{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:10:42Z","timestamp":1759993842779,"version":"build-2065373602"},"reference-count":244,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014013","name":"United Kingdom Research and Innovation","doi-asserted-by":"publisher","award":["MR\/X020754\/1"],"award-info":[{"award-number":["MR\/X020754\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The formation of a functional nervous system during development and its maintenance in adulthood rely on precise regulation of neural stem cell (NSC) proliferation and differentiation. During neurogenesis, progenitor cells use various cellular and molecular mechanisms to balance these processes. Among these, dynamic signal encoding, specifically ultradian oscillations, which are regular protein fluctuations occurring over a few hours, has emerged as a key mechanism underlying NSC fate decisions. In adults, reactivation of quiescent NSCs, proliferation, and differentiation are also controlled by ultradian oscillations. Furthermore, these ultradian dynamics signals are modulated by microRNAs and are considered critical for the ability of neural progenitors to transition between different states. Altogether, these findings may have potential significance for our understanding of NSC reactivation and differentiation in the context of injury or neurodegeneration. The mammalian spinal cord harbours endogenous multipotent NSCs that respond to injury but mostly generate astrocytes and do not undergo neurogenesis. By contrast, many anamniotes regenerate spinal cord neurons from endogenous progenitors, despite the same molecular signalling pathways being activated, suggesting that subtle differences in how these pathways are regulated may result in different regenerative outcomes. Whether oscillatory dynamics could influence the reactivation and differentiation of NSCs upon spinal cord injury remains to be determined. This review explores the role of transcription factor ultradian oscillations in neurogenesis and how microRNAs modulate them. Additionally, we examine evidence for the role of ultradian dynamics in the reactivation of quiescent NSCs and their potential significance for regenerative neurogenesis in the context of spinal cord injury.<\/jats:p>","DOI":"10.3389\/fcell.2025.1680322","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:41:20Z","timestamp":1759902080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Importance of ultradian oscillations in neurogenesis during development and its implications for spinal cord regeneration"],"prefix":"10.3389","volume":"13","author":[{"given":"Sami A.","family":"Leino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10484","DOI":"10.1523\/JNEUROSCI.4721-09.2010","article-title":"Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells","volume":"30","author":"Ables","year":"2010","journal-title":"J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.molcel.2012.11.002","article-title":"Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals","volume":"49","author":"Albeck","year":"2013","journal-title":"Mol. Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1242\/dev.122796","article-title":"A comparative view of regenerative neurogenesis in vertebrates","volume":"143","author":"Alunni","year":"2016","journal-title":"Development"},{"key":"B4","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/35067582","article-title":"A unified hypothesis on the lineage of neural stem cells","volume":"2","author":"Alvarez-Buylla","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.neuron.2014.08.004","article-title":"A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells","volume":"83","author":"Andersen","year":"2014","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ydbio.2025.01.015","article-title":"Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cord","volume":"520","author":"Angell Swearer","year":"2025","journal-title":"Dev. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.ceb.2008.09.002","article-title":"Oscillating signaling pathways during embryonic development","volume":"20","author":"Aulehla","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1242\/dev.02403","article-title":"Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system","volume":"133","author":"Baek","year":"2006","journal-title":"Development"},{"key":"B9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","article-title":"Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation","volume":"122","author":"Bagga","year":"2005","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.devcel.2007.05.014","article-title":"Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1","volume":"13","author":"Bai","year":"2007","journal-title":"Dev. Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/s0959-4388(03)00015-1","article-title":"Induction and patterning of neuronal development, and its connection to cell cycle control","volume":"13","author":"Bally-Cuif","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.stem.2008.06.011","article-title":"Stem cells for spinal cord repair","volume":"3","author":"Barnabe-Heider","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.stem.2010.07.014","article-title":"Origin of new glial cells in intact and injured adult spinal cord","volume":"7","author":"Barnabe-Heider","year":"2010","journal-title":"Cell Stem Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.celrep.2015.09.050","article-title":"Serotonin promotes development and regeneration of spinal motor neurons in zebrafish","volume":"13","author":"Barreiro-Iglesias","year":"2015","journal-title":"Cell Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"B16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1126\/science.1215704","article-title":"Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish","volume":"336","author":"Bazzini","year":"2012","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.mod.2006.07.001","article-title":"Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles","volume":"123","author":"Beck","year":"2006","journal-title":"Mech. Dev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.devcel.2015.01.001","article-title":"Neuronal regeneration from ependymo-radial glial cells: cook, little pot, cook","volume":"32","author":"Becker","year":"2015","journal-title":"Dev. Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"dev199907","DOI":"10.1242\/dev.199907","article-title":"Regenerative neurogenesis: the integration of developmental, physiological and immune signals","volume":"149","author":"Becker","year":"2022","journal-title":"Development"},{"key":"B20","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/(sici)1096-9861(19970127)377:4<577::aid-cne8>3.0.co;2-#","article-title":"Axonal regrowth after spinal cord transection in adult zebrafish","volume":"377","author":"Becker","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7837","DOI":"10.1523\/JNEUROSCI.2420-04.2004","article-title":"L1.1 is involved in spinal cord regeneration in adult zebrafish","volume":"24","author":"Becker","year":"2004","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.pneurobio.2018.04.002","article-title":"The spinal ependymal zone as a source of endogenous repair cells across vertebrates","volume":"170","author":"Becker","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s004270050265","article-title":"Neurogenesis during caudal spinal cord regeneration in adult newts","volume":"209","author":"Benraiss","year":"1999","journal-title":"Dev. Genes Evol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrn874","article-title":"Proneural genes and the specification of neural cell types","volume":"3","author":"Bertrand","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/s0959-437x(03)00083-2","article-title":"Oscillations, clocks and segmentation","volume":"13","author":"Bessho","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"17935","DOI":"10.1523\/JNEUROSCI.3860-12.2012","article-title":"microRNA-21 regulates astrocytic response following spinal cord injury","volume":"32","author":"Bhalala","year":"2012","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrneurol.2013.67","article-title":"The emerging roles of microRNAs in CNS injuries","volume":"9","author":"Bhalala","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e9902","DOI":"10.15252\/msb.20209902","article-title":"A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord","volume":"17","author":"Biga","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.devcel.2010.11.018","article-title":"MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis","volume":"20","author":"Bonev","year":"2011","journal-title":"Dev. Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.celrep.2012.05.017","article-title":"MicroRNA-9 modulates Hes1 ultradian oscillations by forming a double-negative feedback loop","volume":"2","author":"Bonev","year":"2012","journal-title":"Cell Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1038\/s41467-019-11707-7","article-title":"Moving beyond the glial scar for spinal cord repair","volume":"10","author":"Bradbury","year":"2019","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1002\/dvdy.22100","article-title":"Expression of the oscillating gene her1 is directly regulated by hairy\/enhancer of split, T-box, and suppressor of hairless proteins in the zebrafish segmentation clock","volume":"238","author":"Brend","year":"2009","journal-title":"Dev. Dyn."},{"key":"B33","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.expneurol.2014.03.017","article-title":"Radial glial progenitors repair the zebrafish spinal cord following transection","volume":"256","author":"Briona","year":"2014","journal-title":"Exp. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s11571-012-9236-7","article-title":"Functional characteristics of a double negative feedback loop mediated by microRNAs","volume":"7","author":"Cai","year":"2013","journal-title":"Cogn. Neurodyn"},{"key":"B35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ydbio.2017.05.011","article-title":"Reduce, reuse, recycle - developmental signals in spinal cord regeneration","volume":"432","author":"Cardozo","year":"2017","journal-title":"Dev. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1006\/exnr.1998.6785","article-title":"Acute inflammatory response in spinal cord following impact injury","volume":"151","author":"Carlson","year":"1998","journal-title":"Exp. Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/dvdy.22769","article-title":"Cloning and expression of a retinoic acid receptor \u03b22 subtype from the adult newt: evidence for an early role in tail and caudal spinal cord regeneration","volume":"240","author":"Carter","year":"2011","journal-title":"Dev. Dyn."},{"key":"B38","doi-asserted-by":"publisher","first-page":"885269","DOI":"10.3389\/fcell.2022.885269","article-title":"The symmetry of neural stem cell and progenitor divisions in the vertebrate brain","volume":"10","author":"Casas Gimeno","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6170","DOI":"10.1128\/MCB.20.16.6170-6183.2000","article-title":"HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression","volume":"20","author":"Castella","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.devcel.2021.04.031","article-title":"A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord","volume":"56","author":"Cavone","year":"2021","journal-title":"Dev. Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1038\/s41467-021-25052-1","article-title":"Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord","volume":"12","author":"Chang","year":"2021","journal-title":"Nat. Commun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"5355","DOI":"10.1073\/pnas.94.10.5355","article-title":"Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression","volume":"94","author":"Chen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1111\/j.1460-9568.2004.03671.x","article-title":"Recovery of bimodal locomotion in the spinal-transected salamander, Pleurodeles waltlii","volume":"20","author":"Chevallier","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/s41590-021-01101-1","article-title":"Intravital three-photon microscopy allows visualization over the entire depth of mouse lymph nodes","volume":"23","author":"Choe","year":"2022","journal-title":"Nat. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"dmm044131","DOI":"10.1242\/dmm.044131","article-title":"Building bridges, not walls: spinal cord regeneration in zebrafish","volume":"13","author":"Cigliola","year":"2020","journal-title":"Dis. Model Mech."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0304-3940(88)90471-5","article-title":"Regeneration of descending axons in the spinal cord of the axolotl","volume":"89","author":"Clarke","year":"1988","journal-title":"Neurosci. Lett."},{"key":"B47","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/s0022-5193(76)80131-2","article-title":"A clock and wavefront model for control of the number of repeated structures during animal morphogenesis","volume":"58","author":"Cooke","year":"1976","journal-title":"J. Theor. Biol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.devcel.2012.03.003","article-title":"miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors","volume":"22","author":"Coolen","year":"2012","journal-title":"Dev. Cell"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1101\/2025.08.04.668440","article-title":"HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cells","author":"Cottrell","year":"2025","journal-title":"BioRxiv"},{"key":"B50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.expneurol.2013.12.024","article-title":"Functional regeneration beyond the glial scar","volume":"253","author":"Cregg","year":"2014","journal-title":"Exp. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12859-020-03561-y","article-title":"OscoNet: inferring oscillatory gene networks","volume":"21","author":"Cutillo","year":"2020","journal-title":"BMC Bioinforma."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1002\/dvdy.20956","article-title":"MicroRNA expression during chick embryo development","volume":"235","author":"Darnell","year":"2006","journal-title":"Dev. Dyn."},{"key":"B244","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/0014-4886(90)90124-b","article-title":"Time course of salamander spinal cord regeneration and recovery of swimming: HRP retrograde pathway tracing and kinematic analysis","volume":"108","author":"Davis","year":"1990","journal-title":"Exp. Neurol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1634\/stemcells.2005-0138","article-title":"Exogenous and fibroblast growth factor 2\/epidermal growth factor-regulated endogenous cytokines regulate neural precursor cell growth and differentiation","volume":"24","author":"Deleyrolle","year":"2006","journal-title":"Stem Cells"},{"key":"B54","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.brainres.2018.03.013","article-title":"bHLH transcription factors in neural development, disease, and reprogramming","volume":"1705","author":"Dennis","year":"2019","journal-title":"Brain Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1523\/JNEUROSCI.6398-11.2012","article-title":"Notch signaling controls generation of motor neurons in the lesioned spinal cord of adult zebrafish","volume":"32","author":"Dias","year":"2012","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/BJ20121807","article-title":"Spinal cord regeneration: where fish, frogs and salamanders lead the way, can we follow?","volume":"451","author":"Diaz Quiroz","year":"2013","journal-title":"Biochem. J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1242\/dmm.014837","article-title":"Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat","volume":"7","author":"Diaz Quiroz","year":"2014","journal-title":"Dis. Model Mech."},{"key":"B58","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.1215691","article-title":"miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay","volume":"336","author":"Djuranovic","year":"2012","journal-title":"Science"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997","article-title":"Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain","volume":"17","author":"Doetsch","year":"1997","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"dev202640","DOI":"10.1242\/dev.202640","article-title":"Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness","volume":"151","author":"Doostdar","year":"2024","journal-title":"Development"},{"key":"B61","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/0014-4886(72)90085-4","article-title":"The role of ependyma in spinal cord regeneration in the urodele, Triturus","volume":"37","author":"Egar","year":"1972","journal-title":"Exp. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"13794","DOI":"10.1523\/JNEUROSCI.1567-10.2010","article-title":"RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus","volume":"30","author":"Ehm","year":"2010","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.molcel.2014.08.028","article-title":"mRNA destabilization is the dominant effect of mammalian microRNAs by the time substantial repression ensues","volume":"56","author":"Eichhorn","year":"2014","journal-title":"Mol. Cell"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1523\/JNEUROSCI.3547-03.2004","article-title":"Reactive astrocytes protect tissue and preserve function after spinal cord injury","volume":"24","author":"Faulkner","year":"2004","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.stemcr.2014.06.018","article-title":"CRISPR-mediated genomic deletion of Sox2 in the axolotl shows a requirement in spinal cord neural stem cell amplification during tail regeneration","volume":"3","author":"Fei","year":"2014","journal-title":"Stem Cell Rep."},{"key":"B66","doi-asserted-by":"publisher","first-page":"703989","DOI":"10.3389\/fcell.2021.703989","article-title":"Emerging exosomes and exosomal MiRNAs in spinal cord injury","volume":"9","author":"Feng","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e50826","DOI":"10.3791\/50826","article-title":"Implanting glass spinal cord windows in adult mice with experimental autoimmune encephalomyelitis","author":"Fenrich","year":"2013","journal-title":"J. Vis. Exp."},{"key":"B68","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1089\/neu.2013.3034","article-title":"Characterization of vascular disruption and blood-spinal cord barrier permeability following traumatic spinal cord injury","volume":"31","author":"Figley","year":"2014","journal-title":"J. Neurotrauma"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1038\/s41598-024-51340-z","article-title":"Identification of genes with oscillatory expression in glioblastoma: the paradigm of SOX2","volume":"14","author":"Fu","year":"2024","journal-title":"Sci. Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1749-8104-7-13","article-title":"Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells","volume":"7","author":"Gaete","year":"2012","journal-title":"Neural Dev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/ijms21041271","article-title":"Dynamic behavior of p53 driven by delay and a Microrna-34a-Mediated feedback loop","volume":"21","author":"Gao","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/reg2.99","article-title":"Axonal regeneration in zebrafish spinal cord","volume":"5","author":"Ghosh","year":"2018","journal-title":"Regen. (Oxf)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1371\/journal.pbio.0050150","article-title":"Setting the tempo in development: an investigation of the zebrafish somite clock mechanism","volume":"5","author":"Giudicelli","year":"2007","journal-title":"PLoS Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"7477","DOI":"10.1523\/JNEUROSCI.0758-12.2012","article-title":"Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish","volume":"32","author":"Goldshmit","year":"2012","journal-title":"J. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13064-018-0122-9","article-title":"Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish","volume":"13","author":"Goldshmit","year":"2018","journal-title":"Neural Dev."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3399","DOI":"10.1038\/ncomms4399","article-title":"microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states","volume":"5","author":"Goodfellow","year":"2014","journal-title":"Nat. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/0065-2571(65)90067-1","article-title":"Oscillatory behavior in enzymatic control processes","volume":"3","author":"Goodwin","year":"1965","journal-title":"Adv. Enzyme Regul."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1002\/glia.22851","article-title":"Endogenous neural stem cell responses to stroke and spinal cord injury","volume":"63","author":"Gregoire","year":"2015","journal-title":"Glia"},{"key":"B79","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/exnr.2001.7628","article-title":"Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion","volume":"168","author":"Grossman","year":"2001","journal-title":"Exp. Neurol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nature09267","article-title":"mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.neuroscience.2010.10.026","article-title":"Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish","volume":"172","author":"Guo","year":"2011","journal-title":"Neuroscience"},{"key":"B82","doi-asserted-by":"publisher","first-page":"6562","DOI":"10.1038\/s41467-021-26605-0","article-title":"Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module","volume":"12","author":"Harada","year":"2021","journal-title":"Nat. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.celrep.2012.11.012","article-title":"Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene","volume":"3","author":"Harima","year":"2013","journal-title":"Cell Rep."},{"key":"B84","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ydbio.2014.09.018","article-title":"Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration","volume":"396","author":"Hayashi","year":"2014","journal-title":"Dev. Biol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.molimm.2022.03.007","article-title":"Exosomal miR-9-5p derived from BMSCs alleviates apoptosis, inflammation and endoplasmic reticulum stress in spinal cord injury by regulating the HDAC5\/FGF2 axis","volume":"145","author":"He","year":"2022","journal-title":"Mol. Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"e1000238","DOI":"10.1371\/journal.pbio.1000238","article-title":"Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA","volume":"7","author":"Hendrickson","year":"2009","journal-title":"PLoS Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"dev172148","DOI":"10.1242\/dev.172148","article-title":"Mechanisms of notch signaling: a simple logic deployed in time and space","volume":"146","author":"Henrique","year":"2019","journal-title":"Development"},{"key":"B88","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1006\/nbdi.2001.0414","article-title":"Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord","volume":"8","author":"Hermann","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4454","DOI":"10.1093\/emboj\/20.16.4454","article-title":"Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid\/hindbrain","volume":"20","author":"Hirata","year":"2001","journal-title":"EMBO J."},{"key":"B90","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1126\/science.1074560","article-title":"Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop","volume":"298","author":"Hirata","year":"2002","journal-title":"Science"},{"key":"B91","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/ng1372","article-title":"Instability of Hes7 protein is crucial for the somite segmentation clock","volume":"36","author":"Hirata","year":"2004","journal-title":"Nat. Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ydbio.2007.12.031","article-title":"TGF-beta signaling is required for multiple processes during Xenopus tail regeneration","volume":"315","author":"Ho","year":"2008","journal-title":"Dev. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/glia.22725","article-title":"Functional requirement of dicer1 and miR-17-5p in reactive astrocyte proliferation after spinal cord injury in the mouse","volume":"62","author":"Hong","year":"2014","journal-title":"Glia"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3791\/63213","article-title":"Deep-tissue three-photon fluorescence microscopy in intact mouse and zebrafish brain","author":"Hontani","year":"2022","journal-title":"J. Vis. Exp."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/jnr.25118","article-title":"Quantification of functional recovery in a larval zebrafish model of spinal cord injury","volume":"100","author":"Hossainian","year":"2022","journal-title":"J. Neurosci. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"151848","DOI":"10.1016\/j.aanat.2021.151848","article-title":"Multiple functions of hes genes in the proliferation and differentiation of neural stem cells","volume":"239","author":"Hu","year":"2022","journal-title":"Ann. Anat."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1002\/dvdy.22438","article-title":"Cellular response after crush injury in adult zebrafish spinal cord","volume":"239","author":"Hui","year":"2010","journal-title":"Dev. Dyn."},{"key":"B98","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.devcel.2017.11.010","article-title":"Zebrafish regulatory T cells mediate organ-specific regenerative programs","volume":"43","author":"Hui","year":"2017","journal-title":"Dev. Cell"},{"key":"B99","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.neures.2022.04.006","article-title":"Single-nucleus RNA sequencing identified cells with ependymal cell-like features enriched in neonatal mice after spinal cord injury","volume":"181","author":"Ikeda-Yorifuji","year":"2022","journal-title":"Neurosci. Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.tins.2014.07.006","article-title":"Oscillatory control of bHLH factors in neural progenitors","volume":"37","author":"Imayoshi","year":"2014","journal-title":"Trends Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1523\/JNEUROSCI.4987-09.2010","article-title":"Essential roles of notch signaling in maintenance of neural stem cells in developing and adult brains","volume":"30","author":"Imayoshi","year":"2010","journal-title":"J. Neurosci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1126\/science.1242366","article-title":"Oscillatory control of factors determining multipotency and fate in mouse neural progenitors","volume":"342","author":"Imayoshi","year":"2013","journal-title":"Science"},{"key":"B103","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fncel.2015.00288","article-title":"Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells","volume":"9","author":"Imayoshi","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1006\/exnr.1997.6449","article-title":"Local changes in vascular architecture following partial spinal cord lesion in the rat","volume":"145","author":"Imperato-Kalmar","year":"1997","journal-title":"Exp. Neurol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"3627","DOI":"10.1242\/dev.104497","article-title":"Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions","volume":"141","author":"Isomura","year":"2014","journal-title":"Development"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1007\/s00018-014-1815-9","article-title":"Retinoic acid signaling and neuronal differentiation","volume":"72","author":"Janesick","year":"2015","journal-title":"Cell Mol. Life Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1093\/brain\/aws047","article-title":"MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury","volume":"135","author":"Jee","year":"","journal-title":"Brain"},{"key":"B108","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1089\/hum.2011.121","article-title":"Silencing of miR20a is crucial for Ngn1-mediated neuroprotection in injured spinal cord","volume":"23","author":"Jee","year":"","journal-title":"Hum. Gene Ther."},{"key":"B109","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/s0014-5793(03)00279-5","article-title":"Sustained oscillations and time delays in gene expression of protein Hes1","volume":"541","author":"Jensen","year":"2003","journal-title":"FEBS Lett."},{"key":"B110","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/35049541","article-title":"Neuronal specification in the spinal cord: inductive signals and transcriptional codes","volume":"1","author":"Jessell","year":"2000","journal-title":"Nat. Rev. Genet."},{"key":"B111","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0092-8674(00)80956-3","article-title":"Identification of a neural stem cell in the adult mammalian central nervous system","volume":"96","author":"Johansson","year":"1999","journal-title":"Cell"},{"key":"B112","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00441-014-1888-7","article-title":"Dynamic expression and roles of hes factors in neural development","volume":"359","author":"Kageyama","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neures.2018.09.005","article-title":"Dynamic control of neural stem cells by bHLH factors","volume":"138","author":"Kageyama","year":"2019","journal-title":"Neurosci. Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2183\/pjab.96.026","article-title":"The significance of gene expression dynamics in neural stem cell regulation","volume":"96","author":"Kageyama","year":"2020","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1042\/BST20230439","article-title":"Transcriptional control of neural stem cell activity","volume":"52","author":"Kaise","year":"2024","journal-title":"Biochem. Soc. Trans."},{"key":"B117","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1101\/gad.349000.121","article-title":"Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity","volume":"36","author":"Kaise","year":"2022","journal-title":"Genes Dev."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1038\/ncomms2895","article-title":"Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis","volume":"4","author":"Kawaguchi","year":"2013","journal-title":"Nat. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1254927","DOI":"10.1126\/science.1254927","article-title":"Coordination of progenitor specification and growth in mouse and chick spinal cord","volume":"345","author":"Kicheva","year":"2014","journal-title":"Science"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e14668","DOI":"10.1371\/journal.pone.0014668","article-title":"Modelling the Delta1\/Notch1 pathway: in search of the mediator(s) of neural stem cell differentiation","volume":"6","author":"Kiparissides","year":"2011","journal-title":"PLoS One"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1101\/gad.1823109","article-title":"The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells","volume":"23","author":"Kobayashi","year":"2009","journal-title":"Genes Dev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1242\/dev.127.14.2989","article-title":"Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation","volume":"127","author":"Kondo","year":"2000","journal-title":"Development"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1242\/dev.063834","article-title":"Evolutionary plasticity of segmentation clock networks","volume":"138","author":"Krol","year":"2011","journal-title":"Development"},{"key":"B124","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1002\/cne.22739","article-title":"Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish","volume":"520","author":"Kuscha","year":"","journal-title":"J. Comp. Neurol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1002\/cne.23115","article-title":"Lesion-induced generation of interneuron cell types in specific dorsoventral domains in the spinal cord of adult zebrafish","volume":"520","author":"Kuscha","year":"","journal-title":"J. Comp. Neurol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"6019","DOI":"10.1093\/nar\/gkw550","article-title":"Understanding microRNA-mediated gene regulatory networks through mathematical modelling","volume":"44","author":"Lai","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnint.2018.00010","article-title":"The times of our lives: interaction among different biological periodicities","volume":"12","author":"Laje","year":"2018","journal-title":"Front. Integr. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1006\/exnr.2000.7494","article-title":"Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury","volume":"166","author":"Lee","year":"2000","journal-title":"Exp. Neurol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1002\/dvdy.24210","article-title":"RAR\u03b22 expression is induced by the down-regulation of microRNA 133a during caudal spinal cord regeneration in the adult newt","volume":"243","author":"Lepp","year":"2014","journal-title":"Dev. Dyn."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/dvdy.24342","article-title":"MicroRNA dysregulation in response to RAR\u03b22 inhibition reveals a negative feedback loop between MicroRNAs 1, 133a, and RAR\u03b22 during tail and spinal cord regeneration in the adult newt","volume":"244","author":"Lepp","year":"2015","journal-title":"Dev. Dyn."},{"key":"B131","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nn.2115","article-title":"MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary","volume":"11","author":"Leucht","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"e1001252","DOI":"10.1371\/journal.pbio.1001252","article-title":"Pulsed feedback defers cellular differentiation","volume":"10","author":"Levine","year":"2012","journal-title":"PLoS Biol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/s0960-9822(03)00534-7","article-title":"Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator","volume":"13","author":"Lewis","year":"2003","journal-title":"Curr. Biol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1279051","DOI":"10.1155\/2016\/1279051","article-title":"Extrinsic and intrinsic regulation of axon regeneration by MicroRNAs after Spinal cord injury","volume":"2016","author":"Li","year":"2016","journal-title":"Neural Plast."},{"key":"B135","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10867-015-9391-2","article-title":"Neural fate decisions mediated by combinatorial regulation of Hes1 and miR-9","volume":"42","author":"Li S.","year":"2016","journal-title":"J. Biol. Phys."},{"key":"B136","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.ydbio.2008.01.032","article-title":"Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration","volume":"316","author":"Lin","year":"2008","journal-title":"Dev. Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1523\/JNEUROSCI.17-14-05395.1997","article-title":"Neuronal and glial apoptosis after traumatic spinal cord injury","volume":"17","author":"Liu","year":"1997","journal-title":"J. Neurosci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1038\/sj.emboj.7601352","article-title":"A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players","volume":"25","author":"Liu","year":"2006","journal-title":"EMBO J."},{"key":"B139","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.expneurol.2009.06.015","article-title":"Altered microRNA expression following traumatic spinal cord injury","volume":"219","author":"Liu","year":"2009","journal-title":"Exp. Neurol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"eabb8795","DOI":"10.1126\/science.abb8795","article-title":"A latent lineage potential in resident neural stem cells enables spinal cord repair","volume":"370","author":"Llorens-Bobadilla","year":"2020","journal-title":"Science"},{"key":"B141","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/sj.sc.3100632","article-title":"Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury","volume":"36","author":"Lou","year":"1998","journal-title":"Spinal Cord."},{"key":"B142","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/nn718","article-title":"Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex","volume":"4","author":"Lu","year":"2001","journal-title":"Nat. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.3934\/mbe.2023109","article-title":"Dynamic behavior of P53-Mdm2-Wip1 gene regulatory network under the influence of time delay and noise","volume":"20","author":"Luo","year":"2023","journal-title":"Math. Biosci. Eng."},{"key":"B144","doi-asserted-by":"publisher","first-page":"112520","DOI":"10.1016\/j.celrep.2023.112520","article-title":"Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21","volume":"42","author":"Maeda","year":"2023","journal-title":"Cell Rep."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1038\/s41467-019-10734-8","article-title":"Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis","volume":"10","author":"Manning","year":"2019","journal-title":"Nat. Commun."},{"key":"B146","doi-asserted-by":"publisher","first-page":"103198","DOI":"10.1016\/j.isci.2021.103198","article-title":"HES1 protein oscillations are necessary for neural stem cells to exit from quiescence","volume":"24","author":"Marinopoulou","year":"2021","journal-title":"iScience"},{"key":"B147","doi-asserted-by":"publisher","first-page":"e182","DOI":"10.1371\/journal.pbio.0060182","article-title":"Spinal cord injury reveals multilineage differentiation of ependymal cells","volume":"6","author":"Meletis","year":"2008","journal-title":"PLoS Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1016\/j.devcel.2025.06.004","article-title":"NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation","volume":"60","author":"Miller","year":"2025","journal-title":"Dev. Cell"},{"key":"B149","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1126\/science.aaf2679","article-title":"Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish","volume":"354","author":"Mokalled","year":"2016","journal-title":"Science"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/s0960-9822(03)00494-9","article-title":"Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays","volume":"13","author":"Monk","year":"","journal-title":"Curr. Biol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1042\/bst0311457","article-title":"Unravelling Nature's networks","volume":"31","author":"Monk","year":"","journal-title":"Biochem. Soc. Trans."},{"key":"B152","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ydbio.2015.03.009","article-title":"Regeneration of Xenopus laevis spinal cord requires Sox2\/3 expressing cells","volume":"408","author":"Munoz","year":"2015","journal-title":"Dev. Biol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.bbrc.2019.11.060","article-title":"The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation","volume":"522","author":"Nakamura","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B154","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1752-0509-3-45","article-title":"miRNA-regulated dynamics in circadian oscillator models","volume":"3","author":"Nandi","year":"2009","journal-title":"BMC Syst. Biol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.devcel.2021.12.008","article-title":"Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection","volume":"57","author":"Nogueira-Rodrigues","year":"2022","journal-title":"Dev. Cell"},{"key":"B156","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nrm2530","article-title":"Design principles of biochemical oscillators","volume":"9","author":"Novak","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"dev182204","DOI":"10.1242\/dev.182204","article-title":"Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain","volume":"147","author":"Ochi","year":"2020","journal-title":"Development"},{"key":"B158","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neures.2014.07.010","article-title":"Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish","volume":"88","author":"Ogai","year":"2014","journal-title":"Neurosci. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1242\/dev.129155","article-title":"Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish","volume":"143","author":"Ohnmacht","year":"2016","journal-title":"Development"},{"key":"B160","doi-asserted-by":"publisher","first-page":"11948","DOI":"10.1523\/JNEUROSCI.3127-06.2006","article-title":"Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord","volume":"26","author":"Ohori","year":"2006","journal-title":"J. Neurosci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1006\/dbio.1999.9523","article-title":"The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation","volume":"216","author":"Olsen","year":"1999","journal-title":"Dev. Biol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/s0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis","volume":"91","author":"Palmeirim","year":"1997","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jot.2021.09.008","article-title":"Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury","volume":"31","author":"Pan","year":"2021","journal-title":"J. Orthop. Transl."},{"key":"B164","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/embr.201438447","article-title":"Neurogenesis during development of the vertebrate central nervous system","volume":"15","author":"Paridaen","year":"2014","journal-title":"EMBO Rep."},{"key":"B165","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1002\/dvdy.21365","article-title":"An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish","volume":"236","author":"Park","year":"2007","journal-title":"Dev. Dyn."},{"key":"B166","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1038\/sj.emboj.7600447","article-title":"Mash1 specifies neurons and oligodendrocytes in the postnatal brain","volume":"23","author":"Parras","year":"2004","journal-title":"EMBO J."},{"key":"B167","doi-asserted-by":"publisher","first-page":"e50932","DOI":"10.15252\/embr.202050932","article-title":"Foxm1 regulates neural progenitor fate during spinal cord regeneration","volume":"22","author":"Pelzer","year":"2021","journal-title":"EMBO Rep."},{"key":"B168","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/jez.1401290109","article-title":"Regeneration of the spinal cord in the salamander","volume":"129","author":"Piatt","year":"1955","journal-title":"J. Exp. Zool."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1126\/science.1218351","article-title":"p53 dynamics control cell fate","volume":"336","author":"Purvis","year":"2012","journal-title":"Science"},{"key":"B170","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1242\/dev.144337","article-title":"MicroRNAs in neural development: from master regulators to fine-tuners","volume":"144","author":"Rajman","year":"2017","journal-title":"Development"},{"key":"B171","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0301-0082(87)90023-2","article-title":"Why are so many biological systems periodic?","volume":"29","author":"Rapp","year":"1987","journal-title":"Prog. Neurobiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/0022-5193(81)90304-0","article-title":"Frequency encoded biochemical regulation is more accurate than amplitude dependent control","volume":"90","author":"Rapp","year":"1981","journal-title":"J. Theor. Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"8510","DOI":"10.1523\/JNEUROSCI.1189-08.2008","article-title":"Motor neuron regeneration in adult zebrafish","volume":"28","author":"Reimer","year":"2008","journal-title":"J. Neurosci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"15073","DOI":"10.1523\/JNEUROSCI.4748-09.2009","article-title":"Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafish","volume":"29","author":"Reimer","year":"2009","journal-title":"J. Neurosci."},{"key":"B175","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.devcel.2013.04.012","article-title":"Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration","volume":"25","author":"Reimer","year":"2013","journal-title":"Dev. Cell"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","article-title":"Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system","volume":"255","author":"Reynolds","year":"1992","journal-title":"Science"},{"key":"B177","doi-asserted-by":"publisher","first-page":"230103","DOI":"10.1098\/rsob.230103","article-title":"Development and repair of blood vessels in the zebrafish spinal cord","volume":"13","author":"Ribeiro","year":"2023","journal-title":"Open Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"7628","DOI":"10.1021\/jacs.9b03505","article-title":"Optical control of cardiac function with a photoswitchable muscarinic agonist","volume":"141","author":"Riefolo","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"B179","doi-asserted-by":"publisher","first-page":"e2113527118","DOI":"10.1073\/pnas.2113527118","article-title":"Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER(+) breast cancer cells","volume":"118","author":"Sabherwal","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B180","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s42003-019-0335-4","article-title":"AP-1(cFos\/JunB)\/miR-200a regulate the pro-regenerative glial cell response during axolotl spinal cord regeneration","volume":"2","author":"Sabin","year":"2019","journal-title":"Commun. Biol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1002\/jcp.27486","article-title":"An overview of microRNAs: biology, functions, therapeutics, and analysis methods","volume":"234","author":"Saliminejad","year":"2019","journal-title":"J. Cell Physiol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"pgaf009","DOI":"10.1093\/pnasnexus\/pgaf009","article-title":"Control of cortical slow oscillations and epileptiform discharges with photoswitchable type 1 muscarinic ligands","volume":"4","author":"Sanchez-Sanchez","year":"2025","journal-title":"PNAS Nexus"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1126\/science.1155998","article-title":"Control of the reversibility of cellular quiescence by the transcriptional repressor HES1","volume":"321","author":"Sang","year":"2008","journal-title":"Science"},{"key":"B184","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1242\/dev.01906","article-title":"Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration","volume":"132","author":"Schnapp","year":"2005","journal-title":"Development"},{"key":"B185","doi-asserted-by":"publisher","first-page":"3648","DOI":"10.1046\/j.1460-9568.1999.00792.x","article-title":"Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord","volume":"11","author":"Schnell","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.ydbio.2009.08.008","article-title":"miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events","volume":"334","author":"Sehm","year":"2009","journal-title":"Dev. Biol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.tibtech.2018.06.011","article-title":"Near-infrared fluorescent proteins: multiplexing and optogenetics across scales","volume":"36","author":"Shcherbakova","year":"2018","journal-title":"Trends Biotechnol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s12031-024-02242-2","article-title":"Regulation of MicroRNAs after spinal cord injury in adult zebrafish","volume":"74","author":"Shen","year":"2024","journal-title":"J. Mol. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00018-024-05117-2","article-title":"MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6\/calcium activity pathway","volume":"81","author":"Shen","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"B190","doi-asserted-by":"publisher","first-page":"10415","DOI":"10.1523\/JNEUROSCI.3219-08.2008","article-title":"MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium","volume":"28","author":"Shibata","year":"2008","journal-title":"J. Neurosci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1523\/JNEUROSCI.5085-10.2011","article-title":"MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors","volume":"31","author":"Shibata","year":"2011","journal-title":"J. Neurosci."},{"key":"B192","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1006\/exnr.1997.6697","article-title":"FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord","volume":"148","author":"Shihabuddin","year":"1997","journal-title":"Exp. Neurol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.neuron.2008.02.014","article-title":"Oscillations in notch signaling regulate maintenance of neural progenitors","volume":"58","author":"Shimojo","year":"2008","journal-title":"Neuron"},{"key":"B194","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1101\/gad.270785.115","article-title":"Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis","volume":"30","author":"Shimojo","year":"2016","journal-title":"Genes Dev."},{"key":"B195","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1242\/dev.109.3.509","article-title":"Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila","volume":"109","author":"Simpson","year":"1990","journal-title":"Development"},{"key":"B196","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.semcdb.2014.06.019","article-title":"Dynamic signal encoding--from cells to organisms","volume":"34","author":"Sonnen","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"e103558","DOI":"10.15252\/embj.2019103558","article-title":"Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator","volume":"39","author":"Soto","year":"2020","journal-title":"EMBO J."},{"key":"B198","doi-asserted-by":"publisher","first-page":"dev200474","DOI":"10.1242\/dev.200474","article-title":"Sequential and additive expression of miR-9 precursors control timing of neurogenesis","volume":"149","author":"Soto","year":"2022","journal-title":"Development"},{"key":"B199","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1101\/gad.1591507","article-title":"MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation","volume":"21","author":"Standart","year":"2007","journal-title":"Genes Dev."},{"key":"B200","doi-asserted-by":"publisher","first-page":"bio060270","DOI":"10.1242\/bio.060270","article-title":"P2X7 regulates ependymo-radial glial cell proliferation in adult Danio rerio following spinal cord injury","volume":"13","author":"Stefanova","year":"2024","journal-title":"Biol. Open"},{"key":"B201","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1001\/jamaneurol.2014.2927","article-title":"Role of endogenous neural stem cells in spinal cord injury and repair","volume":"72","author":"Stenudd","year":"2015","journal-title":"JAMA Neurol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"110440","DOI":"10.1016\/j.celrep.2022.110440","article-title":"Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties","volume":"38","author":"Stenudd","year":"2022","journal-title":"Cell Rep."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1084101","DOI":"10.3389\/fimmu.2022.1084101","article-title":"Immune response following traumatic spinal cord injury: pathophysiology and therapies","volume":"13","author":"Sterner","year":"2022","journal-title":"Front. Immunol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuroscience.2011.03.063","article-title":"MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair","volume":"186","author":"Strickland","year":"2011","journal-title":"Neuroscience"},{"key":"B205","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/dgd.12626","article-title":"Regulation of active and quiescent somatic stem cells by notch signaling","volume":"62","author":"Sueda","year":"2020","journal-title":"Dev. Growth Differ."},{"key":"B206","doi-asserted-by":"publisher","first-page":"119198","DOI":"10.1016\/j.gep.2021.119198","article-title":"Oscillatory expression of Ascl1 in oligodendrogenesis","volume":"41","author":"Sueda","year":"2021","journal-title":"Gene Expr. Patterns"},{"key":"B207","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1101\/gad.323196.118","article-title":"High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain","volume":"33","author":"Sueda","year":"2019","journal-title":"Genes Dev."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1242\/dev.001255","article-title":"Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord","volume":"134","author":"Sugimori","year":"2007","journal-title":"Development"},{"key":"B209","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1242\/dev.015370","article-title":"Ascl1 is required for oligodendrocyte development in the spinal cord","volume":"135","author":"Sugimori","year":"2008","journal-title":"Development"},{"key":"B210","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/s0092-8674(01)00224-0","article-title":"Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms","volume":"104","author":"Sun","year":"2001","journal-title":"Cell"},{"key":"B211","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/gtc.12009","article-title":"MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain","volume":"17","author":"Tan","year":"2012","journal-title":"Genes cells."},{"key":"B212","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1471-2202-15-92","article-title":"Time-specific microRNA changes during spinal motoneuron degeneration in adult rats following unilateral brachial plexus root avulsion: ipsilateral vs. contralateral changes","volume":"15","author":"Tang","year":"2014","journal-title":"BMC Neurosci."},{"key":"B213","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-213X-14-27","article-title":"Notochord-derived hedgehog is essential for tail regeneration in Xenopus tadpole","volume":"14","author":"Taniguchi","year":"2014","journal-title":"BMC Dev. Biol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ydbio.2017.09.034","article-title":"Salamander spinal cord regeneration: the ultimate positive control in vertebrate spinal cord regeneration","volume":"432","author":"Tazaki","year":"2017","journal-title":"Dev. Biol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/s41596-020-00425-w","article-title":"Imaging and optogenetic modulation of vascular mural cells in the live brain","volume":"16","author":"Tong","year":"2021","journal-title":"Nat. Protoc."},{"key":"B216","doi-asserted-by":"publisher","first-page":"4670","DOI":"10.1038\/s41467-018-07036-w","article-title":"Dynamic control of proinflammatory cytokines Il-1\u03b2 and Tnf-\u03b1 by macrophages in zebrafish spinal cord regeneration","volume":"9","author":"Tsarouchas","year":"2018","journal-title":"Nat. Commun."},{"key":"B217","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3390\/cells10061404","article-title":"Know how to regrow-axon regeneration in the zebrafish spinal cord","volume":"10","author":"Tsata","year":"2021","journal-title":"Cells"},{"key":"B218","doi-asserted-by":"publisher","first-page":"dev193946","DOI":"10.1242\/dev.193946","article-title":"Reactive oligodendrocyte progenitor cells (Re-) myelinate the regenerating zebrafish spinal cord","volume":"147","author":"Tsata","year":"2020","journal-title":"Development"},{"key":"B219","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/jnr.10089","article-title":"Upregulation of the HLH Id gene family in neural progenitors and glial cells of the rat spinal cord following contusion injury","volume":"66","author":"Tzeng","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"B220","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/dgd.12262","article-title":"Genetic oscillators in development","volume":"58","author":"Uriu","year":"2016","journal-title":"Dev. Growth Differ."},{"key":"B221","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s12264-013-1361-8","article-title":"Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation","volume":"29","author":"Vajn","year":"2013","journal-title":"Neurosci. Bull."},{"key":"B222","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0065-1281(98)80021-4","article-title":"Long term effects of spinal cord transection in zebrafish: swimming performances, and metabolic properties of the neuromuscular system","volume":"100","author":"van Raamsdonk","year":"1998","journal-title":"Acta histochem."},{"key":"B223","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1016\/j.devcel.2021.07.021","article-title":"RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish","volume":"56","author":"Vandestadt","year":"2021","journal-title":"Dev. Cell"},{"key":"B224","doi-asserted-by":"publisher","first-page":"113737","DOI":"10.1016\/j.expneurol.2021.113737","article-title":"Regenerated interneurons integrate into locomotor circuitry following spinal cord injury","volume":"342","author":"Vasudevan","year":"2021","journal-title":"Exp. Neurol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/1545968307313500","article-title":"Spinal cord repair: bridging the divide","volume":"22","author":"Verma","year":"2008","journal-title":"Neurorehabil Neural Repair"},{"key":"B226","doi-asserted-by":"publisher","first-page":"dev200033","DOI":"10.1242\/dev.200033","article-title":"Regulation of stem cell identity by miR-200a during spinal cord regeneration","volume":"149","author":"Walker","year":"2022","journal-title":"Development"},{"key":"B227","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/glia.22743","article-title":"MicroRNA-145 as one negative regulator of astrogliosis","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"},{"key":"B228","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.devcel.2017.03.001","article-title":"miR-219 cooperates with miR-338 in myelination and promotes Myelin repair in the CNS","volume":"40","author":"Wang","year":"2017","journal-title":"Dev. Cell"},{"key":"B229","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00441-020-03298-3","article-title":"Lithium alleviated spinal cord injury (SCI)-induced apoptosis and inflammation in rats via BDNF-AS\/miR-9-5p axis","volume":"384","author":"Wang","year":"2021","journal-title":"Cell Tissue Res."},{"key":"B230","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41467-017-00143-0","article-title":"Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish","volume":"8","author":"Wehner","year":"2017","journal-title":"Nat. Commun."},{"key":"B231","doi-asserted-by":"publisher","first-page":"7599","DOI":"10.1523\/JNEUROSCI.16-23-07599.1996","article-title":"Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis","volume":"16","author":"Weiss","year":"1996","journal-title":"J. Neurosci."},{"key":"B232","doi-asserted-by":"publisher","first-page":"4034","DOI":"10.1073\/pnas.0510928103","article-title":"MicroRNAs direct rapid deadenylation of mRNA","volume":"103","author":"Wu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B233","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.bbrc.2007.04.207","article-title":"The role of microRNA in the delayed negative feedback regulation of gene expression","volume":"358","author":"Xie","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B234","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.3892\/mmr.2019.9904","article-title":"MicroRNA-124 improves functional recovery and suppresses Bax-dependent apoptosis in rats following spinal cord injury","volume":"19","author":"Xu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"B235","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1523\/JNEUROSCI.21-24-09814.2001","article-title":"Transcription factor expression and notch-dependent regulation of neural progenitors in the adult rat spinal cord","volume":"21","author":"Yamamoto","year":"2001","journal-title":"J. Neurosci."},{"key":"B236","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1111\/j.1460-9568.2011.07643.x","article-title":"MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish","volume":"33","author":"Yu","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"B237","doi-asserted-by":"publisher","first-page":"e34534","DOI":"10.1371\/journal.pone.0034534","article-title":"MicroRNA dysregulation in the spinal cord following traumatic injury","volume":"7","author":"Yunta","year":"2012","journal-title":"PLoS One"},{"key":"B238","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/0306-4522(93)90247-d","article-title":"Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system","volume":"54","author":"Zammit","year":"1993","journal-title":"Neuroscience"},{"key":"B239","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2025.07.028","article-title":"NG2 glia promote injured spinal cord repair through neuronal transdifferentiation and keratins expression in juvenile mice","author":"Zhao","year":"2025","journal-title":"Spine J."},{"key":"B241","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41580-022-00562-y","article-title":"Regulation of axonal regeneration after mammalian spinal cord injury","volume":"24","author":"Zheng","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B242","doi-asserted-by":"publisher","first-page":"041916","DOI":"10.1103\/PhysRevE.85.041916","article-title":"Mechanisms generating bistability and oscillations in microRNA-mediated motifs","volume":"85","author":"Zhou","year":"2012","journal-title":"Phys. Rev. E Stat. Nonlin Soft Matter Phys."},{"key":"B243","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41586-022-04912-w","article-title":"Molecular landscapes of human hippocampal immature neurons across lifespan","volume":"607","author":"Zhou","year":"2022","journal-title":"Nature"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1680322\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:37:28Z","timestamp":1759991848000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1680322\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":244,"alternative-id":["10.3389\/fcell.2025.1680322"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1680322","relation":{},"ISSN":["2296-634X"],"issn-type":[{"type":"electronic","value":"2296-634X"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"article-number":"1680322"}}