{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:02:54Z","timestamp":1780293774053,"version":"3.54.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    RNA binding proteins have multiple diverse cellular functions and are often mis-regulated in disease. Despite their many cellular functions and implications in disease, very little is known about their physiological functions. Here we describe a novel zebrafish knockout model of the RNA binding proteins Hnrnpa1 and Hnrnpa3. Loss of Hnrnpa3 in zebrafish has no obvious morphological phenotype. Similarly, single mutants of the duplicated zebrafish\n                    <jats:italic>hnrnpa1<\/jats:italic>\n                    genes,\n                    <jats:italic>hnrnpa1a<\/jats:italic>\n                    and\n                    <jats:italic>hnrnpa1b<\/jats:italic>\n                    , have no discernible phenotype, whereas the\n                    <jats:italic>hnrnpa1a<\/jats:italic>\n                    ;\n                    <jats:italic>hnrnpa1b<\/jats:italic>\n                    double mutants are embryonic lethal. They display muscle, vascular and developmental defects with a reduced volume of the yolk extension. Metabolic profiling revealed severe changes in lipid metabolism in the\n                    <jats:italic>hnrnpa1a; hnrnpa1b<\/jats:italic>\n                    double mutants. Our analysis identified the involvement of Hnrnpa1 in many cellular pathways including the regulation of lipid metabolism and opens the door for future therapeutic studies in HNRNPA-associated diseases.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1789605","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:30:29Z","timestamp":1780291829000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hnrnpa1 is essential for early zebrafish development and lipid metabolism: insights from a novel zebrafish knockout model"],"prefix":"10.3389","volume":"14","author":[{"given":"Lara U.","family":"Jansen","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge P.","family":"Burhan","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hruscha","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Tokarz","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen","place":["Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Prehn","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen","place":["Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Cecil","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen","place":["Neuherberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Adamski","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen","place":["Neuherberg, Germany"]},{"name":"German Center for Diabetes Research","place":["Neuherberg, Germany"]},{"name":"Lehrstuhl f\u00fcr Experimentelle Genetik, Technische Universit\u00e4t M\u00fcnchen","place":["Freising-Weihenstephan, Germany"]},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haass","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)","place":["Munich, Germany"]},{"name":"Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","place":["Munich, Germany"]},{"name":"Munich Cluster for Systems Neurology (SyNergy)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology Hamburg (ZMNH)","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bonn","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology Hamburg (ZMNH)","place":["Hamburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Schmid","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1161\/CIRCRESAHA.116.309937","article-title":"AMP-activated protein kinase alpha2 in neutrophils regulates vascular repair via hypoxia-inducible Factor-1alpha and a network of proteins affecting metabolism and apoptosis","volume":"120","author":"Abdel Malik","year":"2017","journal-title":"Circ. 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