{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:36:27Z","timestamp":1790620587457,"version":"4.1.0"},"reference-count":202,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>The significant toxicity associated with anticancer drugs during traditional treatments, such as surgery, radiation, chemotherapy, and hormonal therapy, limits their therapeutic index by causing various adverse effects on healthy cells. Particularly, the clinical application of platinum (Pt)-based anticancer drugs (Pt-ADs), including cisplatin, carboplatin, and others, is challenging and severely hampered by intrinsic drug resistance, oxidative stress, and toxicity. Lipid-based nanodrug delivery systems have emerged as a promising solution to overcome these challenges, offering enhanced drug targeting, controlled release, and improved therapeutic indices. Among lipid-based carriers, coconut oil (CO) has attracted growing interest as a natural, biocompatible component for nanodrug formulations. Rich in medium-chain triglycerides (MCTs) and bioactive fatty acids such as lauric acid (LA), CO not only serves as an efficient solubilizing and stabilizing agent but also exhibits potential antioxidant, anticancer, antimicrobial, and immunomodulatory properties. Recently, we also found coconut kernel extract or a type of oil extracted from coconut kernel demonstrates considerable antioxidant and anticancer properties, as well as the capacity to diminish oxidative stress and the overexpression of the c-MYC proto-oncogene. Therefore, in this review, we explored the emerging role of CO\/LA-based nanodrugs (CO\/LA-NDs) in cancer therapy. We further focused on their anticancer effects with potential mechanistic insight followed by, a brief discussion of a few instances of CO\/LA-based nanoformulation techniques\u2019 capacity to mitigate systemic anticancer drug-mediated toxicity while enhancing anticancer efficacy, and the pharmacokinetic advantages of CO\/LA-NDs in cancer research with an emphasis on pharmacological strategy to target cancer stem cells (CSCs). We also discussed how CO\u2019s antioxidant properties might be used in the future to target CSCs and lessen Pt-AD-mediated toxicity. Therefore, by incorporating natural lipid systems into nanomedicine, CO\/LA-based nanodrug (CO\/LA-ND) formulations may offer a fresh, multifunctional platform for cancer treatment, enhancing efficacy and lowering side effects.<\/jats:p>","DOI":"10.3389\/fcell.2026.1800786","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:29:50Z","timestamp":1778477390000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Coconut oil\/lauric acid-based nanodrug formulation: a multifunctional platform for enhancing cancer therapy and mitigating toxicity"],"prefix":"10.3389","volume":"14","author":[{"given":"Sorra","family":"Sandhya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dibrugarh University (DU)","place":["Dibrugarh, Assam, India"]},{"name":"Department of Cancer Stem Cells and Infectious Diseases, Kavikrishna Laboratory, Indian Institute of Technology (IIT) Guwahati","place":["Guwahati, Assam, India"]},{"name":"Department of Bioengineering and Technology, Gauhati University","place":["Guwahati, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohini","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dibrugarh University (DU)","place":["Dibrugarh, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bani Kumar","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dibrugarh University (DU)","place":["Dibrugarh, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyeeta","family":"Talukdar","sequence":"additional","affiliation":[{"name":"Department of Cancer Stem Cells and Infectious Diseases, Kavikrishna Laboratory, Indian Institute of Technology (IIT) Guwahati","place":["Guwahati, Assam, India"]},{"name":"Department of Bioengineering and Technology, Gauhati University","place":["Guwahati, Assam, India"]},{"name":"Department of Biochemistry, All India Institute of Medical Sciences (AIIMS)","place":["New Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrat","family":"Baishya","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Technology, Gauhati University","place":["Guwahati, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayatri","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Assam Medical College and Hospital","place":["Dibrugarh, Assam, India"]},{"name":"Multidisciplinary Research Unit, Assam Medical College and Hospital","place":["Dibrugarh, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikul","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Cancer Stem Cells and Infectious Diseases, Kavikrishna Laboratory, Indian Institute of Technology (IIT) Guwahati","place":["Guwahati, Assam, India"]},{"name":"Department of Experimental Therapeutics, Thoreau Laboratory for Global Health, M2D2, University of Massachusetts","place":["Lowell, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Mazumder","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Dibrugarh University (DU)","place":["Dibrugarh, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.eujim.2019.05.002","article-title":"Ficus deltoidea: effects of solvent polarity on antioxidant and anti-proliferative activities in breast and colon cancer cells","volume":"28","author":"Abolmaesoomi","year":"2019","journal-title":"Eur. J. Integr. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e5694","DOI":"10.7717\/peerj.5694","article-title":"The antioxidant activities, cytotoxic properties, and identification of water-soluble compounds of Ficus deltoidea leaves","volume":"6","author":"Abrahim","year":"2018","journal-title":"PeerJ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5490468","DOI":"10.1155\/2020\/5490468","article-title":"Antitumor activity of Ficus deltoidea extract on oral cancer: an in vivo study","volume":"2020","author":"Al-Koshab","year":"2020","journal-title":"J. Oncol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors affecting the clearance and biodistribution of polymeric nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"key":"B5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/1061186X.2024.2323056","article-title":"Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma","volume":"32","author":"Ali Alghamdi","year":"2024","journal-title":"J. Drug Target"},{"key":"B6","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1080\/10717544.2020.1736209","article-title":"Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress","volume":"27","author":"Alkhatib","year":"2020","journal-title":"Drug Deliv."},{"key":"B7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/pharmaceutics17030381","article-title":"Oral bioavailability enhancement of anti-cancer drugs through lipid polymer hybrid nanoparticles","volume":"17","author":"Almawash","year":"2025","journal-title":"Pharmaceutics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/21691401.2023.2246145","article-title":"Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines","volume":"51","author":"Alotaibi","year":"2023","journal-title":"Artif. Cells Nanomed Biotechnol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"540","DOI":"10.4103\/2221-1691.297053","article-title":"Coconut oil nanoemulsion attenuates methotrexate-induced hepatotoxicity and nephrotoxicity in Ehrlich ascites carcinoma-bearing mice","volume":"10","author":"Alyamani","year":"2020","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/0959-437x(94)90098-1","article-title":"Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death","volume":"4","author":"Amati","year":"1994","journal-title":"Curr. Opin. Genet. Dev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1007\/s12672-025-02664-3","article-title":"Nanotechnology in oncology: advances in biosynthesis, drug delivery, and theranostics","volume":"16","author":"Ammar","year":"2025","journal-title":"Discov. Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.22178\/pos.96-6","article-title":"Impact of Virgin Coconut oil and carvedilol on neurobehaviour, apoptotic and inflammatory brain markers in Doxorubicin treated mice","volume":"9","author":"Anthonia Chiamaka","year":"2023","journal-title":"Path Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s43088-024-00566-x","article-title":"Surface-modified lipid-based nanocarriers as a pivotal delivery approach for cancer therapy: application and recent advances in targeted cancer treatment\u200f","volume":"13","author":"Anwar","year":"2024","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1017\/S000711451400004X","article-title":"Influence of virgin coconut oil-enriched diet on the transcriptional regulation of fatty acid synthesis and oxidation in rats - a comparative study","volume":"111","author":"Arunima","year":"2014","journal-title":"Br. J. Nutr."},{"key":"B15","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4103\/jpbs.JPBS_232_19","article-title":"An overview of phytochemical and biological activities: Ficus deltoidea Jack and other Ficus spp","volume":"13","author":"Ashraf","year":"2021","journal-title":"J. Pharm. Bioallied Sci."},{"key":"B16","volume-title":"Paclitaxel, in StatPearls","author":"Awosika","year":"2025"},{"key":"B17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3390\/cosmetics7040083","article-title":"Characterization, stability assessment, antioxidant evaluation and cell proliferation activity of virgin coconut oil-based nanostructured lipid carrier loaded with Ficus deltoidea extract","volume":"7","author":"Azmi","year":"2020","journal-title":"Cosmetics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e51280","DOI":"10.15252\/embr.202051280","article-title":"Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity","volume":"22","author":"Babolmorad","year":"2021","journal-title":"EMBO Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1093\/ajcn\/36.5.950","article-title":"Medium-chain triglycerides: an update","volume":"36","author":"Bach","year":"1982","journal-title":"Am. J. Clin. Nutr."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","article-title":"Metformin: historical overview","volume":"60","author":"Bailey","year":"2017","journal-title":"Diabetologia"},{"key":"B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1201\/9781003516651-28","article-title":"Mesenchymal stem cells as ideal candidate for delivering oncolytic viruses in the tumour microenvironment to target cancer stem cells","volume-title":"Viral oncology","author":"Baishya","year":"2025"},{"key":"B22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/B978-0-12-824135-6.00025-8","article-title":"Chapter 30 - chemistry and composition of coconut oil and its biological activities","volume-title":"Multiple biological activities of unconventional seed oils","author":"Barlina","year":"2022"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3390\/nano9030474","article-title":"Application of solid lipid nanoparticles to improve the efficiency of anticancer drugs","volume":"9","author":"Bayon-Cordero","year":"2019","journal-title":"Nanomater. (Basel)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.3390\/ijms18112362","article-title":"ABC transporters in cancer stem cells: beyond chemoresistance","volume":"18","author":"Begicevic","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ijpharm.2017.05.016","article-title":"Paclitaxel: what has been done and the challenges remain ahead","volume":"526","author":"Bernabeu","year":"2017","journal-title":"Int. J. Pharm."},{"key":"B27","doi-asserted-by":"publisher","first-page":"933329","DOI":"10.3389\/fimmu.2022.933329","article-title":"Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense","volume":"13","author":"Bhuyan","year":"2022","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/jox15040126","article-title":"Virgin coconut oil and its lauric acid, between anticancer activity and modulation of chemotherapy toxicity: a review","volume":"15","author":"Bose","year":"2025","journal-title":"J. Xenobiot."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17635","DOI":"10.1074\/jbc.M800109200","article-title":"Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells","volume":"283","author":"Bourguignon","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"B31","doi-asserted-by":"publisher","first-page":"902734","DOI":"10.1155\/2014\/902734","article-title":"Ficus deltoidea jack: a review on its phytochemical and pharmacological importance","volume":"2014","author":"Bunawan","year":"2014","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"5S","DOI":"10.1177\/1091581811400636","article-title":"Final report on the safety assessment of Cocos nucifera (coconut) oil and related ingredients","volume":"30","author":"Burnett","year":"2011","journal-title":"Int. J. Toxicol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1515\/jcim-2023-0262","article-title":"The assessment of the mechanism of action of lauric acid in the context of oral cancer through integrative approach combining network pharmacology and molecular docking technology","volume":"21","author":"Buva","year":"2024","journal-title":"J. Complement. Integr. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.3390\/antiox10071116","article-title":"Oxidative stress and cognitive alterations induced by cancer chemotherapy drugs: a scoping review","volume":"10","author":"Cauli","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.37349\/etat.2024.00272","article-title":"Exploring the therapeutic potential of lipid-based nanoparticles in the management of oral squamous cell carcinoma","volume":"5","author":"Chaudhary","year":"2024","journal-title":"Explor Target Antitumor Ther."},{"key":"B36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s12943-023-01865-0","article-title":"Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation","volume":"22","author":"Chehelgerdi","year":"2023","journal-title":"Mol. Cancer"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41392-018-0008-7","article-title":"Targeting oncogenic Myc as a strategy for cancer treatment","volume":"3","author":"Chen","year":"2018","journal-title":"Signal Transduct. Target Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.2217\/fon-2023-0513","article-title":"The impact of myelosuppression on quality of life of patients treated with chemotherapy","volume":"20","author":"Crawford","year":"2024","journal-title":"Future Oncol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","article-title":"To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery","volume":"148","author":"Danhier","year":"2010","journal-title":"J. Control. Release"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1007\/s12672-025-04057-y","article-title":"Nanomedicine and nutraceutical-based nanocarriers for specific delivery to cancer stem cells: targeted drug delivery at the STEM frontier","volume":"16","author":"Daoud","year":"2025","journal-title":"Discov. Oncol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1593\/neo.08466","article-title":"Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth","volume":"10","author":"Das","year":"2008","journal-title":"Neoplasia"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4015","DOI":"10.1158\/0008-5472.CAN-18-2847","article-title":"MYC regulates the HIF2alpha stemness pathway via nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells","volume":"79","author":"Das","year":"2019","journal-title":"Cancer Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11746-014-2562-7","article-title":"The properties of lauric acid and their significance in coconut oil","volume":"92","author":"Dayrit","year":"2015","journal-title":"J. Am. Oil Chemists' Soc."},{"key":"B44","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"B45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","article-title":"The MYC oncogene - the grand orchestrator of cancer growth and immune evasion","volume":"19","author":"Dhanasekaran","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"121738","DOI":"10.1016\/j.molliq.2023.121738","article-title":"Solid lipid nanoparticles of lauric Acid: a prospective drug carrier for oral drug delivery","volume":"380","author":"Dhanya","year":"2023","journal-title":"J. Mol. Liq."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1367981","DOI":"10.3389\/fphar.2024.1367981","article-title":"Lipid metabolism dynamics in cancer stem cells: potential targets for cancers","volume":"15","author":"Du","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"102154","DOI":"10.1016\/j.ctrv.2021.102154","article-title":"MYC as a target for cancer treatment","volume":"94","author":"Duffy","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.3390\/nano11071755","article-title":"Nanoparticles for targeted drug delivery to cancer stem cells: a review of recent advances","volume":"11","author":"Ertas","year":"2021","journal-title":"Nanomater. (Basel)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1080\/01635580902825597","article-title":"Stearate preferentially induces apoptosis in human breast cancer cells","volume":"61","author":"Evans","year":"2009","journal-title":"Nutr. Cancer"},{"key":"B51","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.biopha.2016.12.123","article-title":"Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats","volume":"87","author":"Famurewa","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"B52","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1159\/000356067","article-title":"Induction of apoptosis by the medium-chain length fatty acid lauric acid in colon cancer cells due to induction of oxidative stress","volume":"59","author":"Fauser","year":"2013","journal-title":"Chemotherapy"},{"key":"B53","volume-title":"Physical and chemical characteristics of oils, fats, and waxes","author":"Firestone","year":"2006"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s11095-010-0130-x","article-title":"Phospholipids and lipid-based formulations in oral drug delivery","volume":"27","author":"Fricker","year":"2010","journal-title":"Pharm. Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3390\/ijms26020664","article-title":"Energy metabolism and stemness and the role of lauric acid in reversing 5-Fluorouracil resistance in colorectal cancer cells","volume":"26","author":"Fujiwara-Tani","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.foodhyd.2018.03.037","article-title":"Impact of virgin coconut oil nanoemulsion on properties of croaker surimi gel","volume":"82","author":"Gani","year":"2018","journal-title":"Food Hydrocoll."},{"key":"B57","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/nano9040638","article-title":"Lipid-Based nanoparticles: application and recent advances in cancer treatment","volume":"9","author":"Garcia-Pinel","year":"2019","journal-title":"Nanomater. (Basel)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"310852","DOI":"10.1155\/2014\/310852","article-title":"Physicochemical and phytochemical analyses of copra and oil of Cocos nucifera L. (West Coast tall variety)","volume":"2014","author":"Ghosh","year":"2014","journal-title":"Int. J. Food Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/pharmaceutics16091158","article-title":"Lipid-based nanocarriers: bridging diagnosis and cancer therapy","volume":"16","author":"Giordano","year":"2024","journal-title":"Pharmaceutics"},{"key":"B60","doi-asserted-by":"publisher","first-page":"629182","DOI":"10.3389\/fcell.2021.629182","article-title":"Anti-tumor effect of oleic acid in hepatocellular carcinoma cell lines via autophagy reduction","volume":"9","author":"Giulitti","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B61","volume-title":"Global Cancer Facts and Figures, 5th edition","year":"2024"},{"key":"B62","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1200\/JCO.1999.17.1.409","article-title":"Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin","volume":"17","author":"Go","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/1097-0142(20000701)89:1<97::aid-cncr14>3.0.co;2-0","article-title":"c-MYC and nodular malignant melanoma. A case report","volume":"89","author":"Greulich","year":"2000","journal-title":"Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"111770","DOI":"10.1016\/j.eurpolymj.2022.111770","article-title":"CD44 and CD133 aptamer directed nanocarriers for cancer stem cells targeting","volume":"183","author":"Grover","year":"2023","journal-title":"Eur. Polym. J."},{"key":"B65","doi-asserted-by":"publisher","first-page":"105150","DOI":"10.1016\/j.chemphyslip.2021.105150","article-title":"Nanostructured lipid carriers for the encapsulation of phloretin: preparation and in vitro characterization studies","volume":"242","author":"Gu","year":"2022","journal-title":"Chem. Phys. Lipids"},{"key":"B66","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/pharmaceutics12030288","article-title":"Nanostructured lipid carriers for delivery of chemotherapeutics: a review","volume":"12","author":"Haider","year":"2020","journal-title":"Pharmaceutics"},{"key":"B67","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/nu17050794","article-title":"Medium-chain fatty acids selectively sensitize cancer cells to ferroptosis by inducing CD36 and ACSL4","volume":"17","author":"Han","year":"2025","journal-title":"Nutrients"},{"key":"B68","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3389\/fphar.2017.00895","article-title":"Vitro pro-apoptotic and anti-migratory effects of Ficus deltoidea L. plant extracts on the human prostate cancer cell lines PC3","volume":"8","author":"Hanafi","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B69","volume-title":"Methotrexate, in StatPearls","author":"Hanoodi","year":"2025"},{"key":"B70","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3389\/fphar.2016.00313","article-title":"Nanomedicine-mediated therapies to target breast cancer stem cells","volume":"7","author":"He","year":"2016","journal-title":"Front. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1634\/theoncologist.2015-0164","article-title":"Preventing and managing toxicities of high-dose methotrexate","volume":"21","author":"Howard","year":"2016","journal-title":"Oncologist"},{"key":"B72","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3892\/etm.2019.8220","article-title":"Dual-targeting nanomicelles with CD133 and CD44 aptamers for enhanced delivery of gefitinib to two populations of lung cancer-initiating cells","volume":"19","author":"Huang","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B201","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3390\/pharmaceutics12050429","article-title":"Encapsulation of oleuropein in nanostructured lipid carriers: biocompatibility and antioxidant efficacy in lung epithelial cells","volume":"12","author":"Huguet-Casquero","year":"2020","journal-title":"Pharmaceutics."},{"key":"B73","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/13880200903062614","article-title":"Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil","volume":"48","author":"Intahphuak","year":"2010","journal-title":"Pharm. Biol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jbiosc.2022.06.009","article-title":"Characterization of entrapment behavior of polyphenols in nanostructured lipid carriers and its effect on their antioxidative activity","volume":"134","author":"Izza","year":"2022","journal-title":"J. Biosci. Bioeng."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1007\/s13197-022-05499-w","article-title":"Triglycerides of medium-chain fatty acids: a concise review","volume":"60","author":"Jadhav","year":"2023","journal-title":"J. Food Sci. Technol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.biopha.2013.04.005","article-title":"The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance","volume":"67","author":"Januchowski","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"B76","doi-asserted-by":"publisher","first-page":"11277","DOI":"10.1038\/s41598-017-11842-5","article-title":"Oleic acid induces apoptosis and autophagy in the treatment of tongue squamous cell carcinomas","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci. Rep."},{"key":"B77","article-title":"Doxorubicin, in StatPearls","author":"Johnson-Arbor","year":"2025"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1126\/science.4001943","article-title":"Microinjected c-myc as a competence factor","volume":"228","author":"Kaczmarek","year":"1985","journal-title":"Science"},{"key":"B117","volume-title":"Virgin Coconut oil (VCO) inhibits cell growth via apoptosis on LungCancer cell lines","author":"Kamalaldin","year":"2013"},{"key":"B79","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s11864-025-01336-2","article-title":"Cancer-related alopecia risk and treatment","volume":"26","author":"Kaufman","year":"2025","journal-title":"Curr. Treat. Options Oncol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"800481","DOI":"10.3389\/fphar.2021.800481","article-title":"CD44-Targeted nanocarrier for cancer therapy","volume":"12","author":"Kesharwani","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.biopha.2018.04.055","article-title":"Nanostructured lipid carriers for site-specific drug delivery","volume":"103","author":"Khosa","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1002\/stem.37","article-title":"Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine","volume":"27","author":"Knoepfler","year":"2009","journal-title":"Stem Cells"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/cjpp-2016-0079","article-title":"The role of cancer stem cells in tumor heterogeneity and resistance to therapy","volume":"95","author":"Konrad","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.3390\/ijms21103483","article-title":"Overview of dual-acting drug methotrexate in different neurological diseases, autoimmune pathologies and cancers","volume":"21","author":"Kozminski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"22399","DOI":"10.1073\/pnas.1903485116","article-title":"Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling","volume":"116","author":"Kreuzaler","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1111\/febs.16772","article-title":"Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells","volume":"290","author":"Kuang","year":"2023","journal-title":"FEBS J."},{"key":"B87","doi-asserted-by":"publisher","first-page":"207","DOI":"10.2174\/0118715206327789241008162423","article-title":"Anticancer properties against select cancer cell lines and metabolomics analysis of tender Coconut water","volume":"25","author":"Lakshmanan","year":"2025","journal-title":"Anticancer Agents Med. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.cden.2007.10.002","article-title":"Management of oral mucositis in patients who have cancer","volume":"52","author":"Lalla","year":"2008","journal-title":"Dent. Clin. North Am."},{"key":"B89","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/cddiscovery.2017.63","article-title":"The lauric acid-activated signaling prompts apoptosis in cancer cells","volume":"3","author":"Lappano","year":"2017","journal-title":"Cell Death Discov."},{"key":"B90","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1476-511X-13-139","article-title":"The effects of virgin coconut oil (VCO) as supplementation on quality of life (QOL) among breast cancer patients","volume":"13","author":"Law","year":"2014","journal-title":"Lipids Health Dis."},{"key":"B91","doi-asserted-by":"publisher","first-page":"9205","DOI":"10.3390\/curroncol30100665","article-title":"Toxicities and quality of life during cancer treatment in advanced solid tumors","volume":"30","author":"Lee","year":"2023","journal-title":"Curr. Oncol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s13402-025-01081-6","article-title":"Lipid metabolism in cancer stem cells: reprogramming, mechanisms, crosstalk, and therapeutic approaches","volume":"48","author":"Lee","year":"","journal-title":"Cell Oncol. (Dordr)"},{"key":"B93","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41392-025-02360-2","article-title":"Cancer stem cells: landscape, challenges and emerging therapeutic innovations","volume":"10","author":"Lee","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40880-017-0184-9","article-title":"Metformin targets multiple signaling pathways in cancer","volume":"36","author":"Lei","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"B95","doi-asserted-by":"publisher","first-page":"4936","DOI":"10.1158\/1078-0432.CCR-10-1499","article-title":"Stem cell quiescence","volume":"17","author":"Li","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/carcin\/bgr092","article-title":"Prevention of carcinogenesis and inhibition of breast cancer tumor burden by dietary stearate","volume":"32","author":"Li","year":"2011","journal-title":"Carcinogenesis"},{"key":"B97","doi-asserted-by":"publisher","first-page":"629266","DOI":"10.3389\/fphar.2020.629266","article-title":"DNA repair pathways in cancer therapy and resistance","volume":"11","author":"Li","year":"","journal-title":"Front. Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.7150\/thno.41388","article-title":"Lipid metabolism alteration contributes to and maintains the properties of cancer stem cells","volume":"10","author":"Li","year":"","journal-title":"Theranostics"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e13167","DOI":"10.1111\/cpr.13167","article-title":"Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"key":"B100","doi-asserted-by":"publisher","first-page":"630","DOI":"10.37349\/etat.2023.00157","article-title":"Nanomedicine strategies to counteract cancer stemness and chemoresistance","volume":"4","author":"Liu","year":"2023","journal-title":"Explor Target Antitumor Ther."},{"key":"B101","doi-asserted-by":"publisher","first-page":"103756","DOI":"10.1016\/j.ebiom.2021.103756","article-title":"Therapeutic targeting of \u201cundruggable\u201d MYC","volume":"75","author":"Llombart","year":"2022","journal-title":"EBioMedicine"},{"key":"B102","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1476-511X-9-106","article-title":"Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction","volume":"9","author":"Lu","year":"2010","journal-title":"Lipids Health Dis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"e62770","DOI":"10.7759\/cureus.62770","article-title":"Biomedical applications of lauric acid: a narrative review","volume":"16","author":"M","year":"2024","journal-title":"Cureus"},{"key":"B104","doi-asserted-by":"crossref","first-page":"056","DOI":"10.30574\/gscbps.2018.5.1.0082","article-title":"Physicochemical properties, antioxidant activity and phyto-nutritional composition of cold and hot pressed coconut oils GSC","volume":"5","author":"MacDonald","year":"2018","journal-title":"Biol. Pharmaceut. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/s0168-3659(99)00248-5","article-title":"Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Control Release"},{"key":"B106","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s40203-025-00521-3","article-title":"Identifying potent ABCG2 inhibitors from the COCONUT database of natural compounds to overcome drug resistance in breast cancer: a comprehensive in silico study targeting ATP-binding cassette (ABC) transporter G2","volume":"14","author":"Mandal","year":"2026","journal-title":"Silico Pharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3390\/ph15070890","article-title":"C-Myc expression in oral squamous cell carcinoma: molecular mechanisms in cell survival and cancer progression","volume":"15","author":"Marconi","year":"2022","journal-title":"Pharm. (Basel)"},{"key":"B108","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1002\/ijc.34216","article-title":"Circulating plasma phospholipid fatty acid levels and breast cancer risk in the cancer prevention study-II nutrition cohort","volume":"151","author":"Matta","year":"2022","journal-title":"Int. J. Cancer"},{"key":"B109","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0169-409x(01)00105-3","article-title":"Solid lipid nanoparticles: production, characterization and applications","volume":"47","author":"Mehnert","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B110","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","article-title":"Lipid-Based nanoparticles for drug\/gene delivery: an overview of the production techniques and difficulties encountered in their industrial development","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater Au"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1232012","DOI":"10.3389\/fddev.2023.1232012","article-title":"Lipid-based oral formulation in capsules to improve the delivery of poorly water-soluble drugs","volume":"3","author":"Mohite","year":"2023","journal-title":"Front. Drug Deliv."},{"key":"B112","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1194\/jlr.TR119000439","article-title":"Lipid rafts as signaling hubs in cancer cell survival\/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid Rafts","volume":"61","author":"Mollinedo","year":"2020","journal-title":"J. Lipid Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3390\/ijms26051953","article-title":"Anti-cancer and pro-immune effects of lauric acid on colorectal cancer cells","volume":"26","author":"Mori","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/s0163-7827(03)00050-x","article-title":"The digestion of dietary triacylglycerols","volume":"43","author":"Mu","year":"2004","journal-title":"Prog. Lipid Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/s0939-6411(00)00087-4","article-title":"Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art","volume":"50","author":"Muller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"B116","doi-asserted-by":"publisher","first-page":"253","DOI":"10.20892\/j.issn.2095-3941.2019.0284","article-title":"ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance","volume":"17","author":"Muriithi","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ijpharm.2013.09.021","article-title":"Encapsulation of paclitaxel into lauric acid-O-carboxymethyl chitosan-transferrin micelles for hydrophobic drug delivery and site-specific targeted delivery","volume":"457","author":"Nam","year":"2013","journal-title":"Int. J. Pharm."},{"key":"B119","doi-asserted-by":"publisher","first-page":"e21267","DOI":"10.1016\/j.heliyon.2023.e21267","article-title":"Effect of Lauric acid against ethanol-induced hepatotoxicity by modulating oxidative stress\/apoptosis signalling and HNF4alpha in Wistar albino rats","volume":"9","author":"Namachivayam","year":"2023","journal-title":"Heliyon"},{"key":"B120","doi-asserted-by":"publisher","first-page":"5014","DOI":"10.3390\/ijms16035014","article-title":"Anticarcinogenic properties of medium chain fatty acids on human colorectal, skin and breast cancer cells in vitro","volume":"16","author":"Narayanan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"6645","DOI":"10.1039\/c8dt00838h","article-title":"The side effects of platinum-based chemotherapy drugs: a review for chemists","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans."},{"key":"B122","doi-asserted-by":"publisher","first-page":"107","DOI":"10.18632\/oncotarget.439","article-title":"Curtailing side effects in chemotherapy: a tale of PKCdelta in cisplatin treatment","volume":"3","author":"Pabla","year":"2012","journal-title":"Oncotarget"},{"key":"B123","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ijpharm.2008.10.003","article-title":"Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products","volume":"366","author":"Pardeike","year":"2009","journal-title":"Int. J. Pharm."},{"key":"B124","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.toxrep.2023.12.010","article-title":"Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro","volume":"12","author":"Pason","year":"2024","journal-title":"Toxicol. Rep."},{"key":"B125","doi-asserted-by":"publisher","first-page":"100923","DOI":"10.1016\/j.phyplu.2025.100923","article-title":"Modulation of apoptotic pathways and epithelial\u2013mesenchymal transition in HeLa cervical cancer cells by Ficus deltoidea-silver nanoparticles (FD-AgNPs)","volume":"6","author":"Permatasari","year":"2026","journal-title":"Phytomedicine Plus"},{"key":"B126","doi-asserted-by":"publisher","first-page":"5416923","DOI":"10.1155\/2018\/5416923","article-title":"Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment","volume":"2018","author":"Phi","year":"2018","journal-title":"Stem Cells Int."},{"key":"B127","doi-asserted-by":"publisher","first-page":"25","DOI":"10.37833\/cord.v32i1.43","article-title":"Liposomal drug delivery of a major component of coconut oil for the treatment of Acne Vulgaris in vitro and in vivo","volume":"32","author":"Pornpattananangkul","year":"2016","journal-title":"CORD"},{"key":"B128","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrd2197","article-title":"Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs","volume":"6","author":"Porter","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"B129","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1056\/NEJMra1703481","article-title":"Immune-related adverse events associated with immune checkpoint blockade","volume":"378","author":"Postow","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"B130","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1093\/jn\/127.11.2142","article-title":"Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle","volume":"127","author":"Power","year":"1997","journal-title":"J. Nutr."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1039\/d4fb00093e","article-title":"Virgin coconut oil: wet production methods and food applications \u2013 a review","volume":"2","author":"Prasanna","year":"2024","journal-title":"Sustain. Food Technol."},{"key":"B132","doi-asserted-by":"crossref","first-page":"101870","DOI":"10.1016\/j.jsps.2023.101870","article-title":"Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: a review","volume":"31","author":"Preeti","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"B133","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.3390\/ijms18122574","article-title":"Drug resistance driven by cancer stem cells and their niche","volume":"18","author":"Prieto-Vila","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1021\/acsomega.2c05976","article-title":"Surface modification of lipid-based nanocarriers: a potential approach to enhance targeted drug delivery","volume":"8","author":"Priya","year":"2023","journal-title":"ACS Omega"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.37833\/cord.v36i.415","article-title":"Integration of in silico and in vitro approach to reveal the anticancer efficacy of virgin coconut oil","volume":"36","author":"Pruseth","year":"2020","journal-title":"CORD"},{"key":"B136","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1615\/critrevtherdrugcarriersyst.v26.i6.10","article-title":"Lipid-based nanoparticles as pharmaceutical drug carriers: from concepts to clinic","volume":"26","author":"Puri","year":"2009","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"B137","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.5455\/OVJ.2025.v15.i8.21","article-title":"Effects of coconut oil (Cocos nucifera L.) on Aeromonas hydrophila infection, immune protein profile, and mortality in zebrafish (Danio rerio)","volume":"15","author":"Qosimah","year":"2025","journal-title":"Open Vet. J."},{"key":"B138","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.2174\/1381612825666190903155321","article-title":"Solid lipid nanoparticles: a promising nanomaterial in drug delivery","volume":"25","author":"Rajpoot","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"B139","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.trecan.2017.08.007","article-title":"New opportunities and challenges to defeat cancer stem cells","volume":"3","author":"Ramos","year":"2017","journal-title":"Trends Cancer"},{"key":"B140","doi-asserted-by":"publisher","first-page":"833630","DOI":"10.3389\/fnins.2022.833630","article-title":"Dual roles of coconut oil and its major component lauric acid on Redox nexus: focus on cytoprotection and cancer cell death","volume":"16","author":"Ramya","year":"2022","journal-title":"Front. Neurosci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"B142","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13287-022-02856-6","article-title":"Drug resistance in cancer therapy: the Pandora\u2019s Box of cancer stem cells","volume":"13","author":"Rezayatmand","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"B143","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/polym16050641","article-title":"Chitosan\/Virgin coconut oil-based emulsions doped with photosensitive curcumin loaded capsules: a functional carrier to topical treatment","volume":"16","author":"Rodrigues","year":"2024","journal-title":"Polym. (Basel)"},{"key":"B144","doi-asserted-by":"publisher","first-page":"104724","DOI":"10.1016\/j.jff.2021.104724","article-title":"Effect of medium chain fatty acid in human health and disease","volume":"87","author":"Roopashree","year":"2021","journal-title":"J. Funct. Foods"},{"key":"B145","doi-asserted-by":"publisher","first-page":"776","DOI":"10.5603\/rpor.103524","article-title":"Targeted nanodelivery systems for personalized cancer therapy","volume":"29","author":"Roszkowski","year":"2024","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1088\/1755-1315\/1083\/1\/012036","article-title":"Identification of Fatty acids in Virgin Coconut Oil (VCO), cocoa beans, Crude Palm Oil (CPO), and Palm Kernel beans using gas chromatography","volume":"1083","author":"Sabahannur","year":"2022","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jconrel.2010.01.036","article-title":"Endocytosis of nanomedicines","volume":"145","author":"Sahay","year":"2010","journal-title":"J. Control Release"},{"key":"B148","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jddst.2019.02.017","article-title":"Nanostructured lipid carriers (NLC) system: a novel drug targeting carrier","volume":"51","author":"Salvi","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"100268","DOI":"10.1016\/j.ejmcr.2025.100268","article-title":"Nanotechnology-based drug delivery for breast cancer treatment: current applications and future directions","volume":"14","author":"Samad","year":"2025","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"B150","article-title":"Identifiaction of Herbal chemopreventive agent","volume-title":"Department of bioengineering and technoology","author":"Sandhya","year":"2017"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.21474\/ijar01\/952","article-title":"Chemical and biological properties of lauric acid: a review","volume":"4","author":"Sandhya","year":"2016","journal-title":"Int. J. Adv. Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"e29385","DOI":"10.1016\/j.heliyon.2024.e29385","article-title":"Impact of coconut kernel extract on carcinogen-induced skin cancer model: oxidative stress, C-MYC proto-oncogene and tumor formation","volume":"10","author":"Sandhya","year":"2024","journal-title":"Heliyon"},{"key":"B153","article-title":"Coconut kernel extract as a novel chemopreventive agent that target cancer stemness [abstract]","volume-title":"Proceedings of the American Association for cancer research annual meeting 2019","author":"Sandhya Sorra","year":"2019"},{"key":"B154","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s40001-024-01657-2","article-title":"Paclitaxel and its semi-synthetic derivatives: comprehensive insights into chemical structure, mechanisms of action, and anticancer properties","volume":"29","author":"Sati","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/j.biopha.2016.10.077","article-title":"The impact of methotrexate on lung inflammatory and apoptotic pathway biomarkers-the role of gallic acid","volume":"84","author":"Saygin","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"B156","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1046\/j.1523-1747.1999.00506.x","article-title":"Influence of increased c-Myc expression on the growth characteristics of human melanoma","volume":"112","author":"Schlagbauer-Wadl","year":"1999","journal-title":"J. Invest Dermatol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.3390\/biomedicines9081033","article-title":"In vitro nephrotoxicity studies of established and experimental platinum-based compounds","volume":"9","author":"Schoch","year":"2021","journal-title":"Biomedicines"},{"key":"B158","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1177\/0960327119839185","article-title":"Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: an in silico and in vitro study","volume":"38","author":"Sheela","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1080\/01635581.2025.2535053","article-title":"Lauric acid promotes esophageal squamous cell carcinoma via GPR84: lipid metabolic dysregulation as a therapeutic target","volume":"77","author":"Shen","year":"2025","journal-title":"Nutr. Cancer"},{"key":"B160","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.ijpharm.2008.09.004","article-title":"Mathematical modeling of drug delivery","volume":"364","author":"Siepmann","year":"2008","journal-title":"Int. J. Pharm."},{"key":"B161","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Singh","year":"2003","journal-title":"Cancer Res."},{"key":"B162","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.3390\/ijms252011185","article-title":"Targeting lipid metabolism in cancer stem cells for anticancer treatment","volume":"25","author":"Singh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B163","doi-asserted-by":"publisher","first-page":"5","DOI":"10.31557\/APJCP.2025.26.1.5","article-title":"Emerging research and future directions on doxorubicin: a snapshot","volume":"26","author":"Sinha","year":"2025","journal-title":"Asian Pac J. Cancer Prev."},{"key":"B164","doi-asserted-by":"publisher","first-page":"11697","DOI":"10.2147\/IJN.S543433","article-title":"Hepatotoxicity of nanoparticle-based anti-cancer drugs: insights into toxicity and mitigation strategies","volume":"20","author":"Skorzynski","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"B165","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1111\/jns.12335","article-title":"Platinum-induced peripheral neurotoxicity: from pathogenesis to treatment","volume":"24","author":"Staff","year":"2019","journal-title":"J. Peripher Nerv. Syst."},{"key":"B166","doi-asserted-by":"publisher","first-page":"17626","DOI":"10.1021\/acsanm.3c02851","article-title":"Aptamer- and lauric acid-modified au nanocrystals for targeted doxorubicin delivery and combined phototherapy, chemotherapy, and immunotherapy","volume":"6","author":"Sun","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"B167","doi-asserted-by":"publisher","first-page":"7506","DOI":"10.3390\/ijms24087506","article-title":"Lauric acid overcomes hypoxia-induced gemcitabine chemoresistance in pancreatic ductal adenocarcinoma","volume":"24","author":"Takagi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B168","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fmolb.2020.00079","article-title":"Cancer stem cell plasticity - a deadly deal","volume":"7","author":"Thankamony","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"29367","DOI":"10.1038\/srep29367","article-title":"Oxidative stress induced by Pt(IV) pro-drugs based on the Cisplatin scaffold and indole carboxylic acids in axial position","volume":"6","author":"Tolan","year":"2016","journal-title":"Sci. Rep."},{"key":"B170","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"B171","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrd4333","article-title":"Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery","volume":"13","author":"Torchilin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B172","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.5713\/ab.23.0489","article-title":"A study of the immunomodulatory effects of coconut oil extract in broilers experimentally infected with velogenic Newcastle disease virus","volume":"37","author":"Usmani","year":"2024","journal-title":"Anim. Biosci."},{"key":"B173","doi-asserted-by":"publisher","first-page":"6095","DOI":"10.1111\/febs.15583","article-title":"New insights into the activities and toxicities of the old anticancer drug doxorubicin","volume":"288","author":"van der Zanden","year":"2021","journal-title":"FEBS J."},{"key":"B174","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.2174\/1871520619666191021160752","article-title":"In vitro anticancer activity of virgin coconut oil and its fractions in liver and oral cancer cells","volume":"19","author":"Verma","year":"2019","journal-title":"Anticancer Agents Med. Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"834","DOI":"10.2174\/1871520620666200310091719","article-title":"Lauric acid modulates cancer-associated microRNA expression and inhibits the growth of the cancer cell","volume":"20","author":"Verma","year":"2020","journal-title":"Anticancer Agents Med. Chem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.13005\/bpj\/2757","article-title":"Nanoparticles -A booming drug delivery system in chemotherapy","volume":"16","author":"Verma","year":"2023","journal-title":"Biomed. Pharmacol. J."},{"key":"B177","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.semcancer.2023.02.001","article-title":"A role for partial epithelial-to-mesenchymal transition in enabling stemness in homeostasis and cancer","volume":"90","author":"Verstappe","year":"2023","journal-title":"Semin. Cancer Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1296091","DOI":"10.3389\/fonc.2024.1296091","article-title":"Lipid-based nanoparticles as drug delivery carriers for cancer therapy","volume":"14","author":"Waheed","year":"2024","journal-title":"Front. Oncol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"9447","DOI":"10.2147\/IJN.S274289","article-title":"Endocytosis and Organelle targeting of nanomedicines in cancer therapy","volume":"15","author":"Wang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"B180","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41392-021-00500-y","article-title":"Alternative approaches to target Myc for cancer treatment","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"B181","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1007\/s12185-018-2525-0","article-title":"Characteristics of methotrexate-induced stroke-like neurotoxicity","volume":"108","author":"Watanabe","year":"2018","journal-title":"Int. J. Hematol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"e02612","DOI":"10.1016\/j.heliyon.2019.e02612","article-title":"Antibacterial and immunomodulator activities of virgin coconut oil (VCO) against Staphylococcus aureus","volume":"5","author":"Widianingrum","year":"2019","journal-title":"Heliyon"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.3390\/ijms16011772","article-title":"Mechanisms and implications of dual-acting methotrexate in folate-targeted nanotherapeutic delivery","volume":"16","author":"Wong","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.addr.2007.04.008","article-title":"Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles","volume":"59","author":"Wong","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B185","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1124\/mol.58.5.920","article-title":"Oxaliplatin-induced damage of cellular DNA","volume":"58","author":"Woynarowski","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.3390\/cancers15194681","article-title":"Decanoic acid exerts its anti-tumor effects via targeting c-Met signaling cascades in hepatocellular carcinoma model","volume":"15","author":"Yang","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B187","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fmolb.2020.00193","article-title":"Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance","volume":"7","author":"Yao","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"B188","first-page":"1","article-title":"An overview of chemotoxicity and radiation toxicity in cancer therapy","volume-title":"Adv. Cancer Res","author":"Yazbeck","year":"2022"},{"key":"B189","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13046-018-0784-5","article-title":"Emerging role of lipid metabolism alterations in cancer stem cells","volume":"37","author":"Yi","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B190","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s40005-013-0087-y","article-title":"Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery","volume":"43","author":"Yoon","year":"2013","journal-title":"J. Pharm. Investigation"},{"key":"B191","doi-asserted-by":"publisher","first-page":"114620","DOI":"10.1016\/j.colsurfb.2025.114620","article-title":"Release dynamics and toxicological analysis of astilbin from lauric acid\/BSA-coated superparamagnetic iron oxide nanoparticles","volume":"252","author":"Yotsomnuk","year":"2025","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"B192","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/cancers15020388","article-title":"Palmitic acid inhibits the growth and metastasis of gastric cancer by blocking the STAT3 signaling pathway","volume":"15","author":"Yu","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B193","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s12672-025-02198-8","article-title":"Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy","volume":"16","author":"Zafar","year":"2025","journal-title":"Discov. Oncol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"112503","DOI":"10.1016\/j.biopha.2021.112503","article-title":"Clinical implications of chemotherapeutic agent organ toxicity on perioperative care","volume":"146","author":"Zeien","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B195","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.7150\/thno.69424","article-title":"Platinum-based drugs for cancer therapy and anti-tumor strategies","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"key":"B196","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/nrd2137","article-title":"Tumour-initiating cells: challenges and opportunities for anticancer drug discovery","volume":"8","author":"Zhou","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"B197","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3389\/fphar.2020.00343","article-title":"The drug-resistance mechanisms of five platinum-based Antitumor Agents","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"120046","DOI":"10.1016\/j.lfs.2021.120046","article-title":"Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K\/Akt pathway","volume":"286","author":"Zhu","year":"2021","journal-title":"Life Sci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"6579","DOI":"10.1038\/s41467-022-34000-6","article-title":"MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling","volume":"13","author":"Zimmerli","year":"2022","journal-title":"Nat. Commun."},{"key":"B200","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1101\/gad.12.15.2424","article-title":"Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization","volume":"12","author":"Zindy","year":"1998","journal-title":"Genes Dev."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1800786\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:29:54Z","timestamp":1778477394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1800786\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":202,"alternative-id":["10.3389\/fcell.2026.1800786"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1800786","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"article-number":"1800786"}}