{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:39:30Z","timestamp":1791661170106,"version":"4.3.4"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    The development, metabolism, and functional maintenance of skeletal muscle is a complex dynamic balance process. Its imbalance may lead to muscular dystrophy, muscle atrophy, and other diseases, which seriously affect human health. Therefore, in-depth exploration of the regulatory mechanisms governing skeletal muscle homeostasis and the identification of effective therapeutic targets have garnered significant attention. Recent studies reveal that the protein arginine methyltransferase\n                    <jats:italic>CARM1<\/jats:italic>\n                    plays a central regulatory role in skeletal muscle biology. Substantial evidence indicates that abnormal\n                    <jats:italic>CARM1<\/jats:italic>\n                    expression and activity disrupt muscle regeneration, metabolic balance, and stress responses, leading to muscle functional decline. This highlights its indispensable role in maintaining skeletal muscle homeostasis. Furthermore, exercise\u2014an effective intervention for improving muscle quality and function\u2014may exert its beneficial effects through mechanisms closely linked to\n                    <jats:italic>CARM1<\/jats:italic>\n                    function. Therefore, this review systematically summarizes the roles of\n                    <jats:italic>CARM1<\/jats:italic>\n                    in skeletal muscle development, regeneration, material metabolism, and homeostasis based on its molecular structure and fundamental functions. It further explores\n                    <jats:italic>CARM1\u2019s<\/jats:italic>\n                    functional manifestations in muscle atrophy and exercise adaptation, providing a theoretical framework for comprehensively understanding its pivotal role in physiological adaptation and muscle diseases, while evaluating its potential value as a therapeutic target.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2025.1709515","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T06:27:08Z","timestamp":1766125628000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent advances in the role of CARM1 in skeletal muscle development, metabolism, and homeostasis maintenance"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaojing","family":"Xie","sequence":"first","affiliation":[{"name":"School of Sports and Health, Shenyang Sport University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Physical Education, Liaoning Normal University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Sports and Health, Shenyang Sport University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Bao","sequence":"additional","affiliation":[{"name":"School of Sports and Health, Shenyang Sport University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejie","family":"Yi","sequence":"additional","affiliation":[{"name":"Sports and Health Research Center, Shenyang Sport University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15290","DOI":"10.1074\/jbc.RA118.004512","article-title":"CARM1 suppresses de novo serine synthesis by promoting PKM2 activity","volume":"293","author":"Abeywardana","year":"2018","journal-title":"J. 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