{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:08:25Z","timestamp":1777637305545,"version":"3.51.4"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) is the most prevalent internal mRNA modification in eukaryotes and serves as a key post-transcriptional regulator in insect development. This review synthesizes current knowledge on m\n                    <jats:sup>6<\/jats:sup>\n                    A in insect sexual development, beginning with its well-established role in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , where it ensures female fate by promoting the female-specific splicing of the master switch gene\n                    <jats:italic>Sex-lethal<\/jats:italic>\n                    (\n                    <jats:italic>Sxl<\/jats:italic>\n                    ). Notably, classical female-lethal genes such as\n                    <jats:italic>Fl(2)d<\/jats:italic>\n                    and\n                    <jats:italic>Virilizer<\/jats:italic>\n                    are now recognized as essential regulatory subunits of the m\n                    <jats:sup>6<\/jats:sup>\n                    A methyltransferase complex, linking classic genetics to epitranscriptomics. In insects lacking an\n                    <jats:italic>Sxl<\/jats:italic>\n                    -centric pathway, such as Coleoptera, Hymenoptera, and Lepidoptera, m\n                    <jats:sup>6<\/jats:sup>\n                    A depletion does not disrupt core sex differentiation but instead plays essential roles in related processes, including metamorphosis in\n                    <jats:italic>Tribolium<\/jats:italic>\n                    , caste differentiation in honey bees, and gametogenesis across multiple orders.These findings underscore that m\n                    <jats:sup>6<\/jats:sup>\n                    A functions extend beyond the initial sex determination switch to regulate a broad spectrum of sex-related developmental processes across insect taxa, providing insights into the evolution of epigenetic regulation.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1802689","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:06:28Z","timestamp":1777442788000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The regulatory role of m6A RNA methylation in insect sexual development: a review"],"prefix":"10.3389","volume":"14","author":[{"given":"Tianxiao","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Quality Management, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binbin","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Disinfection and Vector Control, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabao","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Zhejiang Chinese Medical University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Quality Management, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)","place":["Hangzhou, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"921503","DOI":"10.3389\/fcell.2022.921503","article-title":"Transcriptional expression of m(6)A and m(5)C RNA methyltransferase genes in the brain and fat body of honey bee adult workers","volume":"10","author":"Bataglia","year":"2022","journal-title":"Front. 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