{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:35Z","timestamp":1790885255682,"version":"4.1.0"},"reference-count":148,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Hair follicle miniaturization is a quantifiable histopathological endpoint shared by multiple forms of alopecia. The conventional \u201cstem cell\u2013centric\u201d view often attributes regenerative failure to depletion or intrinsic dysfunction of hair follicle stem cells (HFSCs). However, in canonical trajectories such as human androgenetic alopecia, HFSC-related populations may remain detectable by marker-based analyses, whereas progenitor output is reduced. This pattern suggests that impaired conversion from quiescent HFSCs into an expandable progenitor\/transit-amplifying compartment may contribute to miniaturization, while not excluding concomitant HFSC functional decline. We therefore propose \u201cniche identity,\u201d which treats the follicular niche as a set of measurable, stratifiable, and intervention-amenable structural\u2013mechanical constraints. We posit that the collagen network may act as an integrative hub that influences regenerative thresholds and the stability of lineage output through interfacial continuity, fibrillar topology, and local mechanical states. Niche identity is defined here by five coupled state variables: basement membrane boundary integrity, adhesion\/anchoring apparatuses, fibrillar topological organization, mechanical set-points, and hair cycle\u2013scaled dynamic remodeling windows. We propose that these elements may drift coordinately under androgen-biased profibrotic remodeling, chronic low-grade inflammation with MMP-mediated matrix degradation, and aging\/glycation-associated crosslinking and stiffening, thereby locking follicles into a low-output steady state. Finally, we discuss \u201csignal\u2013structure mismatch\u201d as a plausible basis for unstable therapeutic responses and relapse and propose a niche identity\u2013oriented translational framework intended to guide future experimental testing and endpoint selection.<\/jats:p>","DOI":"10.3389\/fcell.2026.1824126","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:08:00Z","timestamp":1780034880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["From a stem-cell\u2013centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization"],"prefix":"10.3389","volume":"14","author":[{"given":"Zhounan","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Basic Medical Sciences, Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Medical Cosmetic Center, Affiliated Hangzhou First People\u2019s Hospital, Westlake University School of Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"843127","DOI":"10.3389\/fmed.2022.843127","article-title":"Treatment of androgenetic alopecia using PRP to target dysregulated mechanisms and pathways","volume":"9","author":"Abdin","year":"2022","journal-title":"Front. 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