{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:53:40Z","timestamp":1776664420889,"version":"3.51.2"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Postmenopausal osteoporosis (PMOP) is associated with declining estrogen levels, and this hormonal deficiency alters the physiological balance between bone formation and resorption. Substantial evidence indicates that protein homeostasis disorders play a significant role in the pathological process of PMOP. As the core system regulating protein homeostasis, the ubiquitin-proteasome system exerts crucial regulatory effects on bone metabolism under estrogen-deficient conditions. Abnormal activity of these ubiquitin-associated enzymes often leads to excessive degradation or abnormal accumulation of key regulatory proteins in bone metabolism, thereby exacerbating bone loss in PMOP. This review summarizes recent studies, focusing on how ubiquitin E3 ligases and deubiquitinating enzymes influence the function of osteoblasts and osteoclasts in PMOP. By synthesizing evidence from postmenopausal clinical samples and ovariectomized animal models, we further elucidate the specific roles of ubiquitin-related pathways in this disease. A deeper understanding of the mechanisms underlying UPS dysregulation in postmenopausal women holds promise for identifying novel molecular targets for future therapeutic strategies in PMOP.<\/jats:p>","DOI":"10.3389\/fcell.2026.1788812","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:24:36Z","timestamp":1776662676000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ubiquitin-proteasome system regulation of bone remodeling in postmenopausal osteoporosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiangqian","family":"Chen","sequence":"first","affiliation":[{"name":"Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Image Center, The Third Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Northeast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkang","family":"Xu","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Dai","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0235174","DOI":"10.1371\/journal.pone.0235174","article-title":"Increased systemic inflammation and altered distribution of T-cell subsets in postmenopausal women","volume":"15","author":"Abildgaard","year":"2020","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms20143576","article-title":"Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int. 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