{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:05:25Z","timestamp":1784099125590,"version":"3.55.0"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Growing epidemiological evidence shows that psychological stress is strongly associated with pathogenesis in modern society a correlational finding). Its effects on CNS are highly age- and cell-type specific. This review outlines how stress regulates mitophagy and dynamically disrupt CNS homeostasis across different life stages, including fetal development, adolescence, and aging, as well as across distinct cell types such as neurons, astrocytes, and microglia. These alterations ultimately increase susceptibility to neurodevelopmental and neurodegenerative disorders.): We propose an integrated \u201ccell\u2013age\u2013stress\u201d framework (Hypothesis 1) that highlights the bidirectional crosstalk between stress-induced mitochondrial damage and nuclear epigenetic reprogramming. We also present a \u201clifespan intervention hypothesis\u201d (Hypothesis 2) and discuss precision fine-tuning strategies targeted to specific life stages and cell types, offering new directions for neuroprotective therapies.<\/jats:p>","DOI":"10.3389\/fcell.2026.1808059","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:05:57Z","timestamp":1784095557000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The embedding of stress: mitophagy as a mechanism for the central nervous system (CNS) programming and lifelong disease vulnerability"],"prefix":"10.3389","volume":"14","author":[{"given":"Meiling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine, Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Reproductive Medicine Center, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture","place":["Enshi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Sha","sequence":"additional","affiliation":[{"name":"School of Life Science, Chongqing University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture","place":["Enshi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifan","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s11689-021-09409-7","article-title":"MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice","volume":"13","author":"Abell\u00e1n-\u00c1lvaro","year":"2021","journal-title":"J. Neurodev. Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"103859","DOI":"10.1016\/j.redox.2025.103859","article-title":"Mitochondrial membrane potential and compartmentalized signaling: calcium, ROS, and beyond","volume":"86","author":"Ahmed Selim","year":"2025","journal-title":"Redox Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/s42003-021-02255-2","article-title":"Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction","volume":"4","author":"Alhassen","year":"2021","journal-title":"Commun. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.freeradbiomed.2019.06.007","article-title":"Interrogating Parkinson\u2019s disease associated redox targets: potential application of CRISPR editing","volume":"144","author":"Artyukhova","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1083\/jcb.201401070","article-title":"Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin","volume":"206","author":"Ashrafi","year":"2014","journal-title":"J. Cell Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"10045","DOI":"10.1007\/s12035-025-04868-8","article-title":"Epigenetic and mitochondrial metabolic dysfunction in multiple sclerosis: a review of herbal drug approaches and current clinical trials","volume":"62","author":"Ashwani","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41586-024-07282-7","article-title":"Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids","volume":"629","author":"Auger","year":"2024","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1534\/g3.116.034231","article-title":"Ctr9, a key component of the Paf1 complex, affects proliferation and terminal differentiation in the developing drosophila nervous system","volume":"6","author":"Bahrampour","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e1515","DOI":"10.1038\/cddis.2014.458","article-title":"PGC-1\u03b1 buffers ROS-mediated removal of mitochondria during myogenesis","volume":"5","author":"Baldelli","year":"2014","journal-title":"Cell Death Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.biopsych.2019.04.027","article-title":"Depression severity over 27 months in adolescent girls is predicted by stress-linked cortical morphology","volume":"86","author":"Bartlett","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3233\/jpd-201981","article-title":"Mitochondria and Parkinson\u2019s disease: clinical, molecular, and translational aspects","volume":"11","author":"Borsche","year":"2021","journal-title":"J. Park. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.tins.2024.08.015","article-title":"The multiple roles of chronic stress and glucocorticoids in Alzheimer\u2019s disease pathogenesis","volume":"47","author":"Burke","year":"2024","journal-title":"Trends Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"106683","DOI":"10.1016\/j.chiabu.2024.106683","article-title":"Childhood maltreatment, multilocus HPA-axis genetic variation and adolescent comorbidity profiles of depressive and anxiety symptoms","volume":"149","author":"Cao","year":"2024","journal-title":"Child. Abuse Negl."},{"key":"B14","doi-asserted-by":"publisher","first-page":"749737","DOI":"10.3389\/fnmol.2021.749737","article-title":"Psychological stress as a risk factor for accelerated cellular aging and cognitive decline: the involvement of Microglia-Neuron crosstalk","volume":"14","author":"Carrier","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/s43587-023-00524-9","article-title":"A drug-like molecule engages nuclear hormone receptor DAF-12\/FXR to regulate mitophagy and extend lifespan","volume":"3","author":"Chamoli","year":"2023","journal-title":"Nat. Aging"},{"key":"B16","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.biopsych.2017.10.005","article-title":"Parental advisory: maternal and paternal stress can impact offspring neurodevelopment","volume":"83","author":"Chan","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0230-6","article-title":"The cancer driver genes IDH1\/2, JARID1C\/KDM5C, and UTX\/KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism","volume":"51","author":"Chang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1038\/s41467-025-57810-w","article-title":"Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis","volume":"16","author":"Chen","year":"2025","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41467-020-20679-y","article-title":"BNIP3L\/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects","volume":"12","author":"Choi","year":"2021","journal-title":"Nat. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"8245","DOI":"10.3390\/ijms26178245","article-title":"NR3C1\/GLMN-Mediated FKBP12.6 ubiquitination disrupts calcium homeostasis and impairs mitochondrial quality control in stress-induced myocardial damage","volume":"26","author":"Cong","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.biopsych.2021.08.009","article-title":"Cortisol levels in childhood associated with emergence of attenuated psychotic symptoms in early adulthood","volume":"91","author":"Cullen","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"B22","doi-asserted-by":"publisher","first-page":"719","DOI":"10.3390\/cells13080719","article-title":"Epigenetic changes in Alzheimer\u2019s disease: DNA methylation and histone modification","volume":"13","author":"De Plano","year":"2024","journal-title":"Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"154395","DOI":"10.1016\/j.phymed.2022.154395","article-title":"Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats","volume":"106","author":"Deng","year":"2022","journal-title":"Phytomedicine"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1016\/j.molcel.2025.06.005","article-title":"MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction","volume":"85","author":"Ding","year":"2025","journal-title":"Mol. Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13062-023-00445-y","article-title":"Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process","volume":"18","author":"Dongol","year":"2023","journal-title":"Biol. Direct"},{"key":"B26","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1523\/jneurosci.0902-20.2020","article-title":"Reactive oxygen species modulate activity-dependent AMPA receptor transport in C. Elegans","volume":"40","author":"Doser","year":"2020","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1016\/j.neuron.2021.09.008","article-title":"Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience","volume":"109","author":"Duan","year":"2021","journal-title":"Neuron"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1080\/15548627.2024.2340399","article-title":"Mitochondrial import stress and PINK1-mediated mitophagy: the role of the PINK1-TOMM-TIMM23 supercomplex","volume":"20","author":"Eldeeb","year":"2024","journal-title":"Autophagy"},{"key":"B29","doi-asserted-by":"publisher","first-page":"777","DOI":"10.4103\/1673-5374.322452","article-title":"APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes","volume":"17","author":"Eran","year":"2022","journal-title":"Neural Regen. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41413-024-00390-0","article-title":"Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis","volume":"13","author":"Fan","year":"2025","journal-title":"Bone Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s12035-022-03108-7","article-title":"Carbon monoxide stimulates both mitophagy and mitochondrial biogenesis to mediate protection against oxidative stress in astrocytes","volume":"60","author":"Figueiredo-Pereira","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1093\/brain\/awaf360","article-title":"MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis","volume":"149","author":"Fioretti","year":"2026","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e2403862122","DOI":"10.1073\/pnas.2403862122","article-title":"Oncogenic IDH1(mut) drives robust loss of histone acetylation and increases chromatin heterogeneity","volume":"122","author":"Furth","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.pnpbp.2010.07.030","article-title":"Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders","volume":"35","author":"Gardner","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13024-020-00367-7","article-title":"PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson\u2019s disease","volume":"15","author":"Ge","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B37","doi-asserted-by":"publisher","first-page":"100670","DOI":"10.1016\/j.ynstr.2024.100670","article-title":"Effects of chronic stress on cognitive function - from neurobiology to intervention","volume":"33","author":"Girotti","year":"2024","journal-title":"Neurobiol. Stress"},{"key":"B38","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neulet.2010.11.006","article-title":"Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain","volume":"488","author":"Gong","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2026.01.019","article-title":"Mitochondrial DNA 6 mA methylation by METTL4 drives neuroinflammation via cGAS-STING activation in vascular cognitive impairment","volume":"246","author":"Gong","year":"2026","journal-title":"Free Radic. Biol. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"e197010","DOI":"10.1172\/jci197010","article-title":"l-2-Hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression","volume":"136","author":"Gu","year":"2026","journal-title":"J. Clin. Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"102983","DOI":"10.1016\/j.autneu.2022.102983","article-title":"Stress, hypoglycemia, and the autonomic nervous system","volume":"240","author":"Haas","year":"2022","journal-title":"Auton. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e48686","DOI":"10.15252\/embr.201948686","article-title":"PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics","volume":"21","author":"Han","year":"2020","journal-title":"EMBO Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1080\/15548627.2021.1907167","article-title":"The role of mitophagy in the regulation of mitochondrial energetic status in neurons","volume":"17","author":"Han","year":"2021","journal-title":"Autophagy"},{"key":"B44","doi-asserted-by":"publisher","first-page":"102010","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"107437","DOI":"10.1016\/j.phrs.2024.107437","article-title":"Deciphering the multifaceted roles and clinical implications of 2-hydroxyglutarate in cancer","volume":"209","author":"Hao","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41593-023-01568-1","article-title":"A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis","volume":"27","author":"Haynes","year":"2024","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial Ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and TBK1 activation to promote mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.1002\/alz.13847","article-title":"Urolithin A improves Alzheimer\u2019s disease cognition and restores mitophagy and lysosomal functions","volume":"20","author":"Hou","year":"2024","journal-title":"Alzheimers Dement."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1083\/jcb.201904148","article-title":"Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate","volume":"218","author":"Hunt","year":"2019","journal-title":"J. Cell Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/15548627.2023.2259215","article-title":"PA2G4\/EBP1 ubiquitination by PRKN\/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia","volume":"20","author":"Hwang","year":"2024","journal-title":"Autophagy"},{"key":"B51","doi-asserted-by":"publisher","first-page":"100303","DOI":"10.1016\/j.ynstr.2021.100303","article-title":"Chronic adolescent stress causes sustained impairment of cognitive flexibility and hippocampal synaptic strength in female rats","volume":"14","author":"Hyer","year":"2021","journal-title":"Neurobiol. Stress"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1093\/brain\/awac313","article-title":"DJ-1 is an essential downstream mediator in PINK1\/parkin-dependent mitophagy","volume":"145","author":"Imberechts","year":"2022","journal-title":"Brain"},{"key":"B53","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1038\/s41467-024-45044-1","article-title":"Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS\/STING inflammation during aging","volume":"15","author":"Jim\u00e9nez-Loygorri","year":"2024","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41586-024-08350-8","article-title":"Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice","volume":"638","author":"Jin","year":"2025","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nature12018","article-title":"Diverging neural pathways assemble a behavioural state from separable features in anxiety","volume":"496","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.jaac.2016.05.014","article-title":"Stressful life events during pregnancy and offspring depression: evidence from a prospective cohort study","volume":"55","author":"Kingsbury","year":"2016","journal-title":"J. Am. Acad. Child. Adolesc. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/nrc.2016.82","article-title":"Metabolic control of epigenetics in cancer","volume":"16","author":"Kinnaird","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41531-024-00696-0","article-title":"Elevated \u03b1-synuclein levels inhibit mitophagic flux","volume":"10","author":"Kinnart","year":"2024","journal-title":"NPJ Park. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e00292","DOI":"10.1016\/j.neurot.2023.10.002","article-title":"Mitochondrial dysfunction in neurodegenerative disorders","volume":"21","author":"Klemmensen","year":"2024","journal-title":"Neurotherapeutics"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells12232726","article-title":"The role of cortisol in chronic stress, neurodegenerative diseases, and psychological disorders","volume":"12","author":"Knezevic","year":"2023","journal-title":"Cells"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1080\/15548627.2017.1303021","article-title":"Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina","volume":"13","author":"Knuppertz","year":"2017","journal-title":"Autophagy"},{"key":"B63","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.3390\/ijms22116054","article-title":"Mitochondrial glucocorticoid receptors and their actions","volume":"22","author":"Kokkinopoulou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.3390\/ijms26052217","article-title":"The intersection of mitophagy and autism spectrum disorder: a systematic review","volume":"26","author":"Kovacheva","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e13076","DOI":"10.15252\/emmm.202013076","article-title":"SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models","volume":"13","author":"Kwon","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"113183","DOI":"10.1016\/j.celrep.2023.113183","article-title":"ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes","volume":"42","author":"Lee","year":"2023","journal-title":"Cell Rep."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1126\/science.aag3048","article-title":"Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging","volume":"359","author":"Leeman","year":"2018","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1002\/humu.24446","article-title":"Functional correlation of genome-wide DNA methylation profiles in genetic neurodevelopmental disorders","volume":"43","author":"Levy","year":"2022","journal-title":"Hum. Mutat."},{"key":"B69","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.neuron.2021.01.005","article-title":"Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory","volume":"109","author":"Li","year":"2021","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41419-022-04906-6","article-title":"Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death and Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41419-022-04613-2","article-title":"PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"101817","DOI":"10.1016\/j.arr.2022.101817","article-title":"PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases","volume":"84","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.freeradbiomed.2024.01.036","article-title":"Exercise couples mitochondrial function with skeletal muscle fiber type via ROS-mediated epigenetic modification","volume":"213","author":"Li","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1011580","DOI":"10.1371\/journal.pgen.1011580","article-title":"A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs","volume":"21","author":"Li","year":"2025","journal-title":"PLoS Genet."},{"key":"B75","doi-asserted-by":"publisher","first-page":"101507","DOI":"10.1016\/j.arr.2021.101507","article-title":"Stress and telomere shortening: insights from cellular mechanisms","volume":"73","author":"Lin","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1080\/15548627.2020.1848971","article-title":"Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy","volume":"17","author":"Lin","year":"2021","journal-title":"Autophagy"},{"key":"B77","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1080\/15548627.2020.1850008","article-title":"Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK\/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice","volume":"17","author":"Liu","year":"2021","journal-title":"Autophagy"},{"key":"B78","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.bbi.2024.04.036","article-title":"BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy","volume":"119","author":"Liu","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.neuron.2024.04.007","article-title":"MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons","volume":"112","author":"Liu","year":"2024","journal-title":"Neuron"},{"key":"B80","doi-asserted-by":"publisher","first-page":"100972","DOI":"10.1016\/j.mam.2021.100972","article-title":"Neuronal autophagy and mitophagy in Parkinson\u2019s disease","volume":"82","author":"Lizama","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"B81","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"177931","DOI":"10.1016\/j.ejphar.2025.177931","article-title":"Wnt5a-AS knockdown alleviates sevoflurane-induced depression by promoting hippocampal neurogenesis and mitochondrial fusion in adolescent rats","volume":"1003","author":"Lu","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.psyneuen.2007.06.005","article-title":"Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations","volume":"32","author":"Maccari","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.immuni.2019.12.003","article-title":"Microglia, lifestyle stress, and neurodegeneration","volume":"52","author":"Madore","year":"2020","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/s0140-6736(22)00821-2","article-title":"Complex post-traumatic stress disorder","volume":"400","author":"Maercker","year":"2022","journal-title":"Lancet"},{"key":"B86","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.tem.2007.04.004","article-title":"Mitochondria as key components of the stress response","volume":"18","author":"Manoli","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1017\/s003329172100249x","article-title":"Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents","volume":"53","author":"Marques-Feixa","year":"2023","journal-title":"Psychol. Med."},{"key":"B88","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13024-017-0170-3","article-title":"Quantitative proteomic analysis of Parkin substrates in Drosophila neurons","volume":"12","author":"Martinez","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"B89","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/npp.2015.171","article-title":"Stress effects on neuronal structure: hippocampus, Amygdala, and prefrontal cortex","volume":"41","author":"McEwen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.cmet.2017.12.008","article-title":"Basal mitophagy occurs independently of PINK1 in mouse tissues of high metabolic demand","volume":"27","author":"McWilliams","year":"2018","journal-title":"Cell Metab."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.gim.2022.04.003","article-title":"Heterozygous variants in CTR9, which encodes a major component of the PAF1 complex, are associated with a neurodevelopmental disorder","volume":"24","author":"Meuwissen","year":"2022","journal-title":"Genet. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/glia.23474","article-title":"Astrocyte-neuron lactate shuttle sensitizes nociceptive transmission in the spinal cord","volume":"67","author":"Miyamoto","year":"2019","journal-title":"Glia"},{"key":"B93","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/antiox13080985","article-title":"Gut Microbiota dysbiosis, oxidative stress, inflammation, and epigenetic alterations in metabolic diseases","volume":"13","author":"Mostafavi Abdolmaleky","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"B94","doi-asserted-by":"publisher","first-page":"969381","DOI":"10.3389\/fnagi.2022.969381","article-title":"Crosstalk of Alzheimer\u2019s disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: a translational neuroscience approach","volume":"14","author":"Muntsant","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"e06109","DOI":"10.1002\/advs.202506109","article-title":"Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics","volume":"12","author":"Muralidharan","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"B96","doi-asserted-by":"publisher","first-page":"11348","DOI":"10.1038\/s41598-018-29421-7","article-title":"Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy","volume":"8","author":"Napoli","year":"2018","journal-title":"Sci. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1177\/0271678x211027384","article-title":"Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity","volume":"41","author":"Napoli","year":"2021","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate Parkin","volume":"8","author":"Narendra","year":"2010","journal-title":"PLoS Biol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"25744","DOI":"10.1038\/s41598-025-11528-3","article-title":"Neuron-to-glia signaling drives critical period experience-dependent synapse pruning","volume":"15","author":"Nelson","year":"2025","journal-title":"Sci. Rep."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/j.molcel.2023.04.021","article-title":"Unconventional initiation of PINK1\/Parkin mitophagy by Optineurin","volume":"83","author":"Nguyen","year":"2023","journal-title":"Mol. Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.bbi.2019.11.024","article-title":"Childhood trauma, HPA axis activity and antidepressant response in patients with depression","volume":"87","author":"Nikkheslat","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1146\/annurev-psych-062520-122331","article-title":"Stress and health: a review of psychobiological processes","volume":"72","author":"O\u2019Connor","year":"2021","journal-title":"Annu. Rev. Psychol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","article-title":"The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics","volume":"66","author":"Panigrahi","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by Microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"B106","doi-asserted-by":"publisher","first-page":"150","DOI":"10.14336\/ad.2015.0820","article-title":"The role of autophagy, mitophagy and lysosomal functions in modulating bioenergetics and survival in the context of redox and proteotoxic damage: implications for neurodegenerative diseases","volume":"7","author":"Redmann","year":"2016","journal-title":"Aging Dis."},{"key":"B107","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41583-021-00540-x","article-title":"The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders","volume":"23","author":"Sanacora","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"100636","DOI":"10.1016\/j.ynstr.2024.100636","article-title":"Early-life stress impairs acquisition and retrieval of fear memories: sex-effects, corticosterone modulation, and partial prevention by targeting glucocorticoid receptors at adolescent age","volume":"31","author":"Sanguino-G\u00f3mez","year":"2024","journal-title":"Neurobiol. Stress"},{"key":"B109","doi-asserted-by":"publisher","first-page":"115652","DOI":"10.1016\/j.biopha.2023.115652","article-title":"Mitochondrial dysfunction: a fatal blow in depression","volume":"167","author":"Song","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B110","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41586-023-05927-7","article-title":"Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms","volume":"616","author":"Soto","year":"2023","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-cellbio-100818-125242","article-title":"Autophagy in neurons","volume":"35","author":"Stavoe","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.3390\/ijms22094594","article-title":"Mitochondrial DNA methylation and human diseases","volume":"22","author":"Stoccoro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2023","journal-title":"Autophagy"},{"key":"B114","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/neuonc\/noad232","article-title":"Metabolic modulation of histone acetylation mediated by HMGCL activates the FOXM1\/\u03b2-catenin pathway in glioblastoma","volume":"26","author":"Sun","year":"2024","journal-title":"Neuro Oncol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"9661","DOI":"10.3390\/ijms21249661","article-title":"Mitophagy and the brain","volume":"21","author":"Swerdlow","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"e57265","DOI":"10.15252\/embr.202357265","article-title":"Lysosomes in senescence and aging","volume":"24","author":"Tan","year":"2023","journal-title":"EMBO Rep."},{"key":"B117","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/15548627.2019.1607686","article-title":"Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics","volume":"16","author":"Thangaraj","year":"2020","journal-title":"Autophagy"},{"key":"B118","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neubiorev.2017.07.003","article-title":"Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy","volume":"117","author":"Van den Bergh","year":"2020","journal-title":"Neurosci. Biobehav Rev."},{"key":"B160","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","article-title":"Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration","volume":"11","author":"Verma","year":"2022","journal-title":"Transl Neurodegener"},{"key":"B161","doi-asserted-by":"publisher","first-page":"11151","DOI":"10.1523\/jneurosci.3791-16.2017","article-title":"Mitochondrial calcium dysregulation contributes to dendrite degeneration mediated by PD\/LBD-associated LRRK2 mutants","volume":"37","author":"Verma","year":"2017","journal-title":"J. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.1038\/s41380-024-02534-4","article-title":"Brain stars take the lead during critical periods of early postnatal brain development: relevance of astrocytes in health and mental disorders","volume":"29","author":"Vivi","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.3390\/cells12232761","article-title":"Early Age- and sex-dependent regulation of Astrocyte-mediated glutamatergic synapse elimination in the rat prefrontal cortex: establishing an organotypic brain slice culture investigating tool","volume":"12","author":"Vivi","year":"2023","journal-title":"Cells"},{"key":"B121","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1101\/gad.331272.119","article-title":"Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence","volume":"34","author":"Vizioli","year":"2020","journal-title":"Genes Dev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1165\/rcmb.2020-0008OC","article-title":"Mitochondrial fission mediated cigarette smoke-induced pulmonary endothelial injury","volume":"63","author":"Wang","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s40168-023-01656-1","article-title":"Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e0041523","DOI":"10.1128\/msystems.00415-23","article-title":"Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition","volume":"8","author":"Wang","year":"2023","journal-title":"mSystems"},{"key":"B125","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/15548627.2023.2276639","article-title":"CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"key":"B126","doi-asserted-by":"publisher","first-page":"eadk8249","DOI":"10.1126\/scisignal.adk8249","article-title":"Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice","volume":"17","author":"Wang","year":"2024","journal-title":"Sci. Signal"},{"key":"B127","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12035-025-05640-8","article-title":"Microglia mitochondrial metabolism in neurological diseases","volume":"63","author":"Wang","year":"2026","journal-title":"Mol. Neurobiol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40104-025-01180-2","article-title":"ROS-DRP1-mediated excessive mitochondrial fission and autophagic flux inhibition contribute to heat stress-induced apoptosis in goat Sertoli cells","volume":"16","author":"Wen","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1080\/15548627.2020.1802089","article-title":"BNIP3L\/NIX degradation leads to mitophagy deficiency in ischemic brains","volume":"17","author":"Wu","year":"2021","journal-title":"Autophagy"},{"key":"B131","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41551-021-00819-5","article-title":"Amelioration of Alzheimer\u2019s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow","volume":"6","author":"Xie","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"B132","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B133","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.immuni.2024.11.017","article-title":"The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance","volume":"58","author":"Xu","year":"2025","journal-title":"Immunity"},{"key":"B134","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/neuonc\/noy146","article-title":"Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide","volume":"21","author":"Yamashita","year":"2019","journal-title":"Neuro Oncol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1186\/s12967-023-04560-2","article-title":"Knockdown of NR3C1 inhibits the proliferation and migration of clear cell renal cell carcinoma through activating endoplasmic reticulum stress-mitophagy","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"key":"B136","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/nu15010038","article-title":"Glucagon-like peptide 1 receptor activation inhibits microglial pyroptosis via promoting mitophagy to alleviate depression-like behaviors in diabetic mice","volume":"15","author":"Yang","year":"2022","journal-title":"Nutrients"},{"key":"B137","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12974-023-02715-y","article-title":"Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy","volume":"20","author":"Yang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B138","doi-asserted-by":"publisher","first-page":"e174600","DOI":"10.1172\/jci.insight.174600","article-title":"Immunometabolite L-2-HG promotes epigenetic modification of exhausted T cells and improves antitumor immunity","volume":"10","author":"Yang","year":"2025","journal-title":"JCI Insight"},{"key":"B139","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41419-022-05364-w","article-title":"Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"B140","doi-asserted-by":"publisher","first-page":"117784","DOI":"10.1016\/j.bcp.2026.117784","article-title":"Prenatally elevated glucocorticoid disrupts social behavior via GR-Id3\/E47-dependent astroglial dysfunction in LPS-induced autism-like rats","volume":"247","author":"Yuan","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12974-021-02334-5","article-title":"Mitophagy in neurological disorders","volume":"18","author":"Zhang","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"B142","doi-asserted-by":"publisher","first-page":"131750","DOI":"10.1016\/j.jhazmat.2023.131750","article-title":"MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy","volume":"457","author":"Zhang","year":"2023","journal-title":"J. Hazard Mater"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1161\/circulationaha.123.068358","article-title":"Rectifying METTL4-Mediated N(6)-Methyladenine excess in mitochondrial DNA alleviates heart failure","volume":"150","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"B144","doi-asserted-by":"publisher","first-page":"116410","DOI":"10.1016\/j.bcp.2024.116410","article-title":"N6-methyldeoxyadenosine modification difference contributes to homocysteine-induced mitochondrial perturbation in rat hippocampal primary neurons and PC12 cells","volume":"226","author":"Zhang","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12974-024-03285-3","article-title":"Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review","volume":"21","author":"Zhang","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"B146","doi-asserted-by":"publisher","first-page":"118846","DOI":"10.1016\/j.ecoenv.2025.118846","article-title":"Bisphenol AF exposure induced synaptic plasticity and neurobehavioral impairments via triggering the ROS-mediated PERK-eIF2\u03b1-ATF4 signaling pathway in adolescent mice","volume":"303","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B147","doi-asserted-by":"publisher","first-page":"103668","DOI":"10.1016\/j.redox.2025.103668","article-title":"Homocysteine induced N6-methyldeoxyadenosine modification perturbation elicits mitochondria dysfunction contributes to the impairment of learning and memory ability caused by early life stress in rats","volume":"84","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"e13400","DOI":"10.1002\/advs.202513400","article-title":"Flipping the switch: MeCP2-Mediated lactylation rewires microglial metabolism and inflammation via the HK2\/mTOR axis in poststroke neuroinflammation","volume":"13","author":"Zhang","year":"2026","journal-title":"Adv. Sci. (Weinh)"},{"key":"B149","doi-asserted-by":"publisher","first-page":"103156","DOI":"10.1016\/j.redox.2024.103156","article-title":"Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy","volume":"72","author":"Zhao","year":"2024","journal-title":"Redox Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1080\/15548627.2019.1668228","article-title":"The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy","volume":"16","author":"Zheng","year":"2020","journal-title":"Autophagy"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e13622","DOI":"10.1111\/acel.13622","article-title":"Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation","volume":"21","author":"Zhong","year":"2022","journal-title":"Aging Cell"},{"key":"B152","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS-STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"B153","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.jare.2025.07.035","article-title":"MeCP2 dysregulation inhibits mitophagy and impairs neural development in cortical organoids","volume":"82","author":"Zhou","year":"2026","journal-title":"J. Adv. Res."},{"key":"B154","doi-asserted-by":"publisher","first-page":"101854","DOI":"10.1016\/j.redox.2021.101854","article-title":"Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2\/ATF4\/BNIP3-dependent mitophagy in placental trophoblasts","volume":"40","author":"Zhu","year":"2021","journal-title":"Redox Biol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/s41419-021-04433-w","article-title":"Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate A\u03b2 production","volume":"12","author":"Zhuravleva","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1808059\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:05:59Z","timestamp":1784095559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1808059\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":157,"alternative-id":["10.3389\/fcell.2026.1808059"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1808059","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"article-number":"1808059"}}