{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:29:18Z","timestamp":1783758558311,"version":"3.55.0"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The endoplasmic reticulum (ER) plays a central role in protein and lipid biosynthesis, quality control, and secretion. While its functional roles are well characterized, the mechanisms underlying ER biogenesis remain less defined. Developmental transitions in secretory tissues such as liver, pancreas, mammary gland, and plasma cells illustrate the remarkable capacity to expand their ER network in response to physiological demand. Central to this process is the ribosome receptor p180, a vertebrate-specific integral ER membrane protein whose expression is both necessary and sufficient for rough ER proliferation. Studies in yeast first demonstrated that overexpression of membrane proteins, including HMG-CoA reductase and domains of p180, induces membrane proliferation, thereby establishing yeast as a tractable model for ER biogenesis. In mammalian systems, p180 uniquely links membrane protein expression with biosynthetic scaling, enhancing ribosome binding, mRNA stabilization, lipid biosynthesis, and Golgi biogenesis. Gain- and loss-of-function approaches in human monocytic THP-1 cells confirm that p180 is indispensable for establishing a high-capacity secretory cells phenotype, coordinating the transition from sparse to abundant rough ER and secretory output. Importantly, p180-driven ER proliferation occurs independently of the unfolded protein response (UPR), highlighting distinct yet complementary mechanisms of ER remodeling: p180 as a constitutive biosynthetic scaffold and the UPR as a stress-induced regulator. Together, these findings position p180 as a master determinant of secretory architecture, with implications for development, immunity, and disease. Understanding the molecular underpinnings of p180 function and its integration with lipid metabolism and translation control will advance both basic cell biology and therapeutic strategies targeting secretory dysfunction. Recent work also suggests that p180-mediated ER expansion is dynamically tuned to nutrient availability and growth factor signaling, further linking organelle biogenesis to cellular metabolism. Dysregulation of p180 expression or function may contribute to a variety of pathological states such as cancer, neuronal dysregulation, and atherosclerosis where ER homeostasis is disrupted. Due to its vertebrate-specific origin, p180 also represents an evolutionary concerved lineage that enabled the diversification of complex secretory systems. Ultimately, dissecting the molecular circuits that govern p180 function promises to refine our understanding of organelle plasticity and to identify novel targets for therapeutic intervention.<\/jats:p>","DOI":"10.3389\/fcell.2025.1682420","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:29:16Z","timestamp":1758259756000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["ER biogenesis without stress: how the ribosome receptor, p180, defines a developmental program beyond the UPR"],"prefix":"10.3389","volume":"13","author":[{"given":"Payam","family":"Benyamini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41580-024-00794-0","article-title":"Homeostasis control in health and disease by the unfolded protein response","volume":"26","author":"Acosta-Alvear","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0304-4157(01)00005-3","article-title":"Protein translocation across membranes","volume":"1513","author":"Agarraberes","year":"2001","journal-title":"Biochimica Biophysica Acta (BBA)-Biomembranes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0074-7696(01)05004-5","article-title":"Endoplasmic reticulum of animal cells and its organization into structural and functional domains","volume":"205","author":"Baumann","year":"2001","journal-title":"Int. Rev. Cytol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1083\/jcb.146.2.273","article-title":"Expression of the 180-kD ribosome receptor induces membrane proliferation and increased secretory activity in yeast","volume":"146","author":"Becker","year":"1999","journal-title":"J. cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/B978-0-12-386033-0.00005-0","article-title":"Protein quality control, retention, and degradation at the endoplasmic reticulum","volume":"292","author":"Benyair","year":"2011","journal-title":"Int. Rev. cell Mol. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1091\/mbc.e08-07-0682","article-title":"Knockdown of p180 eliminates the terminal differentiation of a secretory cell line","volume":"20","author":"Benyamini","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3976","DOI":"10.1073\/pnas.1101643108","article-title":"Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes","volume":"108","author":"Bian","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1091\/mbc.01-07-0366","article-title":"IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast","volume":"13","author":"Block-Alper","year":"2002","journal-title":"Mol. Biol. cell"},{"key":"B9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1146\/annurev-biochem-062209-093836","article-title":"Protein folding and modification in the mammalian endoplasmic reticulum","volume":"80","author":"Braakman","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1126\/science.aar7899","article-title":"Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum","volume":"360","author":"Braunger","year":"2018","journal-title":"Science"},{"key":"B11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0074-7696(08)62139-7","article-title":"Translocation of proteins across the endoplasmic reticulum membrane","volume":"178","author":"Brodsky","year":"1997","journal-title":"Int. Rev. Cytol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ceb.2011.05.004","article-title":"Protein folding and quality control in the endoplasmic reticulum: recent lessons from yeast and mammalian cell systems","volume":"23","author":"Brodsky","year":"2011","journal-title":"Curr. Opin. cell Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1126\/science.1068999","article-title":"A system for stable expression of short interfering RNAs in mammalian cells","volume":"296","author":"Brummelkamp","year":"2002","journal-title":"science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"13293","DOI":"10.1074\/jbc.271.23.13293","article-title":"Regulation of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae","volume":"271","author":"Carman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1005152","DOI":"10.3389\/fonc.2022.1005152","article-title":"RRBP1 depletion of bone metastatic cancer cells contributes to enhanced expression of the osteoblastic phenotype","volume":"12","author":"Chen","year":"2022","journal-title":"Front. Oncol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-3-642-79275-5_23","article-title":"Regulation of terminal differentiation of human B-cells by IL-6","volume":"194","author":"Chen-Kiang","year":"1994","journal-title":"Mech. B-Cell Neoplasia"},{"key":"B17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ceb.2016.03.021","article-title":"N-linked glycosylation and homeostasis of the endoplasmic reticulum","volume":"41","author":"Cherepanova","year":"2016","journal-title":"Curr. Opin. cell Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12929-023-00905-7","article-title":"ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking","volume":"30","author":"Chiu","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3389\/fnins.2019.00560","article-title":"Linking the endoplasmic reticulum to Parkinson\u2019s disease and alpha-synucleinopathy","volume":"13","author":"Colla","year":"2019","journal-title":"Front. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e1001336","DOI":"10.1371\/journal.pbio.1001336","article-title":"p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum","volume":"10","author":"Cui","year":"2012","journal-title":"PLoS Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1083\/jcb.30.1.73","article-title":"Biogenesis of endoplasmic reticulum membranes: I. Structural and chemical differentiation in developing rat hepatocyte","volume":"30","author":"Dallner","year":"","journal-title":"J. cell Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1083\/jcb.30.1.97","article-title":"Biogenesis of endoplasmic reticulum membranes: II. Synthesis of constitutive microsomal enzymes in developing rat hepatocyte","volume":"30","author":"Dallner","year":"","journal-title":"J. Cell Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1152\/physrev.1966.46.2.323","article-title":"Peroxisomes (microbodies and related particles)","volume":"46","author":"De Duve","year":"1966","journal-title":"Physiol. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0002-9610(97)00140-2","article-title":"Molecular insights into the development of the pancreas","volume":"174","author":"Debas","year":"1997","journal-title":"Am. J. Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.bbrc.2004.05.069","article-title":"The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B","volume":"319","author":"Diefenbach","year":"2004","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/glycob\/cwz084","article-title":"O-glycosylation on cerebrospinal fluid and plasma apolipoprotein E differs in the lipid-binding domain","volume":"30","author":"Flowers","year":"2020","journal-title":"Glycobiology"},{"key":"B27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-60327-017-5_14","article-title":"Regulation of apoptosis by the unfolded protein response","volume-title":"Apoptosis: methods and protocols","author":"Fribley","year":"2009"},{"key":"B28","doi-asserted-by":"publisher","first-page":"a013169","DOI":"10.1101\/cshperspect.a013169","article-title":"Endoplasmic reticulum stress sensing in the unfolded protein response","volume":"5","author":"Gardner","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ydbio.2008.10.024","article-title":"Developmental biology of the pancreas: a comprehensive review","volume":"326","author":"Gittes","year":"2009","journal-title":"Dev. Biol."},{"key":"B30","first-page":"289","article-title":"The ER function BiP is a master regulator of ER function","volume":"71","author":"Hendershot","year":"","journal-title":"Mt. Sinai J. Med."},{"key":"B31","first-page":"289","article-title":"The ER function BiP is a master regulator of ER function","volume":"71","author":"Hendershot","year":"","journal-title":"Mt. Sinai J. Med. N. Y."},{"key":"B32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.aanat.2018.09.008","article-title":"Development of the human pancreas and its vasculature\u2014an integrated review covering anatomical, embryological, histological, and molecular aspects","volume":"221","author":"Henry","year":"2019","journal-title":"Ann. Anatomy-Anatomischer Anzeiger"},{"key":"B33","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.12688\/f1000research.11900.1","article-title":"Golgi structure formation, function, and post-translational modifications in mammalian cells","volume":"6","author":"Huang","year":"2017","journal-title":"F1000Research"},{"key":"B35","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.tibs.2018.06.005","article-title":"Quality control in the endoplasmic reticulum: crosstalk between ERAD and UPR pathways","volume":"43","author":"Hwang","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1083\/jcb.200112008","article-title":"Induction of secretory pathway components in yeast is associated with increased stability of their mRNA","volume":"156","author":"Hyde","year":"2002","journal-title":"J. cell Biol."},{"key":"B37","first-page":"211","article-title":"Lymphocyte activation: IV. The ultrastructural pattern of the response of mouse T and B cells to mitogenic stimulation in vitro","volume":"24","author":"Janossy","year":"1973","journal-title":"Immunology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jprot.2012.05.027","article-title":"Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls","volume":"76","author":"Jaros","year":"2012","journal-title":"J. proteomics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1146\/annurev.cellbio.15.1.799","article-title":"The translocon: a dynamic gateway at the ER membrane","volume":"15","author":"Johnson","year":"1999","journal-title":"Annu. Rev. cell Dev. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1083\/jcb.200711151","article-title":"Regulation of protein O-glycosylation by the endoplasmic reticulum\u2013localized molecular chaperone Cosmc","volume":"182","author":"Ju","year":"2008","journal-title":"J. cell Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e30700","DOI":"10.7554\/eLife.30700","article-title":"An unfolded protein-induced conformational switch activates mammalian IRE1","volume":"6","author":"Karag\u00f6z","year":"2017","journal-title":"Elife"},{"key":"B42","doi-asserted-by":"publisher","first-page":"a033886","DOI":"10.1101\/cshperspect.a033886","article-title":"The unfolded protein response: detecting and responding to fluctuations in the protein-folding capacity of the endoplasmic reticulum","volume":"11","author":"Karag\u00f6z","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13024-022-00572-6","article-title":"Tau interactome and RNA binding proteins in neurodegenerative diseases","volume":"17","author":"Kavanagh","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9802","DOI":"10.1096\/fj.202000659R","article-title":"Increased APOE glycosylation plays a key role in the atherogenicity of L5 low\u2010density lipoprotein","volume":"34","author":"Ke","year":"2020","journal-title":"FASEB J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1146\/annurev.bi.64.070195.001531","article-title":"Eukaryotic phospholipid biosynthesis","volume":"64","author":"Kent","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1080\/15548627.2022.2129763","article-title":"Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1","volume":"19","author":"Killackey","year":"2023","journal-title":"Autophagy"},{"key":"B47","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00109-018-1632-y","article-title":"Cell-specific production, secretion, and function of apolipoprotein E","volume":"96","author":"Kockx","year":"2018","journal-title":"J. Mol. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"49","DOI":"10.12703\/P6-49","article-title":"Protein quality control in the endoplasmic reticulum","volume":"6","author":"Koenig","year":"2014","journal-title":"F1000prime Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1091\/mbc.7.5.769","article-title":"Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations","volume":"7","author":"Koning","year":"1996","journal-title":"Mol. Biol. cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.devcel.2024.05.005","article-title":"Axonal endoplasmic reticulum tubules control local translation via P180\/RRBP1-mediated ribosome interactions","volume":"59","author":"Koppers","year":"2024","journal-title":"Dev. Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1089\/dna.1998.17.449","article-title":"Identification of multiple forms of 180-kDa ribosome receptor in human cells","volume":"17","author":"Langley","year":"1998","journal-title":"DNA cell Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3348","DOI":"10.1021\/acs.jproteome.5b00397","article-title":"Cellular proteome dynamics during differentiation of human primary myoblasts","volume":"14","author":"Le Bihan","year":"2015","journal-title":"J. proteome Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/s1286-4579(99)00254-3","article-title":"The role of TGF-\u03b2 in growth, differentiation, and maturation of B lymphocytes","volume":"1","author":"Lebman","year":"1999","journal-title":"Microbes Infect."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1074\/mcp.M900430-MCP200","article-title":"Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290","volume":"9","author":"Lee","year":"2010","journal-title":"Mol. & Cell. Proteomics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3390\/cells3030824","article-title":"Regulation of endoplasmic reticulum-associated protein degradation (ERAD) by ubiquitin","volume":"3","author":"Lemus","year":"2014","journal-title":"Cells"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.2147\/CMAR.S186632","article-title":"RRBP1 is highly expressed in prostate cancer and correlates with prognosis","volume":"11","author":"Li","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/cas.12666","article-title":"Expression of ribosome\u2010binding protein 1 correlates with shorter survival in Her\u20102 positive breast cancer","volume":"106","author":"Liang","year":"2015","journal-title":"Cancer Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1146\/annurev.cellbio.16.1.557","article-title":"Secretory protein trafficking and organelle dynamics in living cells","volume":"16","author":"Lippincott-Schwartz","year":"2000","journal-title":"Annu. Rev. cell Dev. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.1073\/pnas.93.9.4278","article-title":"Human plectin: organization of the gene, sequence analysis, and chromosome localization (8q24)","volume":"93","author":"Liu","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"R166","DOI":"10.1016\/s0960-9822(02)00732-7","article-title":"Golgi complex: biogenesis de novo?","volume":"12","author":"Lowe","year":"2002","journal-title":"Curr. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1083\/jcb.131.1.81","article-title":"Degradation of HMG-CoA reductase-induced membranes in the fission yeast, Schizosaccharomyces pombe","volume":"131","author":"Lum","year":"1995","journal-title":"J. cell Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/nrc1505","article-title":"The role of the unfolded protein response in tumour development: friend or foe?","volume":"4","author":"Ma","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"B63","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/abbi.1996.0230","article-title":"Topogenesis of a microsomal cytochrome P450 and induction of endoplasmic reticulum membrane proliferation inSaccharomyces cerevisiae","volume":"330","author":"Menzel","year":"1996","journal-title":"Archives Biochem. biophysics"},{"key":"B64","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ng0996-55","article-title":"Apolipoprotein E allele\u2013specific antioxidant activity and effects on cytotoxicity by oxidative insults and \u03b2\u2013amyloid peptides","volume":"14","author":"Miyata","year":"1996","journal-title":"Nat. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1399965","DOI":"10.3389\/fnmol.2024.1399965","article-title":"Human apolipoprotein E glycosylation and sialylation: from structure to function","volume":"17","author":"Moon","year":"2024","journal-title":"Front. Mol. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6835","DOI":"10.1111\/febs.15905","article-title":"Membrane protein biogenesis at the ER: the highways and byways","volume":"289","author":"O'Keefe","year":"2022","journal-title":"FEBS J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1128\/jvi.76.5.2350-2362.2002","article-title":"An endoplasmic reticulum protein, p180, is highly expressed in human cytomegalovirus-permissive cells and interacts with the tegument protein encoded by UL48","volume":"76","author":"Ogawa-Goto","year":"2002","journal-title":"J. virology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1091\/mbc.e06-12-1125","article-title":"p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain","volume":"18","author":"Ogawa-Goto","year":"2007","journal-title":"Mol. Biol. cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1101\/gad.981002","article-title":"Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells","volume":"16","author":"Paddison","year":"2002","journal-title":"Genes & Dev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/bjc.2015.260","article-title":"Endoplasmic reticulum ribosome-binding protein 1, RRBP1, promotes progression of colorectal cancer and predicts an unfavourable prognosis","volume":"113","author":"Pan","year":"2015","journal-title":"Br. J. cancer"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1091\/mbc.6.11.1535","article-title":"Identification of the sequences in HMG-CoA reductase required for karmellae assembly","volume":"6","author":"Parrish","year":"1995","journal-title":"Mol. Biol. cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/0012-1606(72)90083-8","article-title":"An ultrastructural analysis of the developing embryonic pancreas","volume":"29","author":"Pictet","year":"1972","journal-title":"Dev. Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1091\/mbc.10.10.3409","article-title":"The role of the 3-hydroxy 3-methylglutaryl coenzyme A reductase cytosolic domain in karmellae biogenesis","volume":"10","author":"Profant","year":"1999","journal-title":"Mol. Biol. cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"7346","DOI":"10.1021\/bi0504052","article-title":"Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD\/E site in vitro","volume":"44","author":"Raftery","year":"2005","journal-title":"Biochemistry"},{"key":"B75","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1126\/science.1332192","article-title":"Transport of proteins across the endoplasmic reticulum membrane","volume":"258","author":"Rapoport","year":"1992","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1515\/BC.1999.145","article-title":"Posttranslational protein translocation across the membrane of the endoplasmic reticulum","volume":"380","author":"Rapoport","year":"1999","journal-title":"Biol. Chem."},{"key":"B77","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/biology10050384","article-title":"The unfolded protein response: an overview","volume":"10","author":"Read","year":"2021","journal-title":"Biology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. cell Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes & Dev."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.3390\/ijms19103215","article-title":"Unfolded protein response-dependent communication and contact among endoplasmic reticulum, mitochondria, and plasma membrane","volume":"19","author":"Saito","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/346540a0","article-title":"Identification of a ribosome receptor in the rough endoplasmic reticulum","volume":"346","author":"Savitz","year":"1990","journal-title":"Nature"},{"key":"B82","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1083\/jcb.120.4.853","article-title":"180-kD ribosome receptor is essential for both ribosome binding and protein translocation","volume":"120","author":"Savitz","year":"1993","journal-title":"J. cell Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1083\/jcb.200907074","article-title":"Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response","volume":"187","author":"Schuck","year":"2009","journal-title":"J. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.immuni.2004.06.010","article-title":"XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation","volume":"21","author":"Shaffer","year":"2004","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/eji.1830031106","article-title":"Development of rough endoplasmic reticulum in mouse splenic lymphocytes stimulated by mitogens","volume":"3","author":"Shohat","year":"1973","journal-title":"Eur. J. Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/s0925-4439(99)00047-2","article-title":"Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site","volume":"1454","author":"Shuvaev","year":"1999","journal-title":"Biochimica Biophysica Acta (BBA)-Molecular Basis Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","article-title":"Developmental biology of the pancreas","volume":"121","author":"Slack","year":"1995","journal-title":"Development"},{"key":"B88","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1083\/jcb.200406136","article-title":"XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum","volume":"167","author":"Sriburi","year":"2004","journal-title":"J. cell Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-1-60761-657-3_10","article-title":"Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown","author":"Taxman","year":"2010","journal-title":"RNA Ther. Funct. Des. Deliv."},{"key":"B90","doi-asserted-by":"publisher","first-page":"4390","DOI":"10.1091\/mbc.E11-06-0510","article-title":"The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress","volume":"22","author":"Teske","year":"2011","journal-title":"Mol. Biol. cell"},{"key":"B91","doi-asserted-by":"publisher","first-page":"4921","DOI":"10.1038\/onc.2012.514","article-title":"Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78","volume":"32","author":"Tsai","year":"2013","journal-title":"Oncogene"},{"key":"B92","first-page":"1530","article-title":"Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester","volume":"42","author":"Tsuchiya","year":"1982","journal-title":"Cancer Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"29941","DOI":"10.1074\/jbc.M109.094607","article-title":"Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion","volume":"285","author":"Ueno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B94","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1139\/o03-073","article-title":"Phospholipid biosynthesis in mammalian cells","volume":"82","author":"Vance","year":"2004","journal-title":"Biochem. cell Biol."},{"key":"B95","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/B978-044453219-0.50010-6","article-title":"Phospholipid biosynthesis in eukaryotes","volume-title":"Biochemistry of lipids, lipoproteins and membranes","author":"Vance","year":"2008"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"science"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1038\/s41598-022-26556-6","article-title":"Transcriptome-wide analysis reveals the coregulation of RNA-binding proteins and alternative splicing genes in the development of atherosclerosis","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"key":"B98","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1083\/jcb.130.1.29","article-title":"Functional characterization of the 180-kD ribosome receptor in vivo","volume":"130","author":"Wanker","year":"1995","journal-title":"J. cell Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/0960-9822(93)90221-9","article-title":"Insights from inducible membranes","volume":"3","author":"Wright","year":"1993","journal-title":"Curr. Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1083\/jcb.107.1.101","article-title":"Increased amounts of HMG-CoA reductase induce karmellae: a proliferation of stacked membrane pairs surrounding the yeast nucleus","volume":"107","author":"Wright","year":"1988","journal-title":"J. cell Biol."},{"key":"B101","first-page":"915","article-title":"Cell-type control of membrane biogenesis induced by HMG-CoA reductase","volume":"2","author":"Wright","year":"1990","journal-title":"New Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"25935","DOI":"10.1074\/jbc.R400008200","article-title":"Signaling the unfolded protein response from the endoplasmic reticulum","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1682420\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T05:29:18Z","timestamp":1758259758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2025.1682420\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":102,"alternative-id":["10.3389\/fcell.2025.1682420"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2025.1682420","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"article-number":"1682420"}}