{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:44:09Z","timestamp":1790016249519,"version":"4.0.1"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Abdominal aortic aneurysm (AAA) is often asymptomatic in its early stages, and rupture poses a life threatening risk. Currently, no effective pharmacological therapies are available, underscoring the importance of mechanistic research. Metabolic reprogramming\u2014an adaptive process encompassing glucose, lipid, and amino acid metabolism\u2014has increasingly gained attention in the context of AAA. These metabolic shifts, which coordinate cellular energy supply, biosynthesis, and signaling, critically shape vascular smooth muscle cell (VSMC) behavior, macrophage polarization, extracellular matrix remodeling, oxidative stress responses, and immune activation. Importantly, growing evidence suggests that crosstalk among these metabolic pathways orchestrates complex pathophysiological networks driving AAA initiation and progression. Exploring AAA pathogenesis from an integrated metabolic perspective not only helps elucidate underlying mechanisms but also provides new insights and potential therapeutic targets.<\/jats:p>","DOI":"10.3389\/fcell.2025.1718220","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:31:08Z","timestamp":1763015468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanisms of metabolic reprogramming in abdominal aortic aneurysm"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaodong","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyue","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.5551\/jat.38315","article-title":"Low serum levels of EPA are associated with the size and growth rate of abdominal aortic aneurysm","volume":"24","author":"Aikawa","year":"2017","journal-title":"J. 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