{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:47:06Z","timestamp":1789152426574,"version":"build-2803163510"},"reference-count":162,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360976"],"award-info":[{"award-number":["82360976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Exosomes, as key mediators of intercellular communication, play a central regulatory role in cellular physiological and pathological processes through their dynamic interaction with the cytoskeleton. The cytoskeleton is a dynamic network composed of microtubules, microfilaments, and intermediate filaments. Microtubules provide track support for the directional transport of MVBs. Microfilament rearrangement generates contractile forces that promote MVB fusion with the plasma membrane. Therefore, the cytoskeleton directly participates in the biogenesis, intracellular transport, and secretion of exosomes. Moreover, cytoskeletal dynamics, coordinated by molecules such as Rab GTPases, affect exosome secretion efficiency. Conversely, exosomes carry bioactive molecules such as proteins, nucleic acids, and lipids. These molecules can regulate cytoskeletal rearrangement in recipient cells by modulating signaling pathways like the TGF-\u03b2\/Smad signaling pathway and the RhoA\/ROCK signaling pathway. Consequently, they influence target cell functions like morphology maintenance, migration, and proliferation. Dysregulation of this interaction is closely related to the progression of various diseases, including tumors and neurodegenerative diseases. For instance, disrupting the dynamic structure of the cytoskeleton or blocking the cytoskeletal remodeling process can significantly reduce exosome secretion, while abnormal exosome transfer disrupts cytoskeletal homeostasis. Current research still faces challenges, such as unresolved details of the molecular regulatory network and a lack of in-depth mechanistic validation in in vivo models. Future studies need to explore in depth novel regulatory factors and signaling pathways and investigate disease diagnosis and treatment strategies based on this interaction. This will provide a theoretical basis and innovative ideas for the prevention and treatment of related diseases.<\/jats:p>","DOI":"10.3389\/fcell.2026.1718115","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:34:08Z","timestamp":1777872848000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Research progress on the interaction mechanisms and functions between exosomes and the cytoskeleton"],"prefix":"10.3389","volume":"14","author":[{"given":"Shili","family":"Yang","sequence":"first","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Kou","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Lai","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunling","family":"Xu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine","place":["Guiyang, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","article-title":"Phosphorylation and activation of myosin by rho-associated kinase (Rho-kinase). The","volume":"271","author":"Amano","year":"1996","journal-title":"J. Biological Chemistry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1046\/j.1471-4159.2003.02054.x","article-title":"Identification of Tau and MAP2 as novel substrates of rho-kinase and myosin phosphatase","volume":"87","author":"Amano","year":"2003","journal-title":"J. Neurochemistry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9973","DOI":"10.1128\/mcb.25.22.9973-9984.2005","article-title":"Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones","volume":"22","author":"Arimura","year":"2005","journal-title":"Mol. Cellular Biology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.1038\/s41467-023-39700-1","article-title":"Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers","volume":"14","author":"Arnold","year":"2023","journal-title":"Nat. Communications"},{"key":"B5","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/j.1600-0854.2006.00392.x","article-title":"Axonal transport of microtubules: the long and short of it","volume":"7","author":"Baas","year":"2006","journal-title":"Traffic"},{"key":"B6","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.omtn.2021.12.023","article-title":"Exocyst controls exosome biogenesis via Rab11a\u00b7Molecular therapy","volume":"27","author":"Bai","year":"2022","journal-title":"Nucleic Acids."},{"key":"B7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/ncb2502","article-title":"Syndecan-syntenin-ALIX regulates the biogenesis of exosomes","volume":"7","author":"Baietti","year":"2012","journal-title":"Nat. Cell Biology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025817","article-title":"Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles\u00b7Cold Spring Harbor perspectives in biology","volume":"9","author":"Barlan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/s0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cel"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/biology9010021","article-title":"Apoptotic bodies: particular extracellular vesicles involved in intercellular","volume":"1","author":"Battistelli","year":"2020","journal-title":"Communication. Biology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202302112","article-title":"Fusion pore dynamics of large secretory vesicles define a distinct mechanism of exocytosis","volume":"11","author":"Biton","year":"2023","journal-title":"J. Cell Biology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1111\/j.1600-0854.2011.01225.x","article-title":"Exosome secretion: molecular mechanisms and roles in immune responses","volume":"12","author":"Bobrie","year":"2011","journal-title":"Traffic"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e85","DOI":"10.1371\/journal.pbio.0030085","article-title":"Principles of microRNA-target recognition","volume":"3","author":"Brennecke","year":"2005","journal-title":"PLoS Biology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"629097","DOI":"10.3389\/fcell.2021.629097","article-title":"Role of actin Cytoskeleton reorganization in polarized secretory traffic at the immunological synapse","volume":"9","author":"Calvo","year":"2021","journal-title":"Front. Cell Developmental Biology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1038\/s41467-023-37340-z","article-title":"An actin filament branching surveillance system regulates cell cycle progression","volume":"14","author":"Cao","year":"2023","journal-title":"Cytokinesis Primary Ciliogenesis. Nature Communications"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1007\/s12551-018-0467-7","article-title":"BAR domain proteins-a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton","volume":"6","author":"Carman","year":"2018","journal-title":"Biophys. Reviews"},{"key":"B17","doi-asserted-by":"publisher","first-page":"67387","DOI":"10.18632\/oncotarget.11794","article-title":"Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages. Oncotarget 7","volume":"41","author":"Chen","year":"2016"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1073\/pnas.1618088114","article-title":"Phosphoproteins in extracellular vesicles as candidate markers for breast cancer proceedings of the National Academy of Sciences of the United States of America. 114","author":"Chen","year":"2017"},{"key":"B19","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12882-024-03688-7","article-title":"Research progress on miR-124-3p in the field of kidney disease","volume":"25","author":"Chen","year":"2024","journal-title":"BMC Nephrol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"jcs259324","DOI":"10.1242\/jcs.259324","article-title":"Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification","volume":"135","author":"Choezom","year":"2022","journal-title":"J. Cell Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.1073\/pnas.1807028115","article-title":"Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides proceedings of the National Academy of","volume":"116","author":"Chou","year":"2019","journal-title":"Sci. U. S. A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1242\/jcs.133108","article-title":"ERM proteins in cancer progression","volume":"127","author":"Clucas","year":"2014","journal-title":"J. Cell Science"},{"key":"B23","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1242\/jcs.128868","article-title":"Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles","volume":"126","author":"Colombo","year":"2013","journal-title":"J. Cell Science"},{"key":"B24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Review Cell Developmental Biology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"021307","DOI":"10.1063\/5.0198119","article-title":"How cytoskeletal crosstalk makes cells move: bridging cell-free and cell studies","volume":"5","author":"Conboy","year":"2024","journal-title":"Biophys. Reviews"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00261-0","article-title":"Exosomes: key players in cancer and potential therapeutic strategy signal transduction and targeted therapy","volume":"1","author":"Dai","year":"2020"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.1016\/j.apsb.2021.07.027","article-title":"Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo","volume":"11","author":"Deng","year":"2021","journal-title":"Acta Pharmaceutica Sin."},{"key":"B28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13578-025-01441-7","article-title":"Cytoskeleton disruption and plasma membrane damage determine methuosis of normal and malignant cells","volume":"15","author":"Dong","year":"2025","journal-title":"Cell and Bioscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ceb.2020.10.001","article-title":"Recent insight into intermediate filament structure\u00b7current opinion in cell biology","volume":"68","author":"Eldirany","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1172\/jci38339","article-title":"Introducing intermediate filaments: from discovery to disease","volume":"119","author":"Eriksson","year":"2009","journal-title":"J. Clinical Investigation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.bbamcr.2009.09.011","article-title":"TI-VAMP\/VAMP7 and VAMP3\/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy\/multivesicular body","volume":"12","author":"Fader","year":"2009","journal-title":"Pathw. Biophysica Acta"},{"key":"B32","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1600-0854.2010.01041.x","article-title":"Cellular internalization of exosomes occurs through phagocytosis traffic","author":"Feng","year":"2010"},{"key":"B33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/nature08908","article-title":"Cell mechanics and the cytoskeleton","volume":"463","author":"Fletcher","year":"2010","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"10900","DOI":"10.1038\/s41467-025-66351-1","article-title":"Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles","volume":"16","author":"Fujioka","year":"2025","journal-title":"Nat. Communications"},{"key":"B35","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/s0092-8674(02)00800-0","article-title":"Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170","volume":"109","author":"Fukata","year":"2002","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/tra.12083","article-title":"Rab27 effectors, pleiotropic regulators in secretory pathways","volume":"14","author":"Fukuda","year":"2013","journal-title":"Traffic"},{"key":"B37","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1042\/ebc20190016","article-title":"Microtubules in cell migration essays in biochemistry","volume":"5","author":"Garcin","year":"2019"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022608","article-title":"Microtubules and Microtubule-Associated Proteins Cold Spring Harbor perspectives in biology","volume":"10","author":"Goodson","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"19709","DOI":"10.18632\/oncotarget.7573","article-title":"Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis","volume":"15","author":"Gopal","year":"2016","journal-title":"Recipient Endothelial Cells Oncotarget 7"},{"key":"B40","doi-asserted-by":"publisher","first-page":"11728","DOI":"10.1074\/jbc.273.19.11728","article-title":"Phosphorylation of vimentin by rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis","volume":"273","author":"Goto","year":"1998","journal-title":"J. Biological Chemistry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3724\/sp.J.1123.2021.04016","article-title":"Lipid metabolomic analysis in exosomes of osteonecrosis of the femoral head based on ultra performance liquid chromatography-tandem mass spectrometry se pu = Chinese","volume":"40","author":"Guo","year":"2022","journal-title":"Journal Chromatography"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/cells8040307","article-title":"Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes","volume":"8","author":"Gurunathan","year":"2019","journal-title":"Cells"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2147\/ijn.S291956","article-title":"A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes","volume":"16","author":"Gurunathan","year":"2021","journal-title":"Int. Journal Nanomedicine"},{"key":"B44","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/s41594-022-00769-9","article-title":"Cryo-EM structure of an active central apparatus","volume":"29","author":"Han","year":"2022","journal-title":"Nat. Structural and Molecular Biolog"},{"key":"B45","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ceb.2009.04.007","article-title":"The exocyst complex in polarized exocytosis\u00b7current opinion in cell biology","volume":"4","author":"He","year":"2009"},{"key":"B46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.devcel.2011.05.015","article-title":"The ESCRT pathway","volume":"21","author":"Henne","year":"2011","journal-title":"Dev. Cell"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016766","article-title":"Molecular mechanisms of the membrane sculpting ESCRT pathway","volume":"5","author":"Henne","year":"2013","journal-title":"Cold Spring Harb. Perspectives Biology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1101\/cshperspect.a018242\u00b7","article-title":"Intermediate filaments: structure and assembly\u00b7cold Spring Harbor perspectives in biology","author":"Herrmann","year":"2016"},{"key":"B49","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nrm2197","article-title":"Intermediate filaments: from cell architecture to nanomechanics","volume":"8","author":"Herrmann","year":"2007","journal-title":"Nat. Reviews Mol. Cell Biology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1080\/21541248.2015.1044811","article-title":"Rho GTPases at the crossroad of signaling","volume":"2","author":"Herv\u00e9","year":"2015","journal-title":"Networks Mammals Small GTPases"},{"key":"B51","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00018-017-2595-9","article-title":"Current knowledge on exosome biogenesis and release","volume":"75","author":"Hessvik","year":"2018","journal-title":"Cell. Molecular Life Sciences"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.celrep.2013.10.050","article-title":"Exosome secretion is enhanced by invadopodia and drives invasive behavior","volume":"5","author":"Hoshino","year":"2013","journal-title":"Cell Reports"},{"key":"B53","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1083\/jcb.200911018","article-title":"Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. The","volume":"189","author":"Hsu","year":"2010","journal-title":"J. Cell Biology"},{"key":"B54","article-title":"Identification of a Serum Exosome-Derived lncRNA\u2012miRNA\u2012mRNA ceRNA Network","volume-title":"Patients with Endometriosis 51 (2)","author":"Huang","year":"2024"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55038","article-title":"Lipid accumulation controls the balance between surface connection and scission of caveolae","volume-title":"eLife","author":"Hubert","year":"2020"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1038\/emboj.2011.286","article-title":"Endosome maturation. The EMBO journal","author":"Huotari","year":"2011"},{"key":"B57","doi-asserted-by":"publisher","first-page":"108811","DOI":"10.1016\/j.isci.2024.108811","article-title":"Direct observation of cytoskeleton-dependent trafficking of miRNA visualized by the introduction of pre-miRNA","volume":"27","author":"Ishikawa","year":"2024","journal-title":"iScience"},{"key":"B58","doi-asserted-by":"publisher","first-page":"26659","DOI":"10.3402\/jev.v4.26659","article-title":"Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma","volume":"4","author":"Jakobsen","year":"2015","journal-title":"J. Extracellular Vesicles"},{"key":"B59","doi-asserted-by":"publisher","first-page":"135654","DOI":"10.1016\/j.ijbiomac.2024.135654","article-title":"TGF - \u03b2\/smad signaling pathway and protein molecules in the treatment of liver fibrosis: a natural lipid membrane protein of exosomes international","volume":"280","author":"Jia","year":"2024","journal-title":"Journal Biological Macromolecules"},{"key":"B60","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1074\/jbc.M117.808733","article-title":"Involvement of G\u03b2\u03b3 subunits of g(i) protein coupled with S1P receptor on multivesicular endosomes in F-actin formation and cargo sorting into exosomes","volume":"1","author":"Kajimoto","year":"2018","journal-title":"J. Biological Chemistry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1172\/jci81135","article-title":"The biology and function of exosomes in cancer","volume":"126","author":"Kalluri","year":"2016","journal-title":"J. Clinical Investigation"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2424263122","article-title":"Microtubule dynamics are defined by conformations and stability of clustered protofilaments proceedings of the National Academy of Sciences of the United States of America","volume":"22","author":"Kalutskii","year":"2025"},{"key":"B64","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1248\/bpb.b16-01011","article-title":"Pathophysiological roles of Ezrin\/Radixin\/Moesin proteins","volume":"4","author":"Kawaguchi","year":"2017","journal-title":"Biol. and Pharmaceutical Bulletin"},{"key":"B65","doi-asserted-by":"publisher","first-page":"101511","DOI":"10.1016\/j.isci.2020.101511","article-title":"The mechanism of tubulin assembly into microtubules","volume":"23","author":"Knossow","year":"2020","journal-title":"Insights Struct. Studies. iScience"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e83338","DOI":"10.7554\/eLife.83338","article-title":"Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle","volume":"12","author":"Knudsen","year":"2023","journal-title":"Elife"},{"key":"B67","doi-asserted-by":"publisher","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes proceedings of the National Academy of Sciences of the United States of America","author":"Kowal","year":"2016"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3390\/ijms24021337","article-title":"The machinery of exosomes: biogenesis, release","volume":"24","author":"Krylova","year":"2023","journal-title":"Int. Journal Molecular Sciences"},{"key":"B69","doi-asserted-by":"publisher","first-page":"14395","DOI":"10.18632\/oncotarget.14795","article-title":"Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study","volume":"9","author":"Lea","year":"2017","journal-title":"Oncotarget"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1080\/15384101.2017.1345230","article-title":"Intermediate filaments join the action","volume":"16","author":"Leduc","year":"2017","journal-title":"Cell Cycle"},{"key":"B71","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/s0962-8924(01)02180-8","article-title":"Plakins: a family of versatile cytolinker proteins","volume":"1","author":"Leung","year":"2002","journal-title":"Trends Cell Biology"},{"key":"B72","doi-asserted-by":"publisher","first-page":"663207","DOI":"10.3389\/fcell.2021.663207","article-title":"CircGLIS3 promotes high-grade glioma invasion via modulating ezrin phosphorylation","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Developmental Biology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.3390\/ijms24043061","article-title":"The roles of exosomal proteins: classification, function","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"9213","DOI":"10.1038\/s41467-024-53500-1","article-title":"Regulation of minimal spindle midzone organization mitotic kinases","volume":"15","author":"Lim","year":"2024","journal-title":"Nat. Communications"},{"key":"B75","doi-asserted-by":"publisher","first-page":"738031","DOI":"10.3389\/fcvm.2021.738031","article-title":"Exosomes and atherogenesis","volume":"8","author":"Lin","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"657086","DOI":"10.1155\/2015\/657086","article-title":"Exosomes: novel biomarkers for clinical diagnosis","volume":"2015","author":"Lin","year":"2015","journal-title":"The Scientific World Journal"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.636","article-title":"Novel insights into exosomal circular RNAs","volume":"12","author":"Lin","year":"2021","journal-title":"Redefining Intercellular Communication Cancer Biology Clinical Translational Medicine"},{"key":"B78","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13287-021-02151-w","article-title":"Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization","volume":"12","author":"Liu","year":"2021","journal-title":"Stem Cell Research and Therapy"},{"key":"B79","doi-asserted-by":"publisher","first-page":"926769","DOI":"10.3389\/fendo.2022.926769","article-title":"Exosomes of A549 cells induced migration, invasion, and EMT of BEAS-2B cells related to let-7c-5p and miR-181b-5p","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Endocrinology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.1038\/s41467-023-42661-0","article-title":"A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Communications"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.3390\/molecules28072976","article-title":"Rac1: a regulator of cell migration and a potential target for cancer","volume":"28","author":"Ma","year":"2023","journal-title":"Therapy Molecules"},{"key":"B82","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1126\/science.285.5429.895","article-title":"Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase Science","author":"Maekawa","year":"1999"},{"key":"B83","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neuint.2016.04.011","article-title":"Exosomes in Alzheimer's disease","volume":"97","author":"Malm","year":"2016","journal-title":"Neurochem. International"},{"key":"B84","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1042\/ebc20180031","article-title":"Microtubule structure by cryo-EM: snapshots of dynamic instability","volume":"6","author":"Manka","year":"2018","journal-title":"Essays Biochemistry"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/cells5020020","article-title":"Role of intermediate filaments in vesicular","volume":"5","author":"Margiotta","year":"2016","journal-title":"Traffic Cells"},{"key":"B86","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.tcb.2013.09.005","article-title":"Immune synapse: conductor of orchestrated organelle movement","volume":"1","author":"Mart\u00edn-C\u00f3freces","year":"2014","journal-title":"Trends Cell Biology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2024.07.20.604139","DOI":"10.1101\/2024.07.20.604139","article-title":"Secreted exosomes induce filopodia formation\u00b7biorxiv: the preprint server for biology","author":"McAtee","year":"2025","journal-title":"bioRxiv."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.101673","article-title":"Secreted exosomes induce filopodia","volume":"13","author":"McAtee","year":"2026","journal-title":"Formation eLife"},{"key":"B90","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/ncomms1285","article-title":"Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells","volume":"2","author":"Mittelbrunn","year":"2011","journal-title":"Nat. Communications"},{"key":"B91","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/tra.12258","article-title":"Organizing polarized delivery of exosomes at synapses traffic","author":"Mittelbrunn","year":"2015"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO family GTPases","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Mech. Regul. Signaling Cells"},{"key":"B93","doi-asserted-by":"publisher","first-page":"882037","DOI":"10.3389\/fcell.2022.882037","article-title":"Intermediate filaments in cellular mechanoresponsiveness: mediating cytoskeletal crosstalk from membrane to nucleus and back","volume":"10","author":"Ndiaye","year":"2022","journal-title":"Front. Cell Developmental Biology"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add4187","article-title":"Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin va science advances","volume":"49","author":"Niu","year":"2022"},{"key":"B95","doi-asserted-by":"publisher","first-page":"559553","DOI":"10.3389\/fcell.2020.559553","article-title":"A context-dependent role for MiR-124-3p on cell phenotype, viability and chemosensitivity in Neuroblastoma in vitro","volume":"8","author":"Nolan","year":"2020","journal-title":"Front. Cell Developmental Biology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1074\/jbc.275.5.3577","article-title":"Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop the","volume":"275","author":"Ohashi","year":"2000","journal-title":"J. Biological Chemistry"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.227132","article-title":"Dynein activators and adaptors at a glance","volume":"132","author":"Olenick","year":"2019","journal-title":"J. Cell Science"},{"key":"B98","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41586-022-05241-8","article-title":"Structural basis of actin filament assembly and aging","volume":"611","author":"Oosterheert","year":"2022","journal-title":"Nature"},{"key":"B99","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ncb2000","article-title":"Rab27a and Rab27b control different steps of the exosome secretion pathway","volume":"12","author":"Ostrowski","year":"2010","journal-title":"Nat. Cell Biology"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/s41556-024-01432-9","article-title":"CD63 sorts cholesterol into endosomes for storage and distribution via exosomes","volume":"26","author":"Palmulli","year":"2024","journal-title":"Nat. Cell Biology"},{"key":"B101","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro","volume":"33","author":"Pan","year":"1983","journal-title":"Selective Externalization Receptor Cell"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e12293","DOI":"10.1002\/jev2.12293","article-title":"Distinct non-coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages","volume":"11","author":"Pantazi","year":"2022","journal-title":"J. Extracellular Vesicles"},{"key":"B103","doi-asserted-by":"publisher","first-page":"4678","DOI":"10.3390\/ijms22094678","article-title":"Exosomal vimentin from adipocyte progenitors protects fibroblasts against osmotic stress and inhibits apoptosis to enhance wound healing\u00b7international","volume":"22","author":"Parvanian","year":"2021","journal-title":"Journal Molecular Sciences"},{"key":"B104","doi-asserted-by":"publisher","first-page":"101028","DOI":"10.1016\/j.mcpro.2025.101028","article-title":"Extracellular vesicles bearing Vimentin Drive Epithelial-Mesenchymal transition molecular and cellular proteomics","volume":"24","author":"Parvanian","year":"2025","journal-title":"Mol. Cell. Proteomics."},{"key":"B105","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s00018-022-04464-2","article-title":"Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations","volume":"79","author":"Peng","year":"2022","journal-title":"Cell. Molecular Life Sciences CMLS"},{"key":"B106","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1126\/science.1092586","article-title":"BAR domains as sensors of membrane curvature: the amphiphysin BAR structure science","author":"Peter","year":"2004"},{"key":"B107","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1021\/acs.nanolett.2c00736","article-title":"Unique role of vimentin networks in compression stiffening of cells and protection of nuclei from Compressive","volume":"22","author":"Pogoda","year":"2022","journal-title":"Stress Nano Letters"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018226","article-title":"Actin and Actin-Binding Proteins","volume":"8","author":"Pollard","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"102325","DOI":"10.1016\/j.ceb.2024.102325","article-title":"Cytoskeletal crosstalk: a focus on intermediate filaments","volume":"87","author":"Pradeau-Ph\u00e9lut","year":"2024","journal-title":"Curr. Opinion Cell Biology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"54852","DOI":"10.18632\/oncotarget.10243","article-title":"Lung cancer exosomes as drivers of epithelial mesenchymal transition","volume":"7","author":"Rahman","year":"2016","journal-title":"Oncotarget"},{"key":"B111","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbalip.2013.10.004","article-title":"Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies","volume":"1841","author":"Record","year":"2014","journal-title":"Biochimica Biophysica Acta"},{"key":"B112","doi-asserted-by":"publisher","first-page":"e202308049","DOI":"10.1083\/jcb.202308049","article-title":"Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility","volume":"223","author":"Robinson","year":"2024","journal-title":"J. Cell Biology"},{"key":"B113","doi-asserted-by":"publisher","first-page":"849938","DOI":"10.3389\/fcell.2022.849938","article-title":"Extracellular vesicles and transforming growth factor \u03b2 signaling in cancer","volume":"10","author":"Rodrigues-Junior","year":"2022","journal-title":"Front. Cell Developmental Biology"},{"key":"B114","doi-asserted-by":"publisher","first-page":"102263","DOI":"10.1016\/j.ceb.2023.102263","article-title":"The unique biomechanics of intermediate filaments - from single filaments to cells and tissues","volume":"85","author":"R\u00f6lleke","year":"2023","journal-title":"Curr. Opinion Cell Biolog"},{"key":"B115","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1681\/asn.2015090994","article-title":"Proteomics of urinary vesicles links plakins and complement to polycystic kidney disease journal of the","volume":"27","author":"Salih","year":"2016","journal-title":"Am. Soc. Nephrol. JASN"},{"key":"B116","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","author":"Samir","year":"2013","journal-title":"Nat. Reviews Drug Discovery"},{"key":"B117","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fcell.2017.00081","article-title":"Intermediate filaments at the junction of mechanotransduction","volume":"5","author":"Sanghvi-Shah","year":"2017","journal-title":"Migr. Development Frontiers Cell Developmental Biology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/ncb2353","article-title":"An actin-dependent mechanism for long-range vesicle transport","volume":"13","author":"Schuh","year":"2011","journal-title":"Nat. Cell Biology"},{"key":"B119","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1091\/mbc.e04-03-0189","article-title":"Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol","volume":"7","author":"Sharma","year":"2004","journal-title":"Mol. Biology Cell"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202209084","article-title":"Inhibition of endolysosome fusion increases exosome secretion","volume":"6","author":"Shelke","year":"2023","journal-title":"J. Cell Biology"},{"key":"B121","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes--vesicular carriers for intercellular communication","volume":"21","author":"Simons","year":"2009","journal-title":"Curr. Opinion Cell Biology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1083\/jcb.201601025","article-title":"Cortactin promotes exosome secretion by controlling branched actin dynamics","volume":"214","author":"Sinha","year":"2016","journal-title":"J. Cell Biology"},{"key":"B123","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1194\/jlr.R084343","article-title":"Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology","volume":"1","author":"Skotland","year":"2019","journal-title":"J. Lipid Research"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1106435","DOI":"10.3389\/fcell.2022.1106435","article-title":"Editorial: Microtubule-associated molecular motors: transport mechanisms and role in disease","volume":"10","author":"Soppina","year":"2022","journal-title":"Front. Cell Developmental Biology"},{"key":"B125","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1515\/bc.1999.023","article-title":"Plectin: a cytolinker by design Biological chemistry","author":"Steinb\u00f6ck","year":"1999"},{"key":"B126","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1242\/jcs.03147","article-title":"Architecture of the vimentin cytoskeleton is modified by perturbation of the GTPase ARF1","volume":"119","author":"Styers","year":"2006","journal-title":"J. Cell Science"},{"key":"B127","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1080\/19336918.2016.1273307","article-title":"Exosome secretion promotes chemotaxis of cancer cells","volume":"11","author":"Sung","year":"2017","journal-title":"Cell Adhesion and Migration"},{"key":"B128","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1038\/s41467-020-15747-2","article-title":"A live cell reporter of exosome secretion and uptake reveals","volume":"11","author":"Sung","year":"2020","journal-title":"Nat. Commun."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/j.devcel.2021.03.020","article-title":"Extracellular vesicles: critical players during cell migration","volume":"56","author":"Sung","year":"2021","journal-title":"Dev. Cell"},{"key":"B130","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1083\/jcb.201112034","article-title":"Spectraplakins: master orchestrators of cytoskeletal dynamics","volume":"4","author":"Suozzi","year":"2012","journal-title":"J. Cell Biology"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracellular Vesicles"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"key":"B133","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.devcel.2011.08.019","article-title":"The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis","volume":"21","author":"van Niel","year":"2011","journal-title":"Dev. Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Reviews Mol. Cell Biology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"e202112032","DOI":"10.1083\/jcb.202112032","article-title":"ER membrane contact sites support endosomal small GTPase conversion for exosome secretion","volume":"12","author":"Verweij","year":"2022","journal-title":"J. Cell Biology"},{"key":"B137","doi-asserted-by":"publisher","first-page":"101582","DOI":"10.1016\/j.redox.2020.101582","article-title":"Type III intermediate filaments as targets and effectors of electrophiles and oxidants","volume":"36","author":"Viedma-Poyatos","year":"2020","journal-title":"Redox Biology"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103661","article-title":"Distinct retrograde microtubule motor sets drive early and late endosome transport","volume":"24","author":"Villari","year":"2020","journal-title":"EMBO Journal"},{"key":"B139","doi-asserted-by":"publisher","first-page":"L240","DOI":"10.1152\/ajplung.00199.2006","article-title":"Dissociation of Crk-associated substrate from the vimentin network is regulated by p21-activated kinase on ACh activation of airway smooth muscle\u00b7American journal of physiology","volume":"292","author":"Wang","year":"2007","journal-title":"Lung Cellular Molecular Physiolog"},{"key":"B140","doi-asserted-by":"publisher","first-page":"16362","DOI":"10.1021\/jacs.5c02184","article-title":"Self-Adaptive release of stem cell-derived exosomes from a multifunctional hydrogel for accelerating MRSA-Infected diabetic wound Repair Journal of the","volume":"147","author":"Wang","year":"2025","journal-title":"Am. Chem. Society"},{"key":"B141","doi-asserted-by":"publisher","first-page":"e3000647","DOI":"10.1371\/journal.pbio.3000647","article-title":"Endosomal Wnt signaling proteins control microtubule nucleation in dendrites","volume":"3","author":"Weiner","year":"2020","journal-title":"PLoS Biology"},{"key":"B142","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1523\/jneurosci.21-10-03360.2001","article-title":"Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2","volume":"10","author":"Wick","year":"2001","journal-title":"J. Neuroscience The Official Journal Soc. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1042\/bj20050237","article-title":"Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697","volume":"389","author":"Wilson","year":"2005","journal-title":"Biochem. Journal"},{"key":"B144","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/nrm974","article-title":"Sorting out the cellular functions of sorting nexins","volume":"12","author":"Worby","year":"2002","journal-title":"Nat. Reviews Mol. Cell Biology"},{"key":"B145","doi-asserted-by":"publisher","first-page":"627394","DOI":"10.3389\/fphar.2021.627394","article-title":"A small vimentin-binding molecule blocks cancer exosome release and reduces cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Cell Mobility Frontiers Pharmacology"},{"key":"B146","doi-asserted-by":"publisher","first-page":"2198923","DOI":"10.1155\/2022\/2198923","article-title":"Trophoblast exosomal UCA1 induces endothelial injury through the PFN1-RhoA\/ROCK pathway in Preeclampsia","volume":"2022","author":"Wu","year":"2022","journal-title":"A Human-Specific Adapt. Pathogenic Mechanism Oxidative Medicine Cellular Longevity"},{"key":"B147","doi-asserted-by":"publisher","first-page":"18076","DOI":"10.1038\/s41598-023-45188-y","article-title":"Knockdown of lncRNA MALAT1 attenuates renal interstitial fibrosis through miR-124-3p\/ITGB1 axis","volume":"13","author":"Xia","year":"2023","journal-title":"Sci. Reports"},{"key":"B148","doi-asserted-by":"publisher","first-page":"e2100805118","DOI":"10.1073\/pnas.2100805118","article-title":"Actin filament debranching regulates cell polarity during cell migration and asymmetric cell division proceedings of the National Academy of Sciences of the United States of America","volume":"118","author":"Xie","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B149","doi-asserted-by":"publisher","first-page":"957036","DOI":"10.3389\/fphys.2022.957036","article-title":"Nucleic acids and proteins carried by exosomes from various sources: potential role in liver diseases","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Physiology"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/j.gendis.2022.03.021","article-title":"The biogenesis and secretion of exosomes and multivesicular bodies (MVBs)","volume":"10","author":"Xu","year":"2023","journal-title":"Intercell. Shuttles Implications Human Diseases Genes and Diseases"},{"key":"B151","doi-asserted-by":"publisher","first-page":"9875","DOI":"10.2147\/ott.S273008","article-title":"Exosomal miR-548c-5p regulates colorectal cancer cell growth and invasion through HIF1A\/CDC42 axis oncotargets and therapy","volume":"13","author":"Yan","year":"2020","journal-title":"Onco. Targets. Ther."},{"key":"B152","doi-asserted-by":"publisher","first-page":"106902","DOI":"10.4252\/wjsc.v17.i6.106902","article-title":"Mesenchymal stem cell-derived exosomes and the Wnt\/\u03b2-catenin pathway: unifying mechanisms of multi-organ regeneration and the path to precision clinical translation world","volume":"17","author":"Yan","year":"2025","journal-title":"Journal Stem Cells"},{"key":"B153","doi-asserted-by":"publisher","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J. Extracellular Vesicles"},{"key":"B154","doi-asserted-by":"publisher","first-page":"67235","DOI":"10.1021\/acsami.4c13821","article-title":"Magnetic Iron oxide nanoparticles enhance exosome production by upregulating exosome transport and secretion pathways","volume":"49","author":"Yang","year":"2024","journal-title":"ACS Applied Materials and Interface"},{"key":"B155","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12929-025-01182-2","article-title":"Extracellular vesicles: biogenesis mechanism and impacts on tumor immune microenvironment","volume":"32","author":"Yeat","year":"2025","journal-title":"J. Biomedical Science"},{"key":"B156","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41392-021-00554-y","article-title":"Cytosolic DNA sensing by cGAS: regulation, function, and human diseases","author":"Yu","year":"2021","journal-title":"Signal Transduction Targeted Therapy 6"},{"key":"B157","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12943-022-01509-9","article-title":"Exosomes as a new frontier of cancer liquid biopsy","volume":"21","author":"Yu","year":"2022","journal-title":"Mol. Cancer"},{"key":"B158","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.2147\/ijn.S264498","article-title":"Exosome: a review of its classification, isolation techniques","volume":"15","author":"Zhang","year":"2020","journal-title":"Diagnostic Target. Ther. Applications International Journal Nanomedicine"},{"key":"B159","doi-asserted-by":"publisher","first-page":"114194","DOI":"10.1016\/j.yexcr.2024.114194","article-title":"Mechanistic study on lncRNA XIST\/miR-124-3p\/ITGB1 axis in renal fibrosis in obstructive nephropathy","volume":"442","author":"Zhang","year":"2024","journal-title":"Exp. Cell Research"},{"key":"B160","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neuroscience.2020.05.046","article-title":"Vascular endothelial cell-derived exosomes protect neural stem cells against ischemia reperfusion","volume":"441","author":"Zhou","year":"2020","journal-title":"Injury Neuroscience"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1038\/s41565-024-01785-0","article-title":"Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes","volume":"12","author":"Zhuo","year":"2024","journal-title":"Nat. Nanotechnology"},{"key":"B162","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4161\/cib.3.5.12339","article-title":"Exosomes: fit to deliver small RNA","volume":"5","author":"Zomer","year":"2010","journal-title":"Commun. and Integrative Biology"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1718115\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:34:10Z","timestamp":1777872850000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1718115\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":162,"alternative-id":["10.3389\/fcell.2026.1718115"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1718115","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"article-number":"1718115"}}