{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:43:34Z","timestamp":1776062614638,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the expression of the lactate transport-related proteins MCT1, MCT4, and their chaperone CD147 in follicular lymphoma (FL), and to delineate their potential correlations with clinicopathological parameters predictive of prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemistry was employed to evaluate the expression of MCT1, MCT4, and CD147 in tumor cells. Associations between protein expression and clinicopathological variables relevant to patient outcome were statistically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1. MCT1-positive immunoreactivity was significantly associated with elevated serum \u03b22-microglobulin (\u03b22-M, a small circulating protein that rises with disease activity and serves as a marker of tumor load and adverse outcomes in lymphomas) level, male sex, and Ki-67 \u2265 30%; MCT4-positive immunoreactivity was significantly associated with Ki-67 \u2265 30%; CD147-positive immunoreactivity correlated significantly with low-grade FL. 2. Four distinct expression patterns of MCT1\/MCT4 were identified: double-positive, double-negative, MCT1-positive only, and MCT4-positive only. High-grade FL demonstrated a significant predilection for either double-positive or single-positive expression; Ki-67 &amp;lt; 30% was significantly linked to the double-negative expression; elevated serum \u03b22-M was significantly associated with MCT1-positive only expression; age \u226560 years and female sex were significantly associated with MCT4-positive only expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The expression of MCT1, MCT4, and CD147 in FL is correlated with adverse clinicopathological features, thereby furnishing additional evidence for refinement of the Follicular Lymphoma International Prognostic Index (FLIPI, a five-parameter clinical score predicting outcome in newly diagnosed follicular lymphoma). Targeted inhibition of MCT1 and MCT4 may represent a novel therapeutic strategy. Furthermore, the heterogeneous expression of these three proteins suggests metabolic heterogeneity within FL, offering a mechanistic basis for future investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1697031","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:45:04Z","timestamp":1776059104000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the expression of lactate transport-related proteins in follicular lymphoma and their relationship with clinicopathologic features"],"prefix":"10.3389","volume":"14","author":[{"given":"Zheng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology, China-Japan Union Hospital, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, China-Japan Union Hospital, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, China-Japan Union Hospital, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, China-Japan Union Hospital, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, China-Japan Union Hospital, Jilin University","place":["Changchun, Jilin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3390\/cancers14051247","article-title":"Early changes in quantitative ultrasound imaging parameters during neoadjuvant chemotherapy to predict recurrence in patients with locally advanced breast cancer","volume":"14","author":"Bhardwaj","year":"2022","journal-title":"Cancers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1158\/0008-5472.CAN-11-2474","article-title":"Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors","volume":"72","author":"Boidot","year":"2012","journal-title":"Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"242437","DOI":"10.1155\/2015\/242437","article-title":"Prognostic indications of elevated MCT4 and CD147 across cancer types: a meta-analysis","volume":"2015","author":"Bovenzi","year":"2015","journal-title":"BioMed Res. 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