{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:11:34Z","timestamp":1790964694104,"version":"4.1.0"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Solute carrier family 40 member 1 (SLC40A1) encodes ferroportin 1 (FPN1), the only known iron efflux transporter in mammalian cells, which is critical for maintaining systemic iron homeostasis and cellular iron balance. SLC40A1 plays a key role in regulating iron homeostasis and is involved in the pathogenesis of inflammatory, fibrotic, neurodegenerative diseases, and cancer, with dysfunction linked to mutations or epigenetic silencing. Its biological functions and regulatory mechanisms are complex and diverse. This article provides an overview of SLC40A1\u2019s molecular and biological properties, elucidates its involvement in disease progression, and evaluates its clinical potential. The study seeks to enhance understanding of SLC40A1\u2019s mechanisms, laying the groundwork for the development of targeted therapies.<\/jats:p>","DOI":"10.3389\/fcell.2026.1816800","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:30:58Z","timestamp":1778477458000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["SLC40A1 (iron transporter): mechanistic regulation, role in disease pathogenesis, and prospects for targeted therapy"],"prefix":"10.3389","volume":"14","author":[{"given":"Limian","family":"Huang","sequence":"first","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pan","sequence":"additional","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Qin","sequence":"additional","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Qin","sequence":"additional","affiliation":[{"name":"Baise People\u2019s Hospital","place":["Baise, Guangxi, China"]},{"name":"Affiliated Southwest Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/1873-3468.70040","article-title":"Identification of novel small molecule inhibitors of ETS transcription factors","volume":"599","author":"Abdalla","year":"2025","journal-title":"FEBS Lett."},{"key":"B2","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1055\/s-0031-1286059","article-title":"The molecular pathogenesis of hereditary hemochromatosis","volume":"31","author":"Babitt","year":"2011","journal-title":"Semin. 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