{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:40:54Z","timestamp":1787161254802,"version":"build-2736575974"},"reference-count":199,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Mitochondrial fission process 1 (MTFP1) has emerged as a central regulator of mitochondrial dynamics, playing indispensable roles in maintaining organellar integrity, bioenergetic homeostasis, and stress adaptation - particularly in high-energy-demand tissues such as cardiac and skeletal muscle. Mounting evidence implicates MTFP1 dysfunction in the pathogenesis of diverse diseases including cardiovascular disorders, myopathies, and cancer. Beyond its canonical role in mediating mitochondrial fusion-fission balance, recent studies have unveiled MTFP1\u2019s multifaceted involvement in calcium signaling modulation, ROS metabolism, and mitochondria-ER communication networks, substantially expanding its functional repertoire in cellular physiology. The protein\u2019s pleiotropic effects stem from its ability to integrate metabolic status with organelle dynamics and quality control mechanisms. Particularly noteworthy is MTFP1\u2019s cell-type-specific regulation of the ROS-calcium axis, which appears critical for its differential impacts in disease states. These discoveries position MTFP1 as both a mechanistic linchpin connecting mitochondrial dynamics to cellular homeostasis and a promising but challenging therapeutic target requiring precise contextual modulation. Current research frontiers focus on elucidating tissue-specific regulatory mechanisms of MTFP1 activity, developing microenvironment-sensitive targeting strategies, and exploring its potential as a biomarker for mitochondrial dysfunction-related pathologies. This evolving understanding of MTFP1\u2019s integrative functions opens new avenues for developing precision therapies targeting mitochondrial dynamics in energy-metabolism-linked diseases.<\/jats:p>","DOI":"10.3389\/fcell.2025.1646072","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:28:30Z","timestamp":1757914110000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Mitochondrial fission process 1 protein: a comprehensive review of its core roles in mitochondrial dynamics, disease, and therapeutic targets"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingzhi","family":"Ran","sequence":"first","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhui","family":"He","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s11684-023-0983-0","article-title":"Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca(2+) homeostasis in a murine model of HFpEF","volume":"17","author":"Abudureyimu","year":"2023","journal-title":"Front. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"103081","DOI":"10.1016\/j.redox.2024.103081","article-title":"FBXL4 protects against HFpEF through Drp1-mediated regulation of mitochondrial dynamics and the downstream SERCA2a","volume":"70","author":"Abudureyimu","year":"2024","journal-title":"Redox Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"024207","DOI":"10.1117\/1.NPh.11.2.024207","article-title":"Blue-shifted genetically encoded Ca(2+) indicator with enhanced two-photon absorption","volume":"11","author":"Aggarwal","year":"2024","journal-title":"Neurophotonics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.yjmcc.2019.03.020","article-title":"Cardiomyocyte-GSK-3\u03b1 promotes mPTP opening and heart failure in mice with chronic pressure overload","volume":"130","author":"Ahmad","year":"2019","journal-title":"J. Mol. Cell Cardiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1080\/15548627.2021.1985257","article-title":"Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice","volume":"18","author":"Ahuja","year":"2022","journal-title":"Autophagy"},{"key":"B6","doi-asserted-by":"publisher","first-page":"C465","DOI":"10.1152\/ajpcell.00502.2020","article-title":"Molecular nature and physiological role of the mitochondrial calcium uniporter channel","volume":"320","author":"Alevriadou","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/biom11081144","article-title":"Mitochondrial redox signaling and oxidative stress in kidney diseases","volume":"11","author":"Aranda-Rivera","year":"2021","journal-title":"Biomolecules"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e13216","DOI":"10.1111\/apha.13216","article-title":"Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype","volume":"225","author":"Axelrod","year":"2019","journal-title":"Acta Physiol. (Oxf)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/s41388-023-02596-8","article-title":"Mitochondrial structure and function adaptation in residual triple negative breast cancer cells surviving chemotherapy treatment","volume":"42","author":"Baek","year":"2023","journal-title":"Oncogene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1523\/JNEUROSCI.1504-18.2018","article-title":"Chronic energy depletion due to iron deficiency impairs dendritic mitochondrial motility during Hippocampal neuron development","volume":"39","author":"Bastian","year":"2019","journal-title":"J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.yjmcc.2014.12.018","article-title":"Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects","volume":"80","author":"Bhandari","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12933-020-01208-z","article-title":"Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF","volume":"20","author":"Bode","year":"2021","journal-title":"Cardiovasc Diabetol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"L803","DOI":"10.1152\/ajplung.00158.2023","article-title":"Nicotine affects mitochondrial structure and function in human airway smooth muscle cells","volume":"325","author":"Borkar","year":"2023","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/ALN.0b013e318289bc9b","article-title":"Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain","volume":"118","author":"Boscolo","year":"2013","journal-title":"Anesthesiology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/cphy.c160013","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Bravo-Sagua","year":"2017","journal-title":"Compr. Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"987","DOI":"10.7150\/ijbs.89960","article-title":"Glutamine metabolism promotes renal fibrosis through regulation of mitochondrial energy generation and mitochondrial fission","volume":"20","author":"Cai","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e2204750120","DOI":"10.1073\/pnas.2204750120","article-title":"Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics","volume":"120","author":"Campos","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"155578","DOI":"10.1016\/j.metabol.2023.155578","article-title":"Mitochondria-SR interaction and mitochondrial fusion\/fission in the regulation of skeletal muscle metabolism","volume":"144","author":"Castro-Sepulveda","year":"2023","journal-title":"Metabolism"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1111\/bph.12433","article-title":"Unravelling mitochondrial pathways to Parkinson\u2019s disease","volume":"171","author":"Celardo","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.3390\/cells10081876","article-title":"Mitophagy regulates neurodegenerative diseases","volume":"10","author":"Cen","year":"2021","journal-title":"Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B198","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.wjam.2024.03.003","article-title":"Therapeutic effects of electroacupuncture at different sites on rats with neuropathic pain via the spinal Nrf2\/HO-1 pathway","volume":"34","author":"Chen","year":"2024","journal-title":"World J. Acupunct-Mox."},{"key":"B23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12933-024-02254-7","article-title":"MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1","volume":"23","author":"Chen","year":"2024","journal-title":"Cardiovasc Diabetol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"105301","DOI":"10.1016\/j.nbd.2021.105301","article-title":"Glucocorticoid impairs mitochondrial quality control in neurons","volume":"152","author":"Choi","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.tins.2022.01.005","article-title":"Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases","volume":"45","author":"Cisneros","year":"2022","journal-title":"Trends Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10863-016-9646-z","article-title":"Ceramide channels and mitochondrial outer membrane permeability","volume":"49","author":"Colombini","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"148053","DOI":"10.1016\/j.gene.2023.148053","article-title":"Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models","volume":"896","author":"Cui","year":"2024","journal-title":"Gene"},{"key":"B29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.semcancer.2017.05.002","article-title":"Mitochondrial dysfunction in cancer: potential roles of ATF5 and the mitochondrial UPR","volume":"47","author":"Deng","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s10787-021-00889-6","article-title":"Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer\u2019s disease","volume":"29","author":"Dhapola","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.gendis.2023.03.019","article-title":"Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis","volume":"11","author":"Dong","year":"2024","journal-title":"Genes Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1038\/s41467-022-34316-3","article-title":"Mitochondrial fission process 1 controls inner membrane integrity and protects against heart failure","volume":"13","author":"Donnarumma","year":"2022","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12265-010-9174-x","article-title":"Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors","volume":"3","author":"Dorn","year":"2010","journal-title":"J. Cardiovasc Transl. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1113\/JP281752","article-title":"Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice","volume":"599","author":"Dulac","year":"2021","journal-title":"J. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1182\/blood-2016-02-697003","article-title":"miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics","volume":"128","author":"Duroux-Richard","year":"2016","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/j.molcel.2023.04.022","article-title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy","volume":"83","author":"Fukuda","year":"2023","journal-title":"Mol. Cell"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9629","DOI":"10.3390\/s22249629","article-title":"Cascading alignment for unsupervised domain-adaptive DETR with improved DeNoising anchor boxes","volume":"22","author":"Geng","year":"2022","journal-title":"Sensors (Basel)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.cmet.2020.03.005","article-title":"Mitochondria-endoplasmic reticulum contacts in reactive astrocytes promote vascular remodeling","volume":"31","author":"G\u04e7bel","year":"2020","journal-title":"Cell Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s42003-023-05657-6","article-title":"Curvature sensing lipid dynamics in a mitochondrial inner membrane model","volume":"7","author":"Golla","year":"2024","journal-title":"Commun. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/1479-5876-12-208","article-title":"Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?","volume":"12","author":"Grimm","year":"2014","journal-title":"J. Transl. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1161\/ATVBAHA.118.312196","article-title":"Metabolic stress","volume":"39","author":"Grumbach","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"101955","DOI":"10.1016\/j.arr.2023.101955","article-title":"Mitochondrial dysfunction in aging","volume":"88","author":"Guo","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41586-023-05793-3","article-title":"Spatial mapping of mitochondrial networks and bioenergetics in lung cancer","volume":"615","author":"Han","year":"","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","article-title":"PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models","volume":"19","author":"Han","year":"","journal-title":"Autophagy"},{"key":"B45","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41575-024-00931-2","article-title":"Mitochondrial function and gastrointestinal diseases","volume":"21","author":"Haque","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2021.12.255","article-title":"Mitochondrial homeostasis and redox status in cardiovascular diseases: protective role of the vagal system","volume":"178","author":"He","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"112033","DOI":"10.1016\/j.celrep.2023.112033","article-title":"Numb\/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation","volume":"42","author":"He","year":"2023","journal-title":"Cell Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"jcs261612","DOI":"10.1242\/jcs.261612","article-title":"GTPBP8 modulates mitochondrial fission through a Drp1-dependent process","volume":"137","author":"He","year":"2024","journal-title":"J. Cell Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.wjam.2023.12.003","article-title":"Acupuncture for cancer pain: from clinical evidence to scientific research","volume":"34","author":"He","year":"2024","journal-title":"World J. Acupunct. Moxibust"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1093\/nar\/gkz047","article-title":"Mitochondrial RNA granules are critically dependent on mtDNA replication factors twinkle and mtSSB","volume":"47","author":"Hensen","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e129760","DOI":"10.1172\/jci.insight.129760","article-title":"Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy","volume":"4","author":"Hombrebueno","year":"2019","journal-title":"JCI Insight"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.stem.2022.09.002","article-title":"Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy","volume":"29","author":"Hong","year":"2022","journal-title":"Cell Stem Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S1875-5364(24)60671-0","article-title":"Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission","volume":"22","author":"Hong","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1080\/15548627.2020.1749490","article-title":"The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses","volume":"17","author":"Hu","year":"2021","journal-title":"Autophagy"},{"key":"B55","doi-asserted-by":"publisher","first-page":"660095","DOI":"10.3389\/fendo.2021.660095","article-title":"Mitochondrial fission protein 1: emerging roles in organellar form and function in health and disease","volume":"12","author":"Ihenacho","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/cells11010030","article-title":"Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK\/ULK1 axis","volume":"11","author":"Iorio","year":"2021","journal-title":"Cells"},{"key":"B57","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000365947","article-title":"Role of PGC-1\u03b1 in sarcopenia: etiology and potential intervention - a mini-review","volume":"61","author":"Ji","year":"2015","journal-title":"Gerontology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e28440","DOI":"10.1016\/j.heliyon.2024.e28440","article-title":"HIF1A-dependent overexpression of MTFP1 promotes lung squamous cell carcinoma development by activating the glycolysis pathway","volume":"10","author":"Ji","year":"2024","journal-title":"Heliyon"},{"key":"B59","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13045-022-01313-4","article-title":"Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management","volume":"15","author":"Jin","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"108698","DOI":"10.1016\/j.abb.2020.108698","article-title":"Mitochondrial dysfunction in the development and progression of neurodegenerative diseases","volume":"702","author":"Johnson","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"B61","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/antiox9010057","article-title":"Strenuous acute exercise induces slow and fast twitch-dependent NADPH oxidase expression in rat skeletal muscle","volume":"9","author":"Juliana","year":"2020","journal-title":"Antioxidants"},{"key":"B62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/15548627.2017.1309485","article-title":"Autophagy and kidney inflammation","volume":"13","author":"Kimura","year":"2017","journal-title":"Autophagy"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e00292","DOI":"10.1016\/j.neurot.2023.10.002","article-title":"Mitochondrial dysfunction in neurodegenerative disorders","volume":"21","author":"Klemmensen","year":"2024","journal-title":"Neurotherapeutics"},{"key":"B65","doi-asserted-by":"publisher","first-page":"10669","DOI":"10.1038\/s41598-019-46956-5","article-title":"MTP18 is a novel regulator of mitochondrial fission in CNS neuron development, axonal growth, and injury responses","volume":"9","author":"Kreymerman","year":"2019","journal-title":"Sci. Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"21317","DOI":"10.1039\/c7cp02634j","article-title":"Structural changes and picosecond to second dynamics of cytochrome c in interaction with nitric oxide in ferrous and ferric redox states","volume":"19","author":"Kruglik","year":"2017","journal-title":"Phys. Chem. Chem. Phys."},{"key":"B67","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.mito.2023.07.003","article-title":"Mitochondrial dysfunction and skeletal muscle atrophy: causes, mechanisms, and treatment strategies","volume":"72","author":"Kubat","year":"2023","journal-title":"Mitochondrion"},{"key":"B68","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.mito.2023.02.001","article-title":"Mitofusin-2: functional switch between mitochondrial function and neurodegeneration","volume":"69","author":"Kulkarni","year":"2023","journal-title":"Mitochondrion"},{"key":"B69","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12929-022-00859-2","article-title":"Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?","volume":"29","author":"Kuo","year":"2022","journal-title":"J. Biomed. Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"8179","DOI":"10.3390\/ijms22158179","article-title":"Mitochondrial dynamics and mitophagy in skeletal muscle health and aging","volume":"22","author":"Leduc-Gaudet","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/s43018-022-00354-5","article-title":"Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition","volume":"3","author":"Li","year":"","journal-title":"Nat. Cancer"},{"key":"B72","doi-asserted-by":"publisher","first-page":"120834","DOI":"10.1016\/j.lfs.2022.120834","article-title":"Assessment of mitochondrial dysfunction and implications in cardiovascular disorders","volume":"306","author":"Li","year":"","journal-title":"Life Sci."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjam.2025.08.003","article-title":"China Association of Acupuncture and Moxibustion leading the development of acupuncture-moxibustion discipline: Achievement and practice","author":"Li","year":"2025","journal-title":"World J. Acupunct-Mox."},{"key":"B73","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.actbio.2019.12.011","article-title":"A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e50629","DOI":"10.15252\/embr.202050629","article-title":"Mitophagy receptor FUNDC1 is regulated by PGC-1\u03b1\/NRF1 to fine tune mitochondrial homeostasis","volume":"22","author":"Liu","year":"","journal-title":"EMBO Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41589-020-00723-0","article-title":"A Fbxo48 inhibitor prevents pAMPK\u03b1 degradation and ameliorates insulin resistance","volume":"17","author":"Liu","year":"","journal-title":"Nat. Chem. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s40779-024-00536-5","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil. Med. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"100972","DOI":"10.1016\/j.mam.2021.100972","article-title":"Neuronal autophagy and mitophagy in Parkinson\u2019s disease","volume":"82","author":"Lizama","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"102474","DOI":"10.1016\/j.redox.2022.102474","article-title":"Mitochondrial oxidative stress contributes to diastolic dysfunction through impaired mitochondrial dynamics","volume":"57","author":"Lozhkin","year":"2022","journal-title":"Redox Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"e12800","DOI":"10.1111\/jpi.12800","article-title":"Tunneling nanotubes and mesenchymal stem cells: new insights into the role of melatonin in neuronal recovery","volume":"73","author":"Luchetti","year":"2022","journal-title":"J. Pineal Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s00335-023-10026-z","article-title":"Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db\/db mice","volume":"35","author":"Ludwig-S\u0142omczy\u0144ska","year":"2024","journal-title":"Mamm. Genome"},{"key":"B83","doi-asserted-by":"publisher","first-page":"113291","DOI":"10.1016\/j.celrep.2023.113291","article-title":"Mitochondria-lysosome-related organelles mediate mitochondrial clearance during cellular dedifferentiation","volume":"42","author":"Ma","year":"2023","journal-title":"Cell Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.mito.2012.10.011","article-title":"Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?","volume":"13","author":"Malik","year":"2013","journal-title":"Mitochondrion"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.3390\/ijms22052466","article-title":"Targeting mitochondrial metabolism in prostate cancer with triterpenoids","volume":"22","author":"Mamouni","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10741-016-9530-2","article-title":"Mitochondrial dynamics and cell death in heart failure","volume":"21","author":"Marin-Garcia","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"B87","doi-asserted-by":"publisher","first-page":"jcs248534","DOI":"10.1242\/jcs.248534","article-title":"Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases","volume":"135","author":"Markovinovic","year":"2022","journal-title":"J. Cell Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.3390\/mi14122152","article-title":"The second derivative of fullerene C(60) (SD-C(60)) and biomolecular machinery of hydrogen bonds: water-based nanomedicine","volume":"14","author":"Matija","year":"2023","journal-title":"Micromachines (Basel)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1010428317698391","DOI":"10.1177\/1010428317698391","article-title":"Mitochondrial dynamics and cancer","volume":"39","author":"Maycotte","year":"2017","journal-title":"Tumour Biol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/s42255-024-01047-2","article-title":"Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance \u03b2-oxidation and tumor cell proliferation","volume":"6","author":"Meng","year":"2024","journal-title":"Nat. Metab."},{"key":"B91","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.devcel.2021.02.010","article-title":"Autophagy and organelle homeostasis in cancer","volume":"56","author":"Miller","year":"2021","journal-title":"Dev. Cell"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e08878","DOI":"10.1016\/j.heliyon.2022.e08878","article-title":"Mitochondria-targeted drugs for diabetic kidney disease","volume":"8","author":"Mima","year":"2022","journal-title":"Heliyon"},{"key":"B93","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41418-022-01095-9","article-title":"PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment","volume":"30","author":"Missiroli","year":"2023","journal-title":"Cell Death Differ."},{"key":"B94","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.3390\/cancers16152654","article-title":"Anticancer activity of delta-tocotrienol in human hepatocarcinoma: involvement of autophagy induction","volume":"16","author":"Montagnani Marelli","year":"2024","journal-title":"Cancers (Basel)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e0126314","DOI":"10.1371\/journal.pone.0126314","article-title":"A metabotropic-like flux-independent NMDA receptor regulates Ca2+ exit from endoplasmic reticulum and mitochondrial membrane potential in cultured astrocytes","volume":"10","author":"Montes De Oca Balderas","year":"2015","journal-title":"PLoS One"},{"key":"B96","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.molcel.2017.08.013","article-title":"mTOR controls mitochondrial dynamics and cell survival via MTFP1","volume":"67","author":"Morita","year":"2017","journal-title":"Mol. Cell"},{"key":"B97","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","article-title":"The pathogenesis of Parkinson\u2019s disease","volume":"403","author":"Morris","year":"2024","journal-title":"Lancet"},{"key":"B98","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mito.2013.08.006","article-title":"Metabolic features of the cell danger response","volume":"16","author":"Naviaux","year":"2014","journal-title":"Mitochondrion"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e202006043","DOI":"10.1083\/jcb.202006043","article-title":"Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination","volume":"220","author":"Oshima","year":"2021","journal-title":"J. Cell Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature14300","article-title":"Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans","volume":"521","author":"Palikaras","year":"2015","journal-title":"Nature"},{"key":"B101","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s12033-022-00601-1","article-title":"MiR-125b-5p targets MTFP1 to inhibit cell proliferation, migration, and invasion and facilitate cell apoptosis in endometrial carcinoma","volume":"65","author":"Pan","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.wjam.2023.12.005","article-title":"Acupoint selection rules in treatment of cancer with moxibustion","volume":"34","author":"Pan","year":"2024","journal-title":"World J. Acupunct. Moxibust"},{"key":"B103","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.mito.2018.11.002","article-title":"Mitochondrial dynamics, a key executioner in neurodegenerative diseases","volume":"47","author":"Panchal","year":"2019","journal-title":"Mitochondrion"},{"key":"B104","doi-asserted-by":"publisher","first-page":"14800","DOI":"10.1021\/acs.analchem.4c02364","article-title":"Fluorogenic chemical probe strategy for precise tracking of mitochondrial polarity","volume":"96","author":"Pang","year":"2024","journal-title":"Anal. Chem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1158\/2159-8290.CD-20-1765","article-title":"NKX3.1 localization to mitochondria suppresses prostate cancer initiation","volume":"11","author":"Papachristodoulou","year":"2021","journal-title":"Cancer Discov."},{"key":"B106","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.toxlet.2017.12.004","article-title":"PGAM5 regulates PINK1\/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction","volume":"284","author":"Park","year":"2018","journal-title":"Toxicol. Lett."},{"key":"B107","doi-asserted-by":"publisher","first-page":"8474","DOI":"10.1038\/s41467-023-44143-9","article-title":"Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis","volume":"14","author":"Patitucci","year":"2023","journal-title":"Nat. Commun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"19266","DOI":"10.1073\/pnas.2003236117","article-title":"Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1","volume":"117","author":"Peng","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B109","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41389-022-00401-x","article-title":"Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics","volume":"11","author":"Phan","year":"2022","journal-title":"Oncogenesis"},{"key":"B110","doi-asserted-by":"publisher","first-page":"021014","DOI":"10.1117\/1.NPh.2.2.021014","article-title":"Comparison of genetically encoded calcium indicators for monitoring action potentials in mammalian brain by two-photon excitation fluorescence microscopy","volume":"2","author":"Podor","year":"2015","journal-title":"Neurophotonics"},{"key":"B111","doi-asserted-by":"publisher","first-page":"102797","DOI":"10.1016\/j.redox.2023.102797","article-title":"Metabolic reprogramming, oxidative stress, and pulmonary hypertension","volume":"64","author":"Pokharel","year":"2023","journal-title":"Redox Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jad.2024.01.045","article-title":"Suvorexant improves mitochondrial dynamics with the regulation of orexinergic and mTOR activation in rats exhibiting PTSD-like symptoms","volume":"350","author":"Prajapati","year":"2024","journal-title":"J. Affect Disord."},{"key":"B113","doi-asserted-by":"publisher","first-page":"foaa014","DOI":"10.1093\/femsyr\/foaa014","article-title":"Natural extract and its fractions isolated from the marine bacterium Pseudoalteromonas flavipulchra STILL-33 have antioxidant and antiaging activities in Schizosaccharomyces pombe","volume":"20","author":"Prastya","year":"2020","journal-title":"FEMS Yeast Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"802502","DOI":"10.3389\/fcell.2021.802502","article-title":"Neuraminidase1 inhibitor protects against doxorubicin-induced cardiotoxicity via suppressing Drp1-Dependent mitophagy","volume":"9","author":"Qin","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1080\/15548627.2021.1938913","article-title":"Mitochondrial autophagy and cell survival is regulated by the circadian clock gene in cardiac myocytes during ischemic stress","volume":"17","author":"Rabinovich-Nikitin","year":"2021","journal-title":"Autophagy"},{"key":"B117","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s40203-022-00119-z","article-title":"Modelling and targeting mitochondrial protein tyrosine phosphatase 1: a computational approach","volume":"10","author":"Ragunathan","year":"2022","journal-title":"Silico Pharmacol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1080\/15548627.2024.2373676","article-title":"Key considerations for investigating and interpreting autophagy in skeletal muscle","volume":"20","author":"Rahman","year":"2024","journal-title":"Autophagy"},{"key":"B119","doi-asserted-by":"publisher","first-page":"8200","DOI":"10.1523\/JNEUROSCI.1157-19.2019","article-title":"Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease","volume":"39","author":"Rangaraju","year":"2019","journal-title":"J. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3390\/cells8050488","article-title":"Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer\u2019s disease","volume":"8","author":"Reddy","year":"2019","journal-title":"Cells"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/s41556-020-00584-8","article-title":"Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics","volume":"22","author":"Rey","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00018-023-05018-w","article-title":"Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of charcot-marie-tooth type 2A","volume":"80","author":"Rizzo","year":"2023","journal-title":"Cell Mol. Life Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1007\/s00018-021-03775-0","article-title":"Mitochondrial quality control: from molecule to organelle","volume":"78","author":"Roca-Portoles","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1186\/s12967-023-04498-5","article-title":"Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer","volume":"21","author":"Rocca","year":"2023","journal-title":"J. Transl. Med."},{"key":"B125","doi-asserted-by":"publisher","first-page":"C869","DOI":"10.1152\/ajpcell.00429.2024","article-title":"Regulation of cancer cell lipid metabolism and oxidative phosphorylation by microenvironmental acidosis","volume":"327","author":"Rolver","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41556-022-00843-w","article-title":"Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance","volume":"24","author":"Romani","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.redox.2017.01.013","article-title":"Mitochondrial dynamics in type 2 diabetes: pathophysiological implications","volume":"11","author":"Rovira-Llopis","year":"2017","journal-title":"Redox Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"711227","DOI":"10.3389\/fmolb.2021.711227","article-title":"Role of copper on mitochondrial function and metabolism","volume":"8","author":"Ruiz","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3390\/membranes11050327","article-title":"Tauroursodeoxycholic acid (TUDCA)-lipid interactions and antioxidant properties of TUDCA studied in model of photoreceptor membranes","volume":"11","author":"Sabat","year":"2021","journal-title":"Membr. (Basel)"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/s41418-022-01022-y","article-title":"Targeting mitochondrial metabolism for precision medicine in cancer","volume":"29","author":"Sainero-Alcolado","year":"2022","journal-title":"Cell Death Differ."},{"key":"B131","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ijcard.2022.12.003","article-title":"Ferulic acid attenuates high glucose-induced MAM alterations via PACS2\/IP3R2\/FUNDC1\/VDAC1 pathway activating proapoptotic proteins and ameliorates cardiomyopathy in diabetic rats","volume":"372","author":"Salin Raj","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jns.2007.01.033","article-title":"Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders","volume":"257","author":"Sas","year":"2007","journal-title":"J. Neurol. Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"e12484","DOI":"10.1111\/jpi.12484","article-title":"Melatonin activates FIS1, DYN1, and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure","volume":"66","author":"Scarpelli","year":"2019","journal-title":"J. Pineal Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13046-024-03020-z","article-title":"HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis","volume":"43","author":"Schneegans","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B135","doi-asserted-by":"publisher","first-page":"101954","DOI":"10.1016\/j.redox.2021.101954","article-title":"Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a\/HO-1 signaling pathway","volume":"41","author":"Shi","year":"2021","journal-title":"Redox Biol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.wjam.2023.07.001","article-title":"Review acupuncture for fibromyalgia: an evidence map","volume":"34","author":"Shi","year":"2024","journal-title":"World J. Acupunct. Moxibust"},{"key":"B137","doi-asserted-by":"publisher","first-page":"11577","DOI":"10.1038\/s41598-017-11002-9","article-title":"ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain","volume":"7","author":"Shneyer","year":"2017","journal-title":"Sci. Rep."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e1008085","DOI":"10.1371\/journal.pgen.1008085","article-title":"Mitochondrial fusion is required for regulation of mitochondrial DNA replication","volume":"15","author":"Silva Ramos","year":"2019","journal-title":"PLoS Genet."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/humu.22127","article-title":"Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)","volume":"33","author":"Sim","year":"2012","journal-title":"Hum. Mutat."},{"key":"B140","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/j.bbamcr.2018.06.008","article-title":"NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation","volume":"1865","author":"Singh","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"599261","DOI":"10.3389\/fgene.2021.599261","article-title":"Network analysis and transcriptome profiling identify autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection","volume":"12","author":"Singh","year":"2021","journal-title":"Front. Genet."},{"key":"B142","doi-asserted-by":"publisher","first-page":"101951","DOI":"10.1016\/j.mito.2024.101951","article-title":"Mitochondrial bioenergetics of breast cancer","volume":"79","author":"Singh","year":"2024","journal-title":"Mitochondrion"},{"key":"B143","doi-asserted-by":"publisher","first-page":"e0171007","DOI":"10.1371\/journal.pone.0171007","article-title":"Global proteome changes in the rat diaphragm induced by endurance exercise training","volume":"12","author":"Sollanek","year":"2017","journal-title":"PLoS One"},{"key":"B144","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cmet.2014.12.019","article-title":"Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart","volume":"21","author":"Song","year":"2015","journal-title":"Cell Metab."},{"key":"B145","doi-asserted-by":"publisher","first-page":"3960773","DOI":"10.1155\/2021\/3960773","article-title":"Mitochondrial quality control in the maintenance of cardiovascular homeostasis: the roles and interregulation of UPS, mitochondrial dynamics and mitophagy","volume":"2021","author":"Song","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B146","doi-asserted-by":"publisher","first-page":"115652","DOI":"10.1016\/j.biopha.2023.115652","article-title":"Mitochondrial dysfunction: a fatal blow in depression","volume":"167","author":"Song","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B147","doi-asserted-by":"publisher","first-page":"F362","DOI":"10.1152\/ajprenal.00579.2015","article-title":"Delivery of interleukin-10 via injectable hydrogels improves renal outcomes and reduces systemic inflammation following ischemic acute kidney injury in mice","volume":"311","author":"Soranno","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbabio.2017.01.004","article-title":"Mitochondrial dysfunction and mitochondrial dynamics-the cancer connection","volume":"1858","author":"Srinivasan","year":"2017","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"B149","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12013-024-01245-5","article-title":"Drp1: focus on diseases triggered by the mitochondrial pathway","volume":"82","author":"Sun","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"B150","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.molcel.2004.09.026","article-title":"Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis","volume":"16","author":"Szabadkai","year":"2004","journal-title":"Mol. Cell"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1017\/erm.2014.14","article-title":"Mitochondria-targeted therapies for acute kidney injury","volume":"16","author":"T\u00e1bara","year":"2014","journal-title":"Expert Rev. Mol. Med."},{"key":"B152","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1016\/j.cell.2024.05.017","article-title":"MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels","volume":"187","author":"T\u00e1bara","year":"2024","journal-title":"Cell"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e00993-18","DOI":"10.1128\/JVI.00993-18","article-title":"Human immunodeficiency virus type 1 gp120 and tat induce mitochondrial fragmentation and incomplete mitophagy in human neurons","volume":"92","author":"Teodorof-Diedrich","year":"2018","journal-title":"J. Virol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1111\/jcmm.17189","article-title":"Mitochondrial quality control in stroke: from the mechanisms to therapeutic potentials","volume":"26","author":"Tian","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.3390\/genes14101876","article-title":"Role of mitochondrial dynamics in heart diseases","volume":"14","author":"Tokuyama","year":"2023","journal-title":"Genes (Basel)"},{"key":"B156","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.yjmcc.2020.04.015","article-title":"The role of Drp1 in mitophagy and cell death in the heart","volume":"142","author":"Tong","year":"2020","journal-title":"J. Mol. Cell Cardiol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"5507","DOI":"10.2174\/138161282035140911142118","article-title":"Mitochondrial biogenesis: pharmacological approaches","volume":"20","author":"Valero","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"B158","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/JP271301","article-title":"Mitochondrial dynamics, mitophagy and cardiovascular disease","volume":"594","author":"V\u00e1squez-Trincado","year":"2016","journal-title":"J. Physiol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"e1002807","DOI":"10.1371\/journal.pcbi.1002807","article-title":"Electron transfer interactome of cytochrome C","volume":"8","author":"Volkov","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/cdd.2017.61","article-title":"Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression","volume":"24","author":"Wang","year":"","journal-title":"Cell Death Differ."},{"key":"B161","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cell.2017.08.041","article-title":"Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages","volume":"171","author":"Wang","year":"","journal-title":"Cell"},{"key":"B162","doi-asserted-by":"publisher","first-page":"104771","DOI":"10.1016\/j.phrs.2020.104771","article-title":"Mitochondrial quality control in cardiac microvascular ischemia-reperfusion injury: new insights into the mechanisms and therapeutic potentials","volume":"156","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B163","doi-asserted-by":"publisher","first-page":"10707","DOI":"10.1080\/21655979.2022.2051259","article-title":"Long non-coding RNA MIR4435-2HG\/microRNA-125a-5p axis is involved in myocardial ischemic injuries","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"B164","doi-asserted-by":"publisher","first-page":"106608","DOI":"10.1016\/j.phrs.2022.106608","article-title":"ALKBH5 attenuates mitochondrial fission and ameliorates liver fibrosis by reducing Drp1 methylation","volume":"187","author":"Wang","year":"","journal-title":"Pharmacol. Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12929-023-00956-w","article-title":"Role of mitochondrial alterations in human cancer progression and cancer immunity","volume":"30","author":"Wang","year":"","journal-title":"J. Biomed. Sci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.cell.2016.11.042","article-title":"Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor","volume":"168","author":"Wei","year":"2017","journal-title":"Cell"},{"key":"B167","doi-asserted-by":"publisher","first-page":"5448","DOI":"10.1172\/JCI121859","article-title":"MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury","volume":"128","author":"Wei","year":"2018","journal-title":"J. Clin. Invest"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.bbamem.2016.03.012","article-title":"Membrane remodeling and mechanics: experiments and simulations of alpha-Synuclein","volume":"1858","author":"West","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B169","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/978-3-319-55330-6_22","article-title":"High-density lipoprotein regulation of mitochondrial function","volume":"982","author":"White","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3390\/cells11010173","article-title":"Dermatan sulfate affects breast cancer cell function via the induction of necroptosis","volume":"11","author":"Wisowski","year":"2022","journal-title":"Cells"},{"key":"B171","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1161\/CIRCULATIONAHA.117.030235","article-title":"Binding of FUN14 domain containing 1 with inositol 1,4,5-Trisphosphate receptor in mitochondria-associated endoplasmic reticulum membranes maintains mitochondrial dynamics and function in hearts in vivo","volume":"136","author":"Wu","year":"2017","journal-title":"Circulation"},{"key":"B172","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/cac2.12247","article-title":"Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1","volume":"42","author":"Wu","year":"","journal-title":"Cancer Commun. (Lond)"},{"key":"B173","doi-asserted-by":"publisher","first-page":"153884","DOI":"10.1016\/j.phymed.2021.153884","article-title":"Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK","volume":"95","author":"Wu","year":"","journal-title":"Phytomedicine"},{"key":"B174","doi-asserted-by":"publisher","first-page":"116282","DOI":"10.1016\/j.jep.2023.116282","article-title":"QiShenYiQi dripping pill alleviates myocardial ischemia-induced ferroptosis via improving mitochondrial dynamical homeostasis and biogenesis","volume":"308","author":"Wu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.wjam.2023.12.004","article-title":"China Association of Acupuncture and Moxibustion (CAAM): Leading development of acupuncture, contributing Chinese wisdom to the world","volume":"34","author":"Wu","year":"2024","journal-title":"World J. Acupunct-Mox."},{"key":"B175","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12964-024-01490-4","article-title":"Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets","volume":"22","author":"Wu","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"B176","doi-asserted-by":"publisher","first-page":"9502","DOI":"10.3390\/ijms22179502","article-title":"RNA granules in the mitochondria and their organization under mitochondrial stresses","volume":"22","author":"Xavier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B177","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/cbin.11278","article-title":"MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production","volume":"44","author":"Xiao","year":"2020","journal-title":"Cell Biol. Int."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1158\/0008-5472.CAN-21-3910","article-title":"Mitochondrial micropeptide STMP1 enhances mitochondrial fission to promote tumor metastasis","volume":"82","author":"Xie","year":"2022","journal-title":"Cancer Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/15548627.2019.1628520","article-title":"PHB2 (prohibitin 2) promotes PINK1-PRKN\/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis","volume":"16","author":"Yan","year":"2020","journal-title":"Autophagy"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1161\/STROKEAHA.123.043391","article-title":"Oxytocin improves intracerebral hemorrhage outcomes by suppressing neuronal pyroptosis and mitochondrial fission","volume":"54","author":"Yang","year":"2023","journal-title":"Stroke"},{"key":"B181","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.3724\/abbs.2024083","article-title":"PRR34-AS1 promotes mitochondrial division and glycolytic reprogramming in hepatocellular carcinoma cells through upregulation of MIEF2","volume":"56","author":"Yang","year":"2024","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"B182","doi-asserted-by":"publisher","first-page":"112434","DOI":"10.1016\/j.celrep.2023.112434","article-title":"Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways","volume":"42","author":"Yasuda","year":"2023","journal-title":"Cell Rep."},{"key":"B183","doi-asserted-by":"publisher","first-page":"18","DOI":"10.14348\/molcells.2018.2277","article-title":"A molecular approach to mitophagy and mitochondrial dynamics","volume":"41","author":"Yoo","year":"2018","journal-title":"Mol. Cells"},{"key":"B184","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41420-024-01953-0","article-title":"PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration","volume":"10","author":"You","year":"2024","journal-title":"Cell Death Discov."},{"key":"B185","doi-asserted-by":"publisher","first-page":"541","DOI":"10.14670\/HH-18-191","article-title":"The role of mitochondrial fusion and fission in the process of cardiac oxidative stress","volume":"35","author":"Yu","year":"2020","journal-title":"Histol. Histopathol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41392-021-00790-2","article-title":"Fis1 phosphorylation by met promotes mitochondrial fission and hepatocellular carcinoma metastasis","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3390\/antiox12061163","article-title":"Mitochondrial fission as a therapeutic target for metabolic diseases: insights into antioxidant strategies","volume":"12","author":"Yu","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B188","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41392-020-00447-6","article-title":"Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity","volume":"6","author":"Zeng","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1275370","DOI":"10.3389\/fphar.2023.1275370","article-title":"Selective inhibitors targeting Fis1\/Mid51 protein-protein interactions protect against hypoxia-induced damage in cardiomyocytes","volume":"14","author":"Zerihun","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1080\/10717544.2018.1440445","article-title":"Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury","volume":"25","author":"Zhao","year":"2018","journal-title":"Drug Deliv."},{"key":"B191","doi-asserted-by":"publisher","first-page":"4633","DOI":"10.1038\/s41380-021-01038-9","article-title":"Dysbindin-1 regulates mitochondrial fission and gamma oscillations","volume":"26","author":"Zhao","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B192","doi-asserted-by":"publisher","first-page":"e17538","DOI":"10.7717\/peerj.17538","article-title":"Gypenosides exert cardioprotective effects by promoting mitophagy and activating PI3K\/Akt\/GSK-3\u03b2\/Mcl-1 signaling","volume":"12","author":"Zheng","year":"2024","journal-title":"PeerJ"},{"key":"B193","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12967-023-04027-4","article-title":"TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury","volume":"21","author":"Zhong","year":"2023","journal-title":"J. Transl. Med."},{"key":"B194","doi-asserted-by":"publisher","first-page":"e23781","DOI":"10.7554\/eLife.23781","article-title":"Atomistic simulations indicate the c-subunit ring of the F(1)F(o) ATP synthase is not the mitochondrial permeability transition pore","volume":"6","author":"Zhou","year":"2017","journal-title":"Elife"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1080\/15548627.2021.1984656","article-title":"Full-coverage regulations of autophagy by ROS: from induction to maturation","volume":"18","author":"Zhou","year":"2022","journal-title":"Autophagy"},{"key":"B196","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/ddr.21521","article-title":"Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2-induced PSMB5 in endothelial cells","volume":"80","author":"Zhu","year":"2019","journal-title":"Drug Dev. Res."},{"key":"B197","doi-asserted-by":"publisher","first-page":"154015","DOI":"10.1016\/j.phymed.2022.154015","article-title":"Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K\/Akt\/mTOR signaling pathway by voacamine suppress breast cancer progression","volume":"99","author":"Zuo","year":"2022","journal-title":"Phytomedicine"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1646072\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:14:32Z","timestamp":1770801272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1646072\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":199,"alternative-id":["10.3389\/fcell.2025.1646072"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1646072","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]},"article-number":"1646072"}}