{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:32:17Z","timestamp":1790800337503,"version":"4.1.0"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Integrin \u03b15\u03b21 is a key signaling protein between cells and the extracellular matrix. It plays crucial roles in biological processes such as cell adhesion, migration, and differentiation. Recent studies have shown that integrin \u03b15\u03b21 is significantly involved in bone formation and related diseases. Integrin \u03b15\u03b21 participates in the differentiation of mesenchymal stem cells into osteoblasts. It interacts with the CCN family and the bone morphogenetic protein pathway to upregulate the expression of osteogenic markers, promoting the formation of mineralization nodules. Additionally, it can mediate mechanical force stimulation to upregulate osteogenic gene expression and promote bone formation. In diseases such as osteoporosis, osteoarthritis, and bone metastasis, integrin \u03b15\u03b21 mediates abnormal cell-matrix adhesion and migration, promoting pathological bone resorption and inhibiting bone formation, thereby exacerbating bone loss. Therefore, integrin \u03b15\u03b21 may be a potential therapeutic target for these bone diseases. Elucidating its mechanism of action will help understand the homeostatic regulation of bone metabolism and provide ideas for the development of novel therapeutic strategies for skeletal diseases.<\/jats:p>","DOI":"10.3389\/fcell.2025.1632710","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:33:31Z","timestamp":1755149611000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Role and mechanism of Integrin \u03b15\u03b21 in bone formation and disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.3390\/curroncol28060417","article-title":"Potential role of CCN proteins in breast cancer: therapeutic advances and perspectives","volume":"28","author":"Ahmed","year":"2021","journal-title":"Curr. Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1517\/14712598.2012.646985","article-title":"Volociximab in cancer","volume":"12","author":"Almokadem","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0198559","DOI":"10.1371\/journal.pone.0198559","article-title":"Genetic abrogation of the fibronectin-\u03b15\u03b21 integrin interaction in articular cartilage aggravates osteoarthritis in mice","volume":"13","author":"Almonte-Becerril","year":"2018","journal-title":"PLoS One"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of Curcuma longa","volume":"57","author":"Ammon","year":"1991","journal-title":"Planta Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.4049\/jimmunol.164.5.2684","article-title":"Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins","volume":"164","author":"Attur","year":"2000","journal-title":"J. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","article-title":"Integrins","volume":"339","author":"Barczyk","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ygyno.2010.12.362","article-title":"A phase II, single-arm study of the anti-\u03b15\u03b21 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer","volume":"121","author":"Bell-McGuinn","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/annonc\/mds281","article-title":"Phase Ib safety and pharmacokinetic study of volociximab, an anti-\u03b15\u03b21 integrin antibody, in combination with carboplatin and paclitaxel in advanced non-small-cell lung cancer","volume":"24","author":"Besse","year":"2013","journal-title":"Ann. Oncol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"14348","DOI":"10.1038\/ncomms14348","article-title":"\u03b1V-class integrins exert dual roles on \u03b15\u03b21 integrins to strengthen adhesion to fibronectin","volume":"8","author":"Bharadwaj","year":"2017","journal-title":"Nat. Commun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.1111\/febs.15702","article-title":"Domains 12 to 16 of tropoelastin promote cell attachment and spreading through interactions with glycosaminoglycan and integrins alphaV and alpha5beta1","volume":"288","author":"Bochicchio","year":"2021","journal-title":"Febs J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3892\/or.2011.1373","article-title":"Cilengitide inhibits metastatic bone colonization in a nude rat model","volume":"26","author":"Bretschi","year":"2011","journal-title":"Oncol. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"19830","DOI":"10.1038\/s41598-021-99348-z","article-title":"Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates \u03b15\u03b21 integrin endocytosis","volume":"11","author":"Caliva","year":"2021","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"a004994","DOI":"10.1101\/cshperspect.a004994","article-title":"Integrin structure, activation, and interactions","volume":"3","author":"Campbell","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e0156783","DOI":"10.1371\/journal.pone.0156783","article-title":"Alpha 5 integrin mediates osteoarthritic changes in mouse knee joints","volume":"11","author":"Candela","year":"2016","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41413-019-0073-8","article-title":"Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice","volume":"8","author":"Cao","year":"2020","journal-title":"Bone Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"101775","DOI":"10.1016\/j.berh.2022.101775","article-title":"Risk assessment tools for osteoporosis and fractures in 2022","volume":"36","author":"Carey","year":"2022","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.ceb.2003.08.003","article-title":"Integrin avidity regulation: are changes in affinity and conformation underemphasized?","volume":"15","author":"Carman","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1029475","DOI":"10.3389\/fendo.2022.1029475","article-title":"Regulation of bone health through physical exercise: mechanisms and types","volume":"13","author":"Chang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.biocel.2008.07.025","article-title":"Functions and mechanisms of action of CCN matricellular proteins","volume":"41","author":"Chen","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2018.01.038","article-title":"Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production","volume":"99","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3300","DOI":"10.3390\/ijms20133300","article-title":"CCN3 facilitates Runx2 and osterix expression by inhibiting miR-608 through PI3K\/Akt signaling in osteoblasts","volume":"20","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.nutres.2010.03.004","article-title":"Simvastatin promotes osteoblast viability and differentiation via Ras\/Smad\/Erk\/BMP-2 signaling pathway","volume":"30","author":"Chen","year":"2010","journal-title":"Nutr. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.2147\/dddt.S117432","article-title":"The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis","volume":"10","author":"Chin","year":"2016","journal-title":"Drug Des. Devel Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1038\/sj.bjc.6603171","article-title":"Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta Integrin antagonist, in patients with solid tumours","volume":"94","author":"Cianfrocca","year":"2006","journal-title":"Br. J. Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B26","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1242\/jcs.077172","article-title":"Isoaspartate-dependent molecular switches for integrin-ligand recognition","volume":"124","author":"Corti","year":"2011","journal-title":"J. Cell Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5259","DOI":"10.1158\/0008-5472.Can-17-3058","article-title":"miRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis-associated genes","volume":"78","author":"Croset","year":"2018","journal-title":"Cancer Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1177\/0363546519899087","article-title":"Integrin \u03b110\u03b21-Selected mesenchymal stem cells mitigate the progression of osteoarthritis in an equine talar impact model","volume":"48","author":"Delco","year":"2020","journal-title":"Am. J. Sports Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1152\/physrev.00043.2020","article-title":"The osteocyte as a signaling cell","volume":"102","author":"Delgado-Calle","year":"2022","journal-title":"Physiol. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"B31","doi-asserted-by":"publisher","first-page":"20445","DOI":"10.1074\/jbc.R300010200","article-title":"Eukaryotic chemotaxis: distinctions between directional sensing and polarization","volume":"278","author":"Devreotes","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/onc.2015.212","article-title":"Targeting of \u03b21 integrins impairs DNA repair for radiosensitization of head and neck cancer cells","volume":"35","author":"Dickreuter","year":"2016","journal-title":"Oncogene"},{"key":"B33","doi-asserted-by":"publisher","first-page":"44398","DOI":"10.1038\/srep44398","article-title":"Extracellular matrix and \u03b1(5)\u03b2(1) integrin signaling control the maintenance of bone formation capacity by human adipose-derived stromal cells","volume":"7","author":"Di Maggio","year":"2017","journal-title":"Sci. Rep."},{"key":"B34","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/bdrc.21047","article-title":"Osteoblast recruitment to sites of bone formation in skeletal development, homeostasis, and regeneration","volume":"99","author":"Dirckx","year":"2013","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1158\/1078-0432.Ccr-07-4530","article-title":"Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth","volume":"14","author":"Do\u00f1ate","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1172\/jci61350","article-title":"\u03b21Integrin\/FAK\/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy","volume":"122","author":"Eke","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B37","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/1476-4598-13-226","article-title":"Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation","volume":"13","author":"Feng","year":"2014","journal-title":"Mol. Cancer"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.matbio.2021.09.001","article-title":"EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin deposition","author":"Finney","year":"2021","journal-title":"Matrix Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/s0002-9440(10)63348-2","article-title":"WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair","volume":"165","author":"French","year":"2004","journal-title":"Am. J. Pathol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1002\/jcb.24181","article-title":"Peptide-based activation of alpha5 integrin for promoting osteogenesis","volume":"113","author":"Fromigu\u00e9","year":"2012","journal-title":"J. Cell Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1038\/s41591-022-02059-9","article-title":"Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial","volume":"28","author":"Gerwin","year":"2022","journal-title":"Nat. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/s0140-6736(14)60802-3","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.juro.2015.01.079","article-title":"Bone metastasis in renal cell carcinoma is preprogrammed in the primary tumor and caused by AKT and Integrin \u03b15 signaling","volume":"194","author":"Haber","year":"2015","journal-title":"J. Urol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1053\/joca.2002.0524","article-title":"Antisense oligonucleotides to the integrin receptor subunit alpha(5) decrease fibronectin fragment mediated cartilage chondrolysis","volume":"10","author":"Homandberg","year":"2002","journal-title":"Osteoarthr. Cartil."},{"key":"B45","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.matbio.2023.06.006","article-title":"SEMA7a primes integrin \u03b15\u03b21 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming","volume":"121","author":"Hu","year":"2023","journal-title":"Matrix Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/jbmr.5650080503","article-title":"Integrin expression in human bone","volume":"8","author":"Hughes","year":"1993","journal-title":"J. Bone Min. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1021\/bm400639e","article-title":"Bisphosphonate-linked hyaluronic acid hydrogel sequesters and enzymatically releases active bone morphogenetic protein-2 for induction of osteogenic differentiation","volume":"14","author":"Hulsart-Billstr\u00f6m","year":"2013","journal-title":"Biomacromolecules"},{"key":"B48","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/jth.14369","article-title":"Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin-induced thrombocytopenia","volume":"17","author":"Huynh","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1158\/0008-5472.Can-11-4199","article-title":"Integrin \u03b15\u03b21 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma","volume":"72","author":"Janouskova","year":"2012","journal-title":"Cancer Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1038\/s41598-021-82246-9","article-title":"Connective tissue growth factor promotes chemotaxis of preosteoblasts through integrin \u03b15 and Ras during tensile force-induced intramembranous osteogenesis","volume":"11","author":"Jiang","year":"2021","journal-title":"Sci. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"693484","DOI":"10.3389\/fcell.2021.693484","article-title":"Mechanistic Insight into the roles of integrins in osteoarthritis","volume":"9","author":"Jin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"8361","DOI":"10.3390\/ijms21218361","article-title":"Shear stress modulates osteoblast cell and nucleus morphology and volume","volume":"21","author":"Jin","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/19336918.2016.1212139","article-title":"Proteolytic fragments of fibronectin function as matrikines driving the chemotactic affinity of prostate cancer cells to human bone marrow mesenchymal stromal cells via the \u03b15\u03b21 integrin","volume":"11","author":"Joshi","year":"2017","journal-title":"Cell Adh Migr."},{"key":"B54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tem.2014.03.012","article-title":"Diverse roles of ANGPTL2 in physiology and pathophysiology","volume":"25","author":"Kadomatsu","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41580-022-00531-5","article-title":"Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions","volume":"24","author":"Kanchanawong","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/s1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev. Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1158\/1535-7163.Mct-06-0100","article-title":"A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo","volume":"5","author":"Khalili","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"B58","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-cellbio-100109-104104","article-title":"Regulation of integrin activation","volume":"27","author":"Kim","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.biomaterials.2012.10.015","article-title":"Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment","volume":"34","author":"Kisiel","year":"2013","journal-title":"Biomaterials"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1016\/j.yexcr.2013.08.021","article-title":"CCN2 promotes keratinocyte adhesion and migration via integrin \u03b15\u03b21","volume":"319","author":"Kiwanuka","year":"2013","journal-title":"Exp. Cell Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/dvdy.240","article-title":"How faithfully does intramembranous bone regeneration recapitulate embryonic skeletal development?","volume":"250","author":"Ko","year":"2021","journal-title":"Dev. Dyn."},{"key":"B62","doi-asserted-by":"publisher","first-page":"A33","DOI":"10.1016\/j.jvs.2007.02.069","article-title":"Integrin alpha(v)beta(3) as a target in the prevention of neointimal hyperplasia","volume":"45","author":"Kokubo","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"B63","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00003086-200003000-00016","article-title":"Osteoporosis","volume":"372","author":"Lane","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"565826","DOI":"10.3389\/fcell.2020.565826","article-title":"Muscle-derived lumican stimulates bone formation via Integrin \u03b12\u03b21 and the downstream ERK signal","volume":"8","author":"Lee","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1242\/jcs.041624","article-title":"Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails","volume":"122","author":"Legate","year":"2009","journal-title":"J. Cell Sci."},{"key":"B66","first-page":"1012","article-title":"METTL3 enhances cell adhesion through stabilizing integrin \u03b21 mRNA via an m6A-HuR-dependent mechanism in prostatic carcinoma","volume":"10","author":"Li","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/ame2.12342","article-title":"Platelet factor 4 induces bone loss by inhibiting the integrin \u03b15-FAK-ERK pathway","volume":"6","author":"Li","year":"2023","journal-title":"Anim. Model Exp. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.canlet.2016.06.007","article-title":"RUNX2 promotes breast cancer bone metastasis by increasing integrin \u03b15-mediated colonization","volume":"380","author":"Li","year":"2016","journal-title":"Cancer Lett."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/critreveukaryotgeneexpr.v14.10","article-title":"Regulatory controls for osteoblast growth and differentiation: role of Runx\/Cbfa\/AML factors","volume":"14","author":"Lian","year":"2004","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"B70","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejphar.2017.03.019","article-title":"Inhibition of osteoporosis by the \u03b1v\u03b23 integrin antagonist of rhodostomin variants","volume":"804","author":"Lin","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"6869","DOI":"10.1074\/jbc.RA117.000515","article-title":"Leukocyte integrin Mac-1 (CD11b\/CD18, \u03b1(M)\u03b2(2), CR3) acts as a functional receptor for platelet factor 4","volume":"293","author":"Lishko","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cmet.2005.08.006","article-title":"Changes in integrin expression during adipocyte differentiation","volume":"2","author":"Liu","year":"2005","journal-title":"Cell Metab."},{"key":"B73","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/term.1498","article-title":"The interaction between \u03b21 integrins and ERK1\/2 in osteogenic differentiation of human mesenchymal stem cells under fluid shear stress modelled by a perfusion system","volume":"8","author":"Liu","year":"2014","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1177\/0022034520917058","article-title":"RAP1-RAC1 signaling has an important role in adhesion and migration in HNSCC","volume":"99","author":"Liu","year":"2020","journal-title":"J. Dent. Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","article-title":"Integrins and chondrocyte-matrix interactions in articular cartilage","volume":"39","author":"Loeser","year":"2014","journal-title":"Matrix Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/ar3464","article-title":"Integrins and their ligands in rheumatoid arthritis","volume":"13","author":"Lowin","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"B77","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev.immunol.25.022106.141618","article-title":"Structural basis of integrin regulation and signaling","volume":"25","author":"Luo","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ceb.2014.05.010","article-title":"New paradigms in the establishment and maintenance of gradients during directed cell migration","volume":"30","author":"Majumdar","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41420-023-01417-x","article-title":"The role of integrin family in bone metabolism and tumor bone metastasis","volume":"9","author":"Mao","year":"2023","journal-title":"Cell Death Discov."},{"key":"B80","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nrendo.2013.4","article-title":"Targeting integrins to promote bone formation and repair","volume":"9","author":"Marie","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.tem.2014.06.009","article-title":"Integrin and cadherin signaling in bone: role and potential therapeutic targets","volume":"25","author":"Marie","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B82","doi-asserted-by":"publisher","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00280-014-2576-8","article-title":"A first-in-human study of the anti-\u03b15\u03b21 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors","volume":"74","author":"Mateo","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"6238","DOI":"10.1038\/sj.onc.1210429","article-title":"Prostate cancer specific integrin alphavbeta3 modulates bone metastatic growth and tissue remodeling","volume":"26","author":"McCabe","year":"2007","journal-title":"Oncogene"},{"key":"B85","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s0304-3835(98)00195-5","article-title":"Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses","volume":"131","author":"Menzel","year":"1998","journal-title":"Cancer Lett."},{"key":"B86","doi-asserted-by":"publisher","first-page":"eadf8299","DOI":"10.1126\/scisignal.adf8299","article-title":"Redox-active endosomes mediate \u03b15\u03b21 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis","volume":"16","author":"Miao","year":"2023","journal-title":"Sci. Signal"},{"key":"B87","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1242\/jcs.071985","article-title":"Integrin \u03b15\u03b21 facilitates cancer cell invasion through enhanced contractile forces","volume":"124","author":"Mierke","year":"2011","journal-title":"J. Cell Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e0171362","DOI":"10.1371\/journal.pone.0171362","article-title":"Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells","volume":"12","author":"Monti","year":"2017","journal-title":"PLoS One"},{"key":"B89","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-bioeng-062117-121139","article-title":"Bone mechanical properties in healthy and diseased states","volume":"20","author":"Morgan","year":"2018","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"B90","doi-asserted-by":"publisher","first-page":"100977","DOI":"10.1016\/j.bbrep.2021.100977","article-title":"Irisin supports integrin-mediated cell adhesion of lymphocytes","volume":"26","author":"Myint","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1083\/jcb.201111077","article-title":"Crystal structure of \u03b15\u03b21 integrin ectodomain: atomic details of the fibronectin receptor","volume":"197","author":"Nagae","year":"2012","journal-title":"J. Cell Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00774-007-0773-9","article-title":"Involvement of alpha(v)beta3 integrins in osteoclast function","volume":"25","author":"Nakamura","year":"2007","journal-title":"J. Bone Min. Metab."},{"key":"B93","doi-asserted-by":"publisher","first-page":"460","DOI":"10.2967\/jnumed.115.165720","article-title":"Complementary, selective PET imaging of Integrin subtypes \u03b15\u03b21 and \u03b1v\u03b23 using 68Ga-Aquibeprin and 68Ga-Avebetrin","volume":"57","author":"Notni","year":"2016","journal-title":"J. Nucl. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"e0188749","DOI":"10.1371\/journal.pone.0188749","article-title":"The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin \u03b15\u03b21\/ERK\/Runx2 pathway","volume":"12","author":"Oh","year":"2017","journal-title":"PLoS One"},{"key":"B95","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/jbmr.205","article-title":"WISP-1\/CCN4 regulates osteogenesis by enhancing BMP-2 activity","volume":"26","author":"Ono","year":"2011","journal-title":"J. Bone Min. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3727\/000000008783907143","article-title":"Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2","volume":"17","author":"Ono","year":"2008","journal-title":"Cell Transpl."},{"key":"B97","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1172\/jci115586","article-title":"Collagen-induced release of interleukin 1 from human blood mononuclear cells. Potentiation by fibronectin binding to the alpha 5 beta 1 integrin","volume":"89","author":"Pacifici","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B98","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2174\/187152012802650183","article-title":"Modulation of MMPs by cell surface integrin receptor \u03b15\u03b21","volume":"12","author":"Pal","year":"2012","journal-title":"Anticancer Agents Med. Chem."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","article-title":"Targeting integrin pathways: mechanisms and advances in therapy","volume":"8","author":"Pang","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/s41388-020-01603-6","article-title":"Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions","volume":"40","author":"Pantano","year":"2021","journal-title":"Oncogene"},{"key":"B101","doi-asserted-by":"publisher","first-page":"155887","DOI":"10.1016\/j.phymed.2024.155887","article-title":"Icariin promotes cell adhesion for osteogenesis in bone marrow stromal cells via binding to integrin \u03b15\u03b21","volume":"133","author":"Poon","year":"2024","journal-title":"Phytomedicine"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1038\/cddis.2011.71","article-title":"Integrins \u03b12\u03b21 and \u03b111\u03b21 regulate the survival of mesenchymal stem cells on collagen I","volume":"2","author":"Popov","year":"2011","journal-title":"Cell Death Dis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s1098-3597(02)90034-7","article-title":"Prevention and treatment of osteoporosis","volume":"4","author":"Prestwood","year":"2002","journal-title":"Clin. Cornerstone"},{"key":"B104","doi-asserted-by":"publisher","first-page":"4498","DOI":"10.7150\/thno.17949","article-title":"Autophagy maintains the function of bone marrow mesenchymal stem cells to prevent estrogen deficiency-induced osteoporosis","volume":"7","author":"Qi","year":"2017","journal-title":"Theranostics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jot.2022.03.008","article-title":"Osteocyte \u03b21 integrin loss causes low bone mass and impairs bone mechanotransduction in mice","volume":"34","author":"Qin","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"B106","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41413-020-0099-y","article-title":"Molecular mechanosensors in osteocytes","volume":"8","author":"Qin","year":"2020","journal-title":"Bone Res."},{"key":"B107","first-page":"273","article-title":"Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent","volume":"5","author":"Ramakrishnan","year":"2006","journal-title":"J. Exp. Ther. Oncol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/s0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3390\/ijms21031146","article-title":"The role of connexin channels in the response of mechanical loading and unloading of bone","volume":"21","author":"Riquelme","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41413-020-00126-w","article-title":"Mechanotransduction via the coordinated actions of integrins, PI3K signaling and connexin hemichannels","volume":"9","author":"Riquelme","year":"2021","journal-title":"Bone Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev-physiol-021119-034332","article-title":"The osteocyte: new insights","volume":"82","author":"Robling","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.biotechadv.2017.11.004","article-title":"\u03b1v\u03b23 and \u03b15\u03b21 integrin-specific ligands: from tumor angiogenesis inhibitors to vascularization promoters in regenerative medicine?","volume":"36","author":"Rocha","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"B114","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1601-6343.2004.00304.x","article-title":"Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene","volume":"7","author":"Savontaus","year":"2004","journal-title":"Orthod. Craniofac Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3390\/ijms20030506","article-title":"Alpha-5 Integrin mediates Simvastatin-induced osteogenesis of bone marrow mesenchymal stem cells","volume":"20","author":"Shao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1182\/blood-2004-04-1257","article-title":"Integrins: dynamic scaffolds for adhesion and signaling in platelets","volume":"104","author":"Shattil","year":"2004","journal-title":"Blood"},{"key":"B117","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bone.2014.08.008","article-title":"The effect of conditional inactivation of beta 1 integrins using twist 2 cre, osterix cre and osteocalcin cre lines on skeletal phenotype","volume":"68","author":"Shekaran","year":"2014","journal-title":"Bone"},{"key":"B118","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.ceb.2012.08.011","article-title":"Inside-out, outside-in, and inside-outside-in: g protein signaling in integrin-mediated cell adhesion, spreading, and retraction","volume":"24","author":"Shen","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological bone remodeling: systemic regulation and growth factor involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiol. (Bethesda)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41563-019-0580-4","article-title":"Protease-activated receptor signalling initiates \u03b1(5)\u03b2(1)-integrin-mediated adhesion in non-haematopoietic cells","volume":"19","author":"Spoerri","year":"2020","journal-title":"Nat. Mater"},{"key":"B121","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1089\/hum.2011.059","article-title":"Lentiviral-mediated integrin \u03b15 expression in human adult mesenchymal stromal cells promotes bone repair in mouse cranial and long-bone defects","volume":"23","author":"Srouji","year":"2012","journal-title":"Hum. Gene Ther."},{"key":"B122","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bone.2013.05.003","article-title":"Age-related bone deterioration is diminished by disrupted collagen sensing in integrin \u03b12\u03b21 deficient mice","volume":"56","author":"Stange","year":"2013","journal-title":"Bone"},{"key":"B123","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41574-024-00969-x","article-title":"Metabolic regulation of skeletal cell fate and function","volume":"20","author":"Stegen","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/labinvest.2015.82","article-title":"Clinical significance of the integrin \u03b16\u03b24 in human malignancies","volume":"95","author":"Stewart","year":"2015","journal-title":"Lab. Invest."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.3390\/ijms19082343","article-title":"Mesenchymal stem cell migration during bone formation and bone diseases therapy","volume":"19","author":"Su","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"102323","DOI":"10.1016\/j.jbc.2022.102323","article-title":"Dynamics of integrin \u03b15\u03b21, fibronectin, and their complex reveal sites of interaction and conformational change","volume":"298","author":"Su","year":"2022","journal-title":"J. Biol. Chem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"101729","DOI":"10.1016\/j.arr.2022.101729","article-title":"Assessment of functional roles and therapeutic potential of integrin receptors in osteoarthritis: a systematic review and meta-analysis of preclinical studies","volume":"81","author":"Sumsuzzman","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"B128","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13287-018-0798-0","article-title":"Extracellular matrix stiffness controls osteogenic differentiation of mesenchymal stem cells mediated by integrin \u03b15","volume":"9","author":"Sun","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"B129","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12079-013-0204-8","article-title":"CCN2: a master regulator of the genesis of bone and cartilage","volume":"7","author":"Takigawa","year":"2013","journal-title":"J. Cell Commun. Signal"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/jcp.22991","article-title":"CCN3 increases BMP-4 expression and bone mineralization in osteoblasts","volume":"227","author":"Tan","year":"2012","journal-title":"J. Cell Physiol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.joca.2017.10.011","article-title":"Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor","volume":"26","author":"Tanoue","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"B132","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/brv.12345","article-title":"Osteoblast migration in vertebrate bone","volume":"93","author":"Thiel","year":"2018","journal-title":"Biol. Rev. Camb Philos. Soc."},{"key":"B133","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"ar78","DOI":"10.1091\/mbc.E21-12-0609","article-title":"Regulatory roles of fibronectin and integrin \u03b15 in reorganization of the actin cytoskeleton and completion of adipogenesis","volume":"33","author":"Uetaki","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"B136","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"e128616","DOI":"10.1172\/jci.insight.128616","article-title":"Dysregulated integrin \u03b1V\u03b23 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis","volume":"4","author":"Wang","year":"","journal-title":"JCI Insight"},{"key":"B138","doi-asserted-by":"publisher","first-page":"e131692","DOI":"10.1172\/jci.insight.131692","article-title":"Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice","volume":"4","author":"Wang","year":"","journal-title":"JCI Insight"},{"key":"B139","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1016\/j.yexcr.2011.07.015","article-title":"Mechanotransduction activates \u03b15\u03b21 integrin and PI3K\/Akt signaling pathways in mandibular osteoblasts","volume":"317","author":"Watabe","year":"2011","journal-title":"Exp. Cell Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/jbmr.4494","article-title":"Bone microarchitecture phenotypes identified in older adults are associated with different levels of osteoporotic fracture risk","volume":"37","author":"Whittier","year":"2022","journal-title":"J. Bone Min. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/art.39326","article-title":"Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments","volume":"68","author":"Wood","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41422-023-00918-9","article-title":"The roles and regulatory mechanisms of TGF-\u03b2 and BMP signaling in bone and cartilage development, homeostasis and disease","volume":"34","author":"Wu","year":"2024","journal-title":"Cell Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"17863","DOI":"10.1073\/pnas.1420645111","article-title":"Metal ion and ligand binding of integrin \u03b15\u03b21","volume":"111","author":"Xia","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1177\/11297298231192386","article-title":"Functions for platelet factor 4 (PF4\/CXCL4) and its receptors in fibroblast-myofibroblast transition and fibrotic failure of arteriovenous fistulas (AVFs)","volume":"25","author":"Xiao","year":"2024","journal-title":"J. Vasc. Access"},{"key":"B145","doi-asserted-by":"publisher","first-page":"e18183","DOI":"10.1111\/jcmm.18183","article-title":"Research progress on the regulatory mechanism of integrin-mediated mechanical stress in cells involved in bone metabolism","volume":"28","author":"Yang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/sj.cr.7290266","article-title":"Mechanisms of cancer metastasis to the bone","volume":"15","author":"Yin","year":"2005","journal-title":"Cell Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41418-020-0600-6","article-title":"CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin \u03b15 expression","volume":"28","author":"Zhang","year":"2021","journal-title":"Cell Death Differ."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1038\/s41467-022-30105-0","article-title":"EZH2 engages TGF\u03b2 signaling to promote breast cancer bone metastasis via integrin \u03b21-FAK activation","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"B149","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41413-022-00222-z","article-title":"Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin \u03b15","volume":"10","author":"Zhao","year":"2022","journal-title":"Bone Res."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1151838","DOI":"10.3389\/fcell.2023.1151838","article-title":"Connexin 43 hemichannels and prostaglandin E(2) release in anabolic function of the skeletal tissue to mechanical stimulation","volume":"11","author":"Zhao","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1158\/0008-5472.Can-06-4499","article-title":"Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases","volume":"67","author":"Zhao","year":"2007","journal-title":"Cancer Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"101249","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"B153","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1006\/dbio.2000.9633","article-title":"Impaired bone formation in transgenic mice resulting from altered integrin function in osteoblasts","volume":"220","author":"Zimmerman","year":"2000","journal-title":"Dev. Biol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1632710\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:33:33Z","timestamp":1755149613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1632710\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":153,"alternative-id":["10.3389\/fcell.2025.1632710"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1632710","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]},"article-number":"1632710"}}