{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:07:55Z","timestamp":1779084475416,"version":"3.51.4"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Shaping the face requires the coordination of molecular and cellular behaviours that direct tissue-wide dynamics of development. A limited, well-conserved suite of cell behaviours, including cell proliferation, facilitate cellular contributions to morphogenesis, which are in turn regulated by the tissues they comprise. However, the role of cell behaviours in early facial tissues remains poorly characterized, despite underlying both healthy and syndromic facial development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By integrating light-sheet fluorescence microscopy, shape quantification, and semi-automated image segmentation, we resolve individual cell behaviours and their relationships to morphogenesis across large tissue domains in the developing mandible. We focus on cell proliferation and mitotic orientation, but also analyze cellular morphology and cell-tissue relationships via positional orientation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we describe three-dimensional patterns of cell behaviours in the context of mandibular morphogenesis. We show that several cell behaviours are mediolaterally patterned in tandem at E10.5, a critical point in development. These patterns align with preceding growth, and occur several days before the onset of cell fate commitment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These observations reflect the reciprocal interplay between molecular, cellular, and tissue-level processes, highlighting how subtle differences in cell behaviours are connected to complex growth patterns even in largely homogeneous tissues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1823297","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:43:48Z","timestamp":1779083028000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Three-dimensional cellular dynamics and mandibular morphogenesis"],"prefix":"10.3389","volume":"14","author":[{"given":"Andreas","family":"Dauter","sequence":"first","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary","place":["Calgary, AB, Canada"]},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia K.","family":"Malhi","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary","place":["Calgary, AB, Canada"]},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas D.","family":"Lo Vercio","sequence":"additional","affiliation":[{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.","family":"Barretto","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary","place":["Calgary, AB, Canada"]},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M. T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary","place":["Calgary, AB, Canada"]},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassidy","family":"Da Silva","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, University of Calgary","place":["Calgary, AB, Canada"]},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph S.","family":"Marcucio","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of California, San Francisco (UCSF)","place":["San Francisco, CA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Hallgr\u00edmsson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology & Anatomy, Cumming School of Medicine, University of Calgary","place":["Calgary, AB, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1242\/dev.140764","article-title":"Spindle orientation: a question of complex positioning","volume":"144","author":"Bergstralh","year":"2017","journal-title":"Development"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1000420","DOI":"10.1371\/journal.pbio.1000420","article-title":"The role of spatially controlled cell proliferation in limb bud morphogenesis","volume":"8","author":"Boehm","year":"2010","journal-title":"PLOS Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.7863\/jum.1994.13.7.529","article-title":"Fetal micrognathia: associated anomalies and outcome","volume":"13","author":"Bromley","year":"1994","journal-title":"J. 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