{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:25:32Z","timestamp":1771921532446,"version":"3.50.1"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Prenatal alcohol exposure (PAE) has been recognized as a significant public health concern due to its consequential and long-lasting effects on the central nervous system (CNS) and the subsequent behavioral impairments in affected individuals. The current study aims to evaluate postnatal neurobehavioral disturbances, specifically mood state and potential morpho-functional changes, as well as brain oxidative stress in mice prenatally intoxicated with ethanol at the adult stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>female mice with positive vaginal plugs were divided into three groups: Group 1 (ethanol intoxicated): received ethanol at a dose of 1\u00a0g\/kg (i.p.) on gestational days 10 and 13 (two injections in total), along with pyrazole (100\u00a0mg\/kg by i. p.) to inhibit ethanol metabolism and simulate chronic fetal exposure. The second group received pyrazole alone at the same dose (100\u00a0mg\/kg i. p.). Group 3 (controls): received physiological saline solution (NaCl 0.9%) at the same volume as both ethanol and pyrazole. Offspring pups from the intoxicated dams were subjected, at the adult stage (from postnatal days P95 to P103), to a series of morphometric, biometric, neurobehavioral, and biochemical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our data show an obvious decrease in body weight and size, decreased food intake, and skeleton deformations. Additionally, PAE mice exacerbated anxiety-like and depressive-like behaviors as well as elevated brain oxidative stress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current data demonstrate the powerful neurotoxic effect of prenatal ethanol exposure on neuropsychological development as well as the associated morpho-functional changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1742806","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:45:38Z","timestamp":1771915538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal alcohol exposure induces anxiety and depressive-like behaviors with deficits in growth and food intake in mice"],"prefix":"10.3389","volume":"14","author":[{"given":"Kamal","family":"Smimih","sequence":"first","affiliation":[{"name":"Biological Engineering Laboratory, Faculty of Sciences and Technology (FST), Sultan Moulay Slimane University","place":["Beni Mellal, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilal","family":"El-Mansoury","sequence":"additional","affiliation":[{"name":"Nutritional Physiopathology, Neuroscience and Toxicology Team, Laboratory of Anthropogenic, Biotechnology, and Health, Faculty of Sciences, Chouaib Doukkali University","place":["El Jadida, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Marghich","sequence":"additional","affiliation":[{"name":"Nutritional Physiopathology, Neuroscience and Toxicology Team, Laboratory of Anthropogenic, Biotechnology, and Health, Faculty of Sciences, Chouaib Doukkali University","place":["El Jadida, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaima","family":"Azzouhri","sequence":"additional","affiliation":[{"name":"Nutritional Physiopathology, Neuroscience and Toxicology Team, Laboratory of Anthropogenic, Biotechnology, and Health, Faculty of Sciences, Chouaib Doukkali University","place":["El Jadida, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Zouhairi","sequence":"additional","affiliation":[{"name":"Biological Engineering Laboratory, Faculty of Sciences and Technology (FST), Sultan Moulay Slimane University","place":["Beni Mellal, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Agnaou","sequence":"additional","affiliation":[{"name":"Laboratory of Aquatic Systems: Marin and continental Environment, Department of Biology, Faculty of Sciences, Ibn Zohr University","place":["Agadir, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morad","family":"Guennouni","sequence":"additional","affiliation":[{"name":"Science and Technology Team, Higher School of Education and Training, Chouaib Doukkali University","place":["El Jadida, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naima","family":"Fdil","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory\/Metabolic Platform, Faculty of Medicine, University Cadi Ayyad","place":["Marrakech, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelali","family":"Bitar","sequence":"additional","affiliation":[{"name":"Nutritional Physiopathology, Neuroscience and Toxicology Team, Laboratory of Anthropogenic, Biotechnology, and Health, Faculty of Sciences, Chouaib Doukkali University","place":["El Jadida, Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud M. 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