":"21","author":"Yu","year":"2020","journal-title":"Nat. Immunol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/s0145-2126(00)00022-9","article-title":"Disruption of the IFN-\u03b3 cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis","volume":"24","author":"Zaki","year":"2000","journal-title":"Leukemia Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.ccell.2023.09.003","article-title":"Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution","volume":"41","author":"Zhang","year":"2023","journal-title":"Cancer Cell"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1577081\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:23:33Z","timestamp":1744867413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1577081\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":157,"alternative-id":["10.3389\/fcell.2025.1577081"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1577081","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"article-number":"1577081"}}